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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1897 1
1915 1
1916 1
1919 3
1922 2
1936 1
1943 1
1945 2
1946 4
1947 12
1948 8
1949 7
1950 8
1951 20
1952 31
1953 38
1954 46
1955 43
1956 54
1957 62
1958 53
1959 37
1960 23
1961 16
1962 39
1963 88
1964 153
1965 253
1966 559
1967 956
1968 1213
1969 1435
1970 1785
1971 2247
1972 2268
1973 2236
1974 2225
1975 4123
1976 3954
1977 3874
1978 3835
1979 4159
1980 4471
1981 4690
1982 5040
1983 5983
1984 6709
1985 7336
1986 7669
1987 8076
1988 8827
1989 10286
1990 11312
1991 11852
1992 12277
1993 13068
1994 13577
1995 14344
1996 15342
1997 16143
1998 17467
1999 18508
2000 20928
2001 22543
2002 25363
2003 27184
2004 29437
2005 32523
2006 36278
2007 39243
2008 40911
2009 43654
2010 48417
2011 53254
2012 57212
2013 60852
2014 65730
2015 68094
2016 72311
2017 74306
2018 77702
2019 81561
2020 75325
2021 25279
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Search Results

1,204,889 results
Results by year
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Page 1
Drug discovery for alopecia: gone today, hair tomorrow.
Santos Z, Avci P, Hamblin MR. Santos Z, et al. Expert Opin Drug Discov. 2015 Mar;10(3):269-92. doi: 10.1517/17460441.2015.1009892. Epub 2015 Feb 9. Expert Opin Drug Discov. 2015. PMID: 25662177 Free PMC article. Review.
Three main types of alopecia (androgenic [AGA], areata [AA] and chemotherapy-induced [CIA]) are very different, and have their own laboratory models and separate drug-discovery efforts. AREAS COVERED: In this article, the authors review the biology of hair, hair fol …
Three main types of alopecia (androgenic [AGA], areata [AA] and chemotherapy-induced [CIA]) are very different, and have their own laborator …
Soil-transmitted helminth infections: ascariasis, trichuriasis, and hookworm.
Bethony J, Brooker S, Albonico M, Geiger SM, Loukas A, Diemert D, Hotez PJ. Bethony J, et al. Lancet. 2006 May 6;367(9521):1521-32. doi: 10.1016/S0140-6736(06)68653-4. Lancet. 2006. PMID: 16679166 Review.
The gastrointestinal tract of a child living in poverty in a less developed country is likely to be parasitised with at least one, and in many cases all three soil-transmitted helminths, with resultant impairments in physical, intellectual, and cognitive development
The gastrointestinal tract of a child living in poverty in a less developed country is likely to be parasitised with at least one, an …
Cryptosporidiosis Drug Discovery: Opportunities and Challenges.
Manjunatha UH, Chao AT, Leong FJ, Diagana TT. Manjunatha UH, et al. ACS Infect Dis. 2016 Aug 12;2(8):530-7. doi: 10.1021/acsinfecdis.6b00094. Epub 2016 Jul 22. ACS Infect Dis. 2016. PMID: 27626293 Review.
The apicomplexan parasite Cryptosporidium is the second most important diarrheal pathogen causing life-threatening diarrhea in children, which is also associated with long-term growth faltering and cognitive deficiency. Cryptosporidiosis is a parasitic disease of public he …
The apicomplexan parasite Cryptosporidium is the second most important diarrheal pathogen causing life-threatening diarrhea in children, whi …
The Concept of an Ideal Antibiotic: Implications for Drug Design.
Gajdács M. Gajdács M. Molecules. 2019 Mar 3;24(5):892. doi: 10.3390/molecules24050892. Molecules. 2019. PMID: 30832456 Free PMC article. Review.
There is an urgent need for innovation in antibiotic research, as classical discovery platforms (e.g., mining soil Streptomycetes) are no longer viable options. ...Based on 150 references, the aim of this review is to summarize current advances regarding the challenges of …
There is an urgent need for innovation in antibiotic research, as classical discovery platforms (e.g., mining soil Streptomycetes) ar …
Toxin-antitoxin systems in bacterial growth arrest and persistence.
