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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1984 1
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1987 2
1988 2
1989 4
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1992 2
1993 2
1994 3
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1998 3
1999 3
2000 7
2001 7
2002 4
2003 4
2004 5
2005 4
2006 3
2007 8
2008 8
2009 6
2010 7
2011 7
2012 7
2013 6
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210 results

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Page 1
Astrocyte-mediated central amygdala microcircuit gates comorbid anxiety symptoms in chronic pain.
Zan GY, Yao SY, Deng YZ, Jiang YH, Ye RF, Chen Y, Long JD, Cheng YJ, Chai JR, Xu C, Zhao M, Liu ZQ, Liu JG, Wang YJ. Zan GY, et al. Neuron. 2025 Dec 3;113(23):4037-4054.e6. doi: 10.1016/j.neuron.2025.09.004. Epub 2025 Oct 2. Neuron. 2025. PMID: 41043420
Comorbid anxiety symptoms are prominent affective components of chronic pain, yet the central mechanisms underlying these symptoms remain elusive. The central amygdala (CeA) regulates nociceptive processing and associated anxiety in chronic pain. ...Be …
Comorbid anxiety symptoms are prominent affective components of chronic pain, yet the central mechanisms underlying these symp …
Chronic pain recruits hypothalamic dynorphin/kappa opioid receptor signalling to promote wakefulness and vigilance.
Ito H, Navratilova E, Vagnerova B, Watanabe M, Kopruszinski C, Moreira de Souza LH, Yue X, Ikegami D, Moutal A, Patwardhan A, Khanna R, Yamazaki M, Guerrero M, Rosen H, Roberts E, Neugebauer V, Dodick DW, Porreca F. Ito H, et al. Brain. 2023 Mar 1;146(3):1186-1199. doi: 10.1093/brain/awac153. Brain. 2023. PMID: 35485490 Free PMC article.
Chronic pain engages brain stress circuits and increases secretion of dynorphin, an endogenous ligand of the kappa opioid receptor (KOR). ...Notably, while this mechanism is likely beneficial in the short-term, disruption of the homeostatic need for sl …
Chronic pain engages brain stress circuits and increases secretion of dynorphin, an endogenous ligand of the kappa o …
Biochemistry, Endorphin.
Chaudhry SR, Rahimi N. Chaudhry SR, et al. 2025 Aug 19. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2026 Jan–. 2025 Aug 19. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2026 Jan–. PMID: 29262177 Free Books & Documents.
The endogenous opioid system comprises 4 families of neuropeptides: beta-endorphins, enkephalins, dynorphins, and nociceptin. ...Understanding the molecular biology, receptor pharmacology, and signal transduction of endogenous opioids is essential for clinici …
The endogenous opioid system comprises 4 families of neuropeptides: beta-endorphins, enkephalins, dynorphins, and nociceptin. …
Role of Levo-tetrahydropalmatine and its metabolites for management of chronic pain and opioid use disorders.
Liu J, Dai R, Damiescu R, Efferth T, Lee DYW. Liu J, et al. Phytomedicine. 2021 Sep;90:153594. doi: 10.1016/j.phymed.2021.153594. Epub 2021 May 25. Phytomedicine. 2021. PMID: 34144869 Review.
BACKGROUND: Opioids have been prescribed to reduce suffering from pain and to enhance quality of life. Due to the addictive potential and the lack of other effective alternatives to treat severe acute and chronic pains, opioids remain a serious public health …
BACKGROUND: Opioids have been prescribed to reduce suffering from pain and to enhance quality of life. Due to the addictive po …
Pharmacological Modulation of Endogenous Opioid Activity to Attenuate Neuropathic Pain in Rats.
Liu NJ, Storman EM, Gintzler AR. Liu NJ, et al. J Pain. 2019 Feb;20(2):235-243. doi: 10.1016/j.jpain.2018.10.003. Epub 2018 Oct 23. J Pain. 2019. PMID: 30366152 Free PMC article.
