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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1971 1
1974 5
1975 28
1976 27
1977 32
1978 29
1979 40
1980 49
1981 59
1982 71
1983 112
1984 82
1985 111
1986 90
1987 106
1988 114
1989 150
1990 155
1991 194
1992 200
1993 243
1994 262
1995 261
1996 314
1997 339
1998 362
1999 408
2000 467
2001 476
2002 527
2003 605
2004 629
2005 709
2006 756
2007 824
2008 855
2009 822
2010 814
2011 857
2012 842
2013 891
2014 907
2015 914
2016 868
2017 846
2018 876
2019 890
2020 971
2021 979
2022 1010
2023 1005
2024 1172
2025 720
2026 1

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4,690 results

Results by year

Filters applied: Abstract, in the last 5 years. Clear all
Page 1
Antidepressant efficacy of Agomelatine: Meta-analysis of placebo controlled and active comparator studies.
Maddukuri RK, Hema C, Sri Tejaswi K, Venkata Mounika M, Vegesana BP. Maddukuri RK, et al. Asian J Psychiatr. 2021 Nov;65:102866. doi: 10.1016/j.ajp.2021.102866. Epub 2021 Sep 20. Asian J Psychiatr. 2021. PMID: 34592623 Review.
Publication bias was identified in antidepressant trials which can potentially overestimate the treatment efficacy. This meta-analysis was designed to assess the overall antidepressant effect of Agomelatine by pooling all the published and unpublished studies …
Publication bias was identified in antidepressant trials which can potentially overestimate the treatment efficacy. This meta- …
Novel antidepressant drugs: Beyond monoamine targets.
Gonda X, Dome P, Neill JC, Tarazi FI. Gonda X, et al. CNS Spectr. 2023 Feb;28(1):6-15. doi: 10.1017/S1092852921000791. Epub 2021 Sep 30. CNS Spectr. 2023. PMID: 34588093 Review.
Although there are several classes of dissimilar antidepressant drugs approved for MDD, the current drugs have either limited efficacy or are associated with undesirable side effects and withdrawal symptoms. The efficacy and side effects of antidepressant …
Although there are several classes of dissimilar antidepressant drugs approved for MDD, the current drugs have either limited effi …
Antidepressant efficacy of cariprazine in bipolar disorder and the role of its pharmacodynamic properties: A hypothesis based on data.
Fountoulakis KN, Ioannou M, Tohen M, Haarman BCM, Zarate CA Jr. Fountoulakis KN, et al. Eur Neuropsychopharmacol. 2023 Jul;72:30-39. doi: 10.1016/j.euroneuro.2023.03.009. Epub 2023 Apr 14. Eur Neuropsychopharmacol. 2023. PMID: 37060629 Free article. Review.
The neurobiology of bipolar depression and the possible targets of bipolar antidepressant therapy remain elusive. The current study investigated whether the pharmacodynamic properties of cariprazine fit into a previously developed model which was the first to be derived ba …
The neurobiology of bipolar depression and the possible targets of bipolar antidepressant therapy remain elusive. The current study i …
Ketamine: Mechanisms and Relevance to Treatment of Depression.
Kim JW, Suzuki K, Kavalali ET, Monteggia LM. Kim JW, et al. Annu Rev Med. 2024 Jan 29;75:129-143. doi: 10.1146/annurev-med-051322-120608. Epub 2023 Sep 20. Annu Rev Med. 2024. PMID: 37729028 Free article. Review.
Major depressive disorder (MDD) is a leading cause of suicide in the world. Monoamine-based antidepressant drugs are a primary line of treatment for this mental disorder, although the delayed response and incomplete efficacy in some patients highlight the need for i …
Major depressive disorder (MDD) is a leading cause of suicide in the world. Monoamine-based antidepressant drugs are a primary line o …
Influence of an adjuvant antidepressant on the efficacy of electroconvulsive therapy: A systematic review and meta-analysis.
Pluijms EM, Kamperman AM, Hoogendijk WJ, Birkenhäger TK, van den Broek WW. Pluijms EM, et al. Aust N Z J Psychiatry. 2021 Apr;55(4):366-380. doi: 10.1177/0004867420952543. Epub 2020 Sep 8. Aust N Z J Psychiatry. 2021. PMID: 32900217 Free PMC article.
