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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1947 1
1948 1
1949 1
1950 1
1951 3
1952 12
1953 210
1954 150
1955 158
1956 78
1957 19
1958 8
1959 20
1960 17
1961 23
1962 22
1963 23
1964 27
1965 35
1966 28
1967 62
1968 122
1969 455
1970 769
1971 1006
1972 1038
1973 1200
1974 1399
1975 1347
1976 1369
1977 1297
1978 1533
1979 1859
1980 1622
1981 1529
1982 1756
1983 1934
1984 2351
1985 2480
1986 2472
1987 2658
1988 2666
1989 3222
1990 2845
1991 3061
1992 3361
1993 3627
1994 3461
1995 3799
1996 3983
1997 4128
1998 4598
1999 4993
2000 5595
2001 6477
2002 6948
2003 7441
2004 8695
2005 9421
2006 10653
2007 11710
2008 13155
2009 14426
2010 16350
2011 17880
2012 18867
2013 20028
2014 21180
2015 22229
2016 23426
2017 23892
2018 25243
2019 27099
2020 28421
2021 27469
2022 19838
2023 17906
2024 28377
2025 37342
2026 28016
2027 73

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515,898 results

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Page 1
Patient-derived organoids in translational oncology and drug screening.
Yang R, Yu Y. Yang R, et al. Cancer Lett. 2023 May 28;562:216180. doi: 10.1016/j.canlet.2023.216180. Epub 2023 Apr 13. Cancer Lett. 2023. PMID: 37061121 Free article. Review.
Patient-derived organoids (PDO) are a new biomedical research model that can reconstruct phenotypic and genetic characteristics of the original tissue and are useful for research on pathogenesis and drug screening. To introduce the progression in this field, we revi …
Patient-derived organoids (PDO) are a new biomedical research model that can reconstruct phenotypic and genetic characteristics of the origi …
Drug Screening Platforms and RPPA.
Dawson JC, Warchal SJ, Carragher NO. Dawson JC, et al. Adv Exp Med Biol. 2019;1188:203-226. doi: 10.1007/978-981-32-9755-5_11. Adv Exp Med Biol. 2019. PMID: 31820390 Review.
In recent decades, drug discovery strategies have evolved dramatically in response to continual advances in technology platforms supporting high-throughput screening, structure-based drug design, new therapeutic modalities, and increasingly more complex and d …
In recent decades, drug discovery strategies have evolved dramatically in response to continual advances in technology platforms supp …
Personalized drug screening in patient-derived organoids of biliary tract cancer and its clinical application.
Ren X, Huang M, Weng W, Xie Y, Wu Y, Zhu S, Zhang Y, Li D, Lai J, Shen S, Lin J, Kuang M, Li X, Yu J, Xu L. Ren X, et al. Cell Rep Med. 2023 Nov 21;4(11):101277. doi: 10.1016/j.xcrm.2023.101277. Epub 2023 Nov 8. Cell Rep Med. 2023. PMID: 37944531 Free PMC article.
As expected, BTC PDOs show different responses to the chemotherapies of gemcitabine, cisplatin, 5-fluoruracil, oxaliplatin, etc. The drug screening results in PDOs are further validated in PDO-based xenografts and confirmed in 92.3% (12/13) of BTC patients with actu …
As expected, BTC PDOs show different responses to the chemotherapies of gemcitabine, cisplatin, 5-fluoruracil, oxaliplatin, etc. The drug …
Induced Pluripotent Stem Cells (iPSCs)-Roles in Regenerative Therapies, Disease Modelling and Drug Screening.
Aboul-Soud MAM, Alzahrani AJ, Mahmoud A. Aboul-Soud MAM, et al. Cells. 2021 Sep 5;10(9):2319. doi: 10.3390/cells10092319. Cells. 2021. PMID: 34571968 Free PMC article. Review.
