Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Edit custom filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 1
1946 4
1948 4
1949 3
1950 7
1951 12
1952 15
1953 29
1954 21
1955 19
1956 16
1957 28
1958 38
1959 27
1960 20
1961 34
1962 50
1963 76
1964 127
1965 99
1966 130
1967 142
1968 168
1969 181
1970 254
1971 288
1972 294
1973 317
1974 324
1975 338
1976 323
1977 317
1978 336
1979 360
1980 377
1981 476
1982 614
1983 755
1984 835
1985 968
1986 834
1987 971
1988 1050
1989 1323
1990 1371
1991 1433
1992 1540
1993 1570
1994 1799
1995 1851
1996 1933
1997 2036
1998 2421
1999 2689
2000 3043
2001 3404
2002 4036
2003 4578
2004 5726
2005 6649
2006 7740
2007 8947
2008 9814
2009 11257
2010 13243
2011 14495
2012 15918
2013 17422
2014 19031
2015 20800
2016 21772
2017 22852
2018 23580
2019 25007
2020 27842
2021 28342
2022 24812
2023 24874
2024 34015
2025 46943
2026 38734
2027 146

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

461,466 results

Results by year

Filters applied: . Clear all
Page 1
Drug targeting.
Torchilin VP. Torchilin VP. Eur J Pharm Sci. 2000 Oct;11 Suppl 2:S81-91. doi: 10.1016/s0928-0987(00)00166-4. Eur J Pharm Sci. 2000. PMID: 11033430 Review.
Drug targeting, i.e. predominant drug accumulation in the target zone independently on the method and route of drug administration, may resolve many of these problems. Currently, the principal schemes of drug targeting include direct appl …
Drug targeting, i.e. predominant drug accumulation in the target zone independently on the method and route of drug …
Direct Drug Targeting into Intracellular Compartments: Issues, Limitations, and Future Outlook.
Harisa GI, Faris TM. Harisa GI, et al. J Membr Biol. 2019 Dec;252(6):527-539. doi: 10.1007/s00232-019-00082-5. Epub 2019 Aug 2. J Membr Biol. 2019. PMID: 31375855 Review.
This maximizes the therapeutic efficacy and safety of medicines, particularly of anticancer and antiviral drugs. Intracellular compartment drug delivery is either indirectly by targeting of cell nucleus as central compartment of the cell or directly through t …
This maximizes the therapeutic efficacy and safety of medicines, particularly of anticancer and antiviral drugs. Intracellular compartment …
Strategies for drug targeting in pancreatic cancer.
Sharma N, Arora V. Sharma N, et al. Pancreatology. 2022 Nov;22(7):937-950. doi: 10.1016/j.pan.2022.08.001. Epub 2022 Aug 5. Pancreatology. 2022. PMID: 36055937 Review.
OBJECTIVE: Despite the new innovations, research, and improvements in drug design; there are many hurdles limiting their therapeutic applications such as intrinsic resistance to chemotherapeutics, inability to deliver a sufficient concentration of drug to the target …
OBJECTIVE: Despite the new innovations, research, and improvements in drug design; there are many hurdles limiting their therapeutic …
Cell-specific drug targeting in the lung.
Abed S, Turner R, Serniuck N, Tat V, Naiel S, Hayat A, Mekhael O, Vierhout M, Ask K, Rullo AF. Abed S, et al. Biochem Pharmacol. 2021 Aug;190:114577. doi: 10.1016/j.bcp.2021.114577. Epub 2021 Apr 19. Biochem Pharmacol. 2021. PMID: 33887259 Review.
Non-targeted drug delivery systems have several limitations including the decreased bioavailability of the drug, poor stability and rapid clearance in addition to off-target distribution. ...These approaches include;a) directly administered small molec …
Non-targeted drug delivery systems have several limitations including the decreased bioavailability of the drug, …
Targeting strategies for drug delivery to the kidney: From renal glomeruli to tubules.
Liu CP, Hu Y, Lin JC, Fu HL, Lim LY, Yuan ZX. Liu CP, et al. Med Res Rev. 2019 Mar;39(2):561-578. doi: 10.1002/med.21532. Epub 2018 Aug 22. Med Res Rev. 2019. PMID: 30136283 Review.
