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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1917 1
1918 1
1919 2
1921 1
1922 1
1923 1
1928 1
1932 1
1933 2
1939 1
1944 1
1945 9
1946 38
1947 66
1948 81
1949 47
1950 60
1951 117
1952 181
1953 319
1954 271
1955 251
1956 224
1957 197
1958 204
1959 150
1960 144
1961 175
1962 315
1963 802
1964 1212
1965 1111
1966 1248
1967 1752
1968 2117
1969 2270
1970 2463
1971 2742
1972 2954
1973 3010
1974 3216
1975 3312
1976 3327
1977 3427
1978 3535
1979 3876
1980 3803
1981 4081
1982 4570
1983 5222
1984 5815
1985 6186
1986 6126
1987 6180
1988 6196
1989 7167
1990 7537
1991 7647
1992 7904
1993 8340
1994 8692
1995 9196
1996 9683
1997 9867
1998 10500
1999 10808
2000 11686
2001 12674
2002 13712
2003 14674
2004 15934
2005 17735
2006 19051
2007 20496
2008 21436
2009 21478
2010 23219
2011 25385
2012 27260
2013 29046
2014 30705
2015 31323
2016 32035
2017 32438
2018 33760
2019 35717
2020 37061
2021 36847
2022 31720
2023 30399
2024 39940
2025 50038
2026 35724
2027 39

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845,330 results

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Page 1
Drug resistance and tolerance in fungi.
Berman J, Krysan DJ. Berman J, et al. Nat Rev Microbiol. 2020 Jun;18(6):319-331. doi: 10.1038/s41579-019-0322-2. Epub 2020 Feb 11. Nat Rev Microbiol. 2020. PMID: 32047294 Free PMC article. Review.
Treatment options are limited, and antifungal drug resistance is increasing. In addition, a substantial proportion of patients do not respond to therapy despite being infected with fungi that are susceptible to the drug. The discordance between overall treatm …
Treatment options are limited, and antifungal drug resistance is increasing. In addition, a substantial proportion of patients …
Distinguishing between resistance, tolerance and persistence to antibiotic treatment.
Brauner A, Fridman O, Gefen O, Balaban NQ. Brauner A, et al. Nat Rev Microbiol. 2016 Apr;14(5):320-30. doi: 10.1038/nrmicro.2016.34. Nat Rev Microbiol. 2016. PMID: 27080241 Review.
However, unlike resistance, which is commonly measured using the minimum inhibitory concentration (MIC) metric, tolerance is poorly characterized, owing to the lack of a similar quantitative indicator. ...In this Opinion article, we describe recent studies of tol …
However, unlike resistance, which is commonly measured using the minimum inhibitory concentration (MIC) metric, tolerance is p …
Better together-Salmonella biofilm-associated antibiotic resistance.
Aleksandrowicz A, Carolak E, Dutkiewicz A, Błachut A, Waszczuk W, Grzymajlo K. Aleksandrowicz A, et al. Gut Microbes. 2023 Jan-Dec;15(1):2229937. doi: 10.1080/19490976.2023.2229937. Gut Microbes. 2023. PMID: 37401756 Free PMC article. Review.
Salmonella poses a serious threat to public health and socioeconomic development worldwide because of its foodborne pathogenicity and antimicrobial resistance. This biofilm-planktonic lifestyle enables Salmonella to interfere with the host and become resistant to drugs, co …
Salmonella poses a serious threat to public health and socioeconomic development worldwide because of its foodborne pathogenicity and antimi …
Antibiotic tolerance facilitates the evolution of resistance.
Levin-Reisman I, Ronin I, Gefen O, Braniss I, Shoresh N, Balaban NQ. Levin-Reisman I, et al. Science. 2017 Feb 24;355(6327):826-830. doi: 10.1126/science.aaj2191. Epub 2017 Feb 9. Science. 2017. PMID: 28183996
We found that in all cases, tolerance preceded resistance. A mathematical population-genetics model showed how tolerance boosts the chances for resistance mutations to spread in the population. Thus, tolerance mutations pave the way for the rapi …
We found that in all cases, tolerance preceded resistance. A mathematical population-genetics model showed how tolerance …
The Eagle Effect and Antibiotic-Induced Persistence: Two Sides of the Same Coin?
