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Paraben esters: review of recent studies of endocrine toxicity, absorption, esterase and human exposure, and discussion of potential human health risks.
Darbre PD, Harvey PW. Darbre PD, et al. J Appl Toxicol. 2008 Jul;28(5):561-78. doi: 10.1002/jat.1358. J Appl Toxicol. 2008. PMID: 18484575 Review.
This toxicology update reviews research over the past four years since publication in 2004 of the first measurement of intact esters of p-hydroxybenzoic acid (parabens) in human breast cancer tissues, and the suggestion that their presence in the human body might or …
This toxicology update reviews research over the past four years since publication in 2004 of the first measurement of intact esters of p-hy …
A comprehensive review on chlorpyrifos toxicity with special reference to endocrine disruption: Evidence of mechanisms, exposures and mitigation strategies.
Ubaid Ur Rahman H, Asghar W, Nazir W, Sandhu MA, Ahmed A, Khalid N. Ubaid Ur Rahman H, et al. Sci Total Environ. 2021 Feb 10;755(Pt 2):142649. doi: 10.1016/j.scitotenv.2020.142649. Epub 2020 Oct 1. Sci Total Environ. 2021. PMID: 33059141 Review.
Moreover, eye irritation and dermatological defects are also reported due to CPF toxicity. The mechanism of action of CPF involves blocking the active sites of the enzyme, acetylcholinesterase (AChE), thereby producing adverse nervous system effects. Although CPF ha …
Moreover, eye irritation and dermatological defects are also reported due to CPF toxicity. The mechanism of action of CPF involves bl …
Environmental exposure to organophosphate pesticides: assessment of endocrine disruption and hepatotoxicity in pregnant women.
Cecchi A, Rovedatti MG, Sabino G, Magnarelli GG. Cecchi A, et al. Ecotoxicol Environ Saf. 2012 Jun;80:280-7. doi: 10.1016/j.ecoenv.2012.03.008. Epub 2012 Apr 10. Ecotoxicol Environ Saf. 2012. PMID: 22494479
In utero exposure is the first point of contact with environmental xenobiotics that may affect the maternal-placental-fetal balance. Considering that maternal pathophysiological changes affect intrauterine development, this pilot study was conducted to address how environm …
In utero exposure is the first point of contact with environmental xenobiotics that may affect the maternal-placental-fetal balance. …
Prenatal exposure to mixtures of xenoestrogens and genome-wide DNA methylation in human placenta.
Vilahur N, Bustamante M, Morales E, Motta V, Fernandez MF, Salas LA, Escaramis G, Ballester F, Murcia M, Tardon A, Riaño I, Santa-Marina L, Ibarluzea J, Arrebola JP, Estivill X, Bollati V, Sunyer J, Olea N. Vilahur N, et al. Epigenomics. 2016 Jan;8(1):43-54. doi: 10.2217/epi.15.91. Epub 2015 Dec 18. Epigenomics. 2016. PMID: 26679211
BACKGROUND: In utero exposure to xenostrogens may modify the epigenome. We explored the association of prenatal exposure to mixtures of xenoestrogens and genome-wide placental DNA methylation. ...CONCLUSION: Some suggestive genes were differentially methylated in bo …
BACKGROUND: In utero exposure to xenostrogens may modify the epigenome. We explored the association of prenatal exposure to mi …
Bisphenol A drives di(2-ethylhexyl) phthalate promoting thyroid tumorigenesis via regulating HDAC6/PTEN and c-MYC signaling.
Zhang X, Guo N, Jin H, Liu R, Zhang Z, Cheng C, Fan Z, Zhang G, Xiao M, Wu S, Zhao Y, Lu X. Zhang X, et al. J Hazard Mater. 2022 Mar 5;425:127911. doi: 10.1016/j.jhazmat.2021.127911. Epub 2021 Nov 26. J Hazard Mater. 2022. PMID: 34910997 Free article.
Bisphenol A (BPA) and di-(2-ethylhcxyl) phthalate (DEHP) are exist widespread in the environment and produce adverse effect to human as environmental disruptors (EDCs). Epidemiological studies have found that the exposure of DEHP and BPA could increase the susceptib …
Bisphenol A (BPA) and di-(2-ethylhcxyl) phthalate (DEHP) are exist widespread in the environment and produce adverse effect to human
Perinatal phthalate and high-fat diet exposure induce sex-specific changes in adipocyte size and DNA methylation.
