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7 results

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Filters applied: Randomized Controlled Trial, in the last 5 years, Humans, English. Clear all
Page 1
Impact of Banhabaekchulcheonmatang (Banxia Baizhu Tianma Tang) and Hwangryeonhaedoktang (Huang Lian Jie Du Tang) on edoxaban: Herb-drug interaction study in healthy subjects.
Cho SJ, Song J, Kang DW, Kim JH, Kim H, Chung H, Cho HY. Cho SJ, et al. J Ethnopharmacol. 2025 Jan 30;337(Pt 3):118997. doi: 10.1016/j.jep.2024.118997. Epub 2024 Oct 24. J Ethnopharmacol. 2025. PMID: 39461388 Clinical Trial.
ETHNOPHARMACOLOGICAL RELEVANCE: Concurrent use of traditional herbal medicines and conventional drugs, particularly for stroke treatment, is widespread, raising concerns about potential drug interactions. AIM OF THE STUDY: This clinical study aimed to investigate …
ETHNOPHARMACOLOGICAL RELEVANCE: Concurrent use of traditional herbal medicines and conventional drugs, particularly for stroke treatment, is …
The influence of green tea extract on nintedanib's bioavailability in patients with pulmonary fibrosis.
Veerman GDM, van der Werff SC, Koolen SLW, Miedema JR, Oomen-de Hoop E, van der Mark SC, Chandoesing PP, de Bruijn P, Wijsenbeek MS, Mathijssen RHJ. Veerman GDM, et al. Biomed Pharmacother. 2022 Jul;151:113101. doi: 10.1016/j.biopha.2022.113101. Epub 2022 May 17. Biomed Pharmacother. 2022. PMID: 35594703 Free article. Clinical Trial.
Nintedanib is an oral small-molecule kinase inhibitor and first-line treatment for idiopathic pulmonary fibrosis. Nintedanib is a substrate of the drug efflux transporter ABCB1. Green tea flavonoids --especially epigallocatechin gallate (EGCG)-- are potent ABCB1 modulators …
Nintedanib is an oral small-molecule kinase inhibitor and first-line treatment for idiopathic pulmonary fibrosis. Nintedanib is a substrate …
Influence of green tea consumption on endoxifen steady-state concentration in breast cancer patients treated with tamoxifen.
Braal CL, Hussaarts KGAM, Seuren L, Oomen-de Hoop E, de Bruijn P, Buck SAJ, Bos MEMM, Thijs-Visser MF, Zuetenhorst HJM, Mathijssen-van Stein D, Vastbinder MB, van Leeuwen RWF, van Gelder T, Koolen SLW, Jager A, Mathijssen RHJ. Braal CL, et al. Breast Cancer Res Treat. 2020 Nov;184(1):107-113. doi: 10.1007/s10549-020-05829-6. Epub 2020 Aug 16. Breast Cancer Res Treat. 2020. PMID: 32803636 Free PMC article. Clinical Trial.
CONCLUSIONS: This study demonstrated the absence of a pharmacokinetic interaction between green tea supplements and tamoxifen. Therefore, the use of green tea by patients with tamoxifen does not have to be discouraged....
CONCLUSIONS: This study demonstrated the absence of a pharmacokinetic interaction between green tea supplements and tamoxifen. Theref …
Effects of Green Tea Extract on Atorvastatin Pharmacokinetics in Healthy Volunteers.
Abdelkawy KS, Abdelaziz RM, Abdelmageed AM, Donia AM, El-Khodary NM. Abdelkawy KS, et al. Eur J Drug Metab Pharmacokinet. 2020 Jun;45(3):351-360. doi: 10.1007/s13318-020-00608-6. Eur J Drug Metab Pharmacokinet. 2020. PMID: 31997084 Clinical Trial.
BACKGROUND AND OBJECTIVES: Green tea catechins were recently reported to inhibit drug transporters such as organic anion-transporting polypeptides (OATPs) and metabolic enzymes, affecting the bioavailability of many drugs. This study aimed to evaluate the clinical signific …
BACKGROUND AND OBJECTIVES: Green tea catechins were recently reported to inhibit drug transporters such as organic anion-transporting …
A Phase II Randomized Controlled Trial of Renshen Yangrong Tang Herbal Extract Granules for Fatigue Reduction in Cancer Survivors.
Xu Y, Wang XS, Chen Y, Shi Q, Chen TH, Li P. Xu Y, et al. J Pain Symptom Manage. 2020 May;59(5):966-973. doi: 10.1016/j.jpainsymman.2019.10.018. Epub 2019 Oct 24. J Pain Symptom Manage. 2020. PMID: 31668965 Free article. Clinical Trial.
METHODS: Cancer survivors with moderate or severe fatigue (rated 4 on a 0-10 scale) for more than two months were randomized to take herbal extract granules of RSYRT or a low dose of a single herb (huangqi) twice a day for six weeks. Patient-reported fatigue was measured u …
METHODS: Cancer survivors with moderate or severe fatigue (rated 4 on a 0-10 scale) for more than two months were randomized to take herbal …
Effect of Schisandra Chinensis Extract Supplementation on Quadriceps Muscle Strength and Fatigue in Adult Women: A Randomized, Double-Blind, Placebo-Controlled Trial.
Park J, Han S, Park H. Park J, et al. Int J Environ Res Public Health. 2020 Apr 4;17(7):2475. doi: 10.3390/ijerph17072475. Int J Environ Res Public Health. 2020. PMID: 32260466 Free PMC article. Clinical Trial.
The fruit of Schisandra chinensis (SC) is a well-known traditional herb used for pharmacological purposes in Asian countries (e.g., Korea, China, and Japan). ...We used two-factor repeated measures analysis of variance (ANOVA) to determine interaction (group time) e …
The fruit of Schisandra chinensis (SC) is a well-known traditional herb used for pharmacological purposes in Asian countries (e.g., K …
Influence of St. John's Wort on Intravenous Fentanyl Pharmacokinetics, Pharmacodynamics, and Clinical Effects: A Randomized Clinical Trial.
Loughren MJ, Kharasch ED, Kelton-Rehkopf MC, Syrjala KL, Shen DD. Loughren MJ, et al. Anesthesiology. 2020 Mar;132(3):491-503. doi: 10.1097/ALN.0000000000003065. Anesthesiology. 2020. PMID: 31794512 Free PMC article. Clinical Trial.
BACKGROUND: Patients often use complementary and alternative herbal medicines, hence, potential exists for adverse herb-drug interactions. Fentanyl is metabolized by hepatic CYP3A4 and considered transported by blood-brain barrier P-glycoprotein. ...
BACKGROUND: Patients often use complementary and alternative herbal medicines, hence, potential exists for adverse herb-drug …