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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1917 1
1918 1
1919 2
1921 1
1922 1
1923 1
1928 1
1932 1
1933 2
1939 1
1944 1
1945 9
1946 38
1947 66
1948 81
1949 47
1950 60
1951 117
1952 181
1953 319
1954 271
1955 251
1956 224
1957 197
1958 204
1959 150
1960 144
1961 175
1962 315
1963 802
1964 1212
1965 1111
1966 1248
1967 1752
1968 2117
1969 2270
1970 2463
1971 2742
1972 2954
1973 3010
1974 3216
1975 3312
1976 3327
1977 3427
1978 3535
1979 3876
1980 3803
1981 4081
1982 4570
1983 5222
1984 5815
1985 6186
1986 6126
1987 6180
1988 6196
1989 7167
1990 7537
1991 7647
1992 7904
1993 8340
1994 8692
1995 9193
1996 9654
1997 9847
1998 10495
1999 10802
2000 11682
2001 12671
2002 13710
2003 14671
2004 15932
2005 17733
2006 19043
2007 20496
2008 21434
2009 21477
2010 23216
2011 25378
2012 27241
2013 29039
2014 30692
2015 31314
2016 32014
2017 32410
2018 33735
2019 35687
2020 37033
2021 36823
2022 31696
2023 30382
2024 39933
2025 50033
2026 35639
2027 39

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844,959 results

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Page 1
Drug resistance and tolerance in fungi.
Berman J, Krysan DJ. Berman J, et al. Nat Rev Microbiol. 2020 Jun;18(6):319-331. doi: 10.1038/s41579-019-0322-2. Epub 2020 Feb 11. Nat Rev Microbiol. 2020. PMID: 32047294 Free PMC article. Review.
Treatment options are limited, and antifungal drug resistance is increasing. In addition, a substantial proportion of patients do not respond to therapy despite being infected with fungi that are susceptible to the drug. The discordance between overall treatm …
Treatment options are limited, and antifungal drug resistance is increasing. In addition, a substantial proportion of patients …
Distinguishing between resistance, tolerance and persistence to antibiotic treatment.
Brauner A, Fridman O, Gefen O, Balaban NQ. Brauner A, et al. Nat Rev Microbiol. 2016 Apr;14(5):320-30. doi: 10.1038/nrmicro.2016.34. Nat Rev Microbiol. 2016. PMID: 27080241 Review.
However, unlike resistance, which is commonly measured using the minimum inhibitory concentration (MIC) metric, tolerance is poorly characterized, owing to the lack of a similar quantitative indicator. ...In this Opinion article, we describe recent studies of tol …
However, unlike resistance, which is commonly measured using the minimum inhibitory concentration (MIC) metric, tolerance is p …
Antibiotic tolerance facilitates the evolution of resistance.
Levin-Reisman I, Ronin I, Gefen O, Braniss I, Shoresh N, Balaban NQ. Levin-Reisman I, et al. Science. 2017 Feb 24;355(6327):826-830. doi: 10.1126/science.aaj2191. Epub 2017 Feb 9. Science. 2017. PMID: 28183996
We found that in all cases, tolerance preceded resistance. A mathematical population-genetics model showed how tolerance boosts the chances for resistance mutations to spread in the population. Thus, tolerance mutations pave the way for the rapi …
We found that in all cases, tolerance preceded resistance. A mathematical population-genetics model showed how tolerance …
Actionable mechanisms of drug tolerance and resistance in Mycobacterium tuberculosis.
Datta D, Jamwal S, Jyoti N, Patnaik S, Kumar D. Datta D, et al. FEBS J. 2024 Oct;291(20):4433-4452. doi: 10.1111/febs.17142. Epub 2024 Apr 27. FEBS J. 2024. PMID: 38676952 Free article. Review.
While the traditional genetic mutation-driven drug resistance mechanisms operate in Mtb, there are also several additional unique features of drug resistance in this pathogen. ...In the context of TB, such approaches include targeting the efflux capabi …
While the traditional genetic mutation-driven drug resistance mechanisms operate in Mtb, there are also several additional uni …
Targeting acetylcholine signaling modulates persistent drug tolerance in EGFR-mutant lung cancer and impedes tumor relapse.
Nie M, Chen N, Pang H, Jiang T, Jiang W, Tian P, Yao L, Chen Y, DeBerardinis RJ, Li W, Yu Q, Zhou C, Hu Z. Nie M, et al. J Clin Invest. 2022 Oct 17;132(20):e160152. doi: 10.1172/JCI160152. J Clin Invest. 2022. PMID: 36048538 Free PMC article.
