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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1966 1
1976 2
1977 2
1979 1
1980 1
1982 1
1984 2
1985 5
1986 8
1987 5
1988 3
1989 8
1990 19
1991 12
1992 24
1993 18
1994 30
1995 44
1996 42
1997 60
1998 72
1999 120
2000 185
2001 222
2002 328
2003 413
2004 504
2005 556
2006 723
2007 788
2008 882
2009 1160
2010 1326
2011 1464
2012 1681
2013 1972
2014 2202
2015 2510
2016 2908
2017 2958
2018 3210
2019 3524
2020 4111
2021 4440
2022 4172
2023 4173
2024 4835
2025 6099
2026 5340
2027 15

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56,597 results

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Page 1
CETSA and thermal proteome profiling strategies for target identification and drug discovery of natural products.
Tu Y, Tan L, Tao H, Li Y, Liu H. Tu Y, et al. Phytomedicine. 2023 Jul 25;116:154862. doi: 10.1016/j.phymed.2023.154862. Epub 2023 May 20. Phytomedicine. 2023. PMID: 37216761 Review.
BACKGROUND: Monitoring target engagement at various stages of drug development is essential for natural product (NP)-based drug discovery and development. ...This review aims to provide an overview of the work principles of CETSA and its derivative str …
BACKGROUND: Monitoring target engagement at various stages of drug development is essential for natural product (NP)-based …
Drug affinity responsive target stability (DARTS) accelerated small molecules target discovery: Principles and application.
Ren YS, Li HL, Piao XH, Yang ZY, Wang SM, Ge YW. Ren YS, et al. Biochem Pharmacol. 2021 Dec;194:114798. doi: 10.1016/j.bcp.2021.114798. Epub 2021 Oct 19. Biochem Pharmacol. 2021. PMID: 34678227 Review.
Drug affinity responsive target stability (DARTS) is a novel target discovery approach and is particularly adept at screening small molecule (SM) targets without requiring any structural modifications. The DARTS method is capable of revealing drug …
Drug affinity responsive target stability (DARTS) is a novel target discovery approach and is particularly adept …
Network pharmacology: the next paradigm in drug discovery.
Hopkins AL. Hopkins AL. Nat Chem Biol. 2008 Nov;4(11):682-90. doi: 10.1038/nchembio.118. Nat Chem Biol. 2008. PMID: 18936753 Review.
The dominant paradigm in drug discovery is the concept of designing maximally selective ligands to act on individual drug targets. ...Advances in these areas are creating the foundation of the next paradigm in drug discovery: network pharmacolog …
The dominant paradigm in drug discovery is the concept of designing maximally selective ligands to act on individual drug …
Antiviral Drug Target Identification and Ligand Discovery.
Patel H, Sengupta D. Patel H, et al. Methods Mol Biol. 2024;2714:85-99. doi: 10.1007/978-1-0716-3441-7_4. Methods Mol Biol. 2024. PMID: 37676593 Review.
This chapter intends to provide a general overview of web-based resources available for antiviral drug discovery studies. First, we explain how the structure for a potential viral protein target can be obtained and then highlight some of the main consideratio …
This chapter intends to provide a general overview of web-based resources available for antiviral drug discovery studies. Firs …
Drug-Target Association Kinetics in Drug Discovery.
IJzerman AP, Guo D. IJzerman AP, et al. Trends Biochem Sci. 2019 Oct;44(10):861-871. doi: 10.1016/j.tibs.2019.04.004. Epub 2019 May 14. Trends Biochem Sci. 2019. PMID: 31101454 Review.
The important role of ligand-receptor binding kinetics in drug design and discovery is increasingly recognized by the drug research community. Over the past decade, accumulating evidence has shown that optimizing the ligand's dissociation rate constant can le …
The important role of ligand-receptor binding kinetics in drug design and discovery is increasingly recognized by the drug …
The cellular thermal shift assay for evaluating drug target interactions in cells.
Jafari R, Almqvist H, Axelsson H, Ignatushchenko M, Lundbäck T, Nordlund P, Martinez Molina D. Jafari R, et al. Nat Protoc. 2014 Sep;9(9):2100-22. doi: 10.1038/nprot.2014.138. Epub 2014 Aug 7. Nat Protoc. 2014. PMID: 25101824
Such assays have been used extensively on purified proteins in the drug discovery industry and in academia to detect interactions. Recently, we published a proof-of-principle study describing the implementation of thermal shift assays in a cellular format, which we …
Such assays have been used extensively on purified proteins in the drug discovery industry and in academia to detect interacti …
Integration of target discovery, drug discovery and drug delivery: A review on computational strategies.
Duarte Y, Márquez-Miranda V, Miossec MJ, González-Nilo F. Duarte Y, et al. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2019 Jul;11(4):e1554. doi: 10.1002/wnan.1554. Epub 2019 Apr 1. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2019. PMID: 30932351 Review.
In each area: target discovery, drug discovery and drug delivery, different computational strategies are being developed to accelerate the process of selection and discovery of new tools to be applied to different scientific fields …
In each area: target discovery, drug discovery and drug delivery, different computational strategi …
A comprehensive map of molecular drug targets.
Santos R, Ursu O, Gaulton A, Bento AP, Donadi RS, Bologa CG, Karlsson A, Al-Lazikani B, Hersey A, Oprea TI, Overington JP. Santos R, et al. Nat Rev Drug Discov. 2017 Jan;16(1):19-34. doi: 10.1038/nrd.2016.230. Epub 2016 Dec 2. Nat Rev Drug Discov. 2017. PMID: 27910877 Free PMC article. Review.
The success of mechanism-based drug discovery depends on the definition of the drug target. This definition becomes even more important as we try to link drug response to genetic variation, understand stratified clinical efficacy and safety, rat …
The success of mechanism-based drug discovery depends on the definition of the drug target. This definition beco …
Target class drug discovery.
Barnash KD, James LI, Frye SV. Barnash KD, et al. Nat Chem Biol. 2017 Sep 19;13(10):1053-1056. doi: 10.1038/nchembio.2473. Nat Chem Biol. 2017. PMID: 28926557 Free PMC article.
Selection of molecular targets based on disease understanding is a dominant paradigm in drug discovery. We argue that a focus on classes of targets with central roles in biology provides a complementary approach that has higher quality outcomes in early discovery …
Selection of molecular targets based on disease understanding is a dominant paradigm in drug discovery. We argue that a focus …
Evaluation of target-specific natural compounds for drug discovery against Leishmaniasis.
Gouri V, Upreti S, Samant M. Gouri V, et al. Parasitol Int. 2022 Dec;91:102622. doi: 10.1016/j.parint.2022.102622. Epub 2022 Jul 5. Parasitol Int. 2022. PMID: 35798284 Review.
Moreover, these unique enzymes, along with the signaling molecules and metabolic pathways that are crucial for its survival, serve as a suitable drug target for the evaluation of specific natural inhibitors to overcome leishmaniasis. Hence, in this review, we have d …
Moreover, these unique enzymes, along with the signaling molecules and metabolic pathways that are crucial for its survival, serve as a suit …
56,597 results
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