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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1966 1
1968 2
1969 1
1970 2
1971 5
1972 4
1973 3
1974 6
1975 3
1976 2
1978 1
1979 2
1980 1
1981 2
1982 2
1983 1
1984 2
1985 1
1986 3
1987 2
1989 3
1990 7
1991 8
1992 14
1993 5
1994 23
1995 12
1996 12
1997 9
1998 18
1999 9
2000 12
2001 27
2002 10
2003 15
2004 25
2005 22
2006 16
2007 34
2008 43
2009 27
2010 40
2011 37
2012 27
2013 37
2014 38
2015 44
2016 41
2017 42
2018 33
2019 16
2020 5
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692 results
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Page 1
[Drug-induced dyspepsia].
Gross M, Labenz J. Gross M, et al. Dtsch Med Wochenschr. 2015 May;140(10):728-33. doi: 10.1055/s-0041-101921. Epub 2015 May 13. Dtsch Med Wochenschr. 2015. PMID: 25970411 German.
Patients often report upper abdominal pain, an early sense of satiety, epigastric discomfort or pain in the upper abdomen or behind the breastbone, flatulence, diarrhoea or constipation. ...Given the high frequency of these symptoms in the general population and the large number of medications many patients are taking, it can be very difficult in a given patient to differentiate between drug-induced side effects and spontaneously occurring symptoms....
Patients often report upper abdominal pain, an early sense of satiety, epigastric discomfort or pain in the upper abdomen or behind the brea …
Efficacy of Treatments for Opioid-Induced Constipation: Systematic Review and Meta-analysis.
Nee J, Zakari M, Sugarman MA, Whelan J, Hirsch W, Sultan S, Ballou S, Iturrino J, Lembo A. Nee J, et al. Clin Gastroenterol Hepatol. 2018 Oct;16(10):1569-1584.e2. doi: 10.1016/j.cgh.2018.01.021. Epub 2018 Jan 31. Clin Gastroenterol Hepatol. 2018. PMID: 29374616
BACKGROUND & AIMS: Opioid-induced constipation (OIC) is a common problem in patients on chronic opioid therapy for cancer-related and non-cancer-related pain. ...Participants who received μ-opioid-receptor antagonists were significantly more likely to have diarrhea, abdominal pain, nausea, or vomiting than patients who received placebo. ...
BACKGROUND & AIMS: Opioid-induced constipation (OIC) is a common problem in patients on chronic opioid therapy for cancer- …
Constipation and Botanical Medicines: An Overview.
Cirillo C, Capasso R. Cirillo C, et al. Phytother Res. 2015 Oct;29(10):1488-93. doi: 10.1002/ptr.5410. Epub 2015 Jul 14. Phytother Res. 2015. PMID: 26171992 Review.
The causes of constipation are mainly three: lifestyle related (functional constipation), disease related, and drug induced. Constipation can generate considerable suffering, including abdominal pain and distension, anorexia, and nausea. The value of some therapeutic measures such as increased fluid intake, physical activity, diet rich in fiber, and nutritional supplements recommended for the relief of constipation is still questionable. ...
The causes of constipation are mainly three: lifestyle related (functional constipation), disease related, and drug
Analysis of Nausea in Clinical Studies of Lubiprostone for the Treatment of Constipation Disorders.
Cryer B, Drossman DA, Chey WD, Webster L, Habibi S, Wang M. Cryer B, et al. Dig Dis Sci. 2017 Dec;62(12):3568-3578. doi: 10.1007/s10620-017-4680-1. Epub 2017 Aug 28. Dig Dis Sci. 2017. PMID: 28849329 Free PMC article.
BACKGROUND: Lubiprostone is a ClC-2 chloride channel activator approved for the treatment of chronic idiopathic constipation (CIC) and opioid-induced constipation (OIC) in adults and irritable bowel syndrome with constipation (IBS-C) in women. Lubiprostone is generally well tolerated, with nausea being the most common adverse event. AIMS: To characterize nausea with lubiprostone using pooled results from clinical studies in patients with CIC, OIC, or IBS-C. ...
BACKGROUND: Lubiprostone is a ClC-2 chloride channel activator approved for the treatment of chronic idiopathic constipation (CIC) an …
The Ever-Changing Landscape of Drug-Induced Injury of the Lower Gastrointestinal Tract.
Marginean EC. Marginean EC. Arch Pathol Lab Med. 2016 Aug;140(8):748-58. doi: 10.5858/arpa.2015-0451-RA. Arch Pathol Lab Med. 2016. PMID: 27472233 Review.
CONTEXT: -There is an ever-growing armamentarium of pharmacologic agents that can cause gastrointestinal (GI) mucosal injury, the most common symptoms being diarrhea, constipation, nausea, and vomiting. ...It is important for the pathologist to keep in mind that a single drug type can induce many histologic patterns of mucosal injury that can mimic many disease entities. ...
