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Development and characterization of an amorphous curcumin-Eudragit( )E100 solid dispersions with improved solubility, stability, and pharmacokinetic properties.
Wang X, Zhu Y, Zhao X, Zhang S, Cao M, Wang X, Li W. Wang X, et al. Pharm Dev Technol. 2022 Nov;27(9):965-974. doi: 10.1080/10837450.2022.2141778. Epub 2022 Nov 3. Pharm Dev Technol. 2022. PMID: 36305800
The development of amorphous solid dispersions (ASD) is one way to overcome the bioavailability challenges of poorly water-soluble drug. Herein, Curcumin (CUR) was dispersed in the polymeric matrix of Eudragit( )E100 by solvent evaporation, giving ASD, donated as CU …
The development of amorphous solid dispersions (ASD) is one way to overcome the bioavailability challenges of poorly water-soluble drug. Her …
Curcumin--from molecule to biological function.
Esatbeyoglu T, Huebbe P, Ernst IM, Chin D, Wagner AE, Rimbach G. Esatbeyoglu T, et al. Angew Chem Int Ed Engl. 2012 May 29;51(22):5308-32. doi: 10.1002/anie.201107724. Epub 2012 May 4. Angew Chem Int Ed Engl. 2012. PMID: 22566109 Review.
As a consequence of its intense yellow color, turmeric, or curcumin (food additive E100), is used as a food coloring (e.g. mustard). Turmeric contains the curcuminoids curcumin, demethoxycurcumin, and bisdemethoxycurcumin. ...Curcuminoids influence gene expre …
As a consequence of its intense yellow color, turmeric, or curcumin (food additive E100), is used as a food coloring (e.g. mus …
Advantages of introducing an effective crystalline inhibitor in curcumin amorphous solid dispersions formulated by Eudragit E100.
Fan N, Li J, Li J. Fan N, et al. J Pharm Pharmacol. 2021 Mar 4;73(2):185-192. doi: 10.1093/jpp/rgaa012. J Pharm Pharmacol. 2021. PMID: 33793808
OBJECTIVES: This paper was to elucidate the advantages of using an effective crystalline inhibitor, which was hydroxypropyl methylcellulose E5 (HPMC), in inhibiting crystallisation for curcumin amorphous solid dispersion (Cur ASDs) formulated by Eudragit E100 (E1 …
OBJECTIVES: This paper was to elucidate the advantages of using an effective crystalline inhibitor, which was hydroxypropyl methylcellulose …
Storage stability and solubilization ability of HPMC in curcumin amorphous solid dispersions formulated by Eudragit E100.
Fan N, Ma P, Wang X, Li C, Zhang X, Zhang K, Li J, He Z. Fan N, et al. Carbohydr Polym. 2018 Nov 1;199:492-498. doi: 10.1016/j.carbpol.2018.07.036. Epub 2018 Jul 21. Carbohydr Polym. 2018. PMID: 30143154
The present study elucidated the advantages of using hydroxypropyl methylcellulose E5 (HPMC) as auxiliary excipient in maintaining storage stability and solubilization ability for curcumin amorphous solid dispersion (Cur ASDs) formulated by Eudragit E100 (E100 …
The present study elucidated the advantages of using hydroxypropyl methylcellulose E5 (HPMC) as auxiliary excipient in maintaining storage s …
Bioactive evaluation and application of different formulations of the natural colorant curcumin (E100) in a hydrophilic matrix (yogurt).
Almeida HHS, Barros L, Barreira JCM, Calhelha RC, Heleno SA, Sayer C, Miranda CG, Leimann FV, Barreiro MF, Ferreira ICFR. Almeida HHS, et al. Food Chem. 2018 Sep 30;261:224-232. doi: 10.1016/j.foodchem.2018.04.056. Epub 2018 Apr 17. Food Chem. 2018. PMID: 29739587 Free article.