Randomized controlled trials and cohort studies reporting on the influence of an adjuvant antidepressant on the efficacy of electroconvulsive therapy for major depression were included. ...CONCLUSION: An adjuvant antidepressant enhances the efficacy of …
Randomized controlled trials and cohort studies reporting on the influence of an adjuvant antidepressant on the efficacy of el …
Efficacy of antidepressant drugs in the treatment of depression in Alzheimer disease patients: A systematic review and network meta-analysis.
He Y, Li H, Huang J, Huang S, Bai Y, Li Y, Huang W. He Y, et al. J Psychopharmacol. 2021 Aug;35(8):901-909. doi: 10.1177/02698811211030181. Epub 2021 Jul 9. J Psychopharmacol. 2021. PMID: 34238048
Our study was aimed at systematically examining the evidence on the efficacy of antidepressants in the treatment of depression in AD patients. METHODS: We conducted a network meta-analysis of randomized controlled trials retrieved by systematic search of the Cochran …
Our study was aimed at systematically examining the evidence on the efficacy of antidepressants in the treatment of depression …
Antidepressant Efficacy in Managing Nonspecific Chronic Lower Back Pain Among Older Adults: A Review.
Wilczyński K, Mazurski A, Kotucha K. Wilczyński K, et al. J Pain Palliat Care Pharmacother. 2024 Dec;38(4):379-393. doi: 10.1080/15360288.2024.2384961. Epub 2024 Aug 12. J Pain Palliat Care Pharmacother. 2024. PMID: 39133808 Review.
This review evaluates the use of antidepressants in older patients for the treatment of nonspecific chronic lower back pain (LBP), emphasizing age-related physiological changes and common degenerative conditions in this age group. We conducted a comprehensive search target …
This review evaluates the use of antidepressants in older patients for the treatment of nonspecific chronic lower back pain (LBP), em …
Pharmacotherapy: Ketamine and Esketamine.
Feeney A, Papakostas GI. Feeney A, et al. Psychiatr Clin North Am. 2023 Jun;46(2):277-290. doi: 10.1016/j.psc.2023.02.003. Epub 2023 Mar 10. Psychiatr Clin North Am. 2023. PMID: 37149345 Review.
Intravenous ketamine is often administered off-label as an antidepressant, though no standard operating procedures exist. Repeated administrations and the use of a concurrent standard antidepressant may maintain antidepressant effects of ketamine/esketamine. …
Intravenous ketamine is often administered off-label as an antidepressant, though no standard operating procedures exist. Repeated ad …
Ketamine in neuropsychiatric disorders: an update.
Johnston JN, Kadriu B, Kraus C, Henter ID, Zarate CA Jr. Johnston JN, et al. Neuropsychopharmacology. 2024 Jan;49(1):23-40. doi: 10.1038/s41386-023-01632-1. Epub 2023 Jun 20. Neuropsychopharmacology. 2024. PMID: 37340091 Free PMC article. Review.
The discovery of ketamine as a rapid-acting antidepressant led to a new era in the development of neuropsychiatric therapeutics, one characterized by an antidepressant response that occurred within hours or days rather than weeks or months. ...This manuscript: 1) re …
The discovery of ketamine as a rapid-acting antidepressant led to a new era in the development of neuropsychiatric therapeutics, one …
Efficacy of serotonergic antidepressant treatment for the neuropsychiatric symptoms and agitation in dementia: A systematic review and meta-analysis.
Hsu TW, Stubbs B, Liang CS, Chen TY, Yeh TC, Pan CC, Chu CS. Hsu TW, et al. Ageing Res Rev. 2021 Aug;69:101362. doi: 10.1016/j.arr.2021.101362. Epub 2021 May 14. Ageing Res Rev. 2021. PMID: 34000464
OBJECTIVE: Serotonergic dysfunction may be involved in the etiology of overall neuropsychiatric symptoms (NPS) and agitation in patients with dementia; therefore, we aim to perform a systematic review and meta-analysis to investigate the efficacy of serotonergic antidep …
OBJECTIVE: Serotonergic dysfunction may be involved in the etiology of overall neuropsychiatric symptoms (NPS) and agitation in patients wit …
4,690 results