Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Edit custom filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1915 1
1922 1
1945 2
1946 7
1947 14
1948 16
1949 14
1950 20
1951 28
1952 38
1953 49
1954 41
1955 51
1956 59
1957 58
1958 64
1959 59
1960 53
1961 63
1962 58
1963 57
1964 86
1965 118
1966 110
1967 150
1968 184
1969 186
1970 216
1971 221
1972 234
1973 248
1974 255
1975 745
1976 806
1977 728
1978 728
1979 793
1980 781
1981 861
1982 920
1983 1017
1984 1165
1985 1148
1986 1285
1987 1269
1988 1245
1989 1333
1990 1431
1991 1348
1992 1318
1993 1275
1994 1202
1995 1227
1996 1174
1997 1197
1998 1145
1999 1027
2000 1052
2001 978
2002 1062
2003 1138
2004 1103
2005 1228
2006 1405
2007 1253
2008 1200
2009 1165
2010 1268
2011 1368
2012 1407
2013 1449
2014 1492
2015 1379
2016 1463
2017 1438
2018 1616
2019 1483
2020 1534
2021 1430
2022 1185
2023 1204
2024 1403
2025 1648
2026 1086
2027 1

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

61,023 results

Results by year

Filters applied: . Clear all
Page 1
Evaluation of Drug Biliary Excretion Using Sandwich-Cultured Human Hepatocytes.
Fardel O, Moreau A, Le Vée M, Denizot C, Parmentier Y. Fardel O, et al. Eur J Drug Metab Pharmacokinet. 2019 Feb;44(1):13-30. doi: 10.1007/s13318-018-0502-x. Eur J Drug Metab Pharmacokinet. 2019. PMID: 30167999 Review.
In this context, sandwich-cultured human hepatocytes (SCHH) have been proposed as an interesting and integrated tool for predicting in vitro biliary excretion of drugs. The present review was therefore designed to summarize key findings about SCHH, including their establis …
In this context, sandwich-cultured human hepatocytes (SCHH) have been proposed as an interesting and integrated tool for predicting in vitro …
Drug-Induced Kidney Stones and Crystalline Nephropathy: Pathophysiology, Prevention and Treatment.
Daudon M, Frochot V, Bazin D, Jungers P. Daudon M, et al. Drugs. 2018 Feb;78(2):163-201. doi: 10.1007/s40265-017-0853-7. Drugs. 2018. PMID: 29264783 Review.
Drug-induced calculi represent 1-2% of all renal calculi. The drugs reported to produce calculi may be divided into two groups. ...Calculi analysis by physical methods including infrared spectroscopy or X-ray diffraction is needed to demonstrate the presence of the drug …
Drug-induced calculi represent 1-2% of all renal calculi. The drugs reported to produce calculi may be divided into two groups. ...Ca …
Estimates of Drug Metabolism Using Drug Excretion Concentrations.
Cua A, Krock K, Thomas R, Pesce A. Cua A, et al. Ann Clin Lab Sci. 2023 May;53(3):460-468. Ann Clin Lab Sci. 2023. PMID: 37437938
We observed the ratio of metabolite to parent drug could be used for this estimate. As the amount of observed parent drug increased, the metabolic ratio decreased, indicating a shift from first order to zero order metabolism. After making assumptions of bioavailabil …
We observed the ratio of metabolite to parent drug could be used for this estimate. As the amount of observed parent drug incr …
Examination of Urinary Excretion of Unchanged Drug in Humans and Preclinical Animal Models: Increasing the Predictability of Poor Metabolism in Humans.
Bamfo NO, Hosey-Cojocari C, Benet LZ, Remsberg CM. Bamfo NO, et al. Pharm Res. 2021 Jul;38(7):1139-1156. doi: 10.1007/s11095-021-03076-y. Epub 2021 Jul 12. Pharm Res. 2021. PMID: 34254223 Free PMC article. Review.
PURPOSE: A dataset of fraction excreted unchanged in the urine (fe) values was developed and used to evaluate the ability of preclinical animal species to predict high urinary excretion, and corresponding poor metabolism, in humans. METHODS: A literature review of fe value …
PURPOSE: A dataset of fraction excreted unchanged in the urine (fe) values was developed and used to evaluate the ability of preclinical ani …
Drugs in pregnancy: Pharmacologic and physiologic changes that affect clinical care.
