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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1978 1
1979 1
1981 4
1982 2
1983 1
1985 2
1986 3
1988 2
1989 2
1990 2
1991 2
1992 5
1993 3
1996 3
1997 2
1998 5
1999 3
2000 3
2001 2
2002 5
2003 4
2004 7
2005 4
2006 9
2007 6
2008 7
2009 6
2010 15
2011 16
2012 20
2013 19
2014 22
2015 21
2016 25
2017 24
2018 30
2019 26
2020 26
2021 26
2022 15
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355 results
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Page 1
Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses.
Chiappinelli KB, Strissel PL, Desrichard A, Li H, Henke C, Akman B, Hein A, Rote NS, Cope LM, Snyder A, Makarov V, Budhu S, Slamon DJ, Wolchok JD, Pardoll DM, Beckmann MW, Zahnow CA, Merghoub T, Chan TA, Baylin SB, Strick R. Chiappinelli KB, et al. Cell. 2015 Aug 27;162(5):974-86. doi: 10.1016/j.cell.2015.07.011. Cell. 2015. PMID: 26317466 Free PMC article.
Knocking down dsRNA sensors TLR3 and MAVS reduces this response 2-fold and blocking interferon beta or its receptor abrogates it. Upregulation of hypermethylated endogenous retrovirus (ERV) genes accompanies the response and ERV overexpression activates the response …
Knocking down dsRNA sensors TLR3 and MAVS reduces this response 2-fold and blocking interferon beta or its receptor abrogates it. Upregulati …
m6A RNA methylation regulates the fate of endogenous retroviruses.
Chelmicki T, Roger E, Teissandier A, Dura M, Bonneville L, Rucli S, Dossin F, Fouassier C, Lameiras S, Bourc'his D. Chelmicki T, et al. Nature. 2021 Mar;591(7849):312-316. doi: 10.1038/s41586-020-03135-1. Epub 2021 Jan 13. Nature. 2021. PMID: 33442060
Endogenous retroviruses (ERVs) are abundant and heterogenous groups of integrated retroviral sequences that affect genome regulation and cell physiology throughout their RNA-centred life cycle(1). ...Here, using an unbiased genome-scale CRISPR knockout screen in mou
Endogenous retroviruses (ERVs) are abundant and heterogenous groups of integrated retroviral sequences that affect genome regu
Epigenetic therapy in immune-oncology.
Jones PA, Ohtani H, Chakravarthy A, De Carvalho DD. Jones PA, et al. Nat Rev Cancer. 2019 Mar;19(3):151-161. doi: 10.1038/s41568-019-0109-9. Nat Rev Cancer. 2019. PMID: 30723290 Review.
DNA methylation inhibitors have become the mainstay for treatment of certain haematological malignancies. In addition to their abilities to reactivate genes, including tumour suppressors, that have acquired DNA methylation during carcinogenesis, they induce the expr …
DNA methylation inhibitors have become the mainstay for treatment of certain haematological malignancies. In addition to their abilit …
Embryonic stem cell potency fluctuates with endogenous retrovirus activity.
Macfarlan TS, Gifford WD, Driscoll S, Lettieri K, Rowe HM, Bonanomi D, Firth A, Singer O, Trono D, Pfaff SL. Macfarlan TS, et al. Nature. 2012 Jul 5;487(7405):57-63. doi: 10.1038/nature11244. Nature. 2012. PMID: 22722858 Free PMC article.
Transcriptome sequencing and bioinformatic analyses showed that many 2C transcripts are initiated from long terminal repeats derived from endogenous retroviruses, suggesting this foreign sequence has helped to drive cell-fate regulation in placental mammals....
Transcriptome sequencing and bioinformatic analyses showed that many 2C transcripts are initiated from long terminal repeats derived from …
SETDB1-Mediated Silencing of Retroelements.
Fukuda K, Shinkai Y. Fukuda K, et al. Viruses. 2020 May 30;12(6):596. doi: 10.3390/v12060596. Viruses. 2020. PMID: 32486217 Free PMC article. Review.
SETDB1 (SET domain bifurcated histone lysine methyltransferase 1) is a protein lysine methyltransferase and methylates histone H3 at lysine 9 (H3K9). Among other H3K9 methyltransferases, SETDB1 and SETDB1-mediated H3K9 trimethylation (H3K9me3) play pivotal roles for silenc …
SETDB1 (SET domain bifurcated histone lysine methyltransferase 1) is a protein lysine methyltransferase and methylates histone H3 at …
METTL3 regulates heterochromatin in mouse embryonic stem cells.
