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Year Number of Results
2006 1
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2016 4
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21 results

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Page 1
The ETS transcription factor ETV6 constrains the transcriptional activity of EWS-FLI to promote Ewing sarcoma.
Lu DY, Ellegast JM, Ross KN, Malone CF, Lin S, Mabe NW, Dharia NV, Meyer A, Conway A, Su AH, Selich-Anderson J, Taslim C, Byrum AK, Seong BKA, Adane B, Gray NS, Rivera MN, Lessnick SL, Stegmaier K. Lu DY, et al. Among authors: ellegast jm. Nat Cell Biol. 2023 Feb;25(2):285-297. doi: 10.1038/s41556-022-01059-8. Epub 2023 Jan 19. Nat Cell Biol. 2023. PMID: 36658220 Free PMC article.
Unleashing Cell-Intrinsic Inflammation as a Strategy to Kill AML Blasts.
Ellegast JM, Alexe G, Hamze A, Lin S, Uckelmann HJ, Rauch PJ, Pimkin M, Ross LS, Dharia NV, Robichaud AL, Conway AS, Khalid D, Perry JA, Wunderlich M, Benajiba L, Pikman Y, Nabet B, Gray NS, Orkin SH, Stegmaier K. Ellegast JM, et al. Cancer Discov. 2022 Jul 6;12(7):1760-1781. doi: 10.1158/2159-8290.CD-21-0956. Cancer Discov. 2022. PMID: 35405016 Free PMC article.
Targeting acute myeloid leukemia dependency on VCP-mediated DNA repair through a selective second-generation small-molecule inhibitor.
Roux B, Vaganay C, Vargas JD, Alexe G, Benaksas C, Pardieu B, Fenouille N, Ellegast JM, Malolepsza E, Ling F, Sodaro G, Ross L, Pikman Y, Conway AS, Tang Y, Wu T, Anderson DJ, Le Moigne R, Zhou HJ, Luciano F, Hartigan CR, Galinsky I, DeAngelo DJ, Stone RM, Auberger P, Schenone M, Carr SA, Guirouilh-Barbat J, Lopez B, Khaled M, Lage K, Hermine O, Hemann MT, Puissant A, Stegmaier K, Benajiba L. Roux B, et al. Among authors: ellegast jm. Sci Transl Med. 2021 Mar 31;13(587):eabg1168. doi: 10.1126/scitranslmed.abg1168. Sci Transl Med. 2021. PMID: 33790022 Free PMC article.
Identifying targeted therapies for CBFA2T3::GLIS2 acute myeloid leukemia.
Gonzales F, Schneider C, Alexe G, Lin S, Khalid D, Alvarez M, Basanthakumar A, Ellegast JM, Merickel L, Salhotra S, Taillon A, Giaimo M, Wunderlich M, Ansari M, Perry JA, Degar B, Pikman Y, Stegmaier K. Gonzales F, et al. Among authors: ellegast jm. Leukemia. 2026 Feb;40(2):383-396. doi: 10.1038/s41375-025-02845-7. Epub 2026 Jan 8. Leukemia. 2026. PMID: 41507381 Free PMC article.
PPM1D modulates hematopoietic cell fitness and response to DNA damage and is a therapeutic target in myeloid malignancy.
Miller PG, Sperling AS, Mayerhofer C, McConkey ME, Ellegast JM, Da Silva C, Cohen DN, Wang C, Sharda A, Yan N, Saha S, Schluter C, Schechter I, Słabicki M, Sandoval B, Kahn J, Boettcher S, Gibson CJ, Scadden DT, Stegmaier K, Bhatt S, Lindsley RC, Ebert BL. Miller PG, et al. Among authors: ellegast jm. Blood. 2023 Dec 14;142(24):2079-2091. doi: 10.1182/blood.2023020331. Blood. 2023. PMID: 37595362 Free PMC article.
Therapy resistance in AML is mediated by cytoplasmic sequestration of the transcriptional repressor IRF2BP2.
Althoff MJ, Minhajuddin M, Stevens BM, Gillen AE, Gipson S, Patel SB, Shelton IT, Miller R, Vujovic A, Krug A, Young T, Showers WM, Dzieciatkowska M, Stephenson D, Tyagi A, Ellegast JM, Wright T, Stegmaier K, Opferman JT, D'Alessandro A, Smith CA, Jordan CT. Althoff MJ, et al. Among authors: ellegast jm. bioRxiv [Preprint]. 2025 May 24:2025.05.22.655396. doi: 10.1101/2025.05.22.655396. bioRxiv. 2025. PMID: 40475530 Free PMC article. Preprint.
Identifying Targeted Therapies for CBFA2T3::GLIS2 Acute Myeloid Leukemia.
Gonzales F, Schneider C, Alexe G, Lin S, Khalid D, Alvarez M, Basanthakumar A, Ellegast J, Merickel L, Salhotra S, Taillon A, Wunderlich M, Ansari M, Perry J, Degar B, Pikman Y, Stegmaier K. Gonzales F, et al. Among authors: ellegast j. Res Sq [Preprint]. 2025 May 13:rs.3.rs-6528748. doi: 10.21203/rs.3.rs-6528748/v1. Res Sq. 2025. Update in: Leukemia. 2026 Feb;40(2):383-396. doi: 10.1038/s41375-025-02845-7. PMID: 40470252 Free PMC article. Updated. Preprint.
A distinct core regulatory module enforces oncogene expression in KMT2A-rearranged leukemia.
Harada T, Heshmati Y, Kalfon J, Perez MW, Xavier Ferrucio J, Ewers J, Hubbell Engler B, Kossenkov A, Ellegast JM, Yi JS, Bowker A, Zhu Q, Eagle K, Liu T, Kai Y, Dempster JM, Kugener G, Wickramasinghe J, Herbert ZT, Li CH, Vrabič Koren J, Weinstock DM, Paralkar VR, Nabet B, Lin CY, Dharia NV, Stegmaier K, Orkin SH, Pimkin M. Harada T, et al. Among authors: ellegast jm. Genes Dev. 2022 Mar 1;36(5-6):368-389. doi: 10.1101/gad.349284.121. Epub 2022 Mar 17. Genes Dev. 2022. PMID: 35301220 Free PMC article.
Pulmonary Hypertension in the Field of Hematological and Oncological Diseases.
Lichtblau M, Lador F, Lechartier B, Ellegast JM, Pohle S, Preiss H, Genecand L, Wick C, Ulrich S, Reimann L. Lichtblau M, et al. Among authors: ellegast jm. Respiration. 2025;104(7):466-475. doi: 10.1159/000544126. Epub 2025 Feb 12. Respiration. 2025. PMID: 39938488 Free PMC article. Review.
21 results