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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1955 1
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1975 1
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1979 2
1980 2
1981 2
1982 1
1983 3
1984 1
1985 3
1987 3
1988 6
1989 2
1990 3
1991 5
1992 1
1993 4
1994 10
1995 5
1996 5
1997 9
1998 6
1999 8
2000 11
2001 3
2002 10
2003 16
2004 15
2005 17
2006 17
2007 12
2008 13
2009 12
2010 18
2011 20
2012 21
2013 20
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2016 29
2017 36
2018 32
2019 28
2020 29
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2022 17
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517 results

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Page 1
Exploring alpha-synuclein Interaction Partners and their Potential Clinical Implications for Parkinson's Disease.
Chen Y, Gu Y, Cao C, Zheng Q, Sun L, Ding W, Ma L, Wang C, Zhang W. Chen Y, et al. Neurochem Res. 2024 Nov 19;50(1):23. doi: 10.1007/s11064-024-04250-5. Neurochem Res. 2024. PMID: 39560845
Alpha-synuclein aggregates are strongly associated with Parkinson's disease (PD), a degenerative neurological disorder characterized by a progressive loss in motor functions. Our study aimed to unravel the potential interaction partners of alpha-synuclein for …
Alpha-synuclein aggregates are strongly associated with Parkinson's disease (PD), a degenerative neurological disorder …
The structural logic of dynamic signaling in the Escherichia coli serine chemoreceptor.
Reyes GI, Flack CE, Parkinson JS. Reyes GI, et al. Protein Sci. 2024 Dec;33(12):e5209. doi: 10.1002/pro.5209. Protein Sci. 2024. PMID: 39555666 Free PMC article.
Here, we exploited protein crosslinking assays in living cells to follow conformational and dynamic stimulus signals in Tsr, the Escherichia coli serine chemoreceptor. Tsr mediates serine chemotaxis by integrating transmembrane serine-binding inputs with adaptationa …
Here, we exploited protein crosslinking assays in living cells to follow conformational and dynamic stimulus signals in Tsr, the Escheric …
Genetically modified E. Coli secreting melanin (E.melanin) activates the astrocytic PSAP-GPR37L1 pathway and mitigates the pathogenesis of Parkinson's disease.
Kong W, Liu Y, Ai P, Bi Y, Wei C, Guo X, Cai Z, Gao G, Hu P, Zheng J, Liu J, Huo M, Guan Y, Wu Q. Kong W, et al. J Nanobiotechnology. 2024 Nov 10;22(1):690. doi: 10.1186/s12951-024-02955-x. J Nanobiotechnology. 2024. PMID: 39523310 Free PMC article.
The characteristic neuropathology of Parkinson's disease (PD) involves the abnormal accumulation of phosphorylated alpha-synuclein (alphaSyn), as well as a significant decrease in neuromelanin (NM) levels within dopamine neurons (DaNs). Unlike alphaSyn aggreg …
The characteristic neuropathology of Parkinson's disease (PD) involves the abnormal accumulation of phosphorylated alph …
Additional feedforward mechanism of Parkin activation via binding of phospho-UBL and RING0 in trans.
Lenka DR, Dahe SV, Antico O, Sahoo P, Prescott AR, Muqit MMK, Kumar A. Lenka DR, et al. Elife. 2024 Sep 2;13:RP96699. doi: 10.7554/eLife.96699. Elife. 2024. PMID: 39221915 Free PMC article.
Loss-of-function Parkin mutations lead to early-onset of Parkinson's disease. Parkin is an auto-inhibited ubiquitin E3 ligase activated by dual phosphorylation of its ubiquitin-like (Ubl) domain and ubiquitin by the PINK1 kinase. ...
Loss-of-function Parkin mutations lead to early-onset of Parkinson's disease. Parkin is an auto-inhibited ubiquitin E3 …
Difference in gut microbial dysbiotic patterns between body-first and brain-first Parkinson's disease.
Park DG, Kang W, Shin IJ, Chalita M, Oh HS, Hyun DW, Kim H, Chun J, An YS, Lee EJ, Yoon JH. Park DG, et al. Neurobiol Dis. 2024 Oct 15;201:106655. doi: 10.1016/j.nbd.2024.106655. Epub 2024 Aug 30. Neurobiol Dis. 2024. PMID: 39218360 Free article.