Page R, Peti W. Page R, et al. Nat Chem Biol. 2016 Apr;12(4):208-14. doi: 10.1038/nchembio.2044. Nat Chem Biol. 2016. PMID: 26991085 Review.
In contrast, under conditions of stress, the antitoxins are selectively degraded, freeing the toxins to inhibit essential cellular processes, such as DNA replication and protein translation. This inhibition results in rapid growth arrest. In this Review, we highlight recen …
In contrast, under conditions of stress, the antitoxins are selectively degraded, freeing the toxins to inhibit essential cellular processes …
Novel chemical starting points for drug discovery in leishmaniasis and Chagas disease.
Roquero I, Cantizani J, Cotillo I, Manzano MP, Kessler A, Martín JJ, McNamara CW. Roquero I, et al. Int J Parasitol Drugs Drug Resist. 2019 Aug;10:58-68. doi: 10.1016/j.ijpddr.2019.05.002. Epub 2019 May 22. Int J Parasitol Drugs Drug Resist. 2019. PMID: 31158574 Free PMC article.
Due to the partial efficacy and toxicity-related limitations of the existing treatments, there is an urgent need to develop novel therapies with superior efficacy and safety profiles to successfully treat these diseases. ...We disclose these hit structures and associated a …
Due to the partial efficacy and toxicity-related limitations of the existing treatments, there is an urgent need to develop novel the …
Animal models for Niemann-Pick type C: implications for drug discovery & development.
Fog CK, Kirkegaard T. Fog CK, et al. Expert Opin Drug Discov. 2019 May;14(5):499-509. doi: 10.1080/17460441.2019.1588882. Epub 2019 Mar 19. Expert Opin Drug Discov. 2019. PMID: 30887840 Review.
This review provides a high-level evaluation and prioritization of the various models with regard to efficient and clinically translatable drug development, and briefly discusses the relevant developments and opportunities pertaining to this. Expert opinion: …
This review provides a high-level evaluation and prioritization of the various models with regard to efficient and clinically translatable …
Scientific Prediction and Prophetic Patenting in Drug Discovery.
Curry SH, Schneiderman AM. Curry SH, et al. Recent Pat CNS Drug Discov. 2015;10(1):34-44. doi: 10.2174/1574889810666150619104344. Recent Pat CNS Drug Discov. 2015. PMID: 26088613
Pharmaceutical patenting involves writing claims based on both discoveries already made, and on prophesy of future developments in an ongoing project. This is necessitated by the very different timelines involved in the drug discovery and product de
Pharmaceutical patenting involves writing claims based on both discoveries already made, and on prophesy of future developments
Drug discovery and developments in developing countries: bottlenecks and way forward.
Nyigo VA, Malebo HM. Nyigo VA, et al. Tanzan Health Res Bull. 2005 Sep;7(3):154-8. doi: 10.4314/thrb.v7i3.14253. Tanzan Health Res Bull. 2005. PMID: 16941941
The driving force for drug discovery and development by pharmaceutical firms has been the foreseeable profit from drug sells. ...Poor economies and technological capabilities, lack of human resources and good management in these countries are the major …
The driving force for drug discovery and development by pharmaceutical firms has been the foreseeable profit from dr
Application of a Dynamic Map for Learning, Communicating, Navigating, and Improving Therapeutic Development.
Wagner JA, Dahlem AM, Hudson LD, Terry SF, Altman RB, Gilliland CT, DeFeo C, Austin CP. Wagner JA, et al. Clin Transl Sci. 2018 Mar;11(2):166-174. doi: 10.1111/cts.12531. Epub 2017 Dec 22. Clin Transl Sci. 2018. PMID: 29271559 Free PMC article.
Drug discovery and development is commonly schematized as a "pipeline," and, although appreciated by drug developers to be a useful oversimplification, this cartology may perpetuate inaccurate notions of straightforwardness and is of minimal uti
Drug discovery and development is commonly schematized as a "pipeline," and, although appreciated by drug dev
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