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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1955 1
1973 1
1974 1
1975 1
1976 2
1977 1
1978 2
1979 2
1980 2
1981 2
1982 1
1983 3
1984 1
1985 3
1987 3
1988 6
1989 2
1990 3
1991 6
1992 1
1993 4
1994 10
1995 5
1996 6
1997 10
1998 6
1999 8
2000 11
2001 3
2002 10
2003 18
2004 15
2005 17
2006 18
2007 12
2008 13
2009 13
2010 18
2011 20
2012 22
2013 20
2014 23
2015 33
2016 30
2017 39
2018 35
2019 30
2020 32
2021 24
2022 17
2023 17
2024 23
2025 21
2026 6

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570 results

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Page 1
Spontaneous switching in a protein signalling array reveals near-critical cooperativity.
Keegstra JM, Avgidis F, Usher E, Mulla Y, Parkinson JS, Shimizu TS. Keegstra JM, et al. Nat Phys. 2026 Jan 29;22(3):452-60. doi: 10.1038/s41567-025-03158-3. Online ahead of print. Nat Phys. 2026. PMID: 41907765 Free PMC article.
Here, we report in vivo FRET measurements of spontaneous discrete-level transitions in the activity of an entire Escherichia coli chemosensory array - an extensive membrane-associated assembly comprising thousands of molecules. Finite-size scaling analysis of the te …
Here, we report in vivo FRET measurements of spontaneous discrete-level transitions in the activity of an entire Escherichia coli …
Preclinical Evaluation of Synthetic Biology-Driven Engineered Escherichia coli Nissle 1917 as a Living Therapeutic for Sustained L-DOPA Delivery.
Abdalla A, Padhi P, Bakes N, Thyer R, Zenitsky G, Jin H, Anantharam V, Kanthasamy A, Ellington AD, Phillips GJ, Kanthasamy AG. Abdalla A, et al. ACS Synth Biol. 2026 Feb 20;15(2):748-761. doi: 10.1021/acssynbio.5c00786. Epub 2026 Feb 2. ACS Synth Biol. 2026. PMID: 41628253 Free PMC article.
Dopamine deficiency resulting from nigrostriatal dopaminergic neuronal damage manifests as extrapyramidal motor symptoms of Parkinson's disease (PD). Oral tablet dosing of levodopa, administered 3-4 times a day, remains the standard of care due to its tolerab …
Dopamine deficiency resulting from nigrostriatal dopaminergic neuronal damage manifests as extrapyramidal motor symptoms of Parkinson …
What is the Impact of Dopamine D2 Receptor in the Brain-Gut Axis? A Narrative Review of the Mechanism Based on Gut Microbiota in Modulating Emotion and Behavior.
Xie YA, Kong JD, Li S, Wei DF. Xie YA, et al. Alpha Psychiatry. 2025 Nov 19;26(6):39226. doi: 10.31083/AP39226. eCollection 2025 Dec. Alpha Psychiatry. 2025. PMID: 41523964 Free PMC article. Review.
With the development of the brain-gut axis (GBA), the bidirectional communication between gut microbiota and the brain has become critical in emotion regulation research, and dopamine D2 receptors and gut microbiota play key roles in this process, especially in neurological and p …
With the development of the brain-gut axis (GBA), the bidirectional communication between gut microbiota and the brain has become critical i …
A gut microbiota-based predictive model for the treatment efficacy of Parkinson's disease.
Liu C, Yu T. Liu C, et al. Front Neurol. 2025 Dec 18;16:1686882. doi: 10.3389/fneur.2025.1686882. eCollection 2025. Front Neurol. 2025. PMID: 41487429 Free PMC article.
OBJECTIVE: This study aimed to develop and validate a predictive model for the decline in treatment efficacy among Parkinson's disease (PD) patients based on clinical characteristics and biological markers, providing a basis for early risk identification and …
OBJECTIVE: This study aimed to develop and validate a predictive model for the decline in treatment efficacy among Parkinson's …
Identification and enhanced activity of the tyrosine phenol-lyase from Mycobacterium tuberculosis.
