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Did you mean duncan r smith [au] NOT nursing (153 results)?
Limiting DNA polymerase delta alters replication dynamics and leads to a dependence on checkpoint activation and recombination-mediated DNA repair.
Koussa NC, Smith DJ. Koussa NC, et al. Among authors: smith dj. PLoS Genet. 2021 Jan 25;17(1):e1009322. doi: 10.1371/journal.pgen.1009322. eCollection 2021 Jan. PLoS Genet. 2021. PMID: 33493195 Free PMC article.
Here, we analyze how the depletion of Pol delta impacts replication origin firing and lagging-strand synthesis during replication elongation in vivo in S. cerevisiae. By analyzing nascent lagging-strand products, we observe a genome-wide change in both the establishment an ā€¦
Here, we analyze how the depletion of Pol delta impacts replication origin firing and lagging-strand synthesis during replication elongation ā€¦
Separable, Ctf4-mediated recruitment of DNA Polymerase Ī± for initiation of DNA synthesis at replication origins and lagging-strand priming during replication elongation.
Porcella SY, Koussa NC, Tang CP, Kramer DN, Srivastava P, Smith DJ. Porcella SY, et al. Among authors: smith dj. PLoS Genet. 2020 May 7;16(5):e1008755. doi: 10.1371/journal.pgen.1008755. eCollection 2020 May. PLoS Genet. 2020. PMID: 32379761 Free PMC article.
It is unknown whether leading- and lagging-strand priming are mechanistically identical, and whether Pol alpha associates processively or distributively with the replisome. Here, we titrate cellular levels of Pol alpha in S. cerevisiae and analyze Okazaki fragments to stud ā€¦
It is unknown whether leading- and lagging-strand priming are mechanistically identical, and whether Pol alpha associates processively or di ā€¦
Rotational and translational positions determine the structural and dynamic impact of a single ribonucleotide incorporated in the nucleosome.
Fu I, Smith DJ, Broyde S. Fu I, et al. Among authors: smith dj. DNA Repair (Amst). 2019 Jan;73:155-163. doi: 10.1016/j.dnarep.2018.11.012. Epub 2018 Nov 29. DNA Repair (Amst). 2019. PMID: 30522887 Free PMC article.
We find that the presence of the 2'-OH group on the ribose impacts the local conformation and dynamics of both the ribonucleotide and nearby DNA nucleotides as well as their interactions with histones; the nature of these disturbances depends on the rotational and translational s ā€¦
We find that the presence of the 2'-OH group on the ribose impacts the local conformation and dynamics of both the ribonucleotide and nearby ā€¦
Pif1-family helicases cooperatively suppress widespread replication-fork arrest at tRNA genes.
Osmundson JS, Kumar J, Yeung R, Smith DJ. Osmundson JS, et al. Among authors: smith dj. Nat Struct Mol Biol. 2017 Feb;24(2):162-170. doi: 10.1038/nsmb.3342. Epub 2016 Dec 19. Nat Struct Mol Biol. 2017. PMID: 27991904 Free PMC article.
Here, we systematically characterized the roles of Pif1 helicases in replisome progression and lagging-strand synthesis in S. cerevisiae. We demonstrate that either Pif1 or Rrm3 redundantly stimulates strand displacement by DNA polymerase delta during lagging-strand synthe ā€¦
Here, we systematically characterized the roles of Pif1 helicases in replisome progression and lagging-strand synthesis in S. cerevis ā€¦
Detection and Sequencing of Okazaki Fragments in S. cerevisiae.
Smith DJ, Yadav T, Whitehouse I. Smith DJ, et al. Methods Mol Biol. 2015;1300:141-53. doi: 10.1007/978-1-4939-2596-4_10. Methods Mol Biol. 2015. PMID: 25916711 Free PMC article.
We have previously demonstrated that lagging-strand synthesis in budding yeast is coupled with chromatin assembly on newly synthesized DNA. Using a strain of S. cerevisiae in which DNA ligase I can be conditionally depleted, we can enrich and purify Okazaki fragments. ...
We have previously demonstrated that lagging-strand synthesis in budding yeast is coupled with chromatin assembly on newly synthesized DNA. ā€¦
Quantitative, genome-wide analysis of eukaryotic replication initiation and termination.
McGuffee SR, Smith DJ, Whitehouse I. McGuffee SR, et al. Among authors: smith dj. Mol Cell. 2013 Apr 11;50(1):123-35. doi: 10.1016/j.molcel.2013.03.004. Epub 2013 Apr 4. Mol Cell. 2013. PMID: 23562327 Free PMC article.
Via the deep sequencing of Okazaki fragments, we comprehensively document replication fork directionality throughout the S. cerevisiae genome, which permits the systematic analysis of initiation, origin efficiency, fork progression, and termination. ...
Via the deep sequencing of Okazaki fragments, we comprehensively document replication fork directionality throughout the S. cerevisia ā€¦
An Eco1-independent sister chromatid cohesion establishment pathway in S. cerevisiae.
Borges V, Smith DJ, Whitehouse I, Uhlmann F. Borges V, et al. Among authors: smith dj. Chromosoma. 2013 Mar;122(1-2):121-34. doi: 10.1007/s00412-013-0396-y. Epub 2013 Jan 20. Chromosoma. 2013. PMID: 23334284 Free PMC article.
Budding yeast cohesin first associates with chromosomes in G1. Then, during DNA replication in S-phase, the replication fork-associated acetyltransferase Eco1 acetylates the cohesin subunit Smc3 to make cohesin's DNA binding resistant to destabilization by the Wapl ā€¦
Budding yeast cohesin first associates with chromosomes in G1. Then, during DNA replication in S-phase, the replication fork-associat ā€¦
Insights into branch nucleophile positioning and activation from an orthogonal pre-mRNA splicing system in yeast.
Smith DJ, Konarska MM, Query CC. Smith DJ, et al. Mol Cell. 2009 May 15;34(3):333-43. doi: 10.1016/j.molcel.2009.03.012. Mol Cell. 2009. PMID: 19450531 Free PMC article.
The duplex formed between the branch site (BS) of a spliceosomal intron and its cognate sequence in U2 snRNA is important for spliceosome assembly and the first catalytic step of splicing. We describe the development of an orthogonal BS-U2 system in S. cerevisiae in which ā€¦
The duplex formed between the branch site (BS) of a spliceosomal intron and its cognate sequence in U2 snRNA is important for spliceosome as ā€¦
Circulating levels of MCP-1 and eotaxin are not associated with presence of atherosclerosis or previous myocardial infarction.
Mosedale DE, Smith DJ, Aitken S, Schofield PM, Clarke SC, McNab D, Goddard H, Gale CR, Martyn CN, Bethell HW, Barnard C, Hayns S, Nugent C, Panicker A, Grainger DJ. Mosedale DE, et al. Among authors: smith dj. Atherosclerosis. 2005 Dec;183(2):268-74. doi: 10.1016/j.atherosclerosis.2004.11.028. Atherosclerosis. 2005. PMID: 15894320