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Early Development Challenges for Drug Products Containing Nanomaterials.
Grossman JH, Crist RM, Clogston JD. Grossman JH, et al. AAPS J. 2017 Jan;19(1):92-102. doi: 10.1208/s12248-016-9980-4. Epub 2016 Sep 9. AAPS J. 2017. PMID: 27612680
The vast majority of drug product candidates in early development fail to progress to clinics. ...This article reviews experiments that have proven useful in providing "go/no-go" decision-making data for nanomedicines in early preclinical dev …
The vast majority of drug product candidates in early development fail to progress to clinics. ...This article r …
Aqueous eye drops containing drug/cyclodextrin nanoparticles deliver therapeutic drug concentrations to both anterior and posterior segment.
Loftsson T, Stefánsson E. Loftsson T, et al. Acta Ophthalmol. 2022 Feb;100(1):7-25. doi: 10.1111/aos.14861. Epub 2021 Apr 20. Acta Ophthalmol. 2022. PMID: 33876553 Free article. Review.
Using topical application to deliver therapeutic concentrations of drugs to the posterior segment of the eye remains very challenging. As a result, posterior segment diseases are usually treated by intravitreal injection or implant. ...An early study in humans showe …
Using topical application to deliver therapeutic concentrations of drugs to the posterior segment of the eye remains very challenging …
Theranostic nanoparticles engineered for clinic and pharmaceutics.
Ma X, Zhao Y, Liang XJ. Ma X, et al. Acc Chem Res. 2011 Oct 18;44(10):1114-22. doi: 10.1021/ar2000056. Epub 2011 Jul 6. Acc Chem Res. 2011. PMID: 21732606 Review.
Many of these novel nanoparticles contain both drug(s) and imaging agent(s) within an individual nanoparticle for simultaneous disease diagnosis and therapy. ...In this Account, we describe the development of theranostic nanomaterials with low toxicity …
Many of these novel nanoparticles contain both drug(s) and imaging agent(s) within an individual nanoparticle for simultaneous …
Fast and versatile analysis of liposome encapsulation efficiency by nanoParticle exclusion chromatography.
Bian J, Girotti J, Fan Y, Levy ES, Zang N, Sethuraman V, Kou P, Zhang K, Gruenhagen J, Lin J. Bian J, et al. J Chromatogr A. 2022 Jan 11;1662:462688. doi: 10.1016/j.chroma.2021.462688. Epub 2021 Nov 17. J Chromatogr A. 2022. PMID: 34915190
Liposomes are an attractive drug delivery platform for a wide variety of pharmaceutical molecules. ...The determination of encapsulation efficiency requires the measurement of at least two of the three drug populations: total drug, encapsulated drug …
Liposomes are an attractive drug delivery platform for a wide variety of pharmaceutical molecules. ...The determination of enc …
Multi-functional vesicles for cancer therapy: The ultimate magic bullet.
Tavano L, Muzzalupo R. Tavano L, et al. Colloids Surf B Biointerfaces. 2016 Nov 1;147:161-171. doi: 10.1016/j.colsurfb.2016.07.060. Epub 2016 Jul 29. Colloids Surf B Biointerfaces. 2016. PMID: 27500359 Review.
Liposomes and niosomes are nanovesicles that contain amphiphilic molecules arranged in concentric bilayers, delimitating an aqueous core. ...Many multi-functional vesicular devices have shown great promise in clinical application, indicating broad potential as therapeutics …
Liposomes and niosomes are nanovesicles that contain amphiphilic molecules arranged in concentric bilayers, delimitating an aqueous c …
Novel and safe single-dose treatment of cutaneous leishmaniasis with implantable amphotericin B-loaded microparticles.
Sousa-Batista AJ, Pacienza-Lima W, Ré MI, Rossi-Bergmann B. Sousa-Batista AJ, et al. Int J Parasitol Drugs Drug Resist. 2019 Dec;11:148-155. doi: 10.1016/j.ijpddr.2019.06.001. Epub 2019 Jun 17. Int J Parasitol Drugs Drug Resist. 2019. PMID: 31331828 Free PMC article.
