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Endocan in Acute Leukemia: Current Knowledge and Future Perspectives.
Reikvam H, Hatfield KJ, Wendelbo Ø, Lindås R, Lassalle P, Bruserud Ø. Reikvam H, et al. Biomolecules. 2022 Mar 24;12(4):492. doi: 10.3390/biom12040492. Biomolecules. 2022. PMID: 35454082 Free PMC article. Review.
Endocan is a soluble dermatan sulfate proteoglycan expressed by endothelial cells and detected in serum/plasma. ...Therapeutic targeting of endocan is now possible, and the possible role of endocan in acute leukemia should be further investigated to clarify w
Endocan is a soluble dermatan sulfate proteoglycan expressed by endothelial cells and detected in serum/plasma. ...Therapeutic target
COVID-19 and Inflammatory Markers.
Balta S, Balta I. Balta S, et al. Curr Vasc Pharmacol. 2022 Apr 4. doi: 10.2174/1570161120666220404200205. Online ahead of print. Curr Vasc Pharmacol. 2022. PMID: 35379133
Well-known inflammatory markers included complete blood count, C-reactive protein, albumin, cytokines and erythrocyte sedimentation rate. Asymmetric dimethylarginine, endocan, pentraxin 3, serum amyloid A, soluble urokinase plasminogen activator receptor, total oxidant sta …
Well-known inflammatory markers included complete blood count, C-reactive protein, albumin, cytokines and erythrocyte sedimentation rate. As …
Endocan, a Soluble Marker of Endothelial Cell Activation Is a Molecular Marker of Disease Severity in Women with Preeclampsia.
Cross SN, Buhimschi IA, Buniak CD, Shook L, McCarthy M, Hardy J, El-Helou Y, Zhao G, Buhimschi CS. Cross SN, et al. Reprod Sci. 2022 Feb 3. doi: 10.1007/s43032-022-00858-6. Online ahead of print. Reprod Sci. 2022. PMID: 35118598
Endocan and HGF measured by immunoassay were analyzed along with markers of inflammation, angiogenesis, and protein misfolding (urine congophilia). ...Compared to gestational age-matched P-CRL, women with early-onset sPE had higher circulating endocan concent
Endocan and HGF measured by immunoassay were analyzed along with markers of inflammation, angiogenesis, and protein misfolding
Endocan: A Key Player of Cardiovascular Disease.
Chen J, Jiang L, Yu XH, Hu M, Zhang YK, Liu X, He P, Ouyang X. Chen J, et al. Front Cardiovasc Med. 2022 Jan 5;8:798699. doi: 10.3389/fcvm.2021.798699. eCollection 2021. Front Cardiovasc Med. 2022. PMID: 35071362 Free PMC article. Review.
In the case of hypertension, diabetes, angina pectoris and acute myocardial infarction, the increase or decrease of serum endocan levels is of great significance. Here, we reviewed the current research on endocan, and emphasis its possible clinical value as a progno …
In the case of hypertension, diabetes, angina pectoris and acute myocardial infarction, the increase or decrease of serum endocan lev …
Elevated Serum Endocan Levels in Patients with Rosacea: A New Therapeutic Target?
Kılıc S, Mermutlu SI, Şehitoğlu H, Ekinci A. Kılıc S, et al. Indian J Dermatol. 2021 Sep-Oct;66(5):520-524. doi: 10.4103/ijd.ijd_401_21. Indian J Dermatol. 2021. PMID: 35068507 Free PMC article.
Previous studies have shown a relationship between certain inflammatory disorders and serum endocan levels. Endocan (previously known as endothelial cell-specific molecule 1) might play a role in the pathogenesis of various inflammatory diseases. AIMS AND OBJECTIVES …
Previous studies have shown a relationship between certain inflammatory disorders and serum endocan levels. Endocan (previousl …
Therapeutic Effects of Boric Acid in a Septic Arthritis Model Induced by Escherichia coli in Rats.
Yıldız K, Makav M, Adalı Y, Bulut M. Yıldız K, et al. Biol Trace Elem Res. 2022 Jan 16. doi: 10.1007/s12011-021-03065-7. Online ahead of print. Biol Trace Elem Res. 2022. PMID: 35034263
Blood and tissue samples were taken from the rats for biochemical and histopathological analyses. The levels of GSH, MDA, Endoglin, Endocan, and TNF-beta markers were measured in the blood samples taken. ...Histopathologically, it was determined that the reactive surroundi …
Blood and tissue samples were taken from the rats for biochemical and histopathological analyses. The levels of GSH, MDA, Endoglin, Endoc
Endocan alters nitric oxide production in endothelial cells by targeting AKT/eNOS and NFkB/iNOS signaling.