Liu H, Yang X. Liu H, et al. Int J Biol Macromol. 2026 Jan;340(Pt 1):149969. doi: 10.1016/j.ijbiomac.2025.149969. Epub 2025 Dec 29. Int J Biol Macromol. 2026. PMID: 41475646
L-DOPA (3,4-dihydroxyphenyl-L-alanine) is a key drug for the Parkinson's disease. The global demand of L-DOPA is continuously increasing. Tyrosine phenol-lyase (TPL) is the environmentally friendly biocatalyst for L-DOPA biosynthesis. In this study, a novel T …
L-DOPA (3,4-dihydroxyphenyl-L-alanine) is a key drug for the Parkinson's disease. The global demand of L-DOPA is contin …
Taxonomic and mechanistic insights into gut microbiota bioaccumulation of entacapone using bioorthogonal drug labelling.
Guantai LM, Bavinton CE, Shazzad JB, Mahajan S, Thompson S, Pereira FC. Guantai LM, et al. Microbiome Res Rep. 2025 Nov 20;4(4):41. doi: 10.20517/mrr.2025.73. eCollection 2025. Microbiome Res Rep. 2025. PMID: 41438002 Free PMC article.
This study employed bioorthogonal labelling to track and identify gut microbial taxa and molecular mechanisms involved in the bioaccumulation of entacapone, a Parkinson's disease drug. Methods: We synthesised alkyne-tagged derivatives of entacapone and evalua …
This study employed bioorthogonal labelling to track and identify gut microbial taxa and molecular mechanisms involved in the bioaccumulatio …
Metabolic modeling of microbial communities in the chicken ceca reveals a landscape of competition and co-operation.
Utkina I, Fan Y, Willing BP, Parkinson J. Utkina I, et al. Microbiome. 2025 Nov 27;13(1):248. doi: 10.1186/s40168-025-02241-4. Microbiome. 2025. PMID: 41310806 Free PMC article.
In its absence, communities undergo significant functional reconfiguration, with metabolic roles typically fulfilled by B. fragilis assumed by multiple taxa. Beyond B. fragilis, we found Escherichia coli and Lactobacillus crispatus also mediate influential metabolic …
In its absence, communities undergo significant functional reconfiguration, with metabolic roles typically fulfilled by B. fragilis assumed …
L-arginine interferes with functional studies of amyloid proteins.
Chethana HP, Rathan Kumar U, Chakraborty G, Sidhu A. Chethana HP, et al. Protein Expr Purif. 2026 Mar;239:106854. doi: 10.1016/j.pep.2025.106854. Epub 2025 Nov 14. Protein Expr Purif. 2026. PMID: 41242668
Intrinsically disordered proteins/regions are abundant in cancer signalling pathways and neurodegenerative diseases like Parkinson's disease, amyotrophic lateral sclerosis, Alzheimer's disease, etc. Purification of intrinsically disordered proteins can …
Intrinsically disordered proteins/regions are abundant in cancer signalling pathways and neurodegenerative diseases like Parkinson' …
Bioengineered gut bacterium synthesizing levodopa alleviates motor deficits in models of Parkinson's disease.
Padhi P, Abdalla A, Schneider B, Backes N, Otto AA, Scheibe IJ, Thomas JP, Khadse G, Samidurai M, Jochmans AK, George A, Zenitsky G, Jin H, Anantharam V, Kanthasamy A, Mishra A, Allenspach K, Mochel J, Phillips GJ, Kanthasamy AG. Padhi P, et al. Cell Host Microbe. 2025 Nov 12;33(11):1837-1854.e13. doi: 10.1016/j.chom.2025.10.005. Epub 2025 Oct 30. Cell Host Microbe. 2025. PMID: 41172985 Free PMC article.
L-DOPA is the gold-standard treatment for Parkinson's disease (PD), given orally alongside decarboxylase inhibitors (e.g., benserazide) to enhance bioavailability. ...Herein, we show the construction and in vivo efficacy of a programmable, titratable, genetic …
L-DOPA is the gold-standard treatment for Parkinson's disease (PD), given orally alongside decarboxylase inhibitors (e. …
570 results