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Small Intestinal Bacterial Overgrowth: Clinical Features and Therapeutic Management.
Rao SSC, Bhagatwala J. Rao SSC, et al. Clin Transl Gastroenterol. 2019 Oct;10(10):e00078. doi: 10.14309/ctg.0000000000000078. Clin Transl Gastroenterol. 2019. PMID: 31584459 Free PMC article. Review.
Small bowel aspirate/culture with growth of 10-10 cfu/mL is generally accepted as the "best diagnostic method," but it is invasive. Glucose or lactulose breath testing is noninvasive but an indirect method that requires further standardization and validation for SIB …
Small bowel aspirate/culture with growth of 10-10 cfu/mL is generally accepted as the "best diagnostic method," but it is invasive. Glucose …
How to Test and Treat Small Intestinal Bacterial Overgrowth: an Evidence-Based Approach.
Rezaie A, Pimentel M, Rao SS. Rezaie A, et al. Curr Gastroenterol Rep. 2016 Feb;18(2):8. doi: 10.1007/s11894-015-0482-9. Curr Gastroenterol Rep. 2016. PMID: 26780631 Review.
Although known for many decades, there is a lack of consensus and clarity regarding the natural history and methods for its diagnosis. Several tests have been proposed, including the glucose breath test, lactulose breath test, small intes …
Although known for many decades, there is a lack of consensus and clarity regarding the natural history and methods for its diagnosis. Sever …
Effect, Tolerability, and Safety of Exclusive Palatable Elemental Diet in Patients With Intestinal Microbial Overgrowth.
Rezaie A, Chang BW, de Freitas Germano J, Leite G, Mathur R, Houser K, Hosseini A, Brimberry D, Rashid M, Mehravar S, Villanueva-Millan MJ, Sanchez M, Weitsman S, Fajardo CM, Rivera IG, Joo L, Chan Y, Barlow GM, Pimentel M. Rezaie A, et al. Clin Gastroenterol Hepatol. 2025 Nov;23(12):2306-2317.e7. doi: 10.1016/j.cgh.2025.03.002. Epub 2025 Apr 4. Clin Gastroenterol Hepatol. 2025. PMID: 40189034 Free article. Clinical Trial.
METHODS: Adult subjects with positive lactulose breath tests for SIBO and/or IMO completed 1 week of screening, 2 weeks of exclusive oral PED, and 2 weeks of follow-up during reintroduction of regular diet. Primary end point was changes in stool microb …
METHODS: Adult subjects with positive lactulose breath tests for SIBO and/or IMO completed 1 week of screening, 2 weeks …
A 14-day elemental diet is highly effective in normalizing the lactulose breath test.
Pimentel M, Constantino T, Kong Y, Bajwa M, Rezaei A, Park S. Pimentel M, et al. Dig Dis Sci. 2004 Jan;49(1):73-7. doi: 10.1023/b:ddas.0000011605.43979.e1. Dig Dis Sci. 2004. PMID: 14992438
Treatment of small intestinal bacterial overgrowth is frustrated by the low efficacy of antibiotics. Elemental diets have been shown to reduce enteric flora. In this study, we evaluate the ability of an elemental diet to normalize the lactulose brea …
Treatment of small intestinal bacterial overgrowth is frustrated by the low efficacy of antibiotics. Elemental diets have been shown …
Homemade Elemental Diet to Treat Intestinal Methanogen Overgrowth: A Case Report.
O'Dwyer D. O'Dwyer D. Integr Med (Encinitas). 2021 Apr;20(2):32-41. Integr Med (Encinitas). 2021. PMID: 34377092 Free PMC article.
FOLLOW-UP AND OUTCOMES: The homemade elemental diet was conducted for 14 days. The lactulose breath test results on day 15 indicated a reduction of methane levels from an average of 42 ppm to 3 ppm throughout the testing period (120 minutes). .. …
FOLLOW-UP AND OUTCOMES: The homemade elemental diet was conducted for 14 days. The lactulose breath test …
A combined nutrient and lactulose challenge test allows symptom-based clustering of patients with irritable bowel syndrome.