Kumar SK, Mani KP. Kumar SK, et al. Nitric Oxide. 2021 Dec 1;117:26-33. doi: 10.1016/j.niox.2021.09.006. Epub 2021 Sep 27. Nitric Oxide. 2021. PMID: 34592471
Endocan, a secretary proteoglycan, known to induce vascular inflammation. ...Thus, inhibition of endocan-NO signaling could be a one of the strategy to reduce oxidative stress in vascular disease....
Endocan, a secretary proteoglycan, known to induce vascular inflammation. ...Thus, inhibition of endocan-NO signaling c
Can we use endocan level to determine severity of pancreatitis?
Baykan AR, Baydar I, Şebin E, Ozdemir Y, Cerrah S, Albayrak B, Senyurt M. Baykan AR, et al. Acta Gastroenterol Belg. 2021 Apr-Jun;84(2):321-325. doi: 10.51821/84.2.321. Acta Gastroenterol Belg. 2021. PMID: 34217183 Free article.
In some studies, it has been found that endocan have important effects on cell adhesion, inflammation and angiogenesis. ...PATIENTS AND METHODS: A total of 42 patients with pancreatitis and 33 healthy individuals were included in the study. The serum endocan
In some studies, it has been found that endocan have important effects on cell adhesion, inflammation and angiogenesis. ...PAT …
Dexamethasone may improve severe COVID-19 via ameliorating endothelial injury and inflammation: A preliminary pilot study.
Kim WY, Kweon OJ, Cha MJ, Baek MS, Choi SH. Kim WY, et al. PLoS One. 2021 Jul 2;16(7):e0254167. doi: 10.1371/journal.pone.0254167. eCollection 2021. PLoS One. 2021. PMID: 34214123 Free PMC article.
We measured plasma biomarkers of lung epithelial/endothelial injury and inflammation in 31 patients with severe COVID-19 and in 13 controls. ...Relative to controls, patients with severe COVID-19 had significantly higher concentrations of biomarkers related to glycocalyx s …
We measured plasma biomarkers of lung epithelial/endothelial injury and inflammation in 31 patients with severe COVID-19 and in 13 co …
Comparison of the maternal serum endocan levels in preterm premature rupture of membrane and normal pregnancy.
İflazoğlu N, Eroğlu H, Tolunay HE, Yücel A. İflazoğlu N, et al. J Obstet Gynaecol Res. 2021 Sep;47(9):3151-3158. doi: 10.1111/jog.14836. Epub 2021 Jun 9. J Obstet Gynaecol Res. 2021. PMID: 34109715
OBJECTIVE: Endocan is a novel marker of endothelial inflammation. In this study, we aimed to show whether there was a significant difference between the endocan levels of pregnant women with and without preterm premature rupture of membranes (PPROM and non-PP …
OBJECTIVE: Endocan is a novel marker of endothelial inflammation. In this study, we aimed to show whether there was a signific …
Targeting Endothelial Cell-Specific Molecule 1 Protein in Cancer: A Promising Therapeutic Approach.
Zhang H, Shen YW, Zhang LJ, Chen JJ, Bian HT, Gu WJ, Zhang H, Chen HZ, Zhang WD, Luan X. Zhang H, et al. Front Oncol. 2021 May 24;11:687120. doi: 10.3389/fonc.2021.687120. eCollection 2021. Front Oncol. 2021. PMID: 34109132 Free PMC article. Review.
Endothelial cell-specific molecule 1 (ESM-1), a soluble dermatan sulfate proteoglycan, also known as endocan, serves as a diagnostic and prognostic indicator due to its aberrant expression under pathological conditions, including cancer, sepsis, kidney diseases, and cardio …
Endothelial cell-specific molecule 1 (ESM-1), a soluble dermatan sulfate proteoglycan, also known as endocan, serves as a diagnostic …
Endocan and Circulating Progenitor Cells in Women with Systemic Sclerosis: Association with Inflammation and Pulmonary Hypertension.
Lo Gullo A, Mandraffino G, Rodríguez-Carrio J, Scuruchi M, Sinicropi D, Postorino M, Morace C, Giuffrida C, Sciortino D, Gallizzi R, Loddo S, Zito C, Squadrito G. Lo Gullo A, et al. Biomedicines. 2021 May 11;9(5):533. doi: 10.3390/biomedicines9050533. Biomedicines. 2021. PMID: 34064667 Free PMC article.
We tested the relationships among CD34+ cells, endocan, inflammatory markers, vitamin D levels, and clinical parameters in SSc patients with PAH. ...CONCLUSION: CD34+ cell number was significantly correlated with endocan levels and with sPAP in SSc; endocan a …
We tested the relationships among CD34+ cells, endocan, inflammatory markers, vitamin D levels, and clinical parameters in SSc patien …
Endocan: a new marker of endothelial function.