Pinheiro EA, Stika CS. Pinheiro EA, et al. Semin Perinatol. 2020 Apr;44(3):151221. doi: 10.1016/j.semperi.2020.151221. Epub 2020 Jan 25. Semin Perinatol. 2020. PMID: 32115202 Free PMC article. Review.
With the recognition of pregnancy as a special pharmacokinetic population in the late 1990s, investigators have begun to study drug disposition in this unique patient dyad. Many of the basic physiologic changes that occur during pregnancy have significant impact on drug …
With the recognition of pregnancy as a special pharmacokinetic population in the late 1990s, investigators have begun to study drug d …
Ontogeny and Cross-species Comparison of Pathways Involved in Drug Absorption, Distribution, Metabolism, and Excretion in Neonates (Review): Kidney.
Bueters R, Bael A, Gasthuys E, Chen C, Schreuder MF, Frazier KS. Bueters R, et al. Drug Metab Dispos. 2020 May;48(5):353-367. doi: 10.1124/dmd.119.089755. Epub 2020 Feb 29. Drug Metab Dispos. 2020. PMID: 32114509 Review.
Absorption, distribution, metabolism, and excretion (ADME) of drugs vary depending on age and maturation, which will lead to differences in toxicity and efficacy. ...SIGNIFICANCE STATEMENT: This review provides insight in cross-species developmental differences of absorpti …
Absorption, distribution, metabolism, and excretion (ADME) of drugs vary depending on age and maturation, which will lead to differen …
Pharmacogenomics in pregnancy.
Betcher HK, George AL Jr. Betcher HK, et al. Semin Perinatol. 2020 Apr;44(3):151222. doi: 10.1016/j.semperi.2020.151222. Epub 2020 Jan 25. Semin Perinatol. 2020. PMID: 32081407 Free PMC article. Review.
Research on pharmacogenomic and pharmacokinetic influences on drug disposition during pregnancy has lagged behind other fields. Clinical investigators have demonstrated altered activity of several drug metabolizing enzymes during pregnancy. ...Pharmacogenomics also …
Research on pharmacogenomic and pharmacokinetic influences on drug disposition during pregnancy has lagged behind other fields. Clini …
Induction of open-form bile canaliculus formation by hepatocytes for evaluation of biliary drug excretion.
Arakawa H, Nakazono Y, Matsuoka N, Hayashi M, Shirasaka Y, Hirao A, Tamai I. Arakawa H, et al. Commun Biol. 2023 Aug 22;6(1):866. doi: 10.1038/s42003-023-05216-z. Commun Biol. 2023. PMID: 37608051 Free PMC article.
Biliary excretion is a major drug elimination pathway that affects their efficacy and safety. The currently available in vitro sandwich-cultured hepatocyte method is cumbersome because drugs accumulate in the closed bile canalicular lumen formed between hepat …
Biliary excretion is a major drug elimination pathway that affects their efficacy and safety. The currently available i …
Assessing Food Effects on Oral Drug Absorption Based on the Degree of Renal Excretion.
Zhang T, Zou P. Zhang T, et al. AAPS J. 2021 Mar 21;23(3):47. doi: 10.1208/s12248-021-00570-4. AAPS J. 2021. PMID: 33744999
Food intake influences the pharmacokinetics of orally administered drugs by altering drug absorption, metabolism, and excretion. A drug which is mainly excreted into urine as parent drug is usually highly water-soluble and metabolically stable. Food in …
Food intake influences the pharmacokinetics of orally administered drugs by altering drug absorption, metabolism, and excretion …
Pharmacokinetic studies in pregnancy.
Avram MJ. Avram MJ. Semin Perinatol. 2020 Apr;44(3):151227. doi: 10.1016/j.semperi.2020.151227. Epub 2020 Jan 27. Semin Perinatol. 2020. PMID: 32093881 Free PMC article. Review.
The dose-response relationship is affected by pharmacokinetics, or what the body does to a drug, and pharmacodynamics, or what a drug does to the body. Insights into the potential effects of the changes of pregnancy on one aspect of the dose-response relationship of …
The dose-response relationship is affected by pharmacokinetics, or what the body does to a drug, and pharmacodynamics, or what a d …
61,023 results
You have reached the last available page of results. Please see the User Guide for more information.