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21 results

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Page 1
Intra-lesional injection of the novel PKC activator EBC-46 rapidly ablates tumors in mouse models.
Boyle GM, D'Souza MM, Pierce CJ, Adams RA, Cantor AS, Johns JP, Maslovskaya L, Gordon VA, Reddell PW, Parsons PG. Boyle GM, et al. PLoS One. 2014 Oct 1;9(10):e108887. doi: 10.1371/journal.pone.0108887. eCollection 2014. PLoS One. 2014. PMID: 25272271 Free PMC article.
Here we describe a novel diterpene ester, EBC-46, and provide preclinical data supporting its use as an intra-lesional treatment. ...Although EBC-46 showed threefold less potency for inhibiting cell growth than PMA in vitro, it was more effective for c …
Here we describe a novel diterpene ester, EBC-46, and provide preclinical data supporting its use as an intra-lesional treatme …
Cryptic Epoxytiglianes from the Kernels of the Blushwood Tree (Fontainea picrosperma).
Chianese G, Amin HIM, Maioli C, Reddell P, Parsons P, Cullen J, Johns J, Handoko H, Boyle G, Appendino G, Taglialatela-Scafati O, Gaeta S. Chianese G, et al. J Nat Prod. 2022 Aug 26;85(8):1959-1966. doi: 10.1021/acs.jnatprod.2c00226. Epub 2022 Aug 16. J Nat Prod. 2022. PMID: 35973043 Free PMC article. Review.
Long-chain (linoleates and/or oleates) 20-acyl derivatives of the epoxytigliane diesters tigilanol tiglate (EBC-46, 2a), EBC-47 (4a), EBC-59 (5a), EBC-83 (6a), and EBC-177 (7a) were identified. By chemoselective acylation of EBC-46 (2a) and EBC-177 (7a …
Long-chain (linoleates and/or oleates) 20-acyl derivatives of the epoxytigliane diesters tigilanol tiglate (EBC-46, 2a), EBC-4 …
The allylic oxidation of tigliane esters.
Amin HIM, Maioli C, Chianese G, Appendino G, Gaeta S, Taglialatela-Scafati O. Amin HIM, et al. Fitoterapia. 2021 Jan;148:104802. doi: 10.1016/j.fitote.2020.104802. Epub 2020 Dec 9. Fitoterapia. 2021. PMID: 33309651
As part of a study on the structure-activity relationships of the anticancer agent tigilanol tiglate (EBC-46, 2), the allylic oxidation of phorbol triacetate (1c) and of the acetonide of its 3alphaH-dihydroderivative (5) was investigated. ...
As part of a study on the structure-activity relationships of the anticancer agent tigilanol tiglate (EBC-46, 2), the allylic …
Randomized controlled clinical study evaluating the efficacy and safety of intratumoral treatment of canine mast cell tumors with tigilanol tiglate (EBC-46).
De Ridder TR, Campbell JE, Burke-Schwarz C, Clegg D, Elliot EL, Geller S, Kozak W, Pittenger ST, Pruitt JB, Riehl J, White J, Wiest ML, Johannes CM, Morton J, Jones PD, Schmidt PF, Gordon V, Reddell P. De Ridder TR, et al. J Vet Intern Med. 2021 Jan;35(1):415-429. doi: 10.1111/jvim.15806. Epub 2020 Jun 16. J Vet Intern Med. 2021. PMID: 32542733 Free PMC article.
Identification of Gene Biomarkers for Tigilanol Tiglate Content in Fontainea picrosperma.
Mitu SA, Stewart P, Tran TD, Reddell PW, Cummins SF, Ogbourne SM. Mitu SA, et al. Molecules. 2022 Jun 21;27(13):3980. doi: 10.3390/molecules27133980. Molecules. 2022. PMID: 35807225 Free PMC article.
As part of a selective-breeding program to increase EBC-46 yield from F. picrosperma plantations, we investigated potential gene biomarkers associated with biosynthesis of EBC-46. ...Compared to low EBC-46 producers, high-EBC-46 …
As part of a selective-breeding program to increase EBC-46 yield from F. picrosperma plantations, we investigated potential ge …
Response to tigilanol tiglate in dogs with mast cell tumors.
Musser ML, Jones PD, Goodson TL, Roof E, Johannes CM. Musser ML, et al. J Vet Intern Med. 2024 Nov-Dec;38(6):3162-3169. doi: 10.1111/jvim.17211. Epub 2024 Oct 17. J Vet Intern Med. 2024. PMID: 39417411 Free PMC article.
Defining in vitro topical antimicrobial and antibiofilm activity of epoxy-tigliane structures against oral pathogens.
Xue W, Pritchard MF, Khan S, Powell LC, Stokniene J, Wu J, Claydon N, Reddell P, Thomas DW, Hill KE. Xue W, et al. J Oral Microbiol. 2023 Jul 31;15(1):2241326. doi: 10.1080/20002297.2023.2241326. eCollection 2023. J Oral Microbiol. 2023. PMID: 37534218 Free PMC article.
DESIGN: In vitro antimicrobial activity of EBC structures (EBC-46, EBC-1013 and EBC-147) against Streptococcus mutans, Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis in minimum inhibitory concentration, growth curve and permeabilization assays we …
DESIGN: In vitro antimicrobial activity of EBC structures (EBC-46, EBC-1013 and EBC-147) against Streptococcus mutans, Aggrega …
Novel epoxy-tiglianes stimulate skin keratinocyte wound healing responses and re-epithelialization via protein kinase C activation.
Moses RL, Boyle GM, Howard-Jones RA, Errington RJ, Johns JP, Gordon V, Reddell P, Steadman R, Moseley R. Moses RL, et al. Biochem Pharmacol. 2020 Aug;178:114048. doi: 10.1016/j.bcp.2020.114048. Epub 2020 May 22. Biochem Pharmacol. 2020. PMID: 32446889
EBC-46 rapidly destroys treated tumors and consistently promotes wound re-epithelialization at sites of tumor destruction. ...Both EBC-46 and EBC-211 (1.51 nM-15.1 M) accelerated G0/G1-S and S-G2/M cell cycle transitions and HaCaT proliferation. ...
EBC-46 rapidly destroys treated tumors and consistently promotes wound re-epithelialization at sites of tumor destruction. ... …
21 results