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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1959 1
1960 1
1961 1
1962 2
1963 5
1964 3
1965 6
1966 8
1967 8
1968 18
1969 14
1970 24
1971 33
1972 28
1973 32
1974 41
1975 82
1976 86
1977 55
1978 59
1979 54
1980 98
1981 82
1982 97
1983 128
1984 84
1985 94
1986 102
1987 102
1988 102
1989 111
1990 101
1991 105
1992 96
1993 81
1994 69
1995 100
1996 96
1997 95
1998 94
1999 111
2000 109
2001 123
2002 139
2003 150
2004 179
2005 231
2006 195
2007 219
2008 224
2009 221
2010 272
2011 277
2012 295
2013 273
2014 277
2015 288
2016 316
2017 281
2018 277
2019 293
2020 288
2021 284
2022 280
2023 219
2024 234
2025 235
2026 182

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8,130 results

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Page 1
Fundamentals of enzyme kinetics.
Seibert E, Tracy TS. Seibert E, et al. Methods Mol Biol. 2014;1113:9-22. doi: 10.1007/978-1-62703-758-7_2. Methods Mol Biol. 2014. PMID: 24523106 Review.
This chapter provides a general introduction to the kinetics of enzyme-catalyzed reactions, with a focus on drug-metabolizing enzymes. A prerequisite to understanding enzyme kinetics is having a clear grasp of the meanings of "enzyme" and …
This chapter provides a general introduction to the kinetics of enzyme-catalyzed reactions, with a focus on drug-metabolizi …
Prediction of human drug metabolizing enzyme induction.
Mankowski DC, Ekins S. Mankowski DC, et al. Curr Drug Metab. 2003 Oct;4(5):381-91. doi: 10.2174/1389200033489352. Curr Drug Metab. 2003. PMID: 14529370 Review.
New chemical entities are routinely screened in vitro and in vivo for their ability to induce cytochrome P450s (CYP), other drug-metabolizing enzymes and possibly transporters in an attempt to more accurately predict clinical parameters such as drug-drug inte …
New chemical entities are routinely screened in vitro and in vivo for their ability to induce cytochrome P450s (CYP), other drug-m …
Ocular drug-metabolizing enzymes: focus on esterases.
Hammid A, Honkakoski P. Hammid A, et al. Drug Metab Rev. 2024 Aug;56(3):175-189. doi: 10.1080/03602532.2024.2368247. Epub 2024 Jun 19. Drug Metab Rev. 2024. PMID: 38888291 Review.
This review describes current knowledge on the expression of ocular phase I and II drug-metabolizing enzymes in the main animal species used in ocular drug development and in humans, with a focus on ocular esterases and their prodrug substrates. The eye posse …
This review describes current knowledge on the expression of ocular phase I and II drug-metabolizing enzymes in the mai …
INTEDE: interactome of drug-metabolizing enzymes.
Yin J, Li F, Zhou Y, Mou M, Lu Y, Chen K, Xue J, Luo Y, Fu J, He X, Gao J, Zeng S, Yu L, Zhu F. Yin J, et al. Nucleic Acids Res. 2021 Jan 8;49(D1):D1233-D1243. doi: 10.1093/nar/gkaa755. Nucleic Acids Res. 2021. PMID: 33045737 Free PMC article.
Drug-metabolizing enzymes (DMEs) are critical determinant of drug safety and efficacy, and the interactome of DMEs has attracted extensive attention. ...However, no database was designed to systematically provide the data of all types of DME interactions. Her …
Drug-metabolizing enzymes (DMEs) are critical determinant of drug safety and efficacy, and the interactome of DMEs has …
[Evaluation of induction of drug-metabolizing enzyme mRNAs in primary cultures of cryopreserved human and cynomolgus monkey hepatocytes].
Nishimura M. Nishimura M. Yakugaku Zasshi. 2009 Jul;129(7):815-20. doi: 10.1248/yakushi.129.815. Yakugaku Zasshi. 2009. PMID: 19571516 Free article. Review. Japanese.
We introduce a method for measuring drug-metabolizing enzymes and transporters using real-time one-step RT-PCR with TaqMan probes. ...We discuss the usefulness of evaluating the gene induction of drug-metabolizing enzymes and transporters …
We introduce a method for measuring drug-metabolizing enzymes and transporters using real-time one-step RT-PCR with Taq …
[Diagnosis of hepatic enzyme activities of drug metabolizing enzymes-phenotyping and genotyping].
Ozawa S. Ozawa S. Kokuritsu Iyakuhin Shokuhin Eisei Kenkyusho Hokoku. 1999;(117):63-76. Kokuritsu Iyakuhin Shokuhin Eisei Kenkyusho Hokoku. 1999. PMID: 10859937 Review. Japanese.
Drug metabolizing enzymes (DMEs) play an important role in the biotransformation of various xenobiotics, generally by detoxifying and eliminating substrates by converting them to more hydrophilic derivatives, or in some cases, activating substrates by convers …
Drug metabolizing enzymes (DMEs) play an important role in the biotransformation of various xenobiotics, generally by d …
Interactions of drug-metabolizing enzymes with the Chinese herb Psoraleae Fructus.
Zhou QH, Zhu YD, Zhang F, Song YQ, Jia SN, Zhu L, Fang SQ, Ge GB. Zhou QH, et al. Chin J Nat Med. 2019 Nov;17(11):858-870. doi: 10.1016/S1875-5364(19)30103-7. Chin J Nat Med. 2019. PMID: 31831132 Review.
This article reviews the interactions between human drug-metabolizing enzymes and the constituents of Psoraleae Fructus; the major constituents in Psoraleae Fructus, along with their chemical structures and metabolic pathways are summarized, and the inhibitor …
This article reviews the interactions between human drug-metabolizing enzymes and the constituents of Psoraleae Fructus …
Drug-metabolizing enzymes in the skin of man, rat, and pig.
Oesch F, Fabian E, Oesch-Bartlomowicz B, Werner C, Landsiedel R. Oesch F, et al. Drug Metab Rev. 2007;39(4):659-98. doi: 10.1080/03602530701690366. Drug Metab Rev. 2007. PMID: 18058329 Review.
However, many reports clearly show that most drug metabolizing enzymes also occur in the mammalian skin albeit at relatively low specific activities. This review summarizes the current state of knowledge on drug metabolizing enzymes in th …
However, many reports clearly show that most drug metabolizing enzymes also occur in the mammalian skin albeit at relat …
Extrahepatic drug metabolizing enzymes.
Kapitulnik J, Strobel HW. Kapitulnik J, et al. J Biochem Mol Toxicol. 1999;13(5):227-30. doi: 10.1002/(sici)1099-0461(1999)13:5<227::aid-jbt1>3.0.co;2-1. J Biochem Mol Toxicol. 1999. PMID: 10402555 Review.
Drug metabolizing enzymes are known to be present and active in most extrahepatic tissues. In this review, evidence is presented that expression and activity of several extrahepatic drug-metabolizing enzymes are regulated in unique ways, …
Drug metabolizing enzymes are known to be present and active in most extrahepatic tissues. In this review, evidence is …
8,130 results