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Page 1
Role of Fyn and the interleukin-6-STAT-3-autophagy axis in sarcopenia.
Sasaki T, Yamada E, Uehara R, Okada S, Chikuda H, Yamada M. Sasaki T, et al. Among authors: yamada e. iScience. 2023 Aug 25;26(10):107717. doi: 10.1016/j.isci.2023.107717. eCollection 2023 Oct 20. iScience. 2023. PMID: 37744036 Free PMC article.
Sarcopenia is the progressive loss of muscle mass wherein Fyn regulates STAT3 to decrease autophagy. To elucidate the role of inflammation in Fyn-STAT3-dependent autophagy and sarcopenia, here we aimed to investigate the underlying mechanisms using two mouse models …
Sarcopenia is the progressive loss of muscle mass wherein Fyn regulates STAT3 to decrease autophagy. To elucidate the role of inflamm …
Fyn kinase function in lipid utilization: a new upstream regulator of AMPK activity?
Vatish M, Yamada E, Pessin JE, Bastie CC. Vatish M, et al. Among authors: yamada e. Arch Physiol Biochem. 2009 Oct;115(4):191-8. doi: 10.1080/13813450903164348. Arch Physiol Biochem. 2009. PMID: 19728795 Free PMC article. Review.
In this review, we present novel evidence of crosstalk between Fyn, one member of the Src kinase family, and AMPK....
In this review, we present novel evidence of crosstalk between Fyn, one member of the Src kinase family, and AMPK....
Fyn Phosphorylates Transglutaminase 2 (Tgm2) and Modulates Autophagy and p53 Expression in the Development of Diabetic Kidney Disease.
Uehara R, Yamada E, Okada S, Bastie CC, Maeshima A, Ikeuchi H, Horiguchi K, Yamada M. Uehara R, et al. Among authors: yamada e. Cells. 2023 Apr 20;12(8):1197. doi: 10.3390/cells12081197. Cells. 2023. PMID: 37190106 Free PMC article.
Autophagy is involved in the development of diabetic kidney disease (DKD), the leading cause of end-stage renal disease. The Fyn tyrosine kinase (Fyn) suppresses autophagy in the muscle. However, its role in kidney autophagic processes is unclear. ...Using streptozo …
Autophagy is involved in the development of diabetic kidney disease (DKD), the leading cause of end-stage renal disease. The Fyn tyro …
Fyn phosphorylates AMPK to inhibit AMPK activity and AMP-dependent activation of autophagy.
Yamada E, Okada S, Bastie CC, Vatish M, Nakajima Y, Shibusawa R, Ozawa A, Pessin JE, Yamada M. Yamada E, et al. Oncotarget. 2016 Nov 15;7(46):74612-74629. doi: 10.18632/oncotarget.11916. Oncotarget. 2016. PMID: 27626315 Free PMC article.
We previously demonstrated that proto-oncogene Fyn decreased energy expenditure and increased metabolic phenotypes. Also Fyn decreased autophagy-mediated muscle mass by directly inhibiting LKB1 and stimulating STAT3 activities, respectively. ...As pro-inflammatory m …
We previously demonstrated that proto-oncogene Fyn decreased energy expenditure and increased metabolic phenotypes. Also Fyn d …
Fyn Activation of mTORC1 Stimulates the IRE1alpha-JNK Pathway, Leading to Cell Death.
Wang Y, Yamada E, Zong H, Pessin JE. Wang Y, et al. Among authors: yamada e. J Biol Chem. 2015 Oct 9;290(41):24772-83. doi: 10.1074/jbc.M115.687020. Epub 2015 Aug 25. J Biol Chem. 2015. PMID: 26306048 Free PMC article.
To investigate the bases for the loss of muscle fiber mass, we examined the relationship between Fyn activation of mTORC1, JNK, and endoplasmic reticulum stress. Overexpression of Fyn in skeletal muscle in vivo and in HEK293T cells in culture resulted in the activat …
To investigate the bases for the loss of muscle fiber mass, we examined the relationship between Fyn activation of mTORC1, JNK, and e …
Fyn-dependent regulation of energy expenditure and body weight is mediated by tyrosine phosphorylation of LKB1.
