Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Edit custom filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1958 1
1962 1
1963 1
1968 1
1972 2
1973 3
1974 1
1975 2
1976 3
1977 4
1978 2
1979 6
1982 15
1983 7
1984 7
1985 6
1986 12
1987 12
1988 10
1989 15
1990 7
1991 21
1992 23
1993 14
1994 19
1995 20
1996 24
1997 14
1998 9
1999 7
2000 12
2001 16
2002 8
2003 12
2004 9
2005 12
2006 10
2007 12
2008 8
2009 16
2010 11
2011 12
2012 19
2013 15
2014 24
2015 33
2016 23
2017 30
2018 33
2019 38
2020 52
2021 53
2022 38
2023 39
2024 41
2025 63
2026 50

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

891 results

Results by year

Filters applied: . Clear all
Page 1
Collateral sensitivity of natural products in drug-resistant cancer cells.
Efferth T, Saeed MEM, Kadioglu O, Seo EJ, Shirooie S, Mbaveng AT, Nabavi SM, Kuete V. Efferth T, et al. Biotechnol Adv. 2020 Jan-Feb;38:107342. doi: 10.1016/j.biotechadv.2019.01.009. Epub 2019 Jan 29. Biotechnol Adv. 2020. PMID: 30708024 Review.
However, tumors may be specifically hypersensitive to other drugs - a phenomenon also termed collateral sensitivity. This seems to be a general biological mechanism, since it also occurs in drug-resistant Escherichia coli and Saccharomyces cerevisiae. ...Resi …
However, tumors may be specifically hypersensitive to other drugs - a phenomenon also termed collateral sensitivity. This seem …
Collateral sensitivity counteracts the evolution of antifungal drug resistance in Candida auris.
Carolus H, Sofras D, Boccarella G, Jacobs S, Biriukov V, Goossens L, Chen A, Vantyghem I, Verbeeck T, Pierson S, Lobo Romero C, Steenackers H, Lagrou K, van den Berg P, Berman J, Gabaldón T, Van Dijck P. Carolus H, et al. Nat Microbiol. 2024 Nov;9(11):2954-2969. doi: 10.1038/s41564-024-01811-w. Epub 2024 Oct 29. Nat Microbiol. 2024. PMID: 39472696 Free PMC article.
Here we investigated collateral sensitivity (CS), in which resistance to one drug increases sensitivity to another, and cross-resistance (XR), in which one drug resistance mechanism reduces susceptibility to multiple drugs, since CS and XR dynam …
Here we investigated collateral sensitivity (CS), in which resistance to one drug increases sensitivity to anoth …
Collateral sensitivity profiling in drug-resistant Escherichia coli identifies natural products suppressing cephalosporin resistance.
Liu DY, Phillips L, Wilson DM, Fulton KM, Twine SM, Wong A, Linington RG. Liu DY, et al. Nat Commun. 2023 Apr 8;14(1):1976. doi: 10.1038/s41467-023-37624-4. Nat Commun. 2023. PMID: 37031190 Free PMC article.
The rapid emergence of antimicrobial resistance presents serious health challenges to the management of infectious diseases, a problem that is further exacerbated by slowing rates of antimicrobial drug discovery in recent years. The phenomenon of collateral sensi …
The rapid emergence of antimicrobial resistance presents serious health challenges to the management of infectious diseases, a problem that …
Identification of collateral sensitivity and evolutionary landscape of chemotherapy-induced drug resistance using cellular barcoding technology.
Danisik N, Yilmaz KC, Acar A. Danisik N, et al. Front Pharmacol. 2023 Jul 11;14:1178489. doi: 10.3389/fphar.2023.1178489. eCollection 2023. Front Pharmacol. 2023. PMID: 37497108 Free PMC article.
The frequencies of barcodes from resistant cell lines and harvested medium, longitudinally, were determined. Collateral drug sensitivity testing was carried out on resistant Caco-2 and HT-29 cell lines using single agents or drug combinations. ...The t …
The frequencies of barcodes from resistant cell lines and harvested medium, longitudinally, were determined. Collateral drug …
