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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1971 1
1974 5
1975 28
1976 27
1977 32
1978 29
1979 40
1980 49
1981 59
1982 71
1983 112
1984 82
1985 111
1986 90
1987 106
1988 114
1989 150
1990 155
1991 194
1992 200
1993 243
1994 261
1995 261
1996 314
1997 339
1998 362
1999 408
2000 467
2001 476
2002 527
2003 605
2004 629
2005 709
2006 756
2007 824
2008 855
2009 822
2010 814
2011 857
2012 842
2013 891
2014 907
2015 914
2016 868
2017 846
2018 876
2019 890
2020 970
2021 977
2022 1009
2023 1002
2024 571

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4,366 results

Results by year

Filters applied: Abstract, in the last 5 years. Clear all
Page 1
Efficacy of Esketamine Nasal Spray Plus Oral Antidepressant Treatment for Relapse Prevention in Patients With Treatment-Resistant Depression: A Randomized Clinical Trial.
Daly EJ, Trivedi MH, Janik A, Li H, Zhang Y, Li X, Lane R, Lim P, Duca AR, Hough D, Thase ME, Zajecka J, Winokur A, Divacka I, Fagiolini A, Cubala WJ, Bitter I, Blier P, Shelton RC, Molero P, Manji H, Drevets WC, Singh JB. Daly EJ, et al. JAMA Psychiatry. 2019 Sep 1;76(9):893-903. doi: 10.1001/jamapsychiatry.2019.1189. JAMA Psychiatry. 2019. PMID: 31166571 Free PMC article. Clinical Trial.
OBJECTIVE: To assess the efficacy of esketamine nasal spray plus an oral antidepressant compared with an oral antidepressant plus placebo nasal spray in delaying relapse of depressive symptoms in patients with TRD in stable remission after an induction and op …
OBJECTIVE: To assess the efficacy of esketamine nasal spray plus an oral antidepressant compared with an oral antidepressan
Antidepressant efficacy of Agomelatine: Meta-analysis of placebo controlled and active comparator studies.
Maddukuri RK, Hema C, Sri Tejaswi K, Venkata Mounika M, Vegesana BP. Maddukuri RK, et al. Asian J Psychiatr. 2021 Nov;65:102866. doi: 10.1016/j.ajp.2021.102866. Epub 2021 Sep 20. Asian J Psychiatr. 2021. PMID: 34592623 Review.
Publication bias was identified in antidepressant trials which can potentially overestimate the treatment efficacy. ...In comparison (RR 0.99, 0.92-1.07) Agomelatine is an effective antidepressant having similar efficacy with the currently used anti
Publication bias was identified in antidepressant trials which can potentially overestimate the treatment efficacy. ...In comp …
Efficacy and Safety of Fixed-Dose Esketamine Nasal Spray Combined With a New Oral Antidepressant in Treatment-Resistant Depression: Results of a Randomized, Double-Blind, Active-Controlled Study (TRANSFORM-1).
Fedgchin M, Trivedi M, Daly EJ, Melkote R, Lane R, Lim P, Vitagliano D, Blier P, Fava M, Liebowitz M, Ravindran A, Gaillard R, Ameele HVD, Preskorn S, Manji H, Hough D, Drevets WC, Singh JB. Fedgchin M, et al. Int J Neuropsychopharmacol. 2019 Oct 1;22(10):616-630. doi: 10.1093/ijnp/pyz039. Int J Neuropsychopharmacol. 2019. PMID: 31290965 Free PMC article. Clinical Trial.
Based on the predefined statistical testing sequence, esketamine 84 mg/antidepressant had to be significant for esketamine 56 mg/antidepressant to be formally tested. ...This study provides supportive evidence for the safety and efficacy of esketamine nasal s …
Based on the predefined statistical testing sequence, esketamine 84 mg/antidepressant had to be significant for esketamine 56 mg/a
Antidepressant efficacy of cariprazine in bipolar disorder and the role of its pharmacodynamic properties: A hypothesis based on data.
Fountoulakis KN, Ioannou M, Tohen M, Haarman BCM, Zarate CA Jr. Fountoulakis KN, et al. Eur Neuropsychopharmacol. 2023 Jul;72:30-39. doi: 10.1016/j.euroneuro.2023.03.009. Epub 2023 Apr 14. Eur Neuropsychopharmacol. 2023. PMID: 37060629 Free article. Review.
The neurobiology of bipolar depression and the possible targets of bipolar antidepressant therapy remain elusive. The current study investigated whether the pharmacodynamic properties of cariprazine fit into a previously developed model which was the first to be derived ba …
The neurobiology of bipolar depression and the possible targets of bipolar antidepressant therapy remain elusive. The current study i …
Novel antidepressant drugs: Beyond monoamine targets.
Gonda X, Dome P, Neill JC, Tarazi FI. Gonda X, et al. CNS Spectr. 2023 Feb;28(1):6-15. doi: 10.1017/S1092852921000791. Epub 2021 Sep 30. CNS Spectr. 2023. PMID: 34588093 Review.
