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Diabetes and overexpression of proNGF cause retinal neurodegeneration via activation of RhoA pathway.
Al-Gayyar MM, Mysona BA, Matragoon S, Abdelsaid MA, El-Azab MF, Shanab AY, Ha Y, Smith SB, Bollinger KE, El-Remessy AB. Al-Gayyar MM, et al. PLoS One. 2013;8(1):e54692. doi: 10.1371/journal.pone.0054692. Epub 2013 Jan 24. PLoS One. 2013. Retraction in: PLoS One. 2017 Oct 16;12(10):e0186748. doi: 10.1371/journal.pone.0186748 PMID: 23365678 Free PMC article. Retracted.
Effects of proNGF were examined in freshly isolated primary retinal ganglion cell (RGC) cultures and RGC-5 cell line. ...In vitro, proNGF induced 5-fold cell death in RGC-5 cell line, and it induced >10-fold cell death in primary RGC cultures. ...
Effects of proNGF were examined in freshly isolated primary retinal ganglion cell (RGC) cultures and RGC-5 cell line. ...In vitro, …
Inducible overexpression of endothelial proNGF as a mouse model to study microvascular dysfunction.
Mohamed R, Coucha M, Elshaer SL, Artham S, Lemtalsi T, El-Remessy AB. Mohamed R, et al. Biochim Biophys Acta Mol Basis Dis. 2018 Mar;1864(3):746-757. doi: 10.1016/j.bbadis.2017.12.023. Epub 2017 Dec 16. Biochim Biophys Acta Mol Basis Dis. 2018. PMID: 29253516 Free PMC article.
To elucidate the direct impact of proNGF accumulation identified the need to create a transgenic model that can express fully mutated cleavage-resistant proNGF. ...EC-proNGF overexpression was confirmed using colocalization of anti-proNGF within retina …
To elucidate the direct impact of proNGF accumulation identified the need to create a transgenic model that can express fully mutated …
Modulation of p75(NTR) prevents diabetes- and proNGF-induced retinal inflammation and blood-retina barrier breakdown in mice and rats.
Mysona BA, Al-Gayyar MM, Matragoon S, Abdelsaid MA, El-Azab MF, Saragovi HU, El-Remessy AB. Mysona BA, et al. Diabetologia. 2013 Oct;56(10):2329-39. doi: 10.1007/s00125-013-2998-6. Epub 2013 Aug 7. Diabetologia. 2013. PMID: 23918145 Free PMC article.
Diabetes causes imbalance of nerve growth factor (NGF), leading to accumulation of the NGF precursor (proNGF), as well as the NGF receptor, p75 neurotrophin receptor (p75(NTR)), suggesting a possible pathological role of the proNGF-p75(NTR) axis in the diabetic reti …
Diabetes causes imbalance of nerve growth factor (NGF), leading to accumulation of the NGF precursor (proNGF), as well as the NGF rec …
Silencing p75(NTR) prevents proNGF-induced endothelial cell death and development of acellular capillaries in rat retina.
Shanab AY, Mysona BA, Matragoon S, El-Remessy AB. Shanab AY, et al. Mol Ther Methods Clin Dev. 2015 May 6;2:15013. doi: 10.1038/mtm.2015.13. eCollection 2015. Mol Ther Methods Clin Dev. 2015. PMID: 26029724 Free PMC article.
However, whether proNGF contributes to microvascular degeneration remain unexplored. This study seeks to investigate the mechanism by which proNGF/p75(NTR) induce endothelial cell (EC) death and development of acellular capillaries, a surrogate marker of retinal isc …
However, whether proNGF contributes to microvascular degeneration remain unexplored. This study seeks to investigate the mechanism by …
Epicatechin blocks pro-nerve growth factor (proNGF)-mediated retinal neurodegeneration via inhibition of p75 neurotrophin receptor expression in a rat model of diabetes [corrected].