Prasetyoputri A, Jarrad AM, Cooper MA, Blaskovich MAT. Prasetyoputri A, et al. Trends Microbiol. 2019 Apr;27(4):339-354. doi: 10.1016/j.tim.2018.10.007. Epub 2018 Nov 15. Trends Microbiol. 2019. PMID: 30448198 Review.
Proposed underlying mechanism(s) are assessed, and the Eagle effect and microbial persistence are compared and contrasted. The clinical relevance of the Eagle effect is reviewed, incorporating evidence from experimental in vitro and in vivo studies, as well as clinical rep …
Proposed underlying mechanism(s) are assessed, and the Eagle effect and microbial persistence are compared and contrasted. The clinic …
Surviving as a Community: Antibiotic Tolerance and Persistence in Bacterial Biofilms.
Yan J, Bassler BL. Yan J, et al. Cell Host Microbe. 2019 Jul 10;26(1):15-21. doi: 10.1016/j.chom.2019.06.002. Cell Host Microbe. 2019. PMID: 31295420 Free PMC article. Review.
We discuss findings regarding mechanisms underlying bacterial tolerance and persistence in biofilms and how these phenotypes are linked to antibiotic resistance. New strategies for combatting tolerance and persistence in biofilms and possible methods for biof …
We discuss findings regarding mechanisms underlying bacterial tolerance and persistence in biofilms and how these phenotypes are link …
Bacterial persistence as a phenotypic switch.
Balaban NQ, Merrin J, Chait R, Kowalik L, Leibler S. Balaban NQ, et al. Science. 2004 Sep 10;305(5690):1622-5. doi: 10.1126/science.1099390. Epub 2004 Aug 12. Science. 2004. PMID: 15308767
A fraction of a genetically homogeneous microbial population may survive exposure to stress such as antibiotic treatment. Unlike resistant mutants, cells regrown from such persistent bacteria remain sensitive to the antibiotic. ...
A fraction of a genetically homogeneous microbial population may survive exposure to stress such as antibiotic treatment. Unlike resi …
Inhibitors of bacterial H(2)S biogenesis targeting antibiotic resistance and tolerance.
Shatalin K, Nuthanakanti A, Kaushik A, Shishov D, Peselis A, Shamovsky I, Pani B, Lechpammer M, Vasilyev N, Shatalina E, Rebatchouk D, Mironov A, Fedichev P, Serganov A, Nudler E. Shatalin K, et al. Science. 2021 Jun 11;372(6547):1169-1175. doi: 10.1126/science.abd8377. Science. 2021. PMID: 34112687 Free PMC article.
CSE inhibitors also suppress bacterial tolerance, disrupting biofilm formation and substantially reducing the number of persister bacteria that survive antibiotic treatment. Our results establish bacterial H(2)S as a multifunctional defense factor and CSE as a drug …
CSE inhibitors also suppress bacterial tolerance, disrupting biofilm formation and substantially reducing the number of persister bac …
Actionable mechanisms of drug tolerance and resistance in Mycobacterium tuberculosis.
Datta D, Jamwal S, Jyoti N, Patnaik S, Kumar D. Datta D, et al. FEBS J. 2024 Oct;291(20):4433-4452. doi: 10.1111/febs.17142. Epub 2024 Apr 27. FEBS J. 2024. PMID: 38676952 Free article. Review.
While the traditional genetic mutation-driven drug resistance mechanisms operate in Mtb, there are also several additional unique features of drug resistance in this pathogen. ...In the context of TB, such approaches include targeting the efflux capabi …
While the traditional genetic mutation-driven drug resistance mechanisms operate in Mtb, there are also several additional uni …
Resistance or tolerance? Highlighting the need for precise terminology in the field of disinfection.
Krewing M, Mönch E, Bolten A, Niesalla H. Krewing M, et al. J Hosp Infect. 2024 Aug;150:51-60. doi: 10.1016/j.jhin.2024.05.006. Epub 2024 May 21. J Hosp Infect. 2024. PMID: 38782058 Free article. Review.
In addition, this inconsistency in terminology makes it difficult to assess the risk of a disinfectant resistance. This general review aims to discuss existing definitions of the terms 'adaptation', 'susceptibility', 'tolerance', 'persistence' and 'resistance …
In addition, this inconsistency in terminology makes it difficult to assess the risk of a disinfectant resistance. This general revie …
845,330 results
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