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Eicosanoyl-5-hydroxytryptamide (EHT) prevents Alzheimer's disease-related cognitive and electrophysiological impairments in mice exposed to elevated concentrations of oligomeric beta-amyloid.
Asam K, Staniszewski A, Zhang H, Melideo SL, Mazzeo A, Voronkov M, Huber KL, Pérez E, Stock M, Stock JB, Arancio O, Nicholls RE. Asam K, et al. PLoS One. 2017 Dec 18;12(12):e0189413. doi: 10.1371/journal.pone.0189413. eCollection 2017. PLoS One. 2017. PMID: 29253878 Free PMC article.
Here, we tested the hypothesis that EHT protects animals from the pathological effects of exposure to elevated levels of soluble oligomeric Abeta. ...We also found that both chronic and acute EHT administration prevented Abeta-induced impairments in long-term potent …
Here, we tested the hypothesis that EHT protects animals from the pathological effects of exposure to elevated levels of soluble olig …
Therapeutic benefits of a component of coffee in a rat model of Alzheimer's disease.
Basurto-Islas G, Blanchard J, Tung YC, Fernandez JR, Voronkov M, Stock M, Zhang S, Stock JB, Iqbal K. Basurto-Islas G, et al. Neurobiol Aging. 2014 Dec;35(12):2701-2712. doi: 10.1016/j.neurobiolaging.2014.06.012. Epub 2014 Jun 17. Neurobiol Aging. 2014. PMID: 25034344 Free PMC article.
A minor component of coffee unrelated to caffeine, eicosanoyl-5-hydroxytryptamide (EHT), provides protection in a rat model for Alzheimer's disease (AD). ...These findings raise the possibility that EHT may make a substantial contribution to the apparent neur …
A minor component of coffee unrelated to caffeine, eicosanoyl-5-hydroxytryptamide (EHT), provides protection in a rat model fo …
Synergistic neuroprotection by coffee components eicosanoyl-5-hydroxytryptamide and caffeine in models of Parkinson's disease and DLB.
Yan R, Zhang J, Park HJ, Park ES, Oh S, Zheng H, Junn E, Voronkov M, Stock JB, Mouradian MM. Yan R, et al. Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):E12053-E12062. doi: 10.1073/pnas.1813365115. Epub 2018 Dec 3. Proc Natl Acad Sci U S A. 2018. PMID: 30509990 Free PMC article.
This phosphatase deficiency contributes to the accumulation of hyperphosphorylated alpha-synuclein, which tends to fibrillize more than unmodified alpha-synuclein. Eicosanoyl-5-hydroxytryptamide (EHT), a fatty acid derivative of serotonin found in coffee, inhibits t …
This phosphatase deficiency contributes to the accumulation of hyperphosphorylated alpha-synuclein, which tends to fibrillize more than unmo …
Neuroprotective and anti-inflammatory properties of a coffee component in the MPTP model of Parkinson's disease.
Lee KW, Im JY, Woo JM, Grosso H, Kim YS, Cristovao AC, Sonsalla PK, Schuster DS, Jalbut MM, Fernandez JR, Voronkov M, Junn E, Braithwaite SP, Stock JB, Mouradian MM. Lee KW, et al. Neurotherapeutics. 2013 Jan;10(1):143-53. doi: 10.1007/s13311-012-0165-2. Neurotherapeutics. 2013. PMID: 23296837 Free PMC article.
However, coffee contains numerous components that may also be neuroprotective. ...Here, we sought to investigate if EHT has an effect in the MPTP model of PD. Mice fed a diet containing EHT for four weeks exhibited dose-dependent preservation of nigral dopami …
However, coffee contains numerous components that may also be neuroprotective. ...Here, we sought to investigate if EHT has an …