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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 1
1946 4
1948 4
1949 3
1950 7
1951 12
1952 15
1953 32
1954 21
1955 20
1956 16
1957 28
1958 39
1959 28
1960 20
1961 34
1962 51
1963 76
1964 127
1965 102
1966 133
1967 150
1968 183
1969 198
1970 272
1971 318
1972 336
1973 372
1974 378
1975 547
1976 548
1977 522
1978 535
1979 623
1980 707
1981 836
1982 1021
1983 1315
1984 1479
1985 1713
1986 1663
1987 1874
1988 1991
1989 2447
1990 2642
1991 2660
1992 2955
1993 3091
1994 3362
1995 3700
1996 3883
1997 4097
1998 4691
1999 5109
2000 5936
2001 6516
2002 7661
2003 8782
2004 10223
2005 11637
2006 13405
2007 14886
2008 16220
2009 18132
2010 20840
2011 22966
2012 24713
2013 27157
2014 28913
2015 30770
2016 32299
2017 33386
2018 34292
2019 35726
2020 39043
2021 39708
2022 34596
2023 33875
2024 42924
2025 54375
2026 40451
2027 70

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666,943 results

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Page 1
Drug affinity responsive target stability (DARTS) accelerated small molecules target discovery: Principles and application.
Ren YS, Li HL, Piao XH, Yang ZY, Wang SM, Ge YW. Ren YS, et al. Biochem Pharmacol. 2021 Dec;194:114798. doi: 10.1016/j.bcp.2021.114798. Epub 2021 Oct 19. Biochem Pharmacol. 2021. PMID: 34678227 Review.
Drug affinity responsive target stability (DARTS) is a novel target discovery approach and is particularly adept at screening small molecule (SM) targets without requiring any structural modifications. The DARTS method is capable of revealing drug-t …
Drug affinity responsive target stability (DARTS) is a novel target discovery approach and is particularly adept at scr …
Antiviral Drug Target Identification and Ligand Discovery.
Patel H, Sengupta D. Patel H, et al. Methods Mol Biol. 2024;2714:85-99. doi: 10.1007/978-1-0716-3441-7_4. Methods Mol Biol. 2024. PMID: 37676593 Review.
This chapter intends to provide a general overview of web-based resources available for antiviral drug discovery studies. First, we explain how the structure for a potential viral protein target can be obtained and then highlight some of the main considerations in p …
This chapter intends to provide a general overview of web-based resources available for antiviral drug discovery studies. First, we e …
Drug-Target Association Kinetics in Drug Discovery.
IJzerman AP, Guo D. IJzerman AP, et al. Trends Biochem Sci. 2019 Oct;44(10):861-871. doi: 10.1016/j.tibs.2019.04.004. Epub 2019 May 14. Trends Biochem Sci. 2019. PMID: 31101454 Review.
The important role of ligand-receptor binding kinetics in drug design and discovery is increasingly recognized by the drug research community. Over the past decade, accumulating evidence has shown that optimizing the ligand's dissociation rate constant can lead to d …
The important role of ligand-receptor binding kinetics in drug design and discovery is increasingly recognized by the drug res …
Drug target therapy and emerging clinical relevance of exosomes in meningeal tumors.
Sharma S, Rana R, Prakash P, Ganguly NK. Sharma S, et al. Mol Cell Biochem. 2024 Jan;479(1):127-170. doi: 10.1007/s11010-023-04715-1. Epub 2023 Apr 4. Mol Cell Biochem. 2024. PMID: 37016182 Free PMC article. Review.
Surgery and radiotherapy remain the standard treatment options for these tumors. Drug therapy comes to play its role when both surgery and radiotherapy fail to treat the tumor. ...The latest studies have shown the involvement of exosomes in the theragnostic of various canc …
Surgery and radiotherapy remain the standard treatment options for these tumors. Drug therapy comes to play its role when both surger …
State-of-the-art drug delivery system to target the lymphatics.