Al-Gayyar MM, Matragoon S, Pillai BA, Ali TK, Abdelsaid MA, El-Remessy AB. Al-Gayyar MM, et al. Diabetologia. 2011 Mar;54(3):669-80. doi: 10.1007/s00125-010-1994-3. Epub 2010 Dec 7. Diabetologia. 2011. PMID: 21136036
AIMS/HYPOTHESIS: Accumulation of pro-nerve growth factor (NGF), the pro form of NGF, has been detected in neurodegenerative diseases. However, the role of proNGF in the diabetic retina and the molecular mechanisms by which proNGF causes retinal neurodegeneration rem …
AIMS/HYPOTHESIS: Accumulation of pro-nerve growth factor (NGF), the pro form of NGF, has been detected in neurodegenerative diseases. Howeve …
Electroporation-mediated gene delivery of cleavage-resistant pro-nerve growth factor causes retinal neuro- and vascular degeneration.
Matragoon S, Al-Gayyar MM, Mysona BA, Abdelsaid MA, Pillai BA, Neet KE, Fagan SC, El-Remessy AB. Matragoon S, et al. Mol Vis. 2012;18:2993-3003. Epub 2012 Dec 14. Mol Vis. 2012. PMID: 23288991 Free PMC article.
PURPOSE: Neurotrophins, including nerve growth factor (NGF), are secreted by glia as a pro-form (proNGF) that is normally cleaved into the mature ligand. Increases of proNGF has been well documented in retinal neurodegenerative diseases. ...RESULTS: Successful pGFP- …
PURPOSE: Neurotrophins, including nerve growth factor (NGF), are secreted by glia as a pro-form (proNGF) that is normally cleaved int …
Imbalance of the nerve growth factor and its precursor as a potential biomarker for diabetic retinopathy.
Mysona BA, Matragoon S, Stephens M, Mohamed IN, Farooq A, Bartasis ML, Fouda AY, Shanab AY, Espinosa-Heidmann DG, El-Remessy AB. Mysona BA, et al. Biomed Res Int. 2015;2015:571456. doi: 10.1155/2015/571456. Epub 2015 Mar 17. Biomed Res Int. 2015. PMID: 25853140 Free PMC article.
Here we test the hypothesis that alteration of proNGF and NGF levels observed in retina and vitreous will be mirrored in serum of diabetic patients. ...In contrast, vitreous and sera from diabetic patients showed significant 44% and 64% reductions in NGF levels, respective …
Here we test the hypothesis that alteration of proNGF and NGF levels observed in retina and vitreous will be mirrored in serum of dia …
Diabetes-induced peroxynitrite impairs the balance of pro-nerve growth factor and nerve growth factor, and causes neurovascular injury.
Ali TK, Al-Gayyar MM, Matragoon S, Pillai BA, Abdelsaid MA, Nussbaum JJ, El-Remessy AB. Ali TK, et al. Diabetologia. 2011 Mar;54(3):657-68. doi: 10.1007/s00125-010-1935-1. Epub 2010 Oct 19. Diabetologia. 2011. PMID: 20957344
RESULTS: Diabetes-induced peroxynitrite formation impaired production and activity of matrix metalloproteinase-7 (MMP-7), which cleaves proNGF extracellularly, leading to accumulation of proNGF and reducing NGF in samples from diabetic retinopathy patients and exper …
RESULTS: Diabetes-induced peroxynitrite formation impaired production and activity of matrix metalloproteinase-7 (MMP-7), which cleaves p …
Modulation of the p75 neurotrophin receptor using LM11A-31 prevents diabetes-induced retinal vascular permeability in mice via inhibition of inflammation and the RhoA kinase pathway.
Elshaer SL, Alwhaibi A, Mohamed R, Lemtalsi T, Coucha M, Longo FM, El-Remessy AB. Elshaer SL, et al. Diabetologia. 2019 Aug;62(8):1488-1500. doi: 10.1007/s00125-019-4885-2. Epub 2019 May 9. Diabetologia. 2019. PMID: 31073629 Free PMC article.
Modulating p75(NTR) significantly inhibited proNGF-mediated RhoA activation, occludin phosphorylation (at serine 490) and cell permeability. ProNGF induced redistribution of ZO-1 in the cell wall and formation of F-actin stress fibres; these effects were mitigated b …
Modulating p75(NTR) significantly inhibited proNGF-mediated RhoA activation, occludin phosphorylation (at serine 490) and cell permea …
14 results