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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1993 1
1994 3
1995 11
1996 10
1997 16
1998 26
1999 28
2000 41
2001 47
2002 91
2003 89
2004 121
2005 185
2006 219
2007 309
2008 392
2009 354
2010 348
2011 371
2012 454
2013 404
2014 438
2015 457
2016 511
2017 490
2018 468
2019 524
2020 645
2021 150
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6,249 results
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Page 1
The Endocannabinoid System and its Modulation by Phytocannabinoids.
Di Marzo V, Piscitelli F. Di Marzo V, et al. Neurotherapeutics. 2015 Oct;12(4):692-8. doi: 10.1007/s13311-015-0374-6. Neurotherapeutics. 2015. PMID: 26271952 Free PMC article. Review.
The endocannabinoid system is currently defined as the ensemble of the two 7-transmembrane-domain and G protein-coupled receptors for delta(9)-tetrahydrocannabinol (but not for most other plant cannabinoids or phytocannabinoids)-cannabinoid receptor type-1 (CB1R) an …
The endocannabinoid system is currently defined as the ensemble of the two 7-transmembrane-domain and G protein-coupled recept …
Endocannabinoid system in neurodegenerative disorders.
Basavarajappa BS, Shivakumar M, Joshi V, Subbanna S. Basavarajappa BS, et al. J Neurochem. 2017 Sep;142(5):624-648. doi: 10.1111/jnc.14098. Epub 2017 Jul 5. J Neurochem. 2017. PMID: 28608560 Free PMC article. Review.
These mechanisms may proceed concurrently or successively, and they differ among cell types at different developmental stages in distinct brain regions. The endocannabinoid system, which involves cannabinoid receptors type 1 (CB1R) and type 2 (CB2R), endogenous cann …
These mechanisms may proceed concurrently or successively, and they differ among cell types at different developmental stages in distinct br …
Cannabinoids and the expanded endocannabinoid system in neurological disorders.
Cristino L, Bisogno T, Di Marzo V. Cristino L, et al. Nat Rev Neurol. 2020 Jan;16(1):9-29. doi: 10.1038/s41582-019-0284-z. Epub 2019 Dec 12. Nat Rev Neurol. 2020. PMID: 31831863 Review.
The discovery of CB2 and of endogenous cannabinoid receptor ligands (endocannabinoids) raised new possibilities for safe targeting of this endocannabinoid system. However, clinical success has been limited, complicated by the discovery of an expanded endoc
The discovery of CB2 and of endogenous cannabinoid receptor ligands (endocannabinoids) raised new possibilities for safe targeting of …
Distribution of the Endocannabinoid System in the Central Nervous System.
Hu SS, Mackie K. Hu SS, et al. Handb Exp Pharmacol. 2015;231:59-93. doi: 10.1007/978-3-319-20825-1_3. Handb Exp Pharmacol. 2015. PMID: 26408158 Review.
The endocannabinoid system consists of endogenous cannabinoids (endocannabinoids), the enzymes that synthesize and degrade endocannabinoids, and the receptors that transduce the effects of endocannabinoids. Much of what we know about the functio …
The endocannabinoid system consists of endogenous cannabinoids (endocannabinoids), the enzymes that synthesize and degr …
Endocannabinoid System Components: Overview and Tissue Distribution.
Joshi N, Onaivi ES. Joshi N, et al. Adv Exp Med Biol. 2019;1162:1-12. doi: 10.1007/978-3-030-21737-2_1. Adv Exp Med Biol. 2019. PMID: 31332731 Review.
Evidence based research and remarkable biotechnological advances demonstrate that phytocannabinoids and endocannabinoid (eCBs) acting on cannabinoid receptors (CBRs) regulate various aspects of human physiological, behavioral, immunological and metabolic functions. The dis …
Evidence based research and remarkable biotechnological advances demonstrate that phytocannabinoids and endocannabinoid (eCBs) acting …
Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System.
Zou S, Kumar U. Zou S, et al. Int J Mol Sci. 2018 Mar 13;19(3):833. doi: 10.3390/ijms19030833. Int J Mol Sci. 2018. PMID: 29533978 Free PMC article. Review.
The biological effects of cannabinoids, the major constituents of the ancient medicinal plant Cannabis sativa (marijuana) are mediated by two members of the G-protein coupled receptor family, cannabinoid receptors 1 (CB1R) and 2. The CB1R is the prominent subtype in the central n …
The biological effects of cannabinoids, the major constituents of the ancient medicinal plant Cannabis sativa (marijuana) are mediated by tw …
Endocannabinoid System in the Airways.
Bozkurt TE. Bozkurt TE. Molecules. 2019 Dec 17;24(24):4626. doi: 10.3390/molecules24244626. Molecules. 2019. PMID: 31861200 Free PMC article. Review.
Cannabinoids and the mammalian endocannabinoid system is an important research area of interest and attracted many researchers because of their widespread biological effects. ...In this review, the contribution of cannabinoids and the endocannabinoid syste
Cannabinoids and the mammalian endocannabinoid system is an important research area of interest and attracted many researchers …
The endocannabinoid system as an emerging target of pharmacotherapy.
Pacher P, Bátkai S, Kunos G. Pacher P, et al. Pharmacol Rev. 2006 Sep;58(3):389-462. doi: 10.1124/pr.58.3.2. Pharmacol Rev. 2006. PMID: 16968947 Free PMC article. Review.
In the past decade, the endocannabinoid system has been implicated in a growing number of physiological functions, both in the central and peripheral nervous systems and in peripheral organs. ...Here, we provide a comprehensive overview on the current state o …
In the past decade, the endocannabinoid system has been implicated in a growing number of physiological functions, both in the …
The role of the endocannabinoid system in pain.
Woodhams SG, Sagar DR, Burston JJ, Chapman V. Woodhams SG, et al. Handb Exp Pharmacol. 2015;227:119-43. doi: 10.1007/978-3-662-46450-2_7. Handb Exp Pharmacol. 2015. PMID: 25846617 Review.
Preparations of the Cannabis sativa plant have been used to analgesic effect for millenia, but only in recent decades has the endogenous system responsible for these effects been described. The endocannabinoid (EC) system is now known to be one of the key end …
Preparations of the Cannabis sativa plant have been used to analgesic effect for millenia, but only in recent decades has the endogenous …
Marijuana, the Endocannabinoid System and the Female Reproductive System.
Brents LK. Brents LK. Yale J Biol Med. 2016 Jun 27;89(2):175-91. eCollection 2016 Jun. Yale J Biol Med. 2016. PMID: 27354844 Free PMC article. Review.
Tolerance to these effects has been shown in rhesus monkeys, but the effects of chronic marijuana use on human female reproduction are largely unknown. Marijuana-induced analgesia, drug reinforcement properties, tolerance, and dependence are influenced by ovarian hormones, …
Tolerance to these effects has been shown in rhesus monkeys, but the effects of chronic marijuana use on human female reproduction are large …
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