Curcumin (E100) is a natural colorant that, besides conferring color, has bioactivity, serving as an alternative to some artificial colorants. As a hydrophobic colorant, its modification/compatibilization with the aqueous medium is required to improve stability and …
Curcumin (E100) is a natural colorant that, besides conferring color, has bioactivity, serving as an alternative to some artif …
Curcumin amorphous solid dispersions: the influence of intra and intermolecular bonding on physical stability.
Wegiel LA, Zhao Y, Mauer LJ, Edgar KJ, Taylor LS. Wegiel LA, et al. Pharm Dev Technol. 2014 Dec;19(8):976-86. doi: 10.3109/10837450.2013.846374. Epub 2013 Nov 6. Pharm Dev Technol. 2014. PMID: 24192454
We have investigated the physical stability of amorphous curcumin dispersions and the role of curcumin-polymer intermolecular interactions in delaying crystallization. ...Curcumin chemical stability was monitored by UV-Vis spectroscopy. Isolation of stable am …
We have investigated the physical stability of amorphous curcumin dispersions and the role of curcumin-polymer intermolecular …
Curcumin-polymeric nanoparticles against colon-26 tumor-bearing mice: cytotoxicity, pharmacokinetic and anticancer efficacy studies.
Chaurasia S, Chaubey P, Patel RR, Kumar N, Mishra B. Chaurasia S, et al. Drug Dev Ind Pharm. 2016;42(5):694-700. doi: 10.3109/03639045.2015.1064941. Epub 2015 Jul 13. Drug Dev Ind Pharm. 2016. PMID: 26165247
CONTEXT: Curcumin (CUR), can inhibit proliferation and induce apoptosis of tumor cells, its extreme insolubility and limited bioavailability restricted its clinical application. ...
CONTEXT: Curcumin (CUR), can inhibit proliferation and induce apoptosis of tumor cells, its extreme insolubility and limited bioavail …
Bioactivity of Curcumin on the Cytochrome P450 Enzymes of the Steroidogenic Pathway.
Rodríguez Castaño P, Parween S, Pandey AV. Rodríguez Castaño P, et al. Int J Mol Sci. 2019 Sep 17;20(18):4606. doi: 10.3390/ijms20184606. Int J Mol Sci. 2019. PMID: 31533365 Free PMC article.
Turmeric is rich in curcuminoids, including curcumin, demethoxycurcumin, and bisdemethoxycurcumin. Curcuminoids have potent wound healing, anti-inflammatory, and anti-carcinogenic activities. ...Molecular docking studies confirmed that curcumin could dock onto the a …
Turmeric is rich in curcuminoids, including curcumin, demethoxycurcumin, and bisdemethoxycurcumin. Curcuminoids have potent wound hea …
Synthetic versus natural curcumin: bioequivalence in an in vitro oral mucositis model.
Lüer SC, Goette J, Troller R, Aebi C. Lüer SC, et al. BMC Complement Altern Med. 2014 Feb 11;14:53. doi: 10.1186/1472-6882-14-53. BMC Complement Altern Med. 2014. PMID: 24517289 Free PMC article.
BACKGROUND: Curcumin (CUR) is a dietary spice and food colorant (E100). Its potent anti-inflammatory activity by inhibiting the activation of Nuclear Factor-kappaB is well established. ...
BACKGROUND: Curcumin (CUR) is a dietary spice and food colorant (E100). Its potent anti-inflammatory activity by inhibiting th …
Methods for the determination of European Union-permitted added natural colours in foods: a review.
Scotter MJ. Scotter MJ. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2011 May;28(5):527-96. doi: 10.1080/19440049.2011.555844. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2011. PMID: 21424961 Review.
The nine designated natural colour classes covered are: 1. Curcumin (E100), 2. Riboflavins (E101i-ii), 3. Cochineal (E120), 4. Chlorophylls--including chlorophyllins and copper analogues (E140-141), 5. ...
The nine designated natural colour classes covered are: 1. Curcumin (E100), 2. Riboflavins (E101i-ii), 3. Cochineal (E120), 4. …
17 results