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Page 1
The skin hydration and anti-ageing benefits of Ectoine, achieved through enhanced Src-ERK-mediated HAS-2 and JNK-driven AQP-3 expression in human keratinocytes, along with the inhibition of MMP-1-induced collagen-I degradation in human fibroblasts, both with and without UVB irradiation.
Wu PY, Hseu JH, Chen YR, Pandey S, Chen SJ, Yang HL, Hseu YC. Wu PY, et al. Int J Cosmet Sci. 2026 Apr;48(2):285-295. doi: 10.1111/ics.70036. Epub 2025 Oct 20. Int J Cosmet Sci. 2026. PMID: 41116229
CONCLUSION: We demonstrated that Ectoine exerts skin hydration effects without or with UVB exposure in human skin keratinocyte (HaCaT) cells and anti-ageing in fibroblast (Hs68) cells. Therefore, Ectoine could serve as a potential natural compou …
CONCLUSION: We demonstrated that Ectoine exerts skin hydration effects without or with UVB exposure in human skin …
Ectoine disperses keratin and alters hydration kinetics in stratum corneum.
Bow JR, Sonoki Y, Uchiyama M, Dauskardt RH. Bow JR, et al. Biochem Biophys Rep. 2021 Sep 17;28:101134. doi: 10.1016/j.bbrep.2021.101134. eCollection 2021 Dec. Biochem Biophys Rep. 2021. PMID: 34584987 Free PMC article.
We find new evidence of keratin dispersion caused by the moisturizing compound ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid), and provide the first characterization of its impacts on the hydration kinetics and biomechanics of SC. ...Studies were …
We find new evidence of keratin dispersion caused by the moisturizing compound ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarbo …
Topical Ectoine Application in Children and Adults to Treat Inflammatory Diseases Associated with an Impaired Skin Barrier: A Systematic Review.
Kauth M, Trusova OV. Kauth M, et al. Dermatol Ther (Heidelb). 2022 Feb;12(2):295-313. doi: 10.1007/s13555-021-00676-9. Epub 2022 Jan 17. Dermatol Ther (Heidelb). 2022. PMID: 35038127 Free PMC article. Review.
Emollients are used in basic therapy to restore the natural skin barrier and relieve symptoms. A systematic review was performed to evaluate the efficacy and safety of ectoine-containing topical formulations in inflammatory skin diseases characterized by an i …
Emollients are used in basic therapy to restore the natural skin barrier and relieve symptoms. A systematic review was performed to e …
Marine-Derived Compounds with Potential Use as Cosmeceuticals and Nutricosmetics.
Alves A, Sousa E, Kijjoa A, Pinto M. Alves A, et al. Molecules. 2020 May 29;25(11):2536. doi: 10.3390/molecules25112536. Molecules. 2020. PMID: 32486036 Free PMC article. Review.
Marine organisms are not only an important renewable source of valuable bulk compounds used in cosmetic industry such as agar and carrageenan, which are used as gelling and thickening agents to increase the viscosity of cosmetic formulations, but also of small molecules such as …
Marine organisms are not only an important renewable source of valuable bulk compounds used in cosmetic industry such as agar and carrageena …
A Comprehensive Review of the Strategies to Reduce Retinoid-Induced Skin Irritation in Topical Formulation.
Narsa AC, Suhandi C, Afidika J, Ghaliya S, Elamin KM, Wathoni N. Narsa AC, et al. Dermatol Res Pract. 2024 Aug 17;2024:5551774. doi: 10.1155/2024/5551774. eCollection 2024. Dermatol Res Pract. 2024. PMID: 39184919 Free PMC article. Review.
Currently, retinoids are known for their abundant benefits to skin health, ranging from reducing signs of aging and decreasing hyperpigmentation to treating acne. ...The findings obtained indicate that the following methods can be used to lessen retinoid-induced irritation …
Currently, retinoids are known for their abundant benefits to skin health, ranging from reducing signs of aging and decreasing hyperp …
Anti-inflammatory and antioxidant effects on skin based on supramolecular hyaluronic acid-ectoin.