The use of iPSCs have transformed biological research, wherein increasing number of studies are documenting nuclear reprogramming strategies to make them beneficial models for drug screening as well as disease modelling. The flexibility around the use of iPSCs inclu …
The use of iPSCs have transformed biological research, wherein increasing number of studies are documenting nuclear reprogramming strategies …
Medulloblastoma and high-grade glioma organoids for drug screening, lineage tracing, co-culture and in vivo assay.
Lago C, Gianesello M, Santomaso L, Leva G, Ballabio C, Anderle M, Antonica F, Tiberi L. Lago C, et al. Nat Protoc. 2023 Jul;18(7):2143-2180. doi: 10.1038/s41596-023-00839-2. Epub 2023 May 29. Nat Protoc. 2023. PMID: 37248391 Review.
We also show detailed protocols to use medulloblastoma and high-grade glioma organoids for orthotopic transplantation and co-culture experiments aimed to study cell biology in vivo and in vitro, for lineage tracing to investigate the cell of origin and for drug screenin …
We also show detailed protocols to use medulloblastoma and high-grade glioma organoids for orthotopic transplantation and co-culture experim …
Microfluidics in High-Throughput Drug Screening: Organ-on-a-Chip and C. elegans-Based Innovations.
Yoon S, Kilicarslan You D, Jeong U, Lee M, Kim E, Jeon TJ, Kim SM. Yoon S, et al. Biosensors (Basel). 2024 Jan 21;14(1):55. doi: 10.3390/bios14010055. Biosensors (Basel). 2024. PMID: 38275308 Free PMC article. Review.
The development of therapeutic interventions for diseases necessitates a crucial step known as drug screening, wherein potential substances with medicinal properties are rigorously evaluated. ...Through this review, we aim to contribute to the collective knowledge b …
The development of therapeutic interventions for diseases necessitates a crucial step known as drug screening, wherein potenti …
Tailored Biosensors for Drug Screening, Efficacy Assessment, and Toxicity Evaluation.
Tao Y, Chen L, Pan M, Zhu F, Zhu D. Tao Y, et al. ACS Sens. 2021 Sep 24;6(9):3146-3162. doi: 10.1021/acssensors.1c01600. Epub 2021 Sep 13. ACS Sens. 2021. PMID: 34516080 Review.
Biosensors have been flourishing in the field of drug discovery with pronounced developments in the past few years. They facilitate the screening and discovery of innovative drugs. ...This contribution presents a critical and up-to-date overview on the recent progre …
Biosensors have been flourishing in the field of drug discovery with pronounced developments in the past few years. They facilitate t …
An overview of drug discovery and development.
Berdigaliyev N, Aljofan M. Berdigaliyev N, et al. Future Med Chem. 2020 May;12(10):939-947. doi: 10.4155/fmc-2019-0307. Epub 2020 Apr 9. Future Med Chem. 2020. PMID: 32270704 Review.
New technologies such as ultra-high-throughput drug screening and artificial intelligence are being heavily employed to reduce the cost and the time of early drug discovery, but they remain relatively unchanged. However, are there other potentially faster and …
New technologies such as ultra-high-throughput drug screening and artificial intelligence are being heavily employed to reduce …
Heart-on-a-chip platforms and biosensor integration for disease modeling and phenotypic drug screening.
Criscione J, Rezaei Z, Hernandez Cantu CM, Murphy S, Shin SR, Kim DH. Criscione J, et al. Biosens Bioelectron. 2023 Jan 15;220:114840. doi: 10.1016/j.bios.2022.114840. Epub 2022 Oct 25. Biosens Bioelectron. 2023. PMID: 36402101 Review.
The integration of novel biosensors into these platforms is also a critical step in the development of these models, as they allow for increased throughput, real-time and longitudinal phenotypic assessment, and improved efficiency during preclinical disease modeling and …
The integration of novel biosensors into these platforms is also a critical step in the development of these models, as they allow for incre …
515,898 results
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