Xu W, Li J, He C, Wen J, Ma H, Rong B, Diao J, Wang L, Wang J, Wu F, Tan L, Shi YG, Shi Y, Shen H. Xu W, et al. Nature. 2021 Mar;591(7849):317-321. doi: 10.1038/s41586-021-03210-1. Epub 2021 Jan 27. Nature. 2021. PMID: 33505026
METTL3 (methyltransferase-like 3) mediates the N(6)-methyladenosine (m(6)A) methylation of mRNA, which affects the stability of mRNA and its translation into protein(1). ...METTL3 predominantly localizes to the intracisternal A particle (IAP)-type family of endogenous
METTL3 (methyltransferase-like 3) mediates the N(6)-methyladenosine (m(6)A) methylation of mRNA, which affects the stability of mRNA …
Targeting CDK9 Reactivates Epigenetically Silenced Genes in Cancer.
Zhang H, Pandey S, Travers M, Sun H, Morton G, Madzo J, Chung W, Khowsathit J, Perez-Leal O, Barrero CA, Merali C, Okamoto Y, Sato T, Pan J, Garriga J, Bhanu NV, Simithy J, Patel B, Huang J, Raynal NJ, Garcia BA, Jacobson MA, Kadoch C, Merali S, Zhang Y, Childers W, Abou-Gharbia M, Karanicolas J, Baylin SB, Zahnow CA, Jelinek J, Graña X, Issa JJ. Zhang H, et al. Cell. 2018 Nov 15;175(5):1244-1258.e26. doi: 10.1016/j.cell.2018.09.051. Epub 2018 Oct 25. Cell. 2018. PMID: 30454645 Free PMC article.
Through a live cell drug screen with genetic confirmation, we discovered that CDK9 inhibition reactivates epigenetically silenced genes in cancer, leading to restored tumor suppressor gene expression, cell differentiation, and activation of endogenous retrovirus gen …
Through a live cell drug screen with genetic confirmation, we discovered that CDK9 inhibition reactivates epigenetically silenced genes in c …
Silencing and Transcriptional Regulation of Endogenous Retroviruses: An Overview.
Geis FK, Goff SP. Geis FK, et al. Viruses. 2020 Aug 13;12(8):884. doi: 10.3390/v12080884. Viruses. 2020. PMID: 32823517 Free PMC article. Review.
Almost half of the human genome is made up of transposable elements (TEs), and about 8% consists of endogenous retroviruses (ERVs). ERVs are remnants of ancient exogenous retrovirus infections of the germ line. ...Sumoylation and ATP-dependent chromatin remod …
Almost half of the human genome is made up of transposable elements (TEs), and about 8% consists of endogenous retroviruses (E …
Diverse epigenetic mechanisms maintain parental imprints within the embryonic and extraembryonic lineages.
Andergassen D, Smith ZD, Kretzmer H, Rinn JL, Meissner A. Andergassen D, et al. Dev Cell. 2021 Nov 8;56(21):2995-3005.e4. doi: 10.1016/j.devcel.2021.10.010. Dev Cell. 2021. PMID: 34752748 Free article.
Here, we systematically disrupt essential epigenetic pathways within polymorphic embryos in order to examine canonical and non-canonical genomic imprinting as well as XCI. We find that DNA methylation and Polycomb group repressors are indispensable for autosomal imprinting …
Here, we systematically disrupt essential epigenetic pathways within polymorphic embryos in order to examine canonical and non-canonical gen …
DNA methylation of the endogenous retrovirus Fematrin-1 in fetal placenta is associated with survival rate of cloned calves.
Silveira MM, Vargas LN, Bayão HXS, Schumann NAB, Caetano AR, Rumpf R, Franco MM. Silveira MM, et al. Placenta. 2019 Dec;88:52-60. doi: 10.1016/j.placenta.2019.09.012. Epub 2019 Sep 24. Placenta. 2019. PMID: 31671312
METHODS: We tested the hypothesis that alterations in DNA methylation and gene expression profiles of the endogenous retroviruses (ERVs) and genes related to epigenetic reprogramming in placenta of cloned calves result in abnormal offspring phenotypes. ...RES …
METHODS: We tested the hypothesis that alterations in DNA methylation and gene expression profiles of the endogenous retrov
355 results