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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1967 1
1969 1
1971 1
1974 1
1975 2
1978 1
1979 1
1980 1
1981 1
1982 1
1983 1
1984 2
1985 4
1986 3
1987 2
1988 3
1990 7
1991 2
1992 5
1993 6
1994 16
1995 16
1996 14
1997 32
1998 30
1999 33
2000 58
2001 58
2002 88
2003 68
2004 69
2005 58
2006 78
2007 64
2008 66
2009 76
2010 97
2011 110
2012 126
2013 107
2014 114
2015 110
2016 132
2017 133
2018 139
2019 114
2020 136
2021 127
2022 85
2023 63
2024 103
2025 130
2026 70

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2,529 results

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Page 1
Human disease models in Drosophila melanogaster and the role of the fly in therapeutic drug discovery.
Pandey UB, Nichols CD. Pandey UB, et al. Pharmacol Rev. 2011 Jun;63(2):411-36. doi: 10.1124/pr.110.003293. Epub 2011 Mar 17. Pharmacol Rev. 2011. PMID: 21415126 Free PMC article. Review.
The common fruit fly, Drosophila melanogaster, is a well studied and highly tractable genetic model organism for understanding molecular mechanisms of human diseases. ...The fly can effectively be used for low- to high-throughput drug screens as well as in ta …
The common fruit fly, Drosophila melanogaster, is a well studied and highly tractable genetic model organism for understanding molecu …
Animal Models of Kidney Disease: Challenges and Perspectives.
Liang J, Liu Y. Liang J, et al. Kidney360. 2023 Oct 1;4(10):1479-1493. doi: 10.34067/KID.0000000000000227. Kidney360. 2023. PMID: 37526653 Free PMC article. Review.
Despite many limitations and pitfalls, animal models play an essential and irreplaceable role in gaining novel insights into the mechanisms, pathologies, and therapeutic targets of kidney disease. In this review, we highlight commonly used animal models of kidney …
Despite many limitations and pitfalls, animal models play an essential and irreplaceable role in gaining novel insights into the mechanisms, …
Hedgehog signaling mechanism and role in cancer.
Jiang J. Jiang J. Semin Cancer Biol. 2022 Oct;85:107-122. doi: 10.1016/j.semcancer.2021.04.003. Epub 2021 Apr 6. Semin Cancer Biol. 2022. PMID: 33836254 Free PMC article. Review.
Deregulation of these signaling pathways has been implicated in a wide range of human diseases including cancer. One such pathway is the Hedgehog (Hh) pathway, which was originally discovered in Drosophila and later found to play a fundamental role in huma …
Deregulation of these signaling pathways has been implicated in a wide range of human diseases including cancer. One such path …
Drosophila melanogaster: How and Why It Became a Model Organism.
Giansanti MG, Frappaolo A, Piergentili R. Giansanti MG, et al. Int J Mol Sci. 2025 Aug 2;26(15):7485. doi: 10.3390/ijms26157485. Int J Mol Sci. 2025. PMID: 40806617 Free PMC article. Review.
Drosophila melanogaster is one of the most known and used organisms worldwide, not just to study general biology problems but above all for modeling complex human diseases. ...We also provide some examples of how it is used to study human diseases …
Drosophila melanogaster is one of the most known and used organisms worldwide, not just to study general biology problems but above a …
Drosophila Innate Immunity Involves Multiple Signaling Pathways and Coordinated Communication Between Different Tissues.
Yu S, Luo F, Xu Y, Zhang Y, Jin LH. Yu S, et al. Front Immunol. 2022 Jul 7;13:905370. doi: 10.3389/fimmu.2022.905370. eCollection 2022. Front Immunol. 2022. PMID: 35911716 Free PMC article. Review.
In this review, we discuss the signaling pathways activated in Drosophila innate immunity, namely, the Toll, Imd, JNK, JAK/STAT pathways, and other factors, as well as relevant regulatory networks. ...Furthermore, the latest studies in this field are outlined in thi …
In this review, we discuss the signaling pathways activated in Drosophila innate immunity, namely, the Toll, Imd, JNK, JAK/STA …
Exploring the versatility of Drosophila melanogaster as a model organism in biomedical research: a comprehensive review.
Victor Atoki A, Aja PM, Shinkafi TS, Ondari EN, Adeniyi AI, Fasogbon IV, Dangana RS, Shehu UU, Akin-Adewumi A. Victor Atoki A, et al. Fly (Austin). 2025 Dec;19(1):2420453. doi: 10.1080/19336934.2024.2420453. Epub 2024 Dec 25. Fly (Austin). 2025. PMID: 39722550 Free PMC article. Review.
Drosophila melanogaster is a highly versatile model organism that has profoundly advanced our understanding of human diseases. ...Articles were selected based on their relevance, impact and contribution to the field, with a particular focus on studies offerin …
Drosophila melanogaster is a highly versatile model organism that has profoundly advanced our understanding of human diseas …
Relating the Biogenesis and Function of P Bodies in Drosophila to Human Disease.
Wilby EL, Weil TT. Wilby EL, et al. Genes (Basel). 2023 Aug 24;14(9):1675. doi: 10.3390/genes14091675. Genes (Basel). 2023. PMID: 37761815 Free PMC article. Review.
Drosophila has been a premier model organism for over a century and many discoveries in flies have furthered our understanding of human disease. ...Condensate biology has exciting research prospects because of their diverse roles within cells, links to dis …
Drosophila has been a premier model organism for over a century and many discoveries in flies have furthered our understanding of …
From Drosophila to Human: Biological Function of E3 Ligase Godzilla and Its Role in Disease.
Cabana VC, Lussier MP. Cabana VC, et al. Cells. 2022 Jan 23;11(3):380. doi: 10.3390/cells11030380. Cells. 2022. PMID: 35159190 Free PMC article. Review.
Because the E3 ligases regulate so many physiological events, they are also associated with pathologic conditions, such as cancer, neurological disorders, and immune-related diseases. This review focuses specifically on the protease-associated transmembrane-containi …
Because the E3 ligases regulate so many physiological events, they are also associated with pathologic conditions, such as cancer, neurologi …
Lysosome-related organelles.
Dell'Angelica EC, Mullins C, Caplan S, Bonifacino JS. Dell'Angelica EC, et al. FASEB J. 2000 Jul;14(10):1265-78. doi: 10.1096/fj.14.10.1265. FASEB J. 2000. PMID: 10877819 Review.
Abnormalities in both lysosomes and lysosome-related organelles have been observed in human genetic diseases such as the Chediak-Higashi and Hermansky-Pudlak syndromes, further demonstrating the close relationship between these organelles. Identification of genes mu …
Abnormalities in both lysosomes and lysosome-related organelles have been observed in human genetic diseases such as the Chedi …
Human mitochondrial DNA diseases and Drosophila models.
Chen Z, Zhang F, Xu H. Chen Z, et al. J Genet Genomics. 2019 Apr 20;46(4):201-212. doi: 10.1016/j.jgg.2019.03.009. Epub 2019 Apr 23. J Genet Genomics. 2019. PMID: 31076279 Review.
Mutations that disrupt the mitochondrial genome cause a number of human diseases whose phenotypic presentation varies widely among tissues and individuals. ...In this review, we summarize mtDNA genetics and human mtDNA-related diseases. We highl …
Mutations that disrupt the mitochondrial genome cause a number of human diseases whose phenotypic presentation varies widely a …
2,529 results