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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1953 1
1956 1
1958 1
1959 2
1960 1
1961 1
1962 1
1963 2
1964 7
1965 10
1966 22
1967 25
1968 37
1969 37
1970 41
1971 72
1972 89
1973 127
1974 164
1975 192
1976 178
1977 178
1978 159
1979 202
1980 200
1981 184
1982 210
1983 318
1984 331
1985 393
1986 435
1987 447
1988 533
1989 691
1990 822
1991 926
1992 1003
1993 1166
1994 1393
1995 1472
1996 1661
1997 1701
1998 1862
1999 1990
2000 2204
2001 2404
2002 2669
2003 3004
2004 3398
2005 3869
2006 4127
2007 4552
2008 4834
2009 5058
2010 5755
2011 6335
2012 7055
2013 7602
2014 8319
2015 8714
2016 9265
2017 9451
2018 9873
2019 10793
2020 10988
2021 10915
2022 8860
2023 8324
2024 11620
2025 14775
2026 10384
2027 7

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193,368 results

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Page 1
Overcoming anti-cancer drug resistance via restoration of tumor suppressor gene function.
Gao L, Wu ZX, Assaraf YG, Chen ZS, Wang L. Gao L, et al. Drug Resist Updat. 2021 Jul;57:100770. doi: 10.1016/j.drup.2021.100770. Epub 2021 Jun 18. Drug Resist Updat. 2021. PMID: 34175687 Review.
Some small molecule compounds targeting these approaches re-activated TSGs and reversed cancer drug resistance. Along this vein, functional restoration of TSGs is a novel and promising approach to surmount cancer drug resistance. In the current review, …
Some small molecule compounds targeting these approaches re-activated TSGs and reversed cancer drug resistance. Along this vei …
Antimicrobial Resistance in Escherichia coli.
Poirel L, Madec JY, Lupo A, Schink AK, Kieffer N, Nordmann P, Schwarz S. Poirel L, et al. Microbiol Spectr. 2018 Jul;6(4):10.1128/microbiolspec.arba-0026-2017. doi: 10.1128/microbiolspec.ARBA-0026-2017. Microbiol Spectr. 2018. PMID: 30003866 Free PMC article. Review.
E. coli is intrinsically susceptible to almost all clinically relevant antimicrobial agents, but this bacterial species has a great capacity to accumulate resistance genes, mostly through horizontal gene transfer. The most problematic mechanisms in E. coli co …
E. coli is intrinsically susceptible to almost all clinically relevant antimicrobial agents, but this bacterial species has a great capacity …
Gene therapy with drug resistance genes.
Zaboikin M, Srinivasakumar N, Schuening F. Zaboikin M, et al. Cancer Gene Ther. 2006 Apr;13(4):335-45. doi: 10.1038/sj.cgt.7700912. Cancer Gene Ther. 2006. PMID: 16211086 Review.
A major side effect of cancer chemotherapy is myelosuppression. Expression of drug-resistance genes in hematopoietic stem cells (HSC) using gene transfer methodologies holds the promise of overcoming marrow toxicity in cancer chemotherapy. ...In this r …
A major side effect of cancer chemotherapy is myelosuppression. Expression of drug-resistance genes in hematopoietic st …
DRdriver: identifying drug resistance driver genes using individual-specific gene regulatory network.
Huang YE, Zhou S, Liu H, Zhou X, Yuan M, Hou F, Chen S, Chen J, Wang L, Jiang W. Huang YE, et al. Brief Bioinform. 2023 Mar 19;24(2):bbad066. doi: 10.1093/bib/bbad066. Brief Bioinform. 2023. PMID: 36869849 Free article.
In addition, drug resistance is heterogeneous, which makes an urgent need to explore the personalized driver genes of drug resistance. ...In total, we identified 1202 drug resistance driver genes for 8 cancer types and 10 dr …
In addition, drug resistance is heterogeneous, which makes an urgent need to explore the personalized driver genes of …
Contribution of the pfmdr1 gene to antimalarial drug-resistance.
