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Page 1
Autoimmune connective tissue diseases in the COVID-19 pandemic.
Dourmishev L, Guleva D, Pozharashka J, Drenovska K, Miteva L, Vassileva S. Dourmishev L, et al. Clin Dermatol. 2021 Jan-Feb;39(1):56-63. doi: 10.1016/j.clindermatol.2020.12.013. Epub 2020 Dec 15. Clin Dermatol. 2021. PMID: 33972054 Free PMC article. Review.
Immune mechanisms are substantial for the control and ceasing of viral infections, and their impairment may cause serious complications; however, data from immunosuppressed transplant patients do not reveal a higher frequency or diseases' severity in those infected by COVID …
Immune mechanisms are substantial for the control and ceasing of viral infections, and their impairment may cause serious complications; how …
Probe-based confocal laser endomicroscopy in COVID-19.
Vasilev IV, Mamenko IS, Makarova AV, Sokolova OP, Lee VF, Mortada MM, Novickaya TA, Yablonskii PK. Vasilev IV, et al. Adv Respir Med. 2021;89(4):456-459. doi: 10.5603/ARM.a2021.0067. Epub 2021 Jul 16. Adv Respir Med. 2021. PMID: 34269405 Free article.
We report a case ot a patient with negative nasopharyngeal swabs and suspected lung cancer who underwent pCLE. The diagnosis of COVID-19 was confirmed by PCR analyses of lavage fluid and transbrohial biopsy. The pCLE image shows density of alveolar thickened fibres, …
We report a case ot a patient with negative nasopharyngeal swabs and suspected lung cancer who underwent pCLE. The diagnosis of COVID …
Biomimetic SARS-CoV-2 Spike Protein Nanoparticles.
Phan A, Avila H, MacKay JA. Phan A, et al. Biomacromolecules. 2023 May 8;24(5):2030-2041. doi: 10.1021/acs.biomac.2c01465. Epub 2023 Mar 31. Biomacromolecules. 2023. PMID: 37001147 Free PMC article.
COVID-19 is an infectious respiratory disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). ...Biomimetic nanoparticles such as these may enable future strategies to target …
COVID-19 is an infectious respiratory disease caused by the severe acute respiratory syndrome c …
The "Elastic Perspective" of SARS-CoV-2 Infection and the Role of Intrinsic and Extrinsic Factors.
Boraldi F, Lofaro FD, Cossarizza A, Quaglino D. Boraldi F, et al. Int J Mol Sci. 2022 Jan 29;23(3):1559. doi: 10.3390/ijms23031559. Int J Mol Sci. 2022. PMID: 35163482 Free PMC article. Review.
Elastin represents the structural component of the extracellular matrix providing elastic recoil to tissues such as skin, blood vessels and lungs. ...Within the lungs, destruction of the elastic network may lead to the permanent impairment of pulmonary function, thus sugge …
Elastin represents the structural component of the extracellular matrix providing elastic recoil to tissues such as skin, blood vesse …
Neutrophil Activity and Extracellular Matrix Degradation: Drivers of Lung Tissue Destruction in Fatal COVID-19 Cases and Implications for Long COVID.
Narasaraju T, Neeli I, Criswell SL, Krishnappa A, Meng W, Silva V, Bila G, Vovk V, Serhiy Z, Bowlin GL, Meyer N, Luning Prak ET, Radic M, Bilyy R. Narasaraju T, et al. Biomolecules. 2024 Feb 17;14(2):236. doi: 10.3390/biom14020236. Biomolecules. 2024. PMID: 38397474 Free PMC article.
This study analyzed the histopathology of lung specimens from eight COVID-19 and six non-COVID-19 postmortems. We assessed the distribution and changes in extracellular matrix (ECM) proteins, including elastin and collagen, in lung alveoli throu …
This study analyzed the histopathology of lung specimens from eight COVID-19 and six non-COVID-19 postmortems. W …
Isolation of nucleic acids using liquid-liquid phase separation of pH-sensitive elastin-like polypeptides.