Balta S, Balta I, Mikhailidis DP. Balta S, et al. Curr Opin Cardiol. 2021 Jul 1;36(4):462-468. doi: 10.1097/HCO.0000000000000867. Curr Opin Cardiol. 2021. PMID: 33929364 Review.
PURPOSE OF REVIEW: To consider the role of endocan as an inflammatory marker in cardiovascular diseases. RECENT FINDINGS: Endocan, an endothelial inflammatory marker, is associated with cardiovascular disease. ...We discuss the role of endocan mainly in the c …
PURPOSE OF REVIEW: To consider the role of endocan as an inflammatory marker in cardiovascular diseases. RECENT FINDINGS: Endocan
Endocan: A Novel Predictor of Endothelial Dysfunction in Silent Brain Infarction.
Erdal Y, Yavuz N, Oguz O, Mahmutoglu AS, Emre U. Erdal Y, et al. Angiology. 2021 Oct;72(9):850-854. doi: 10.1177/00033197211012135. Epub 2021 Apr 27. Angiology. 2021. PMID: 33902352
Silent brain infarction is defined as a hyperintense lesion that was 3 mm in 1 dimension on fluid-attenuated inversion recovery T2-weighted magnetic resonance image, if the patient had normal neurological examination or had an abnormality that was not consistent with the brain le …
Silent brain infarction is defined as a hyperintense lesion that was 3 mm in 1 dimension on fluid-attenuated inversion recovery T2-weighted …
Does Familial Mediterranean Fever Provoke Atherosclerosis in Children? Evaluation of Arterial Stiffness and Serum Endocan Levels.
Türkuçar S, Yıldız K, Küme T, Açarı C, Dundar HA, Makay B, Kır M, Ünsal E. Türkuçar S, et al. Clin Rheumatol. 2021 Oct;40(10):4199-4206. doi: 10.1007/s10067-021-05721-8. Epub 2021 Apr 4. Clin Rheumatol. 2021. PMID: 33813620
OBJECTIVES: This study aimed to evaluate the risk for atherosclerosis by using echocardiographic arterial stiffness (AS) parameters and serum endocan levels, as a biomarker of endothelial dysfunction (ED) in children with FMF. ...Distribution of MEFV gene mutations KEY POI …
OBJECTIVES: This study aimed to evaluate the risk for atherosclerosis by using echocardiographic arterial stiffness (AS) parameters and seru …
Impaired endothelial function irrespective of systemic inflammation or atherosclerosis in mastocytosis.
Öztop N, Özer PK, Demir S, Beyaz Ş, Tiryaki TO, Özkan G, Aydogan M, Bugra MZ, Çolakoglu B, Büyüköztürk S, Nalçacı M, Yavuz AS, Gelincik A. Öztop N, et al. Ann Allergy Asthma Immunol. 2021 Jul;127(1):76-82. doi: 10.1016/j.anai.2021.03.020. Epub 2021 Mar 26. Ann Allergy Asthma Immunol. 2021. PMID: 33775901
The FMD and CIMT during transthoracic echocardiography biomarkers including endocan, endothelin-1, and vascular endothelial growth factor (VEGF) were measured in the sera of participants. ...CONCLUSION: Endothelial dysfunction in mastocytosis becomes evident with decreased …
The FMD and CIMT during transthoracic echocardiography biomarkers including endocan, endothelin-1, and vascular endothelial growth fa …
Evaluation of serum endocan levels in relation to epicardial fat tissue thickness in metabolic syndrome patients.
Boyuk B, Cetin SI, Erman H, Sevinc S, Bulut U, Guzel S. Boyuk B, et al. Arch Med Sci Atheroscler Dis. 2020 Dec 26;5:e290-e296. doi: 10.5114/amsad.2020.103031. eCollection 2020. Arch Med Sci Atheroscler Dis. 2020. PMID: 33644488 Free PMC article.
Our aim was to evaluate endocan serum levels for the first time in metabolic syndrome patients, in relation to EFT thickness. ...The serum levels of endocan were measured with a Sunred ELISA kit. EFT thickness of patients was measured by echocardiography. ...
Our aim was to evaluate endocan serum levels for the first time in metabolic syndrome patients, in relation to EFT thickness. ...The …
Endocan expression correlated with total volume of coronary artery dilation in patients with coronary artery ectasia.
Sylwia I, Araszkiewicz A, Borger M, Kamiński M, Wrotyński M, Chmara E, Cieślewicz A, Radziemski A, Lesiak M. Sylwia I, et al. Postepy Kardiol Interwencyjnej. 2020 Sep;16(3):294-299. doi: 10.5114/aic.2020.99264. Epub 2020 Oct 2. Postepy Kardiol Interwencyjnej. 2020. PMID: 33597994 Free PMC article.
