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A Drosophila model of the rhabdomyosarcoma initiator PAX7-FKHR.
Galindo RL, Allport JA, Olson EN. Galindo RL, et al. Proc Natl Acad Sci U S A. 2006 Sep 5;103(36):13439-44. doi: 10.1073/pnas.0605926103. Epub 2006 Aug 28. Proc Natl Acad Sci U S A. 2006. PMID: 16938866 Free PMC article.
Alveolar rhabdomyosarcoma (ARMS) is an aggressive myogenic-type tumor and a gain-of-function disease, caused by misexpression of the PAX3-FKHR or PAX7-FKHR fusion oncoprotein from structurally rearranged chromosomes. PAX3-FKHR misexpressed in terminally differentiating mou …
Alveolar rhabdomyosarcoma (ARMS) is an aggressive myogenic-type tumor and a gain-of-function disease, caused by misexpression of the …
Zebrafish models of rhabdomyosarcoma.
Chen EY, Langenau DM. Chen EY, et al. Methods Cell Biol. 2011;105:383-402. doi: 10.1016/B978-0-12-381320-6.00016-3. Methods Cell Biol. 2011. PMID: 21951539 Free PMC article.
Rhabdomyosarcoma (RMS), an aggressive malignant neoplasm that shows features of skeletal muscle, is the most common soft tissue tumor of childhood. ...Several in vivo models of RMS have been developed in mouse, human xenografts, zebrafish, and Drosophila to better u …
Rhabdomyosarcoma (RMS), an aggressive malignant neoplasm that shows features of skeletal muscle, is the most common soft tissue tumor …
Hedgehog signalling in cancer.
Toftgård R. Toftgård R. Cell Mol Life Sci. 2000 Nov;57(12):1720-31. doi: 10.1007/PL00000654. Cell Mol Life Sci. 2000. PMID: 11130178 Free PMC article. Review.
It now appears that constitutive activation of Hedgehog signalling, by inactivating mutations in PTCH1 or activating mutations in the coreceptor SMOH, is required and possibly sufficient for basal cell carcinoma development and also contributes to the formation of a variety of ot …
It now appears that constitutive activation of Hedgehog signalling, by inactivating mutations in PTCH1 or activating mutations in the corece …
A rapid one-generation genetic screen in a Drosophila model to capture rhabdomyosarcoma effectors and therapeutic targets.
Galindo KA, Endicott TR, Avirneni-Vadlamudi U, Galindo RL. Galindo KA, et al. G3 (Bethesda). 2014 Dec 9;5(2):205-17. doi: 10.1534/g3.114.015818. G3 (Bethesda). 2014. PMID: 25491943 Free PMC article.
Rhabdomyosarcoma (RMS) is an aggressive childhood malignancy of neoplastic muscle-lineage precursors that fail to terminally differentiate into syncytial muscle. ...These studies show the utility of the PAX-FOXO1 Drosophila system as a robust one-generation (F1) RMS …
Rhabdomyosarcoma (RMS) is an aggressive childhood malignancy of neoplastic muscle-lineage precursors that fail to terminally differen …
Drosophila and mammalian models uncover a role for the myoblast fusion gene TANC1 in rhabdomyosarcoma.
Avirneni-Vadlamudi U, Galindo KA, Endicott TR, Paulson V, Cameron S, Galindo RL. Avirneni-Vadlamudi U, et al. J Clin Invest. 2012 Jan;122(1):403-7. doi: 10.1172/JCI59877. Epub 2011 Dec 19. J Clin Invest. 2012. PMID: 22182840 Free PMC article.
Rhabdomyosarcoma (RMS) is a malignancy of muscle myoblasts, which fail to exit the cell cycle, resist terminal differentiation, and are blocked from fusing into syncytial skeletal muscle. In some patients, RMS is caused by a translocation that generates the fusion oncoprot …
Rhabdomyosarcoma (RMS) is a malignancy of muscle myoblasts, which fail to exit the cell cycle, resist terminal differentiation, and a …
The role of glypicans in Hedgehog signaling.