The development of an effective amphotericin B (AmB) topical formulation to replace the systemically toxic injections currently used in cutaneous leishmaniasis (CL) treatment is challenging due to poor absorption through the skin. ...In vivo, the efficacy of a singl …
The development of an effective amphotericin B (AmB) topical formulation to replace the systemically toxic injections currently used …
Sialic acid-engineered mesoporous polydopamine dual loaded with ferritin gene and SPIO for achieving endogenous and exogenous synergistic T2-weighted magnetic resonance imaging of HCC.
Fan K, Lu C, Shu G, Lv XL, Qiao E, Zhang N, Chen M, Song J, Wu F, Zhao Z, Xu X, Xu M, Chen C, Yang W, Sun J, Du Y, Ji J. Fan K, et al. J Nanobiotechnology. 2021 Mar 17;19(1):76. doi: 10.1186/s12951-021-00821-8. J Nanobiotechnology. 2021. PMID: 33731140 Free PMC article.
Thus, the development of effective MR agents is highly needed for the early diagnosis of HCC. RESULTS: Herein, we fabricated an HCC-targeted nanocomplexes containing SPIO-loaded mesoporous polydopamine (MPDA@SPIO), sialic acid (SA)-modified polyethyleneimine …
Thus, the development of effective MR agents is highly needed for the early diagnosis of HCC. RESULTS: Herein, we fabricated a …
Tick immunity using mRNA, DNA and protein-based Salp14 delivery strategies.
Matias J, Kurokawa C, Sajid A, Narasimhan S, Arora G, Diktas H, Lynn GE, DePonte K, Pardi N, Valenzuela JG, Weissman D, Fikrig E. Matias J, et al. Vaccine. 2021 Dec 20;39(52):7661-7668. doi: 10.1016/j.vaccine.2021.11.003. Epub 2021 Nov 30. Vaccine. 2021. PMID: 34862075 Free PMC article.
We therefore utilized Salp14 as a model antigen to examine tick immunity using mRNA lipid nanoparticles (LNPs), plasmid DNA, or recombinant protein platforms. salp14 containing mRNA-LNPs vaccination elicited erythema at the tick bite site after tick challenge that o …
We therefore utilized Salp14 as a model antigen to examine tick immunity using mRNA lipid nanoparticles (LNPs), plasmid DNA, or recombinant …
mRNA vaccination induces tick resistance and prevents transmission of the Lyme disease agent.
Sajid A, Matias J, Arora G, Kurokawa C, DePonte K, Tang X, Lynn G, Wu MJ, Pal U, Strank NO, Pardi N, Narasimhan S, Weissman D, Fikrig E. Sajid A, et al. Sci Transl Med. 2021 Nov 17;13(620):eabj9827. doi: 10.1126/scitranslmed.abj9827. Epub 2021 Nov 17. Sci Transl Med. 2021. PMID: 34788080
Guinea pigs were immunized with a 19ISP mRNA vaccine and subsequently challenged with I. scapularis. Animals administered 19ISP developed erythema at the bite site shortly after ticks began to attach, and these ticks fed poorly, marked by early detachment and …
Guinea pigs were immunized with a 19ISP mRNA vaccine and subsequently challenged with I. scapularis. Animals administered 19ISP de …
Wood-based nanocellulose and bioactive glass modified gelatin-alginate bioinks for 3D bioprinting of bone cells.
Ojansivu M, Rashad A, Ahlinder A, Massera J, Mishra A, Syverud K, Finne-Wistrand A, Miettinen S, Mustafa K. Ojansivu M, et al. Biofabrication. 2019 Apr 26;11(3):035010. doi: 10.1088/1758-5090/ab0692. Biofabrication. 2019. PMID: 30754034
A challenge in the extrusion-based bioprinting is to find a bioink with optimal biological and physicochemical properties. ...For bioprinting, 4-layer structures were printed from cell-containing gels and crosslinked with CaCl(2). Viability, proliferation and alkali …
A challenge in the extrusion-based bioprinting is to find a bioink with optimal biological and physicochemical properties. ...For bio …
11 results