Endocan (endothelial cell-specific molecule-1 - ESM-1) regulates both inflammatory and angiogenetic processes. ...CONCLUSIONS: Endocan is a potential marker of vascular wall damage mainly as a result of inflammation in the course of atherosclerosis, but also
Endocan (endothelial cell-specific molecule-1 - ESM-1) regulates both inflammatory and angiogenetic processes. ...CONCLUSIONS: End
Serum endocan levels in relation to traditional and non-traditional anthropometric indices in adult population.
Klisić A, Kavarić N, Spasojević-Kalimanovska V, Kotur-Stevuljević J, Ninić A. Klisić A, et al. J Med Biochem. 2021 Jan 26;40(1):41-48. doi: 10.5937/jomb0-25170. J Med Biochem. 2021. PMID: 33584139 Free PMC article.
Endocan is a novel inflammation biomarker with its higher levels involved in cardiometabolic diseases development. ...A total of 20.1% of variation in endocan levels could be explained by this Model. CONCLUSIONS: Non-traditional obesity indices, BAI and CMI i
Endocan is a novel inflammation biomarker with its higher levels involved in cardiometabolic diseases development. ...A total
Angiopoietin-2 outperforms other endothelial biomarkers associated with severe acute kidney injury in patients with severe sepsis and respiratory failure.
Yu WK, McNeil JB, Wickersham NE, Shaver CM, Bastarache JA, Ware LB. Yu WK, et al. Crit Care. 2021 Feb 4;25(1):48. doi: 10.1186/s13054-021-03474-z. Crit Care. 2021. PMID: 33541396 Free PMC article.
Plasma endothelial dysfunction and injury biomarkers, including angiopoietin-2, soluble vascular endothelial cadherin (sVE-cadherin), endocan and syndecan-1, were measured at study enrollment. Primary analysis focused on the association between endothelial biomarker levels …
Plasma endothelial dysfunction and injury biomarkers, including angiopoietin-2, soluble vascular endothelial cadherin (sVE-cadherin), end
Endocan, a novel inflammatory marker, is upregulated in human chondrocytes stimulated with IL-1 beta.
Scuruchi M, D'Ascola A, Avenoso A, Mandraffino G, Campo S, Campo GM. Scuruchi M, et al. Mol Cell Biochem. 2021 Mar;476(3):1589-1597. doi: 10.1007/s11010-020-04001-4. Epub 2021 Jan 5. Mol Cell Biochem. 2021. PMID: 33398666
Endocan is a circulating proteoglycan, involved in immunity, inflammation, and endothelial function. ...High endocan levels were also shown in arthritic joint tissues and particularly in sites characterized by severe inflammation. ...
Endocan is a circulating proteoglycan, involved in immunity, inflammation, and endothelial function. ...High endocan le
Endocan as a potential biomarker of disease severity and exacerbations in COPD.
İn E, Kuluöztürk M, Turgut T, Altıntop Geçkil A, İlhan N. İn E, et al. Clin Respir J. 2021 Apr;15(4):445-453. doi: 10.1111/crj.13320. Epub 2020 Dec 28. Clin Respir J. 2021. PMID: 33319462
INTRODUCTION: Endocan is a proteoglycan that is regarded as a novel marker of endothelial dysfunction. Endothelial dysfunction in pulmonary vascular bed is known to play an important role for the pathogenesis of COPD. OBJECTIVE: This study aimed to determine serum endoc
INTRODUCTION: Endocan is a proteoglycan that is regarded as a novel marker of endothelial dysfunction. Endothelial dysfunction in pul …
Is endocan a novel potential biomarker of liver steatosis and fibrosis?
Klisić A, Kavarić N, Abenavoli L, Stanišić V, Spasojević-Kalimanovska V, Kotur-Stevuljević J, Ninić A. Klisić A, et al. J Med Biochem. 2020 Sep 2;39(3):363-371. doi: 10.2478/jomb-2019-0042. J Med Biochem. 2020. PMID: 33269025 Free PMC article.
BACKGROUND: Studies that evaluated endocan levels in nonalcoholic fatty liver disease (NAFLD) and liver fibrosis are scarce. ...CONCLUSIONS: Endocan independently correlated with both FLI and BARD score. However, when tested in models (with other biomarkers), end
BACKGROUND: Studies that evaluated endocan levels in nonalcoholic fatty liver disease (NAFLD) and liver fibrosis are scarce. ...CONCL …
Endothelial dysfunction in patients with acromegaly and It's association with Endocan.
Kul S, Caklili OT, Tutuncu Y, Ozcan FB, Aksu F, Baycan OF, Atici A, Bilgili UZ, Takir M, Caliskan M. Kul S, et al. Growth Horm IGF Res. 2021 Feb;56:101362. doi: 10.1016/j.ghir.2020.101362. Epub 2020 Nov 2. Growth Horm IGF Res. 2021. PMID: 33221710

As FMD increased endocan and IGF-1 decreased. A moderate negative relation between FMD and endocan was identified (p < 0.001, r:-0.409) as well as FMD and IGF-1 levels (p:0.011, r:-0.377). ...Endocan may prove to be a marker for endothelial dysfunction in

As FMD increased endocan and IGF-1 decreased. A moderate negative relation between FMD and endocan was identified (p < 0.00

Serum Copeptin, NLPR3, and suPAR Levels among Patients with Autosomal-Dominant Polycystic Kidney Disease with and without Impaired Renal Function.
