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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1930 1
1945 1
1946 6
1947 12
1948 17
1949 12
1950 20
1951 25
1952 36
1953 43
1954 37
1955 48
1956 44
1957 55
1958 47
1959 56
1960 46
1961 61
1962 60
1963 51
1964 57
1965 48
1966 25
1967 32
1968 39
1969 41
1970 48
1971 47
1972 61
1973 69
1974 97
1975 301
1976 324
1977 364
1978 342
1979 422
1980 503
1981 561
1982 677
1983 770
1984 844
1985 866
1986 944
1987 989
1988 905
1989 1037
1990 1101
1991 981
1992 940
1993 1007
1994 953
1995 990
1996 1018
1997 1006
1998 1036
1999 1079
2000 1005
2001 1031
2002 1048
2003 1103
2004 1150
2005 1219
2006 1283
2007 1252
2008 1342
2009 1349
2010 1416
2011 1632
2012 1685
2013 1817
2014 1954
2015 2054
2016 2249
2017 2310
2018 2503
2019 2532
2020 2811
2021 2760
2022 2328
2023 2250
2024 2711
2025 3010
2026 2111
2027 1

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65,698 results

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Page 1
Concomitant Drug Treatment and Elimination in the RCC-affected Kidneys: Can We Kill Two Birds with One Stone?
Ahmed MB, Salman Ul Islam, Lee YS. Ahmed MB, et al. Curr Drug Metab. 2020;21(13):1009-1021. doi: 10.2174/1389200221666201112112707. Curr Drug Metab. 2020. PMID: 33183198 Review.
For effective cancer therapy, a delicate balance is required in the drug treatment and its elimination, which is critical for drug accumulation, toxicity, and kidney malfunction. ...Recent advancements in dose adjustment have added to our understanding regard …
For effective cancer therapy, a delicate balance is required in the drug treatment and its elimination, which is critical for …
Drug Class, Renal Elimination, and Outcomes of Direct Oral Anticoagulants in Asian Patients: A Meta-Analysis.
Wang KL, Chiu CC, Giugliano RP, Tan DS, Lin CY, Lai EY, Goto S, Chiang CE. Wang KL, et al. J Stroke Cerebrovasc Dis. 2018 Apr;27(4):857-864. doi: 10.1016/j.jstrokecerebrovasdis.2017.10.027. Epub 2017 Nov 26. J Stroke Cerebrovasc Dis. 2018. PMID: 29239808 Review.
Whether treatment effects could be modified by drug class and dependency on renal elimination of studied agents has not yet been explored. ...Efficacy and safety outcomes were pooled according to drug class and dependency on renal elimination of DOACs …
Whether treatment effects could be modified by drug class and dependency on renal elimination of studied agents has not yet be …
Drug-Induced Kidney Stones and Crystalline Nephropathy: Pathophysiology, Prevention and Treatment.
Daudon M, Frochot V, Bazin D, Jungers P. Daudon M, et al. Drugs. 2018 Feb;78(2):163-201. doi: 10.1007/s40265-017-0853-7. Drugs. 2018. PMID: 29264783 Review.
Drug-induced calculi represent 1-2% of all renal calculi. The drugs reported to produce calculi may be divided into two groups. ...Calculi analysis by physical methods including infrared spectroscopy or X-ray diffraction is needed to demonstrate the presence of the drug …
Drug-induced calculi represent 1-2% of all renal calculi. The drugs reported to produce calculi may be divided into two groups. ...Ca …
Augmented Renal Clearance in Critically Ill Patients: A Systematic Review.
Bilbao-Meseguer I, Rodríguez-Gascón A, Barrasa H, Isla A, Solinís MÁ. Bilbao-Meseguer I, et al. Clin Pharmacokinet. 2018 Sep;57(9):1107-1121. doi: 10.1007/s40262-018-0636-7. Clin Pharmacokinet. 2018. PMID: 29441476
Nevertheless, augmented renal clearance (ARC) is a less well-studied phenomenon that could lead to faster elimination of drugs, resulting in subtherapeutic concentrations and poorer clinical outcomes when standard dosage guidelines are followed. ...CONCLUSION: ARC is a pre …
Nevertheless, augmented renal clearance (ARC) is a less well-studied phenomenon that could lead to faster elimination of drugs, resul …
Methods to study mechanisms underlying altered hepatic drug elimination during pregnancy.
