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Doxycycline prophylaxis for the prevention of sexually transmitted infections: A systematic review and meta-analysis of randomized controlled trials.
Szondy I, Meznerics FA, Lőrincz K, Kemény LV, Walter A, Mohammed AA, Hegyi P, Kiss N, Bánvölgyi A. Szondy I, et al. Int J Infect Dis. 2024 Oct;147:107186. doi: 10.1016/j.ijid.2024.107186. Epub 2024 Aug 8. Int J Infect Dis. 2024. PMID: 39122208 Free article.
For doxy-PEP, including MSM and TGW only, the RR observed for overall STI incidence was 0.40 (95% CI: 0.28-0.57; I2 = 37%), 0.19 (95% CI: 0.08-0.44; I2 = 39%) for chlamydia, 0.23 (0.14-0.36; I2 = 0%) for syphilis and 0.55 (95% CI: 0.34-0.87; I2 = 41%) for gon …
For doxy-PEP, including MSM and TGW only, the RR observed for overall STI incidence was 0.40 (95% CI: 0.28-0.57; I2 = 3 …
CDC Clinical Guidelines on the Use of Doxycycline Postexposure Prophylaxis for Bacterial Sexually Transmitted Infection Prevention, United States, 2024.
Bachmann LH, Barbee LA, Chan P, Reno H, Workowski KA, Hoover K, Mermin J, Mena L. Bachmann LH, et al. MMWR Recomm Rep. 2024 Jun 6;73(2):1-8. doi: 10.15585/mmwr.rr7302a1. MMWR Recomm Rep. 2024. PMID: 38833414 Free PMC article.
This report outlines CDC's recommendation for the use of doxycycline postexposure prophylaxis (doxy PEP), a novel, ongoing, patient-managed biomedical STI prevention strategy for a selected population. CDC recommends that MSM and TGW who have ha …
This report outlines CDC's recommendation for the use of doxycycline postexposure prophylaxis (doxy PEP), a novel, ongoing, pa …
Characteristics of Kenyan women using HIV PrEP enrolled in a randomized trial on doxycycline postexposure prophylaxis for sexually transmitted infection prevention.
Oware K, Adiema L, Rono B, Violette LR, McClelland RS, Donnell D, Scoville CW, Odoyo J, Baeten JM, Bukusi E, Stewart J. Oware K, et al. BMC Womens Health. 2023 Jun 3;23(1):296. doi: 10.1186/s12905-023-02413-0. BMC Womens Health. 2023. PMID: 37270546 Free PMC article. Clinical Trial.
Young women in sub-Saharan Africa have a high prevalence and incidence of both curable STIs and HIV. The use of doxycycline as a prophylaxis to prevent STIs is promising; however, clinical trials, to date, have only been conducted among men who have se …
Young women in sub-Saharan Africa have a high prevalence and incidence of both curable STIs and HIV. The use of doxycycline as a prop …
Position statement of the German STI Society on the prophylactic use of doxycycline to prevent STIs (Doxy-PEP, Doxy-PrEP).
Werner RN, Schmidt AJ, Potthoff A, Spornraft-Ragaller P, Brockmeyer NH; German STI Society (DSTIG). Werner RN, et al. J Dtsch Dermatol Ges. 2024 Mar;22(3):466-478. doi: 10.1111/ddg.15282. Epub 2023 Dec 20. J Dtsch Dermatol Ges. 2024. PMID: 38123738
Over the past two decades, there has been a rise in the incidence of syphilis, particularly among men who have sex with men (MSM). This has sparked interest in studying the prophylactic use of doxycycline to prevent syphilis and other sexually transmitted inf …
Over the past two decades, there has been a rise in the incidence of syphilis, particularly among men who have sex with men (MSM). Th …
Doxycycline post-exposure prophylaxis for sexually transmitted infections in South Africa.
Peters RPH, McIntyre JA, Garrett N, Brink AJ, Celum CL, Bekker LG. Peters RPH, et al. South Afr J HIV Med. 2023 Sep 28;24(1):1510. doi: 10.4102/sajhivmed.v24i1.1510. eCollection 2023. South Afr J HIV Med. 2023. PMID: 37795430 Free PMC article.