CONTEXT: -There is an ever-growing armamentarium of pharmacologic agents that can cause gastrointestinal (GI) mucosal injury, the most commo …
Advances in pharmacotherapy for opioid-induced constipation - a systematic review.
Siemens W, Gaertner J, Becker G. Siemens W, et al. Expert Opin Pharmacother. 2015 Mar;16(4):515-32. doi: 10.1517/14656566.2015.995625. Epub 2014 Dec 24. Expert Opin Pharmacother. 2015. PMID: 25539282 Review.
INTRODUCTION: Opioid-induced constipation (OIC) is one of the most frequent and burdening adverse events (AE) of opioid therapy. ...Besides nausea and diarrhea, abdominal pain was the most frequent AE for all drugs (risk ratio, range: 1.52 - 5.06) except for alvimopan. ...
INTRODUCTION: Opioid-induced constipation (OIC) is one of the most frequent and burdening adverse events (AE) of opioid therap …
Olanzapine with ondansetron and dexamethasone for the prevention of cisplatin-based chemotherapy-induced nausea and vomiting in lung cancer.
Wang W, Lou G, Zhang Y. Wang W, et al. Medicine (Baltimore). 2018 Sep;97(37):e12331. doi: 10.1097/MD.0000000000012331. Medicine (Baltimore). 2018. PMID: 30212982 Free PMC article.
Olanzapine is an atypical antipsychotic that has shown efficacy for the treatment of nausea, anxiety, and insomnia. This study was conducted to evaluate the efficacy of olanzapine (5 mg) combined with 5-HT3 receptor antagonists and dexamethasone for the prevention of chemotherapy-induced nausea and vomiting (CINV) in lung patients receiving cisplatin-based (25 mg/m2 d1-3) highly emetogenic chemotherapy (HEC).Olanzapine (5 mg) was administered a day prior to cisplatin administration and continued on days 1 to 5. ...The main side effects were grade 1 somnolence (35.0%) and mild constipation (52.5%).Around 5 mg olanzapine may be used as a potential, safe, and cost-beneficial alternative to prevent nausea and vomiting for HEC, particular for multiday chemotherapy regimen....
Olanzapine is an atypical antipsychotic that has shown efficacy for the treatment of nausea, anxiety, and insomnia. This study was co …
Central Neuromodulators for Treating Functional GI Disorders: A Primer.
Sobin WH, Heinrich TW, Drossman DA. Sobin WH, et al. Am J Gastroenterol. 2017 May;112(5):693-702. doi: 10.1038/ajg.2017.57. Epub 2017 Mar 28. Am J Gastroenterol. 2017. PMID: 28349992 Review.
These agents can benefit mood, pain, diarrhea, constipation, nausea, sleep, and depression. The mechanisms by which they work, the differences between classes and individual agents, and the various adverse effects are outlined. Dosing, augmentation strategies, and treatment scenarios specifically for painful FGIDs, FD with PDS, and chronic nausea and vomiting syndrome are outlined....
These agents can benefit mood, pain, diarrhea, constipation, nausea, sleep, and depression. The mechanisms by which they work, …
Efficacy and Safety of Subcutaneous Neostigmine for Ileus, Acute Colonic Pseudo-obstruction, or Refractory Constipation.
Kram B, Greenland M, Grant M, Campbell ME, Wells C, Sommer C. Kram B, et al. Ann Pharmacother. 2018 Jun;52(6):505-512. doi: 10.1177/1060028018754302. Epub 2018 Jan 23. Ann Pharmacother. 2018. PMID: 29359574 Clinical Trial.
Safety events evaluated were cardiac arrest, bradycardia, bronchospasm requiring intervention, nausea requiring intervention, or severe salivation, lacrimation, or diarrhea. ...Three patients (1.65%) experienced an adverse drug event leading to drug discontinuation, with 2 developing bradycardia that resolved with drug discontinuation alone. ...
Safety events evaluated were cardiac arrest, bradycardia, bronchospasm requiring intervention, nausea requiring intervention, or seve …
The safety of antiemetic medications for the prevention of chemotherapy-induced nausea and vomiting.
Navari RM. Navari RM. Expert Opin Drug Saf. 2016;15(3):343-56. doi: 10.1517/14740338.2016.1135899. Epub 2016 Jan 14. Expert Opin Drug Saf. 2016. PMID: 26699406 Review.
INTRODUCTION: Chemotherapy-induced nausea and vomiting (CINV) is associated with a significant deterioration in quality of life and is perceived by patients as a major adverse effect of the treatment. ...EXPERT OPINION: The current antiemetics that are recommended by the various international antiemetic guidelines are safe and effective in the prevention of chemotherapy-induced nausea and vomiting when used in the recommended doses. ...
INTRODUCTION: Chemotherapy-induced nausea and vomiting (CINV) is associated with a significant deterioration in quality of lif …
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