Moody L, Kougias D, Jung PM, Digan I, Hong A, Gorski A, Chen H, Juraska J, Pan YX. Moody L, et al. J Nutr Biochem. 2019 Mar;65:15-25. doi: 10.1016/j.jnutbio.2018.11.005. Epub 2018 Dec 4. J Nutr Biochem. 2019. PMID: 30599393 Free PMC article.
Environmental factors such as diet and endocrine-disrupting chemicals have individually been shown to mediate metabolic function. ...Hematoxylin and eosin staining revealed larger adipocyte size in HF-0 vs. C-0 females. Exposure to 200 or 1000 mug/kg/day phthalates …
Environmental factors such as diet and endocrine-disrupting chemicals have individually been shown to mediate metabolic function. ... …
Beyond Cholinesterase Inhibition: Developmental Neurotoxicity of Organophosphate Ester Flame Retardants and Plasticizers.
Patisaul HB, Behl M, Birnbaum LS, Blum A, Diamond ML, Rojello Fernández S, Hogberg HT, Kwiatkowski CF, Page JD, Soehl A, Stapleton HM. Patisaul HB, et al. Environ Health Perspect. 2021 Oct;129(10):105001. doi: 10.1289/EHP9285. Epub 2021 Oct 6. Environ Health Perspect. 2021. PMID: 34612677 Free PMC article.
By highlighting this scientific evidence, we hope to elevate the level of concern for widespread human exposure to these OPEs and to provide recommendations for how to better protect public health. ...Application of a pathways framework indicates several specific me …
By highlighting this scientific evidence, we hope to elevate the level of concern for widespread human exposure to these OPEs …
Long-term 1-nitropyrene exposure induces endoplasmic reticulum stress and inhibits steroidogenesis in mice testes.
Li J, Gao L, Zhu BB, Lin ZJ, Chen J, Lu X, Wang H, Zhang C, Chen YH, Xu DX. Li J, et al. Chemosphere. 2020 Jul;251:126336. doi: 10.1016/j.chemosphere.2020.126336. Epub 2020 Feb 27. Chemosphere. 2020. PMID: 32145574
To investigate long-term 1-NP exposure on spermatogenesis and steroidogenesis, male mice were exposed to 1-NP (1.0 mg/kg/day) by gavage for 70 days. ...Testicular GSH and GSH/GSSG were decreased in 1-NP-exposed mice. These results suggest that long-term 1-NP exposure
To investigate long-term 1-NP exposure on spermatogenesis and steroidogenesis, male mice were exposed to 1-NP (1.0 mg/kg/day) by gava …
Temephos Decreases Sperm Quality and Fertilization Rate and Is Metabolized in Rat Reproductive Tissues at Low-Dose Exposure.
Ramos-Flores Á, Camacho-Hernández I, Sierra-Santoyo A, Solís-Heredia MJ, Verdín-Betancourt FA, Parra-Forero LY, López-González ML, Hernández-Ochoa I, Quintanilla-Vega B. Ramos-Flores Á, et al. Toxicol Sci. 2021 Oct 27;184(1):57-66. doi: 10.1093/toxsci/kfab100. Toxicol Sci. 2021. PMID: 34382084
Temephos inhibits acetylcholinesterase (AChE) and is metabolized in different tissues, probably by mixed-function oxidases; one of its metabolites is bisphenol S (BPS), which is considered an endocrine disruptor. The aim of this study was to evaluate the effects of …
Temephos inhibits acetylcholinesterase (AChE) and is metabolized in different tissues, probably by mixed-function oxidases; one of its metab …
Biochemical and genotoxic effects in women exposed to pesticides in Southern Ecuador.
Arévalo-Jaramillo P, Idrobo A, Salcedo L, Cabrera A, Vintimilla A, Carrión M, Bailon-Moscoso N. Arévalo-Jaramillo P, et al. Environ Sci Pollut Res Int. 2019 Aug;26(24):24911-24921. doi: 10.1007/s11356-019-05725-7. Epub 2019 Jun 26. Environ Sci Pollut Res Int. 2019. PMID: 31243655
Toxicity refers to the potential of a substance such as a pesticide to cause damage to the structure or functions of an exposed organism. Pesticides can lead to harmful biological effects in exposed animals and their offspring over the medium and long term. They can affect
Toxicity refers to the potential of a substance such as a pesticide to cause damage to the structure or functions of an exposed organ
65 results