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261 results

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Extrachromosomal DNA (ecDNA) in cancer: mechanisms, functions, and clinical implications.
Dong Y, He Q, Chen X, Yang F, He L, Zheng Y. Dong Y, et al. Front Oncol. 2023 Jun 28;13:1194405. doi: 10.3389/fonc.2023.1194405. eCollection 2023. Front Oncol. 2023. PMID: 37448518 Free PMC article. Review.
Extrachromosomal DNA (ecDNA) is circular DNA that plays an important role in the development and heterogeneity of cancer. The rapid evolution of methods to detect ecDNA, including microscopic and sequencing approaches, has greatly enhanced our knowledge of th …
Extrachromosomal DNA (ecDNA) is circular DNA that plays an important role in the development and heterogeneity of cancer. The …
Extrachromosomal DNA (ecDNA) in cancer pathogenesis.
Wu S, Bafna V, Mischel PS. Wu S, et al. Curr Opin Genet Dev. 2021 Feb;66:78-82. doi: 10.1016/j.gde.2021.01.001. Epub 2021 Jan 18. Curr Opin Genet Dev. 2021. PMID: 33477016 Review.
Further, the circular topology of ecDNA leads to enhanced chromatin accessibility, altered gene regulation, and massive oncogene transcription, driving tumor growth and progression, and placing ecDNA at the interface of cancer genomics and epigenetics. Recent …
Further, the circular topology of ecDNA leads to enhanced chromatin accessibility, altered gene regulation, and massive oncogene tran …
The Fanconi anemia pathway induces chromothripsis and ecDNA-driven cancer drug resistance.
Engel JL, Zhang X, Wu M, Wang Y, Espejo Valle-Inclán J, Hu Q, Woldehawariat KS, Sanders MA, Smogorzewska A, Chen J, Cortés-Ciriano I, Lo RS, Ly P. Engel JL, et al. Cell. 2024 Oct 17;187(21):6055-6070.e22. doi: 10.1016/j.cell.2024.08.001. Epub 2024 Aug 23. Cell. 2024. PMID: 39181133 Free PMC article.
Notably, FA-pathway-induced chromothripsis generates complex genomic rearrangements and extrachromosomal DNA that confer acquired resistance to anti-cancer therapies. Our findings demonstrate how pathological activation of a central DNA repair mechanism paradoxically trigg …
Notably, FA-pathway-induced chromothripsis generates complex genomic rearrangements and extrachromosomal DNA that confer acquired resistance …
Imaging extrachromosomal DNA (ecDNA) in cancer.
Purshouse K, Pollard SM, Bickmore WA. Purshouse K, et al. Histochem Cell Biol. 2024 Jul;162(1-2):53-64. doi: 10.1007/s00418-024-02280-2. Epub 2024 Apr 16. Histochem Cell Biol. 2024. PMID: 38625562 Free PMC article. Review.
Extrachromosomal DNA (ecDNA) are circular regions of DNA that are found in many cancers. They are an important means of oncogene amplification, and correlate with treatment resistance and poor prognosis. Consequently, there is great interest in exploring and targeti …
Extrachromosomal DNA (ecDNA) are circular regions of DNA that are found in many cancers. They are an important means of oncoge …
The interplay of mutagenesis and ecDNA shapes urothelial cancer evolution.
Nguyen DD, Hooper WF, Liu W, Chu TR, Geiger H, Shelton JM, Shah M, Goldstein ZR, Winterkorn L, Helland A, Sigouros M, Manohar J, Moyer J, Al Assaad M, Semaan A, Cohen S, Madorsky Rowdo F, Wilkes D, Osman M, Singh RR, Sboner A, Valentine HL, Abbosh P, Tagawa ST, Nanus DM, Nauseef JT, Sternberg CN, Molina AM, Scherr D, Inghirami G, Mosquera JM, Elemento O, Robine N, Faltas BM. Nguyen DD, et al. Nature. 2024 Nov;635(8037):219-228. doi: 10.1038/s41586-024-07955-3. Epub 2024 Oct 9. Nature. 2024. PMID: 39385020 Free PMC article.
Advanced urothelial cancer is a frequently lethal disease characterized by marked genetic heterogeneity(1). ...We discovered that most CCND1 amplifications in urothelial cancer arise within circular ecDNA-forming SVs. ecDNA-forming SVs persisted and in …
Advanced urothelial cancer is a frequently lethal disease characterized by marked genetic heterogeneity(1). ...We discovered that mos …
Circular ecDNA promotes accessible chromatin and high oncogene expression.