Yamada E, Pessin JE, Kurland IJ, Schwartz GJ, Bastie CC. Yamada E, et al. Cell Metab. 2010 Feb 3;11(2):113-24. doi: 10.1016/j.cmet.2009.12.010. Cell Metab. 2010. PMID: 20142099 Free PMC article.
Fyn null mice display reduced adiposity associated with increased fatty acid oxidation, energy expenditure, and activation of the AMP-dependent protein kinase (AMPK) in skeletal muscle and adipose tissue. ...These data demonstrate a crosstalk between Fyn tyrosine ki …
Fyn null mice display reduced adiposity associated with increased fatty acid oxidation, energy expenditure, and activation of the AMP …
Differential activation of Fyn kinase distinguishes saturated and unsaturated fats in mouse macrophages.
Tarabra E, An Lee TW, Zammit VA, Vatish M, Yamada E, Pessin JE, Bastie CC. Tarabra E, et al. Among authors: yamada e. Oncotarget. 2017 Sep 21;8(49):86634-86645. doi: 10.18632/oncotarget.21258. eCollection 2017 Oct 17. Oncotarget. 2017. PMID: 29156823 Free PMC article.
Similarly, Fyn activity is increased in cells of adipose tissue stromal vascular fraction of high fat-fed control mice, with Fyn protein being located in the nucleus of these cells. We demonstrate that Fyn modulates palmitate-dependent oxidative stress in mac …
Similarly, Fyn activity is increased in cells of adipose tissue stromal vascular fraction of high fat-fed control mice, with Fyn …
Disruption of Fyn SH3 domain interaction with a proline-rich motif in liver kinase B1 results in activation of AMP-activated protein kinase.
Yamada E, Bastie CC. Yamada E, et al. PLoS One. 2014 Feb 25;9(2):e89604. doi: 10.1371/journal.pone.0089604. eCollection 2014. PLoS One. 2014. PMID: 24586906 Free PMC article.
Fyn-deficient mice display increased AMP-activated Protein Kinase (AMPK) activity as a result of Fyn-dependent regulation of Liver Kinase B1 (LKB1) in skeletal muscle. ...In vivo disruption of the Fyn/LKB1 interaction using LKB1 proline-rich motif mimicking c …
Fyn-deficient mice display increased AMP-activated Protein Kinase (AMPK) activity as a result of Fyn-dependent regulation of L …
Mouse skeletal muscle fiber-type-specific macroautophagy and muscle wasting are regulated by a Fyn/STAT3/Vps34 signaling pathway.
Yamada E, Bastie CC, Koga H, Wang Y, Cuervo AM, Pessin JE. Yamada E, et al. Cell Rep. 2012 May 31;1(5):557-69. doi: 10.1016/j.celrep.2012.03.014. Epub 2012 May 3. Cell Rep. 2012. PMID: 22745922 Free PMC article.
Physiologically, in the fed state endogenous Fyn kinase activity was increased in glycolytic but not oxidative skeletal muscle. In parallel, Y705-STAT3 phosphorylation increased with decreased Vps34 protein levels. Moreover, fed/starved regulation of Y705-STAT3 phosphoryla …
Physiologically, in the fed state endogenous Fyn kinase activity was increased in glycolytic but not oxidative skeletal muscle. In pa …
CDK5-dependent phosphorylation of the Rho family GTPase TC10(alpha) regulates insulin-stimulated GLUT4 translocation.
Okada S, Yamada E, Saito T, Ohshima K, Hashimoto K, Yamada M, Uehara Y, Tsuchiya T, Shimizu H, Tatei K, Izumi T, Yamauchi K, Hisanaga S, Pessin JE, Mori M. Okada S, et al. Among authors: yamada e. J Biol Chem. 2008 Dec 19;283(51):35455-63. doi: 10.1074/jbc.M806531200. Epub 2008 Oct 23. J Biol Chem. 2008. PMID: 18948252 Free article.
Insulin stimulation results in the activation of cyclin-dependent kinase-5 (CDK5) in lipid raft domains via a Fyn-dependent phosphorylation on tyrosine residue 15. In turn, activated CDK5 phosphorylates the Rho family GTP-binding protein TC10alpha on threonine 197 that is …
Insulin stimulation results in the activation of cyclin-dependent kinase-5 (CDK5) in lipid raft domains via a Fyn-dependent phosphory …
11 results