Le Nevé B, Posserud I, Böhn L, Guyonnet D, Rondeau P, Tillisch K, Naliboff B, Mayer EA, Simrén M. Le Nevé B, et al. Am J Gastroenterol. 2013 May;108(5):786-95. doi: 10.1038/ajg.2013.75. Epub 2013 Apr 16. Am J Gastroenterol. 2013. PMID: 23588235 Clinical Trial.
METHODS: We included 43 patients with IBS (Rome III) and 29 healthy controls. The fasted subjects were served three test meals consisting of a 400-ml liquid breakfast alone or containing lactulose (15 or 25 g) in a double-blind crossover design. ...This clustering w …
METHODS: We included 43 patients with IBS (Rome III) and 29 healthy controls. The fasted subjects were served three test meals consis …
Orocaecal transit time in patients with Crohn disease.
Götze H, Ptok A. Götze H, et al. Eur J Pediatr. 1993 Mar;152(3):193-6. doi: 10.1007/BF01956142. Eur J Pediatr. 1993. PMID: 8444243
Orocaecal transit time (OCTT) using the lactulose hydrogen breath test was investigated in 16 patients (age 10-19.4 years) with active Crohn disease (CD). ...Following nutritional therapy with a semi-elemental diet over a period of 6 weeks OCTT …
Orocaecal transit time (OCTT) using the lactulose hydrogen breath test was investigated in 16 patients (age 10-19.4 yea …
Nutritional support in alcoholic cirrhotic patients improves host defenses.
Hirsch S, de la Maza MP, Gattás V, Barrera G, Petermann M, Gotteland M, Muñoz C, Lopez M, Bunout D. Hirsch S, et al. J Am Coll Nutr. 1999 Oct;18(5):434-41. doi: 10.1080/07315724.1999.10718881. J Am Coll Nutr. 1999. PMID: 10511325
Liver function tests and LPS-induced monocyte production of cytokines, salivary secretory IgA, lactulose/mannitol ratio and breath hydrogen tests were also measured in these intervals. ...REE, total body fat and serum albumin increased, basal breath …
Liver function tests and LPS-induced monocyte production of cytokines, salivary secretory IgA, lactulose/mannitol ratio and …
Apparent nutrient absorption and upper gastrointestinal transit with fiber-containing enteral feedings.
Shinnick FL, Hess RL, Fischer MH, Marlett J. Shinnick FL, et al. Am J Clin Nutr. 1989 Mar;49(3):471-5. doi: 10.1093/ajcn/49.3.471. Am J Clin Nutr. 1989. PMID: 2538050 Clinical Trial.
Serum concentrations of folate, zinc, and glucose were determined at timed intervals for 4 h after ingestion of nutritionally complete liquid meals containing test doses of folate and Zn of two and six times the RDA, respectively, with or without addition of 10 or 15 g of …
Serum concentrations of folate, zinc, and glucose were determined at timed intervals for 4 h after ingestion of nutritionally complete liqui …
Effect of a liquid diet with and without soluble fiber supplementation on intestinal transit and cholecystokinin release in volunteers.
Meier R, Beglinger C, Schneider H, Rowedder A, Gyr K. Meier R, et al. JPEN J Parenter Enteral Nutr. 1993 May-Jun;17(3):231-5. doi: 10.1177/0148607193017003231. JPEN J Parenter Enteral Nutr. 1993. PMID: 8389406 Clinical Trial.
We have therefore compared the effects of a standardized normal diet and two liquid formula diets with and without supplementation of a soluble fiber (21 g/L) on orocecal transit time measured by the hydrogen lactulose breath test, colonic transit time …
We have therefore compared the effects of a standardized normal diet and two liquid formula diets with and without supplementation of …
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