PERSPECTIVE: Intrathecal treatments that enhance spinal endomorphin 2 analgesic responsiveness under basal conditions lessen mechanical allodynia in a chronic pain model. Findings provide a foundation for developing drugs that harness endogenous opi …
PERSPECTIVE: Intrathecal treatments that enhance spinal endomorphin 2 analgesic responsiveness under basal conditions lessen mechanic …
Are endogenous opioid mechanisms involved in the effects of aerobic exercise training on chronic low back pain? A randomized controlled trial.
Bruehl S, Burns JW, Koltyn K, Gupta R, Buvanendran A, Edwards D, Chont M, Wu YH, Qu'd D, Stone A. Bruehl S, et al. Pain. 2020 Dec;161(12):2887-2897. doi: 10.1097/j.pain.0000000000001969. Pain. 2020. PMID: 32569082 Free PMC article. Clinical Trial.
Chronic pain intensity and interference were assessed before and after the intervention. Endogenous opioid analgesia was indexed by naloxone-placebo condition differences in evoked pain responses (blockade effects). ...
Chronic pain intensity and interference were assessed before and after the intervention. Endogenous opioid analg …
Kappa Opioid Receptors Drive a Tonic Aversive Component of Chronic Pain.
Liu SS, Pickens S, Burma NE, Ibarra-Lecue I, Yang H, Xue L, Cook C, Hakimian JK, Severino AL, Lueptow L, Komarek K, Taylor AMW, Olmstead MC, Carroll FI, Bass CE, Andrews AM, Walwyn W, Trang T, Evans CJ, Leslie FM, Cahill CM. Liu SS, et al. J Neurosci. 2019 May 22;39(21):4162-4178. doi: 10.1523/JNEUROSCI.0274-19.2019. Epub 2019 Mar 12. J Neurosci. 2019. PMID: 30862664 Free PMC article.
It is well established that the kappa opioid system contributes to depressive and dysphoric states, but whether this system contributes to the negative affect precipitated by the occurrence of chronic pain remains tenuous. ...Using in vivo microdialysis and m …
It is well established that the kappa opioid system contributes to depressive and dysphoric states, but whether this system contribut …
The pharmacology of nociceptor priming.
Kandasamy R, Price TJ. Kandasamy R, et al. Handb Exp Pharmacol. 2015;227:15-37. doi: 10.1007/978-3-662-46450-2_2. Handb Exp Pharmacol. 2015. PMID: 25846612 Free PMC article. Review.
This plasticity is thought to underlie the development of chronic pain states. Hence, further understanding of the molecular mechanisms driving and maintaining this plasticity has the potential to lead to novel therapeutic approaches for the treatment of chronic …
This plasticity is thought to underlie the development of chronic pain states. Hence, further understanding of the molecular m …
Endogenous Opioid-Masked Latent Pain Sensitization: Studies from Mouse to Human.
Pereira MP, Donahue RR, Dahl JB, Werner M, Taylor BK, Werner MU. Pereira MP, et al. PLoS One. 2015 Aug 25;10(8):e0134441. doi: 10.1371/journal.pone.0134441. eCollection 2015. PLoS One. 2015. PMID: 26305798 Free PMC article.
Following the resolution of a severe inflammatory injury in rodents, administration of mu-opioid receptor inverse agonists leads to reinstatement of pain hypersensitivity. The mechanisms underlying this form of latent pain sensitization (LS) likely contribute …
Following the resolution of a severe inflammatory injury in rodents, administration of mu-opioid receptor inverse agonists leads to r …
Opiates as antidepressants.
Berrocoso E, Sánchez-Blázquez P, Garzón J, Mico JA. Berrocoso E, et al. Curr Pharm Des. 2009;15(14):1612-22. doi: 10.2174/138161209788168100. Curr Pharm Des. 2009. PMID: 19442177 Review.
In view of this, there is an intense search to identify novel targets (receptors) for antidepressant therapy. Opioid peptides and their receptors are potential candidates for the development of novel antidepressant treatment. In this context, endogenous op …
In view of this, there is an intense search to identify novel targets (receptors) for antidepressant therapy. Opioid peptides …
210 results