Raptis V, Loutradis C, Boutou AK, Faitatzidou D, Sioulis A, Ferro CJ, Papagianni A, Sarafidis PA. Raptis V, et al. Cardiorenal Med. 2020;10(6):440-451. doi: 10.1159/000510834. Epub 2020 Nov 17. Cardiorenal Med. 2020. PMID: 33202410
In patients with ADPKD, all studied biomarkers were correlated positively with asymmetric-dimethylarginine (ADMA) and endocan levels, and negatively with eGFR. ADMA and endocan levels were the only parameters independently associated with increased copeptin levels. …
In patients with ADPKD, all studied biomarkers were correlated positively with asymmetric-dimethylarginine (ADMA) and endocan levels, …
COVID-19 and Endocan Levels.
Balta Ş. Balta Ş. Angiology. 2021 Mar;72(3):209. doi: 10.1177/0003319720965817. Epub 2020 Oct 22. Angiology. 2021. PMID: 33086860 No abstract available.
In Vivo Magnetic Resonance Imaging-Based Detection of Heterogeneous Endothelial Response in Thoracic and Abdominal Aorta to Short-Term High-Fat Diet Ascribed to Differences in Perivascular Adipose Tissue in Mice.
Bar A, Kieronska-Rudek A, Proniewski B, Suraj-Prażmowska J, Czamara K, Marczyk B, Matyjaszczyk-Gwarda K, Jasztal A, Kuś E, Majka Z, Kaczor A, Kurpińska A, Walczak M, Pieterman EJ, Princen HMG, Chlopicki S. Bar A, et al. J Am Heart Assoc. 2020 Nov 3;9(21):e016929. doi: 10.1161/JAHA.120.016929. Epub 2020 Oct 19. J Am Heart Assoc. 2020. PMID: 33073641 Free PMC article.
In contrast, short-term HFD-induced endothelial dysfunction could not be linked to systemic insulin resistance, changes in plasma concentration of nitrite, or concentration of biomarkers of glycocalyx disruption (syndecan-1 and endocan), endothelial inflammation (so …
In contrast, short-term HFD-induced endothelial dysfunction could not be linked to systemic insulin resistance, changes in plasma concentrat …
Non-invasive diagnosis of endometriosis and moderate-severe endometriosis with serum CA125, endocan, YKL-40, and copeptin quadruple panel.
Guralp O, Kaya B, Tüten N, Kucur M, Malik E, Tüten A. Guralp O, et al. J Obstet Gynaecol. 2021 Aug;41(6):927-932. doi: 10.1080/01443615.2020.1803245. Epub 2020 Oct 16. J Obstet Gynaecol. 2021. PMID: 33064040
Considering the complex pathogenesis of endometriosis, which is associated with many cellular or molecular processes, such as proliferation, angiogenesis, inflammation, we evaluated the diagnostic value of a quadruple panel of serum markers CA125, endocan, YKL-40 an …
Considering the complex pathogenesis of endometriosis, which is associated with many cellular or molecular processes, such as proliferation, …
Reactive hyperemia correlates with the presence of sepsis and glycocalyx degradation in the intensive care unit: a prospective cohort study.
Malheiro LFG, Gaio R, Silva MVD, Martins S, Sampaio S, Quelhas-Santos J, Cerqueira A, Sarmento A, Santos L. Malheiro LFG, et al. Rev Bras Ter Intensiva. 2020 Jul-Sep;32(3):363-373. doi: 10.5935/0103-507X.20200064. Rev Bras Ter Intensiva. 2020. PMID: 33053025 Free PMC article.
Endothelial dysfunction was assessed on admission by quantifying reactive hyperemia-peripheral arterial tonometry and plasma levels of endothelin-1, soluble E-selectin, endocan and syndecan-1. Septic patients were compared to patients without evidence of infection. ...
Endothelial dysfunction was assessed on admission by quantifying reactive hyperemia-peripheral arterial tonometry and plasma levels of endot …
Serum Endocan Levels Predict Angiographic No-Reflow Phenomenon in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary Coronary Intervention.