Lu B, Zhao S, Zhang J, Zhan J, Zhang J, Liu Z, Zhang J. Lu B, et al. J Mater Chem B. 2024 Aug 28;12(34):8408-8419. doi: 10.1039/d4tb00459k. J Mater Chem B. 2024. PMID: 39086221
This supramolecule has good stability, safety, and skin permeability and can penetrate the stratum corneum of the skin, reaching the epidermis and dermis of the skin. Compared with ectoin, the permeability of the supramolecule HA-ECT was 3.39-fold high …
This supramolecule has good stability, safety, and skin permeability and can penetrate the stratum corneum of the skin, reachi …
Hydrogel facial mask for sensitive skin: A pilot study of long-term effects on hydration, barrier function and mechanical properties.
Rokita B, Kozlowska J, Adamus-Wlodarczyk A, Olejnik AK, Czechowska-Biskup R, Wach RA. Rokita B, et al. Int J Cosmet Sci. 2026 Aug;48(4):864-883. doi: 10.1111/ics.70133. Epub 2026 Jul 28. Int J Cosmet Sci. 2026. PMID: 42521242 Free PMC article.
The hydrogel was manufactured using radiation-induced crosslinking technology originally developed for medical applications and evaluated in individuals with sensitive and allergy-prone skin, with particular emphasis on hydration, skin barrier function and me …
The hydrogel was manufactured using radiation-induced crosslinking technology originally developed for medical applications and evaluated in …
Efficacy and safety of commercially available cosmetic perioperative skincare products for non-invasive energy-based device treatment: a single-centre, randomized, placebo-controlled trial.
Wang Y, Ning J, Zhu J, Fang X, Lee Y, Liao C, Zhang X, Liu W, Ma Y. Wang Y, et al. Eur J Dermatol. 2025 Jun 1;35(3):209-217. doi: 10.1684/ejd.2025.4890. Eur J Dermatol. 2025. PMID: 40742058 Clinical Trial.
However, these treatments can also impair the integrity of the skin barrier, making post-treatment repair of skin barrier function essential to maintain perioperative curative effects. ...Both commercially available skincare products tested in the present study were …
However, these treatments can also impair the integrity of the skin barrier, making post-treatment repair of skin barrier func …
Development and Evaluation of a Novel Anti-Ageing Cream Based on Hyaluronic Acid and Other Innovative Cosmetic Actives.
Juncan AM, Morgovan C, Rus LL, Loghin F. Juncan AM, et al. Polymers (Basel). 2023 Oct 18;15(20):4134. doi: 10.3390/polym15204134. Polymers (Basel). 2023. PMID: 37896378 Free PMC article.
The importance of incorporating hyaluronic acid (HA) as a cosmetic ingredient in skin care formulations emerged lately because the amount of HA naturally found in the epidermis decreases with age, and when applied to the skin through cosmetic products, it confers …
The importance of incorporating hyaluronic acid (HA) as a cosmetic ingredient in skin care formulations emerged lately because the am …
Extremophile-Derived Bioactives in Cosmeceuticals: Bridging Nutraceuticals and Skincare for Holistic Wellness.
Maresca E, Carbone M, Gallo G, Fusco S, Aulitto M. Maresca E, et al. Life (Basel). 2025 Nov 21;15(12):1787. doi: 10.3390/life15121787. Life (Basel). 2025. PMID: 41465727 Free PMC article. Review.
The integration of extremophile-derived bioactives into cosmeceuticals and nutricosmetics offers a novel strategy to enhance skin health through both topical and systemic approaches. Extremophile microorganisms, adapted to extreme conditions, produce unique compounds such …
The integration of extremophile-derived bioactives into cosmeceuticals and nutricosmetics offers a novel strategy to enhance skin hea …
14 results