Filmus J, Capurro M. Filmus J, et al. Matrix Biol. 2014 Apr;35:248-52. doi: 10.1016/j.matbio.2013.12.007. Epub 2014 Jan 8. Matrix Biol. 2014. PMID: 24412155 Free article. Review.
In addition, GPCs have been shown to be involved in the formation of Hh gradients in the imaginal wing disks in Drosophila. In this review we will discuss the role of various glypicans in specific developmental events in the embryo that are regulated by Hh signaling. In ad …
In addition, GPCs have been shown to be involved in the formation of Hh gradients in the imaginal wing disks in Drosophila. In this r …
Selective Targeting of Myoblast Fusogenic Signaling and Differentiation-Arrest Antagonizes Rhabdomyosarcoma Cells.
Granados VA, Avirneni-Vadlamudi U, Dalal P, Scarborough SR, Galindo KA, Mahajan P, Galindo RL. Granados VA, et al. Cancer Res. 2019 Sep 15;79(18):4585-4591. doi: 10.1158/0008-5472.CAN-18-2096. Epub 2019 Jul 22. Cancer Res. 2019. PMID: 31331911 Free PMC article.
Rhabdomyosarcoma (RMS) is an aggressive soft tissue malignancy comprised histologically of skeletal muscle lineage precursors that fail to exit the cell cycle and fuse into differentiated syncytial muscle-for which the underlying pathogenetic mechanisms remain unclear. ... …
Rhabdomyosarcoma (RMS) is an aggressive soft tissue malignancy comprised histologically of skeletal muscle lineage precursors that fa …
Alveolar rhabdomyosarcoma-associated PAX3-FOXO1 promotes tumorigenesis via Hippo pathway suppression.
Crose LE, Galindo KA, Kephart JG, Chen C, Fitamant J, Bardeesy N, Bentley RC, Galindo RL, Chi JT, Linardic CM. Crose LE, et al. J Clin Invest. 2014 Jan;124(1):285-96. doi: 10.1172/JCI67087. Epub 2013 Dec 16. J Clin Invest. 2014. PMID: 24334454 Free PMC article.
Alveolar rhabdomyosarcoma (aRMS) is an aggressive sarcoma of skeletal muscle characterized by expression of the paired box 3-forkhead box protein O1 (PAX3-FOXO1) fusion oncogene. ...
Alveolar rhabdomyosarcoma (aRMS) is an aggressive sarcoma of skeletal muscle characterized by expression of the paired box 3-forkhead …
Nucleoli and the nucleoli-centromere association are dynamic during normal development and in cancer.
Rodrigues A, MacQuarrie KL, Freeman E, Lin A, Willis AB, Xu Z, Alvarez AA, Ma Y, White BEP, Foltz DR, Huang S. Rodrigues A, et al. Mol Biol Cell. 2023 Apr 1;34(4):br5. doi: 10.1091/mbc.E22-06-0237. Epub 2023 Feb 8. Mol Biol Cell. 2023. PMID: 36753381 Free PMC article.
Centromeres are known to cluster around nucleoli in Drosophila and mammalian cells, but the significance of the nucleoli-centromere interaction remains underexplored. ...This idea is supported in a case of pediatric rhabdomyosarcoma, in which induced differentiation …
Centromeres are known to cluster around nucleoli in Drosophila and mammalian cells, but the significance of the nucleoli-centromere i …
Molecular characterization of Patched-associated rhabdomyosarcoma.
Kappler R, Calzada-Wack J, Schnitzbauer U, Koleva M, Herwig A, Piontek G, Graedler F, Adamski J, Heinzmann U, Schlegel J, Hemmerlein B, Quintanilla-Martinez L, Hahn H. Kappler R, et al. J Pathol. 2003 Jul;200(3):348-56. doi: 10.1002/path.1361. J Pathol. 2003. PMID: 12845631
Mutations in the human homologue of Drosophila Patched1 (PTCH1) have been found in several common tumours including basal cell carcinoma, medulloblastoma, and rhabdomyosarcoma (RMS). ...
Mutations in the human homologue of Drosophila Patched1 (PTCH1) have been found in several common tumours including basal cell carcin …
23 results