Jeong H, Stika CS. Jeong H, et al. Semin Perinatol. 2020 Apr;44(3):151228. doi: 10.1016/j.semperi.2020.151228. Epub 2020 Jan 25. Semin Perinatol. 2020. PMID: 32122644 Free PMC article. Review.
Hepatic drug metabolism is a major route of drug elimination, mediated by multiple drug-metabolizing enzymes. Any changes in the rate and extent of hepatic drug metabolism can lead to altered drug efficacy or toxicity. Accumulating clinic …
Hepatic drug metabolism is a major route of drug elimination, mediated by multiple drug-metabolizing enzymes. An …
Predicting Clearance Mechanism in Drug Discovery: Extended Clearance Classification System (ECCS).
Varma MV, Steyn SJ, Allerton C, El-Kattan AF. Varma MV, et al. Pharm Res. 2015 Dec;32(12):3785-802. doi: 10.1007/s11095-015-1749-4. Epub 2015 Jul 9. Pharm Res. 2015. PMID: 26155985
Early prediction of clearance mechanisms allows for the rapid progression of drug discovery and development programs, and facilitates risk assessment of the pharmacokinetic variability associated with drug interactions and pharmacogenomics. ...We discuss the general …
Early prediction of clearance mechanisms allows for the rapid progression of drug discovery and development programs, and facilitates …
Drugs in pregnancy: Pharmacologic and physiologic changes that affect clinical care.
Pinheiro EA, Stika CS. Pinheiro EA, et al. Semin Perinatol. 2020 Apr;44(3):151221. doi: 10.1016/j.semperi.2020.151221. Epub 2020 Jan 25. Semin Perinatol. 2020. PMID: 32115202 Free PMC article. Review.
With the recognition of pregnancy as a special pharmacokinetic population in the late 1990s, investigators have begun to study drug disposition in this unique patient dyad. Many of the basic physiologic changes that occur during pregnancy have significant impact on drug …
With the recognition of pregnancy as a special pharmacokinetic population in the late 1990s, investigators have begun to study drug d …
Pharmacogenomics in pregnancy.
Betcher HK, George AL Jr. Betcher HK, et al. Semin Perinatol. 2020 Apr;44(3):151222. doi: 10.1016/j.semperi.2020.151222. Epub 2020 Jan 25. Semin Perinatol. 2020. PMID: 32081407 Free PMC article. Review.
Research on pharmacogenomic and pharmacokinetic influences on drug disposition during pregnancy has lagged behind other fields. Clinical investigators have demonstrated altered activity of several drug metabolizing enzymes during pregnancy. ...Pharmacogenomics also …
Research on pharmacogenomic and pharmacokinetic influences on drug disposition during pregnancy has lagged behind other fields. Clini …
Drug Elimination Alteration in Acute Lymphoblastic Leukemia Mediated by Renal Transporters and Glomerular Filtration.
Zhou Y, Du B, Kan M, Chen S, Tang BH, Nie AQ, Ye PP, Shi HY, Hao GX, Guo XL, Han QJ, Zheng Y, Zhao W. Zhou Y, et al. Pharm Res. 2020 Aug 2;37(8):158. doi: 10.1007/s11095-020-02896-8. Pharm Res. 2020. PMID: 32743772
PURPOSE: Drug elimination alteration has been well reported in acute lymphoblastic leukemia (ALL). Considering that transporters and glomerular filtration influence, to different extents, the drug disposition, and possible side effects, we evaluated the effec …
PURPOSE: Drug elimination alteration has been well reported in acute lymphoblastic leukemia (ALL). Considering that transporte …
65,698 results
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