Dogdus M, Yenercag M, Ozyasar M, Yilmaz A, Can LH, Kultursay H. Dogdus M, et al. Angiology. 2021 Mar;72(3):221-227. doi: 10.1177/0003319720961954. Epub 2020 Sep 30. Angiology. 2021. PMID: 32996338
No-reflow phenomenon (NRP) is an important problem in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (pPCI). Endocan is synthesized and secreted by activated vascular endothelium, and it has been shown …
No-reflow phenomenon (NRP) is an important problem in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary pe …
Effect of a novel extracorporeal cytokine apheresis method on endocan, copeptin And interleukin-6 levels in sepsis: An observational prospective study.
Kaya Uğur B, Çiçek H, Kul S, Mete Ö, Yılmaz M. Kaya Uğur B, et al. Transfus Apher Sci. 2020 Dec;59(6):102919. doi: 10.1016/j.transci.2020.102919. Epub 2020 Aug 25. Transfus Apher Sci. 2020. PMID: 32912735
The aim of the study is to evaluate the effect of each Cytosorb hemoadsorption therapy course on blood levels of inflammatory biomarkers of sepsis including endocan, copeptin, interleukin-6, procalcitonin, C-reactive protein. ...CONCLUSION: Cytosorb courses achieved signif …
The aim of the study is to evaluate the effect of each Cytosorb hemoadsorption therapy course on blood levels of inflammatory biomarkers of …
Endothelial cell-specific-molecule-1 (endocan) levels in women with premature ovarian insufficiency: a prospective comparative study.
Ovayolu A, Karaman E, Turgut A, Cekici Y, Ortabag T, Chiara Rapisarda AM, Noventa M, Cianci A. Ovayolu A, et al. J Obstet Gynaecol. 2021 May;41(4):637-641. doi: 10.1080/01443615.2020.1789952. Epub 2020 Aug 18. J Obstet Gynaecol. 2021. PMID: 32808833
There is an increased risk of cardiovascular disease in women with premature ovarian insufficiency (POI). A relationship between cardiovascular disease and endocan levels has been shown. Endocan is a marker that is prominent in many diseases caused by endothelial dy …
There is an increased risk of cardiovascular disease in women with premature ovarian insufficiency (POI). A relationship between cardiovascu …
Endocan: A novel biomarker for risk stratification, prognosis and therapeutic monitoring in human cardiovascular and renal diseases.
Bessa J, Albino-Teixeira A, Reina-Couto M, Sousa T. Bessa J, et al. Clin Chim Acta. 2020 Oct;509:310-335. doi: 10.1016/j.cca.2020.07.041. Epub 2020 Jul 22. Clin Chim Acta. 2020. PMID: 32710940 Review.
The vascular endothelium is localized at the interface between the blood and surrounding tissues, playing a pivotal role in the maintenance of tissue-fluid homeostasis and in the regulation of host defense, inflammation, vascular tone and remodeling, angiogenesis and haemo …
The vascular endothelium is localized at the interface between the blood and surrounding tissues, playing a pivotal role in the maintenance …
Association of Biomarker Level with Cardiovascular Events: Results of a 4-Year Follow-Up Study.
Turgunova L, Baidildina B, Laryushina Y, Koichubekov B, Turmukhambetova A, Akhmaltdinova L. Turgunova L, et al. Cardiol Res Pract. 2020 Jun 23;2020:8020674. doi: 10.1155/2020/8020674. eCollection 2020. Cardiol Res Pract. 2020. PMID: 32676207 Free PMC article.
BACKGROUND: Given the high rates of morbidity and mortality from cardiovascular disease (CVD), the primary and secondary CVD prevention is one of the public health priority. Inflammation and endothelial dysfunction are the major drivers of atherosclerosis development and p …
BACKGROUND: Given the high rates of morbidity and mortality from cardiovascular disease (CVD), the primary and secondary CVD prevention is o …
A Comparison of the Circulating Endocan Levels between the Inflammatory and Malignant Diseases of the Same Organ: The Breast.
Basim P, Argun D. Basim P, et al. J Invest Surg. 2021 Nov;34(11):1207-1213. doi: 10.1080/08941939.2020.1792008. Epub 2020 Jul 14. J Invest Surg. 2021. PMID: 32660374
RESULTS: The endocan level was found to be significantly higher in the BC group than in the control group (p = 0.003). ...These findings indicate the potential role of endocan in the pathogenesis of BC....
RESULTS: The endocan level was found to be significantly higher in the BC group than in the control group (p = 0.003). ...These findi …
Endocan and advanced oxidation protein products in adult population with hypertension.
Klisic A, Kavaric N, Vujcic S, Spasojevic-Kalimanovska V, Ninic A, Kotur-Stevuljevic J. Klisic A, et al. Eur Rev Med Pharmacol Sci. 2020 Jun;24(12):7131-7137. doi: 10.26355/eurrev_202006_21707. Eur Rev Med Pharmacol Sci. 2020. PMID: 32633408 Free article.