BACKGROUND: This study aims to identify distinct microbial and functional biomarkers characteristic of body-first or brain-first subtypes of Parkinson's disease (PD). This could illuminate the unique pathogenic mechanisms within these subtypes. ...The gut mic …
BACKGROUND: This study aims to identify distinct microbial and functional biomarkers characteristic of body-first or brain-first subtypes of …
On the pH-dependence of α-synuclein amyloid polymorphism and the role of secondary nucleation in seed-based amyloid propagation.
Frey L, Ghosh D, Qureshi BM, Rhyner D, Guerrero-Ferreira R, Pokharna A, Kwiatkowski W, Serdiuk T, Picotti P, Riek R, Greenwald J. Frey L, et al. Elife. 2024 Aug 28;12:RP93562. doi: 10.7554/eLife.93562. Elife. 2024. PMID: 39196271 Free PMC article.
The aggregation of the protein alpha-synuclein is closely associated with several neurodegenerative disorders and as such the structures of the amyloid fibril aggregates have high scientific and medical significance. ...The results also suggest the possibility of producing …
The aggregation of the protein alpha-synuclein is closely associated with several neurodegenerative disorders and as such the structu …
ClpL Chaperone as a Possible Component of the Disaggregase Activity of Limosilactobacillus fermentum U-21.
Al Ebrahim RN, Alekseeva MG, Bazhenov SV, Fomin VV, Mavletova DA, Nesterov AA, Poluektova EU, Danilenko VN, Manukhov IV. Al Ebrahim RN, et al. Biology (Basel). 2024 Aug 6;13(8):592. doi: 10.3390/biology13080592. Biology (Basel). 2024. PMID: 39194530 Free PMC article.
The L. fermentum U-21 strain, known for secreting chaperones into the extracellular milieu, emerges as a promising candidate for the development of novel therapeutics termed disaggregases for Parkinson's disease. Our study focuses on characterizing the secret …
The L. fermentum U-21 strain, known for secreting chaperones into the extracellular milieu, emerges as a promising candidate for the develop …
Acute Neuroinflammation Alters the Transport of a Model Therapeutic Protein from the Brain into Lymph and Blood.
Hoang TA, Jin L, Nicolazzo JA, Trevaskis NL. Hoang TA, et al. Mol Pharm. 2024 Oct 7;21(10):5138-5149. doi: 10.1021/acs.molpharmaceut.4c00516. Epub 2024 Aug 26. Mol Pharm. 2024. PMID: 39185947
The drainage of fluid and solutes along lymphatic pathways from the brain has been found to be impaired in mouse models of multiple sclerosis, Alzheimer's disease, and Parkinson's disease where neuroinflammation is present. We recently demonstrated tha …
The drainage of fluid and solutes along lymphatic pathways from the brain has been found to be impaired in mouse models of multiple sclerosi …
Opsoclonus-myoclonus-ataxia syndrome associated with bacterial urinary tract infection.
Jayasekara H, Wickramarathne JS, Liyanage DS, Jayasinghe PA. Jayasekara H, et al. BMJ Case Rep. 2024 Aug 22;17(8):e261533. doi: 10.1136/bcr-2024-261533. BMJ Case Rep. 2024. PMID: 39179267
While predominantly affecting children, it can rarely manifest in adults and could be associated with infections, paraneoplastic syndrome, drugs or other neurological disorders. We present a case of an elderly gentleman presenting with OMAS associated with a culture-positi …
While predominantly affecting children, it can rarely manifest in adults and could be associated with infections, paraneoplastic syndrome, d …
Oral aged garlic (Allium sativum) alleviates ulcerative colitis in mice by improving gut homeostasis.
Han D, Guan X, Zhu F, Yang Q, Su D. Han D, et al. Food Funct. 2024 Aug 27;15(17):8935-8951. doi: 10.1039/d4fo03105a. Food Funct. 2024. PMID: 39145619
Oral AG obviously alleviated colitis, reducing colon damage and enhancing anti-oxidative and anti-inflammatory effects. Escherichia coli and Streptococcus equinus dramatically were enriched in the colon of mice with colitis that were strongly associated with Park …
Oral AG obviously alleviated colitis, reducing colon damage and enhancing anti-oxidative and anti-inflammatory effects. Escherichia …
517 results