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Synergistic neuroprotection by coffee components eicosanoyl-5-hydroxytryptamide and caffeine in models of Parkinson's disease and DLB.
Yan R, Zhang J, Park HJ, Park ES, Oh S, Zheng H, Junn E, Voronkov M, Stock JB, Mouradian MM. Yan R, et al. Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):E12053-E12062. doi: 10.1073/pnas.1813365115. Epub 2018 Dec 3. Proc Natl Acad Sci U S A. 2018. PMID: 30509990 Free PMC article.
Hyperphosphorylated α-synuclein in Lewy bodies and Lewy neurites is a characteristic neuropathological feature of Parkinson's disease (PD) and Dementia with Lewy bodies (DLB). ...Eicosanoyl-5-hydroxytryptamide (EHT), a fatty acid derivative of serotonin found in …
Hyperphosphorylated α-synuclein in Lewy bodies and Lewy neurites is a characteristic neuropathological feature of Parkinson's disease …
Eicosanoyl-5-hydroxytryptamide (EHT) prevents Alzheimer's disease-related cognitive and electrophysiological impairments in mice exposed to elevated concentrations of oligomeric beta-amyloid.
Asam K, Staniszewski A, Zhang H, Melideo SL, Mazzeo A, Voronkov M, Huber KL, Pérez E, Stock M, Stock JB, Arancio O, Nicholls RE. Asam K, et al. PLoS One. 2017 Dec 18;12(12):e0189413. doi: 10.1371/journal.pone.0189413. eCollection 2017. PLoS One. 2017. PMID: 29253878 Free PMC article.
In addition, eicosanoyl-5-hydroxytryptamide (EHT), a naturally occurring component from coffee beans that modulates PP2A methylation, was shown to confer therapeutic benefits in rodent models of AD and Parkinson's disease. Here, we tested the hypothesis that …
In addition, eicosanoyl-5-hydroxytryptamide (EHT), a naturally occurring component from coffee beans that modulates PP2A methy …
Neuroprotective and anti-inflammatory properties of a coffee component in the MPTP model of Parkinson's disease.
Lee KW, Im JY, Woo JM, Grosso H, Kim YS, Cristovao AC, Sonsalla PK, Schuster DS, Jalbut MM, Fernandez JR, Voronkov M, Junn E, Braithwaite SP, Stock JB, Mouradian MM. Lee KW, et al. Neurotherapeutics. 2013 Jan;10(1):143-53. doi: 10.1007/s13311-012-0165-2. Neurotherapeutics. 2013. PMID: 23296837 Free PMC article.
Consumption of coffee is associated with reduced risk of Parkinson's disease (PD), an effect that has largely been attributed to caffeine. ...Our data, therefore, reveal a strong beneficial effect of a novel component of coffee in multiple endpoints relevant …
Consumption of coffee is associated with reduced risk of Parkinson's disease (PD), an effect that has largely been attributed …
Therapeutic benefits of a component of coffee in a rat model of Alzheimer's disease.
Basurto-Islas G, Blanchard J, Tung YC, Fernandez JR, Voronkov M, Stock M, Zhang S, Stock JB, Iqbal K. Basurto-Islas G, et al. Neurobiol Aging. 2014 Dec;35(12):2701-2712. doi: 10.1016/j.neurobiolaging.2014.06.012. Epub 2014 Jun 17. Neurobiol Aging. 2014. PMID: 25034344 Free PMC article.
A minor component of coffee unrelated to caffeine, eicosanoyl-5-hydroxytryptamide (EHT), provides protection in a rat model for Alzheimer's disease (AD). ...These findings raise the possibility that EHT may make a substantial contribution to the appare …
A minor component of coffee unrelated to caffeine, eicosanoyl-5-hydroxytryptamide (EHT), provides protection in a rat model fo …
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