The efficacy and side effects of antidepressant drugs are mainly attributed to their actions on different monoamine neurotransmitters (serotonin, norepinephrine, and dopamine). ...Going beyond the monoamine targets appears to be an effective strategy to develop nove …
The efficacy and side effects of antidepressant drugs are mainly attributed to their actions on different monoamine neurotrans …
Comparative efficacy and acceptability of antidepressants, psychotherapies, and their combination for acute treatment of children and adolescents with depressive disorder: a systematic review and network meta-analysis.
Zhou X, Teng T, Zhang Y, Del Giovane C, Furukawa TA, Weisz JR, Li X, Cuijpers P, Coghill D, Xiang Y, Hetrick SE, Leucht S, Qin M, Barth J, Ravindran AV, Yang L, Curry J, Fan L, Silva SG, Cipriani A, Xie P. Zhou X, et al. Lancet Psychiatry. 2020 Jul;7(7):581-601. doi: 10.1016/S2215-0366(20)30137-1. Lancet Psychiatry. 2020. PMID: 32563306 Free PMC article.
BACKGROUND: Depressive disorders are common in children and adolescents. Antidepressants, psychotherapies, and their combination are often used in routine clinical practice; however, available evidence on the comparative efficacy and safety of these interventions is …
BACKGROUND: Depressive disorders are common in children and adolescents. Antidepressants, psychotherapies, and their combination are …
Efficacy, safety, and tolerability of antidepressants for pain in adults: overview of systematic reviews.
Ferreira GE, Abdel-Shaheed C, Underwood M, Finnerup NB, Day RO, McLachlan A, Eldabe S, Zadro JR, Maher CG. Ferreira GE, et al. BMJ. 2023 Feb 1;380:e072415. doi: 10.1136/bmj-2022-072415. BMJ. 2023. PMID: 36725015 Free PMC article. Review.
OBJECTIVE: To provide a comprehensive overview of the efficacy, safety, and tolerability of antidepressants for pain according to condition. ...For the other 31 comparisons, antidepressants were either inefficacious or evidence on efficacy was inconclu …
OBJECTIVE: To provide a comprehensive overview of the efficacy, safety, and tolerability of antidepressants for pain according …
Gepirone hydrochloride: a novel antidepressant with 5-HT1A agonistic properties.
Kaur Gill A, Bansal Y, Bhandari R, Kaur S, Kaur J, Singh R, Kuhad A, Kuhad A. Kaur Gill A, et al. Drugs Today (Barc). 2019 Jul;55(7):423-437. doi: 10.1358/dot.2019.55.7.2958474. Drugs Today (Barc). 2019. PMID: 31347611 Review.
There are psychological and pharmacological treatments for depression which mainly focus on monoaminergic neurotransmission theory. The main concern regarding available antidepressants is the lag period and other side effects, such as sexual dysfunction. ...Gepirone underg …
There are psychological and pharmacological treatments for depression which mainly focus on monoaminergic neurotransmission theory. The main …
Efficacy of serotonergic antidepressant treatment for the neuropsychiatric symptoms and agitation in dementia: A systematic review and meta-analysis.
Hsu TW, Stubbs B, Liang CS, Chen TY, Yeh TC, Pan CC, Chu CS. Hsu TW, et al. Ageing Res Rev. 2021 Aug;69:101362. doi: 10.1016/j.arr.2021.101362. Epub 2021 May 14. Ageing Res Rev. 2021. PMID: 34000464 Review.
OBJECTIVE: Serotonergic dysfunction may be involved in the etiology of overall neuropsychiatric symptoms (NPS) and agitation in patients with dementia; therefore, we aim to perform a systematic review and meta-analysis to investigate the efficacy of serotonergic antidep
OBJECTIVE: Serotonergic dysfunction may be involved in the etiology of overall neuropsychiatric symptoms (NPS) and agitation in patients wit …
Efficacy of non-invasive brain stimulation combined with antidepressant medications for depression: a systematic review and meta-analysis of randomized controlled trials.
Tao Y, Liang Q, Zhang F, Guo S, Fan L, Zhao F. Tao Y, et al. Syst Rev. 2024 Mar 20;13(1):92. doi: 10.1186/s13643-024-02480-w. Syst Rev. 2024. PMID: 38509623 Free PMC article. Review.
However, this advantage was not evident during the follow-up period. (p > 0.05). And the combination's efficacy in improving anxiety was found to be lacking. Post-treatment serum levels of 5-HT, DA, and GABA were higher in the rTMS group were higher than antidepressa
However, this advantage was not evident during the follow-up period. (p > 0.05). And the combination's efficacy in improving anxie …
4,366 results