OBJECTIVE: Hypertension is closely related to oxidative stress and inflammation. Endocan is a new inflammation marker whose role is not completely elucidated in hypertension. ...In the multivariable logistic regression analysis, AOPP and endocan kept t …
OBJECTIVE: Hypertension is closely related to oxidative stress and inflammation. Endocan is a new inflammation marker w …
Spontaneous delivery is associated with increased endothelial activity in cord blood compared to elective cesarean section.
Sibikova M, Vitkova V, Jamrichova L, Haluzik M, Zivny J, Janota J. Sibikova M, et al. Eur J Obstet Gynecol Reprod Biol. 2020 Aug;251:229-234. doi: 10.1016/j.ejogrb.2020.05.059. Epub 2020 Jun 1. Eur J Obstet Gynecol Reprod Biol. 2020. PMID: 32544752
Irrespective of the delivery mode endothelial markers sVEGFR1, Endocan, Angiopoietin-2, VEGF, and sICAM1, were significantly increased in neonatal compared to cord blood. ...
Irrespective of the delivery mode endothelial markers sVEGFR1, Endocan, Angiopoietin-2, VEGF, and sICAM1, were significantly increase …
Evaluation of Endocan and Tumor Necrosis Factor-α as Inflammatory Biomarkers in Type 2 Diabetes and Periodontal Disease.
Kumar G, Ponnaiyan D, Parthasarathy H, Tadepalli A, Veeramani S. Kumar G, et al. Genet Test Mol Biomarkers. 2020 Jul;24(7):431-435. doi: 10.1089/gtmb.2020.0037. Epub 2020 Jun 8. Genet Test Mol Biomarkers. 2020. PMID: 32513032
Results: Endocan levels were elevated in CP subjects with type 2 DM at baseline. There was a significant reduction in the Endocan and HbA1c levels (p < 0.01) among all the groups after NSPT. ...
Results: Endocan levels were elevated in CP subjects with type 2 DM at baseline. There was a significant reduction in the Endocan
Maternal plasma endocan levels in intrauterine growth restriction.
Kucukbas GN, Kara O, Yüce D, Uygur D. Kucukbas GN, et al. J Matern Fetal Neonatal Med. 2022 Apr;35(7):1295-1300. doi: 10.1080/14767058.2020.1749591. Epub 2020 Apr 14. J Matern Fetal Neonatal Med. 2022. PMID: 32290736
Endothelial dysfunction is a common pathogenetic pathway underlying IUGR etiology. Endocan (ESM-1) is a novel marker of endothelial dysfunction and inflammation found in the maternal circulation. ...STUDY DESIGN: Forty-four pregnancies complicated with IUGR and 47 h …
Endothelial dysfunction is a common pathogenetic pathway underlying IUGR etiology. Endocan (ESM-1) is a novel marker of endothelial d …
Cleaved endocan acts as a biologic competitor of endocan in the control of ICAM-1-dependent leukocyte diapedesis.
Gaudet A, Portier L, Mathieu D, Hureau M, Tsicopoulos A, Lassalle P, De Freitas Caires N. Gaudet A, et al. J Leukoc Biol. 2020 May;107(5):833-841. doi: 10.1002/JLB.3AB0320-612RR. Epub 2020 Apr 9. J Leukoc Biol. 2020. PMID: 32272492
Recent data have highlighted the hypothetic role of p14, endocan's major catabolite found in the bloodstream of septic patients, as a potential antagonist of endocan, thus participating in the regulation of acute inflammation. We hereby characterize th …
Recent data have highlighted the hypothetic role of p14, endocan's major catabolite found in the bloodstream of septic patient …
Serum Endocan Levels Predict Drug-Eluting Stent Restenosis in Patients with Stable Angina Pectoris.
Küp A, Toprak C, Bayam E, İzcı S, Uslu A, Çelık M, Balaban İ, Cerşıt S, Barutçu S, Gündoğmuş PD. Küp A, et al. Acta Cardiol Sin. 2020 Mar;36(2):111-117. doi: 10.6515/ACS.202003_36(2).20190731A. Acta Cardiol Sin. 2020. PMID: 32201461 Free PMC article.
BACKGROUND: Endothelial cell-specific molecule 1 (ESM-1 or endocan) is an immunoinflammatory marker strongly associated with inflammation, vascular endothelial dysfunction and atherosclerosis. ...Receiver operating characteristic curve analysis was used to explore t …
BACKGROUND: Endothelial cell-specific molecule 1 (ESM-1 or endocan) is an immunoinflammatory marker strongly associated with infla
Development of an Algorithm to Predict Mortality in Patients With Sepsis and Coagulopathy.
Walborn A, Rondina M, Fareed J, Hoppensteadt D. Walborn A, et al. Clin Appl Thromb Hemost. 2020 Jan-Dec;26:1076029620902849. doi: 10.1177/1076029620902849. Clin Appl Thromb Hemost. 2020. PMID: 32129085 Free PMC article.

