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Selection of DNA-Encoded Libraries to Protein Targets within and on Living Cells.

Cai B, Kim D, Akhand S, Sun Y, Cassell RJ, Alpsoy A, Dykhuizen EC, Van Rijn RM, Wendt MK, Krusemark CJ. Cai B, et al. Among authors: dykhuizen ec. J Am Chem Soc. 2019 Oct 30;141(43):17057-17061. doi: 10.1021/jacs.9b08085. Epub 2019 Oct 22. J Am Chem Soc. 2019. PMID: 31613623

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A chemoproteomic portrait of the oncometabolite fumarate.

Kulkarni RA, Bak DW, Wei D, Bergholtz SE, Briney CA, Shrimp JH, Alpsoy A, Thorpe AL, Bavari AE, Crooks DR, Levy M, Florens L, Washburn MP, Frizzell N, Dykhuizen EC, Weerapana E, Linehan WM, Meier JL. Kulkarni RA, et al. Among authors: dykhuizen ec. Nat Chem Biol. 2019 Apr;15(4):391-400. doi: 10.1038/s41589-018-0217-y. Epub 2019 Feb 4. Nat Chem Biol. 2019. PMID: 30718813 Free PMC article.

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BAF complexes facilitate decatenation of DNA by topoisomerase IIα.

Dykhuizen EC, Hargreaves DC, Miller EL, Cui K, Korshunov A, Kool M, Pfister S, Cho YJ, Zhao K, Crabtree GR. Dykhuizen EC, et al. Nature. 2013 May 30;497(7451):624-7. doi: 10.1038/nature12146. Epub 2013 May 22. Nature. 2013. PMID: 23698369 Free PMC article.

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PBRM1 Regulates Stress Response in Epithelial Cells.

Porter EG, Dhiman A, Chowdhury B, Carter BC, Lin H, Stewart JC, Kazemian M, Wendt MK, Dykhuizen EC. Porter EG, et al. Among authors: dykhuizen ec. iScience. 2019 May 31;15:196-210. doi: 10.1016/j.isci.2019.04.027. Epub 2019 Apr 26. iScience. 2019. PMID: 31077944 Free PMC article.

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Glioma tumor suppressor candidate region gene 1 (GLTSCR1) and its paralog GLTSCR1-like form SWI/SNF chromatin remodeling subcomplexes.

Alpsoy A, Dykhuizen EC. Alpsoy A, et al. Among authors: dykhuizen ec. J Biol Chem. 2018 Mar 16;293(11):3892-3903. doi: 10.1074/jbc.RA117.001065. Epub 2018 Jan 26. J Biol Chem. 2018. PMID: 29374058 Free PMC article.

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A Novel CRISPR/Cas9-Based Cellular Model to Explore Adenylyl Cyclase and cAMP Signaling.

Soto-Velasquez M, Hayes MP, Alpsoy A, Dykhuizen EC, Watts VJ. Soto-Velasquez M, et al. Among authors: dykhuizen ec. Mol Pharmacol. 2018 Sep;94(3):963-972. doi: 10.1124/mol.118.111849. Epub 2018 Jun 27. Mol Pharmacol. 2018. PMID: 29950405 Free PMC article.

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Small Molecule Targeting of Specific BAF (mSWI/SNF) Complexes for HIV Latency Reversal.

Marian CA, Stoszko M, Wang L, Leighty MW, de Crignis E, Maschinot CA, Gatchalian J, Carter BC, Chowdhury B, Hargreaves DC, Duvall JR, Crabtree GR, Mahmoudi T, Dykhuizen EC. Marian CA, et al. Among authors: dykhuizen ec. Cell Chem Biol. 2018 Dec 20;25(12):1443-1455.e14. doi: 10.1016/j.chembiol.2018.08.004. Epub 2018 Sep 6. Cell Chem Biol. 2018. PMID: 30197195 Free PMC article.

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Analysis of Human Nuclear Protein Complexes by Quantitative Mass Spectrometry Profiling.

Connelly KE, Hedrick V, Paschoal Sobreira TJ, Dykhuizen EC, Aryal UK. Connelly KE, et al. Among authors: dykhuizen ec. Proteomics. 2018 Jun;18(11):e1700427. doi: 10.1002/pmic.201700427. Epub 2018 May 4. Proteomics. 2018. PMID: 29655301 Free PMC article.

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Optimization of Ligands Using Focused DNA-Encoded Libraries To Develop a Selective, Cell-Permeable CBX8 Chromodomain Inhibitor.

Wang S, Denton KE, Hobbs KF, Weaver T, McFarlane JMB, Connelly KE, Gignac MC, Milosevich N, Hof F, Paci I, Musselman CA, Dykhuizen EC, Krusemark CJ. Wang S, et al. Among authors: dykhuizen ec. ACS Chem Biol. 2020 Jan 17;15(1):112-131. doi: 10.1021/acschembio.9b00654. Epub 2019 Dec 12. ACS Chem Biol. 2020. PMID: 31755685

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Engagement of DNA and H3K27me3 by the CBX8 chromodomain drives chromatin association.

Connelly KE, Weaver TM, Alpsoy A, Gu BX, Musselman CA, Dykhuizen EC. Connelly KE, et al. Among authors: dykhuizen ec. Nucleic Acids Res. 2019 Mar 18;47(5):2289-2305. doi: 10.1093/nar/gky1290. Nucleic Acids Res. 2019. PMID: 30597065 Free PMC article.

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