Khaire OT, Mhaske A, Prasad AG, Almalki WH, Srivastava N, Kesharwani P, Shukla R. Khaire OT, et al. J Drug Target. 2024 Apr;32(4):347-364. doi: 10.1080/1061186X.2024.2309671. Epub 2024 Feb 5. J Drug Target. 2024. PMID: 38253594 Review.
PRIMARY OBJECTIVE: The primary objective of the review is to assess the potential of lymphatic-targeted drug delivery systems, with a particular emphasis on their role in tumour therapy and vaccination efficacy. ...OUTCOME: Nanotechnologies and innovative bio …
PRIMARY OBJECTIVE: The primary objective of the review is to assess the potential of lymphatic-targeted drug delivery syste …
Validation guidelines for drug-target prediction methods.
Tanoli Z, Schulman A, Aittokallio T. Tanoli Z, et al. Expert Opin Drug Discov. 2025 Jan;20(1):31-45. doi: 10.1080/17460441.2024.2430955. Epub 2024 Nov 21. Expert Opin Drug Discov. 2025. PMID: 39568436 Free article. Review.
INTRODUCTION: Mapping the interactions between pharmaceutical compounds and their molecular targets is a fundamental aspect of drug discovery and repurposing. Drug-target interactions are important for elucidating mechanisms of action and optimizing drug …
INTRODUCTION: Mapping the interactions between pharmaceutical compounds and their molecular targets is a fundamental aspect of drug d …
A survey of drug-target interaction and affinity prediction methods via graph neural networks.
Zhang Y, Hu Y, Han N, Yang A, Liu X, Cai H. Zhang Y, et al. Comput Biol Med. 2023 Sep;163:107136. doi: 10.1016/j.compbiomed.2023.107136. Epub 2023 Jun 7. Comput Biol Med. 2023. PMID: 37329615 Review.
The tasks of drug-target interaction (DTI) and drug-target affinity (DTA) prediction play important roles in the field of drug discovery. ...Recently, computational-based approaches have accelerated the process of drug-target relat …
The tasks of drug-target interaction (DTI) and drug-target affinity (DTA) prediction play important roles in the …
Drug-target interaction prediction: databases, web servers and computational models.
Chen X, Yan CC, Zhang X, Zhang X, Dai F, Yin J, Zhang Y. Chen X, et al. Brief Bioinform. 2016 Jul;17(4):696-712. doi: 10.1093/bib/bbv066. Epub 2015 Aug 17. Brief Bioinform. 2016. PMID: 26283676 Free article. Review.
Identification of drug-target interactions is an important process in drug discovery. Although high-throughput screening and other biological assays are becoming available, experimental methods for drug-target interaction identification remain t …
Identification of drug-target interactions is an important process in drug discovery. Although high-throughput screenin …
Target-mediated drug disposition and dynamics.
Mager DE. Mager DE. Biochem Pharmacol. 2006 Jun 28;72(1):1-10. doi: 10.1016/j.bcp.2005.12.041. Epub 2006 Feb 15. Biochem Pharmacol. 2006. PMID: 16469301 Review.
Whereas traditional pharmacokinetic/pharmacodynamic models assume that the amount of the drug-target complex is negligible relative to the total amount of drug in the body, integrated mechanism-based models of TMDD incorporate the binding and stoichiometry of …
Whereas traditional pharmacokinetic/pharmacodynamic models assume that the amount of the drug-target complex is negligible rel …
Machine Learning for Drug-Target Interaction Prediction.
Chen R, Liu X, Jin S, Lin J, Liu J. Chen R, et al. Molecules. 2018 Aug 31;23(9):2208. doi: 10.3390/molecules23092208. Molecules. 2018. PMID: 30200333 Free PMC article. Review.
Identifying drug-target interactions will greatly narrow down the scope of search of candidate medications, and thus can serve as the vital first step in drug discovery. Considering that in vitro experiments are extremely costly and time-consuming, high effic …
Identifying drug-target interactions will greatly narrow down the scope of search of candidate medications, and thus can serve …
666,943 results
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