South Africa has a large burden of bacterial sexually transmitted infections (STIs) with high rates among men who have sex with men (MSM). Randomised controlled trials have recently demonstrated high effectiveness of doxycycline post-exposure prophylax …
South Africa has a large burden of bacterial sexually transmitted infections (STIs) with high rates among men who have sex with men (MSM …
Doxycycline Post-Exposure Prophylaxis for Bacterial Sexually Transmitted Infections: The Current Landscape and Future Directions.
Allan-Blitz LT, Mayer KH. Allan-Blitz LT, et al. Curr HIV/AIDS Rep. 2024 Oct 30;22(1):1. doi: 10.1007/s11904-024-00709-w. Curr HIV/AIDS Rep. 2024. PMID: 39476167 Free PMC article. Review.
PURPOSE OF REVIEW: The incidence of bacterial sexually transmitted infections (STI) continues to rise particularly among men who have sex with men (MSM). Doxycycline post-exposure prophylaxis (doxy-PEP) has emerged as a promising biomedical preventi …
PURPOSE OF REVIEW: The incidence of bacterial sexually transmitted infections (STI) continues to rise particularly among men who have …
Non-conventional interventions to prevent gonorrhea or syphilis among men who have sex with men: A scoping review.
Tran J, Fairley CK, Bowesman H, Aung ET, Ong JJ, Chow EPF. Tran J, et al. Front Med (Lausanne). 2022 Sep 20;9:952476. doi: 10.3389/fmed.2022.952476. eCollection 2022. Front Med (Lausanne). 2022. PMID: 36203757 Free PMC article.
These studies were conducted in Australia (n = 3), Belgium (n = 2), China (n = 3), the Netherlands (n = 1) and the US (n = 4). Two randomized controlled trials (RCTs) of doxycycline as pre-exposure prophylaxis (PrEP) and post-exposure prophylaxis (PEP) …
These studies were conducted in Australia (n = 3), Belgium (n = 2), China (n = 3), the Netherlands (n = 1) and the US (n = 4). Two random …
Doxycycline prophylaxis is effective as pre-exposure and post-exposure regimens in the prevention of sexually transmitted infections: an updated systematic review and meta-analysis.
Zhao P, Zou Q, Tucker J, Fitzpatrick T, Tang W. Zhao P, et al. Sex Health. 2026 Apr 9;23(2):SH25227. doi: 10.1071/SH25227. Sex Health. 2026. PMID: 41800911
BACKGROUND: Recent systematic reviews have demonstrated the efficacy of doxycycline prophylaxis in preventing bacterial sexually transmitted infections (STIs) in randomised controlled trials (RCTs). ...Integrating doxy PrEP or doxy PEP as a biom …
BACKGROUND: Recent systematic reviews have demonstrated the efficacy of doxycycline prophylaxis in preventing bacterial sexual …
Pay-it-forward and social network distribution to increase doxycycline post-exposure prophylaxis uptake among men who have sex with men and transgender women in China: study protocol for a three-arm randomised controlled trial.
Zhao P, Xu W, Tucker JD, Tang W, Weideman AM, Enders K, Liang P, Huang S, Fitzpatrick T, Wang C. Zhao P, et al. BMJ Open. 2025 Aug 12;15(8):e093944. doi: 10.1136/bmjopen-2024-093944. BMJ Open. 2025. PMID: 40803730 Free PMC article.
INTRODUCTION: Doxycycline postexposure prophylaxis (doxy-PEP) can prevent sexually transmitted infections (STIs) among men who have sex with men (MSM) and transgender women (TGW). STI rates are high among MSM and TGW in China, and impleme …
INTRODUCTION: Doxycycline postexposure prophylaxis (doxy-PEP) can prevent sexually transmitted infections (STIs) among …
Doxycycline post-exposure prophylaxis (Doxy-PEP) in Czech clinical practice: a review of efficacy, safety, and implications for antimicrobial resistance.
Broul M, Dlouhý P. Broul M, et al. Cas Lek Cesk. 2025;164(7-8):311-315. Cas Lek Cesk. 2025. PMID: 41615788 Review. English.
In 2024, the U.S. Centers for Disease Control and Prevention (CDC) published the first clinical guidance recommending targeted use of Doxy-PEP for MSM/TGW with a bacterial sexually transmitted infection (STI) in the previous 12 mon …
In 2024, the U.S. Centers for Disease Control and Prevention (CDC) published the first clinical guidance recomme …
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