Collateral sensitivity: An evolutionary trade-off between antibiotic resistance mechanisms, attractive for dealing with drug-resistance crisis.
Yekani M, Azargun R, Sharifi S, Nabizadeh E, Nahand JS, Ansari NK, Memar MY, Soki J. Yekani M, et al. Health Sci Rep. 2023 Jul 11;6(7):e1418. doi: 10.1002/hsr2.1418. eCollection 2023 Jul. Health Sci Rep. 2023. PMID: 37448730 Free PMC article.
In an evolutionary trade-off known as collateral sensitivity, the resistance mechanism to a certain drug may be mediated by the hypersensitivity to other drugs. ...Collateral sensitivity-based antimicrobial therapy may have the potential to limi …
In an evolutionary trade-off known as collateral sensitivity, the resistance mechanism to a certain drug may be mediate …
Collateral Sensitivity to beta-Lactam Drugs in Drug-Resistant Tuberculosis Is Driven by the Transcriptional Wiring of BlaI Operon Genes.
Trigos AS, Goudey BW, Bedő J, Conway TC, Faux NG, Wyres KL. Trigos AS, et al. mSphere. 2021 Jun 30;6(3):e0024521. doi: 10.1128/mSphere.00245-21. Epub 2021 May 28. mSphere. 2021. PMID: 34047652 Free PMC article.
The evolution of resistance to one antimicrobial can result in enhanced sensitivity to another, known as "collateral sensitivity." This underexplored phenomenon opens new therapeutic possibilities for patients infected with pathogens unresponsive to classical …
The evolution of resistance to one antimicrobial can result in enhanced sensitivity to another, known as "collateral sensit …
Exploiting evolutionary steering to induce collateral drug sensitivity in cancer.
Acar A, Nichol D, Fernandez-Mateos J, Cresswell GD, Barozzi I, Hong SP, Trahearn N, Spiteri I, Stubbs M, Burke R, Stewart A, Caravagna G, Werner B, Vlachogiannis G, Maley CC, Magnani L, Valeri N, Banerji U, Sottoriva A. Acar A, et al. Nat Commun. 2020 Apr 21;11(1):1923. doi: 10.1038/s41467-020-15596-z. Nat Commun. 2020. PMID: 32317663 Free PMC article.
However, evolving resistance to one drug may come at a cost of decreased fecundity or increased sensitivity to another drug. ...We demonstrate evolutionary steering in a lung cancer model, showing that it shifts the clonal composition of the tumour in our fav …
However, evolving resistance to one drug may come at a cost of decreased fecundity or increased sensitivity to another drug …
High levels of NRF2 sensitize temozolomide-resistant glioblastoma cells to ferroptosis via ABCC1/MRP1 upregulation.
de Souza I, Monteiro LKS, Guedes CB, Silva MM, Andrade-Tomaz M, Contieri B, Latancia MT, Mendes D, Porchia BFMM, Lazarini M, Gomes LR, Rocha CRR. de Souza I, et al. Cell Death Dis. 2022 Jul 8;13(7):591. doi: 10.1038/s41419-022-05044-9. Cell Death Dis. 2022. PMID: 35803910 Free PMC article.
Moreover, silencing of ABCC1, a well-known NRF2 target that diminishes GSH levels, has demonstrated a similar collateral sensitivity. T98G-siABCC1 cells were more sensitive to TMZ and resistant to Erastin. Furthermore, we found that NRF2 positively correlates with A …
Moreover, silencing of ABCC1, a well-known NRF2 target that diminishes GSH levels, has demonstrated a similar collateral sensitivi …
Collateral sensitivity of antibiotic-resistant microbes.
Pál C, Papp B, Lázár V. Pál C, et al. Trends Microbiol. 2015 Jul;23(7):401-7. doi: 10.1016/j.tim.2015.02.009. Epub 2015 Mar 25. Trends Microbiol. 2015. PMID: 25818802 Free PMC article. Review.
Strikingly, mutations that caused multidrug resistance in bacteria simultaneously enhanced sensitivity to many other unrelated drugs (collateral sensitivity). Here, we explore how this emerging research sheds new light on resistance mechanisms and the way it …
Strikingly, mutations that caused multidrug resistance in bacteria simultaneously enhanced sensitivity to many other unrelated drugs …
891 results