Kidney diseases have become a global public health problem. The application of kidney-targeted drug-delivery systems in the management of kidney diseases has profound transformative potential. ...Finally, we summarized the literature examples of drug …
Kidney diseases have become a global public health problem. The application of kidney-targeted drug-delivery systems in …
Current Drug Targeting using siRNA-based Nano Therapeutics for Pulmonary Diseases.
Krishnaswami V, Kandasamy R. Krishnaswami V, et al. Curr Pharm Des. 2022;28(28):2279-2282. doi: 10.2174/1381612828666220727144223. Curr Pharm Des. 2022. PMID: 35894459 Review.
The importance of siRNA in nano drug delivery systems to target important pulmonary disorders, such as chronic obstructive pulmonary disease (COPD), asthma, lung cancer, and others, is reviewed in this perspective. ...These issues could be solved with a nano- …
The importance of siRNA in nano drug delivery systems to target important pulmonary disorders, such as chronic obstruct …
Drug targeting strategies into the brain for treating neurological diseases.
Barnabas W. Barnabas W. J Neurosci Methods. 2019 Jan 1;311:133-146. doi: 10.1016/j.jneumeth.2018.10.015. Epub 2018 Oct 16. J Neurosci Methods. 2019. PMID: 30336221 Review.
Brain specific drug delivery is one of the most interesting and challenging areas of research. The blood-brain barrier separates the brain from blood and acts as a barrier to protect the brain from microorganisms, neurotoxins and chemical substances. ...This number …
Brain specific drug delivery is one of the most interesting and challenging areas of research. The blood-brain barrier separat …
Drug targeting with nano-sized carrier systems.
Yokoyama M. Yokoyama M. J Artif Organs. 2005;8(2):77-84. doi: 10.1007/s10047-005-0285-0. J Artif Organs. 2005. PMID: 16094510 Review.
This paper discusses the present status of, and future perspectives on, drug targeting through the bloodstream by describing the drug targeting concept, its methodologies, types of drug carriers, and recent clinical examples. This explanation an …
This paper discusses the present status of, and future perspectives on, drug targeting through the bloodstream by describing t …
Development of Drug Targeting and Delivery in Cervical Cancer.
Aggarwal U, Goyal AK, Rath G. Aggarwal U, et al. Curr Cancer Drug Targets. 2018;18(8):792-806. doi: 10.2174/1568009617666171009165105. Curr Cancer Drug Targets. 2018. PMID: 29032751 Review.
Recently nanocarriers based drug delivery systems owing to their unique properties have been extensively investigated for anticancer drug delivery. ...Localized drug delivery systems allow passive drug targeting …
Recently nanocarriers based drug delivery systems owing to their unique properties have been extensively investigated f …
Drug Targeting Strategies Based on Charge Dependent Uptake of Nanoparticles into Cancer Cells.
Saadat M, Zahednezhad F, Zakeri-Milani P, Reza Heidari H, Shahbazi-Mojarrad J, Valizadeh H. Saadat M, et al. J Pharm Pharm Sci. 2019;22(1):191-220. doi: 10.18433/jpps30318. J Pharm Pharm Sci. 2019. PMID: 31112672 Free article. Review.
The aim of this review was to describe the preferred charged nano-particles (CNPs) for targeted delivery in tumor cells. Zeta Potential (ZP), which represents the surface charge of NPs was highlighted in cell entrance and interactions. ...Cells prefer to endocyte the NPs w …
The aim of this review was to describe the preferred charged nano-particles (CNPs) for targeted delivery in tumor cells. Zeta Potenti …
461,466 results
You have reached the last available page of results. Please see the User Guide for more information.