Although first-line epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) therapy is effective for treating EGFR-mutant non-small cell lung cancer (NSCLC), it is now understood that drug-tolerant persister (DTP) cells escaping from initial treatment event …
Although first-line epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) therapy is effective for treating EGFR-mutant no …
Single-cell transcriptional changes associated with drug tolerance and response to combination therapies in cancer.
Aissa AF, Islam ABMMK, Ariss MM, Go CC, Rader AE, Conrardy RD, Gajda AM, Rubio-Perez C, Valyi-Nagy K, Pasquinelli M, Feldman LE, Green SJ, Lopez-Bigas N, Frolov MV, Benevolenskaya EV. Aissa AF, et al. Nat Commun. 2021 Mar 12;12(1):1628. doi: 10.1038/s41467-021-21884-z. Nat Commun. 2021. PMID: 33712615 Free PMC article.
However, the duration of clinical response is often limited, and patients ultimately develop drug resistance. Here, we use single-cell RNA sequencing to demonstrate the existence of multiple cancer cell subpopulations within cell lines, xenograft tumors and patient …
However, the duration of clinical response is often limited, and patients ultimately develop drug resistance. Here, we use sin …
Ciprofloxacin-induced persister-cells in Campylobacter jejuni.
Ovsepian A, Larsen MH, Vegge CS, Ingmer H. Ovsepian A, et al. Microbiology (Reading). 2020 Sep;166(9):849-853. doi: 10.1099/mic.0.000953. Epub 2020 Jul 22. Microbiology (Reading). 2020. PMID: 32697188 Free article.
Ciprofloxacin is an important antibiotic for the treatment of C. jejuni, albeit high rates of fluoroquinolone resistance have limited its usefulness. Persister-cells are transiently antibiotic-tolerant fractions of bacterial populations and their occurrence has been associ …
Ciprofloxacin is an important antibiotic for the treatment of C. jejuni, albeit high rates of fluoroquinolone resistance have limited …
Resistance or tolerance? Highlighting the need for precise terminology in the field of disinfection.
Krewing M, Mönch E, Bolten A, Niesalla H. Krewing M, et al. J Hosp Infect. 2024 Aug;150:51-60. doi: 10.1016/j.jhin.2024.05.006. Epub 2024 May 21. J Hosp Infect. 2024. PMID: 38782058 Free article. Review.
In addition, this inconsistency in terminology makes it difficult to assess the risk of a disinfectant resistance. This general review aims to discuss existing definitions of the terms 'adaptation', 'susceptibility', 'tolerance', 'persistence' and 'resistance …
In addition, this inconsistency in terminology makes it difficult to assess the risk of a disinfectant resistance. This general revie …
Inhibitors of bacterial H(2)S biogenesis targeting antibiotic resistance and tolerance.
Shatalin K, Nuthanakanti A, Kaushik A, Shishov D, Peselis A, Shamovsky I, Pani B, Lechpammer M, Vasilyev N, Shatalina E, Rebatchouk D, Mironov A, Fedichev P, Serganov A, Nudler E. Shatalin K, et al. Science. 2021 Jun 11;372(6547):1169-1175. doi: 10.1126/science.abd8377. Science. 2021. PMID: 34112687 Free PMC article.
CSE inhibitors also suppress bacterial tolerance, disrupting biofilm formation and substantially reducing the number of persister bacteria that survive antibiotic treatment. Our results establish bacterial H(2)S as a multifunctional defense factor and CSE as a drug …
CSE inhibitors also suppress bacterial tolerance, disrupting biofilm formation and substantially reducing the number of persister bac …
Antifungal Tolerance and Resistance Emerge at Distinct Drug Concentrations and Rely upon Different Aneuploid Chromosomes.
Yang F, Scopel EFC, Li H, Sun LL, Kawar N, Cao YB, Jiang YY, Berman J. Yang F, et al. mBio. 2023 Apr 25;14(2):e0022723. doi: 10.1128/mbio.00227-23. Epub 2023 Mar 6. mBio. 2023. PMID: 36877011 Free PMC article.
Antifungal drug tolerance is a response distinct from resistance, in which cells grow slowly above the MIC. ...IMPORTANCE Antifungal drug tolerance differs from drug resistance: tolerant cells grow slowly in drug, while resi …
Antifungal drug tolerance is a response distinct from resistance, in which cells grow slowly above the MIC. ...IMPORTAN …
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