Wu S, Turner KM, Nguyen N, Raviram R, Erb M, Santini J, Luebeck J, Rajkumar U, Diao Y, Li B, Zhang W, Jameson N, Corces MR, Granja JM, Chen X, Coruh C, Abnousi A, Houston J, Ye Z, Hu R, Yu M, Kim H, Law JA, Verhaak RGW, Hu M, Furnari FB, Chang HY, Ren B, Bafna V, Mischel PS. Wu S, et al. Nature. 2019 Nov;575(7784):699-703. doi: 10.1038/s41586-019-1763-5. Epub 2019 Nov 20. Nature. 2019. PMID: 31748743 Free PMC article.
Oncogenes are commonly amplified on particles of extrachromosomal DNA (ecDNA) in cancer(1,2), but our understanding of the structure of ecDNA and its effect on gene regulation is limited. ...Furthermore, ecDNA is shown to have a significantly greater n …
Oncogenes are commonly amplified on particles of extrachromosomal DNA (ecDNA) in cancer(1,2), but our understanding of the str …
Guilt by association: EcDNA as a mobile transactivator in cancer.
Zhu Y, Gong L, Wei CL. Zhu Y, et al. Trends Cancer. 2022 Sep;8(9):747-758. doi: 10.1016/j.trecan.2022.04.011. Epub 2022 Jun 23. Trends Cancer. 2022. PMID: 35753910 Free PMC article. Review.
Extrachromosomal DNA (ecDNA), first described in the 1960s, is emerging as a prevalent but poorly characterized oncogenic alteration in cancer. ecDNA is a reservoir for oncogene amplification and is associated with an aggressive tumor phenotype and poor patie …
Extrachromosomal DNA (ecDNA), first described in the 1960s, is emerging as a prevalent but poorly characterized oncogenic alteration …
Extrachromosomal DNA in cancer.
Yan X, Mischel P, Chang H. Yan X, et al. Nat Rev Cancer. 2024 Apr;24(4):261-273. doi: 10.1038/s41568-024-00669-8. Epub 2024 Feb 26. Nat Rev Cancer. 2024. PMID: 38409389 Review.
Extrachromosomal DNA (ecDNA) has recently been recognized as a major contributor to cancer pathogenesis that is identified in most cancer types and is associated with poor outcomes. ...The application of modern imaging and computational techniques has yielded …
Extrachromosomal DNA (ecDNA) has recently been recognized as a major contributor to cancer pathogenesis that is identified in …
ecDNA hubs drive cooperative intermolecular oncogene expression.
Hung KL, Yost KE, Xie L, Shi Q, Helmsauer K, Luebeck J, Schöpflin R, Lange JT, Chamorro González R, Weiser NE, Chen C, Valieva ME, Wong IT, Wu S, Dehkordi SR, Duffy CV, Kraft K, Tang J, Belk JA, Rose JC, Corces MR, Granja JM, Li R, Rajkumar U, Friedlein J, Bagchi A, Satpathy AT, Tjian R, Mundlos S, Bafna V, Henssen AG, Mischel PS, Liu Z, Chang HY. Hung KL, et al. Nature. 2021 Dec;600(7890):731-736. doi: 10.1038/s41586-021-04116-8. Epub 2021 Nov 24. Nature. 2021. PMID: 34819668 Free PMC article.
Extrachromosomal DNA (ecDNA) is prevalent in human cancers and mediates high expression of oncogenes through gene amplification and altered gene regulation(1). ...Each ecDNA is more likely to transcribe the oncogene when spatially clustered with additional ec …
Extrachromosomal DNA (ecDNA) is prevalent in human cancers and mediates high expression of oncogenes through gene amplificatio …
Extrachromosomal DNA (ecDNA): Unveiling its role in cancer progression and implications for early detection.
Wu S, Tao T, Zhang L, Zhu X, Zhou X. Wu S, et al. Heliyon. 2023 Oct 29;9(11):e21327. doi: 10.1016/j.heliyon.2023.e21327. eCollection 2023 Nov. Heliyon. 2023. PMID: 38027570 Free PMC article. Review.
Among these studies, the most noteworthy research pertains to cancer-related investigations into ecDNA. Numerous studies have underscored the significance of ecDNA in the pathogenesis of cancer and its role in accelerating cancer evolution. This …
Among these studies, the most noteworthy research pertains to cancer-related investigations into ecDNA. Numerous studies have …
261 results