Duraisingh MT, Cowman AF. Duraisingh MT, et al. Acta Trop. 2005 Jun;94(3):181-90. doi: 10.1016/j.actatropica.2005.04.008. Acta Trop. 2005. PMID: 15876420 Review.
The emergence of drug-resistance poses a major obstacle to the control of malaria. A homolog of the major multidrug-transporter in mammalian cells was identified, Plasmodium falciparum multidrug resistance protein-1, pfmdr1, also known as the P-glycoprotein h …
The emergence of drug-resistance poses a major obstacle to the control of malaria. A homolog of the major multidrug-transporte …
Drug resistance in diploid yeast is acquired through dominant alleles, haploinsufficiency, gene duplication and aneuploidy.
Barney JB, Chandrashekarappa DG, Soncini SR, Schmidt MC. Barney JB, et al. PLoS Genet. 2021 Sep 23;17(9):e1009800. doi: 10.1371/journal.pgen.1009800. eCollection 2021 Sep. PLoS Genet. 2021. PMID: 34555030 Free PMC article.
In this study, diploid cells were used in the hope of identifying the distinct genetic mechanisms used by diploid cells to acquire drug resistance. While haploid cells acquire resistance to 2-deoxyglucose primarily through recessive alleles in specific gen …
In this study, diploid cells were used in the hope of identifying the distinct genetic mechanisms used by diploid cells to acquire drug …
[Gene therapy using anticancer drug-resistance genes].
Sugimoto Y. Sugimoto Y. Hum Cell. 1999 Sep;12(3):115-23. Hum Cell. 1999. PMID: 10695018 Review. Japanese.
Among such genes, human multidrug-resistance gene (MDR1) has been studied most extensively for this purpose, and clinical trials of drug-resistance gene therapy have been started in the US for cancer patients who undergo high-dose chemoth …
Among such genes, human multidrug-resistance gene (MDR1) has been studied most extensively for this purpose, and clinic …
[Gene therapy using anticancer drug-resistance genes].
Sugimoto Y. Sugimoto Y. Gan To Kagaku Ryoho. 1999 Jan;26(1):1-9. Gan To Kagaku Ryoho. 1999. PMID: 9987494 Review. Japanese.
Myelosuppression is a major dose-limiting factor in cancer chemotherapy. Introduction of drug-resistance genes into bone marrow cells of cancer patients has been proposed to overcome this limitation. ...Among such genes, human multidrug-resistance …
Myelosuppression is a major dose-limiting factor in cancer chemotherapy. Introduction of drug-resistance genes into bon …
[Mechanisms of endogenous drug resistance acquisition by spontaneous chromosomal gene mutation].
Fukuda H, Hiramatsu K. Fukuda H, et al. Nihon Rinsho. 1997 May;55(5):1185-90. Nihon Rinsho. 1997. PMID: 9155173 Review. Japanese.
However, this type of resistance acquisition are now prevalent in clinical setting. Chromosomal genes that afford endogenous resistance are the genes correlated with the target of the drug, the drug inactivating enzymes, and permeability …
However, this type of resistance acquisition are now prevalent in clinical setting. Chromosomal genes that afford endogenous …
Gene amplification and drug resistance in cultured murine cells.
Schimke RT, Kaufman RJ, Alt FW, Kellems RF. Schimke RT, et al. Science. 1978 Dec 8;202(4372):1051-5. doi: 10.1126/science.715457. Science. 1978. PMID: 715457
Analogies are made to antibiotic and insecticide resistance wherein selection of organisms with increased capacity to counteract the drug effect results in emergence of resistance. Gene amplification may underlie many such resistance phenomena.. …
Analogies are made to antibiotic and insecticide resistance wherein selection of organisms with increased capacity to counteract the …
193,368 results
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