Sepsis is a systemic response to infection with a high rate of mortality and complex pathophysiology involving inflammation, infection response, hemostasis, endothelium, and platelets. ...Significant differences (P < .05) were observed between survivors and nonsurvivors

Sepsis is a systemic response to infection with a high rate of mortality and complex pathophysiology involving inflammation, infectio …
Endocan serum concentration in uninfected newborn infants.
Zonda GI, Zonda R, Cernomaz AT, Paduraru L, Grigoriu BD. Zonda GI, et al. J Infect Dev Ctries. 2019 Sep 30;13(9):817-822. doi: 10.3855/jidc.11660. J Infect Dev Ctries. 2019. PMID: 32074091 Free article.
INTRODUCTION: Endocan is a specific endothelial mediator involved in the inflammatory response. ...METHODOLOGY: Mean endocan serum concentration (ESC) was measured in term and preterm newborns without clinical suspicion of EOS at different moments from birth. ...
INTRODUCTION: Endocan is a specific endothelial mediator involved in the inflammatory response. ...METHODOLOGY: Mean endocan s …
Systemic Endothelial Activation Is Associated With Early Acute Respiratory Distress Syndrome in Children With Extrapulmonary Sepsis.
Whitney JE, Zhang B, Koterba N, Chen F, Bush J, Graham K, Lacey SF, Melenhorst JJ, Teachey DT, Mensinger JL, Yehya N, Weiss SL. Whitney JE, et al. Crit Care Med. 2020 Mar;48(3):344-352. doi: 10.1097/CCM.0000000000004091. Crit Care Med. 2020. PMID: 32058372 Free PMC article.
Among patients with sepsis, those with acute respiratory distress syndrome had higher angiopoietin-2/angiopoietin-1 ratio, vascular endothelial growth factor, vascular cell adhesion molecule, thrombomodulin, endocan, interleukin-6, and interleukin-8 than those without acut …
Among patients with sepsis, those with acute respiratory distress syndrome had higher angiopoietin-2/angiopoietin-1 ratio, vascular endothel …
Endocan and a novel score for dyslipidemia, oxidative stress and inflammation (DOI score) are independently correlated with glycated hemoglobin (HbA1c) in patients with prediabetes and type 2 diabetes.
Klisic A, Kavaric N, Stanisic V, Vujcic S, Spasojevic-Kalimanovska V, Ninic A, Kotur-Stevuljevic J. Klisic A, et al. Arch Med Sci. 2019 Aug 27;16(1):42-50. doi: 10.5114/aoms.2019.87541. eCollection 2020. Arch Med Sci. 2019. PMID: 32051704 Free PMC article.
INTRODUCTION: We aimed to examine serum endocan level and the summary involvement of dyslipidemia, oxidative stress (OS) and inflammation by calculation of its comprehensive score (i.e. ...CONCLUSIONS: Endocan and DOI score are independently correlated with H …
INTRODUCTION: We aimed to examine serum endocan level and the summary involvement of dyslipidemia, oxidative stress (OS) and infla
Sirtuin 1: Endocan and Sestrin 2 in Different Biological Samples in Patients with Asthma. Does Severity Make the Difference?
Tsilogianni Z, Baker JR, Papaporfyriou A, Papaioannou AI, Papathanasiou E, Koulouris NG, Daly L, Ito K, Hillas G, Papiris S, Bakakos P, Loukides S. Tsilogianni Z, et al. J Clin Med. 2020 Feb 9;9(2):473. doi: 10.3390/jcm9020473. J Clin Med. 2020. PMID: 32050426 Free PMC article.
BACKGROUND: Sestrin 2, Endocan, and Sirtuin 1 are distinct molecules with some biologic actions associated with asthma pathophysiology. ...Demographics, test results of lung function, and treatment regimes of all patients were recorded. Sestrin 2, Endocan, and Sirtu …
BACKGROUND: Sestrin 2, Endocan, and Sirtuin 1 are distinct molecules with some biologic actions associated with asthma pathophysiolog …
Endocan - a potential diagnostic marker for early onset sepsis in neonates.
Zonda GI, Zonda R, Cernomaz AT, Paduraru L, Avasiloaiei AL, Grigoriu BD. Zonda GI, et al. J Infect Dev Ctries. 2019 Apr 30;13(4):311-317. doi: 10.3855/jidc.11202. J Infect Dev Ctries. 2019. PMID: 32045375 Free article.
The purpose of this study is to evaluate the utility of serum endocan serum levels as a biomarker for the diagnosis of neonatal early onset sepsis (EOS). ...CONCLUSIONS: These results suggest a potential role for endocan as an early marker for diagnosis and follow-u …
The purpose of this study is to evaluate the utility of serum endocan serum levels as a biomarker for the diagnosis of neonatal early …
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