Díez Pérez T, Tafoya AN, Peabody DS, Lakin MR, Hurwitz I, Carroll NJ, López GP. Díez Pérez T, et al. Sci Rep. 2024 May 2;14(1):10157. doi: 10.1038/s41598-024-60648-9. Sci Rep. 2024. PMID: 38698072 Free PMC article.
NA extraction has been extensively studied and optimized for a wide range of applications and its importance to society has significantly increased. The COVID-19 pandemic highlighted the importance of early and efficient NA testing, for which NA extraction is a crit …
NA extraction has been extensively studied and optimized for a wide range of applications and its importance to society has significantly in …
Inflammation, abdominal aortic aneurysm enlargement and rupture. Lessons learned from the Covid19 pandemic.
Sterpetti AV, Miceli F, Di Girolamo A, Bozzani A, Arici V, Ascione M, Marzo LD. Sterpetti AV, et al. Curr Probl Cardiol. 2025 Oct;50(10):103151. doi: 10.1016/j.cpcardiol.2025.103151. Epub 2025 Aug 5. Curr Probl Cardiol. 2025. PMID: 40769234 Free article. Review.
Although intracranial and coronary arterial aneurysms have been described in adults and children with COVID19, few reports have correlated COVID19 infection and sudden degeneration of aortic aneurysms and dissections. We analyzed the risk factor for enlargement and …
Although intracranial and coronary arterial aneurysms have been described in adults and children with COVID19, few reports have corre …
Novel high-yield potato protease inhibitor panels block a wide array of proteases involved in viral infection and crucial tissue damage.
Visser N, Herreman LCM, Vandooren J, Pereira RVS, Opdenakker G, Spelbrink REJ, Wilbrink MH, Bremer E, Gosens R, Nawijn MC, van der Ende-Metselaar HH, Smit JM, Laus MC, Laman JD. Visser N, et al. J Mol Med (Berl). 2024 Apr;102(4):521-536. doi: 10.1007/s00109-024-02423-x. Epub 2024 Feb 21. J Mol Med (Berl). 2024. PMID: 38381158 Free PMC article.
Individual fractions showed varying inhibitory efficacy towards a panel of proteases including trypsin, chymotrypsin, ACE2, elastase, and cathepsins B and L. The fractions did not interfere with SARS-CoV-2 infection of Vero E6 cells in vitro. Importantly, two …
Individual fractions showed varying inhibitory efficacy towards a panel of proteases including trypsin, chymotrypsin, ACE2, elastase, and ca …
Revealing In Silico that Bacteria's Outer Membrane Proteins may Help our Bodies Replicate and Carry Severe Acute Respiratory Syndrome Coronavirus 2.
Aktaş E, Özdemir Özgentürk N. Aktaş E, et al. Bioinform Biol Insights. 2022 Aug 8;16:11779322221116320. doi: 10.1177/11779322221116320. eCollection 2022. Bioinform Biol Insights. 2022. PMID: 35966808 Free PMC article.
Furthermore, it is said that bacteria are prone to attachment mammalian cells during a viral illness using their surface proteins that bind to host extracellular matrix proteins such as fibronectin, fibrinogen, vitronectin, and elastin. A recent study identified the cooper …
Furthermore, it is said that bacteria are prone to attachment mammalian cells during a viral illness using their surface proteins that bind …
Engineering Elastin-Like Peptide-Based Nanoparticles displaying Variable Domain of the Heavy Chain of Heavy-Chain-Only Antibodies for SARS-CoV-2 Neutralization.
Le DHT, van Oostrum J, van de Westerlo E, Wang J, Overheul GJ, van Rij RP, Leenders WPJ, Bijlsma J, Roodink I, van Hest JCM, Verdurmen WPR. Le DHT, et al. Biomacromolecules. 2026 Feb 9;27(2):1446-1458. doi: 10.1021/acs.biomac.5c02042. Epub 2026 Jan 21. Biomacromolecules. 2026. PMID: 41566147
Elastin-like polypeptides (ELPs) are self-assembling recombinant biopolymers that can be precisely engineered to display functional targeting ligands. In this study, we developed ELP-based nanoparticles (NPs) displaying the variable domain of the heavy chain of heavy-chain …
Elastin-like polypeptides (ELPs) are self-assembling recombinant biopolymers that can be precisely engineered to display functional t …