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92 results

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Page 1
The Role of Mast Cells in the Development and Advancement of Endometriosis.
Makoui MH, Fekri S, Makoui RH, Ansari N, Esmaeilzadeh A. Makoui MH, et al. Am J Reprod Immunol. 2025 Mar;93(3):e70019. doi: 10.1111/aji.70019. Am J Reprod Immunol. 2025. PMID: 40028674 Review.
Endometriosis is a medical condition identified by the presence of endometrium-like tissue outside the uterus. ...Mast cells (MCs), a type of immune cell, are renowned for their involvement in allergic and inflammatory responses. ...
Endometriosis is a medical condition identified by the presence of endometrium-like tissue outside the uterus. ...Mast cell …
Targeting mast cells: a new way to treat endometriosis.
Binda MM, Donnez J, Dolmans MM. Binda MM, et al. Expert Opin Ther Targets. 2017 Jan;21(1):67-75. doi: 10.1080/14728222.2017.1260548. Epub 2016 Nov 28. Expert Opin Ther Targets. 2017. PMID: 27841046 Review.
Efforts are now focusing on understanding new mechanisms involved in its physiopathology, like novel target pathways and different molecules. There is evidence that mast cells (MCs) play a role in this disease. This article summarizes recent achievements in preclini …
Efforts are now focusing on understanding new mechanisms involved in its physiopathology, like novel target pathways and different molecules …
Unravelling the Intricate Link: Mast Cells and Estrogen-Induced Pain Sensitization in Endometriosis.
Wang J, Mao X, Zhu L, Zhang X. Wang J, et al. Int J Biol Sci. 2025 Sep 21;21(13):5891-5904. doi: 10.7150/ijbs.116635. eCollection 2025. Int J Biol Sci. 2025. PMID: 41079937 Free PMC article. Review.
Pain-particularly dysmenorrhea, chronic pelvic pain, and dyspareunia-is the hallmark symptom of endometriosis. While pain mechanisms remain poorly understood, mast cells are now recognized as central mediators of estrogen-induced pain sensitization. ...This c …
Pain-particularly dysmenorrhea, chronic pelvic pain, and dyspareunia-is the hallmark symptom of endometriosis. While pain mechanisms …
Targeting mast cells in endometriosis with janus kinase 3 inhibitor, JANEX-1.
D'Cruz OJ, Uckun FM. D'Cruz OJ, et al. Am J Reprod Immunol. 2007 Aug;58(2):75-97. doi: 10.1111/j.1600-0897.2007.00502.x. Am J Reprod Immunol. 2007. PMID: 17631002 Review.
Presence of activated and degranulating mast cells within the nerve structures can contribute to the development of pain and hyperalgesia by direct effects on primary nociceptive neurons. Therefore, treatments targeting endometrial mast cells may prove …
Presence of activated and degranulating mast cells within the nerve structures can contribute to the development of pain and h …
Endometriosis: An Immunologist's Perspective.
Garmendia JV, De Sanctis CV, Hajdúch M, De Sanctis JB. Garmendia JV, et al. Int J Mol Sci. 2025 May 28;26(11):5193. doi: 10.3390/ijms26115193. Int J Mol Sci. 2025. PMID: 40508002 Free PMC article. Review.
Genetic predisposition and cytokine gene polymorphisms have been documented. Macrophages, dendritic cells, mast cells, Th1 in the early phase, Th2 in the late phase, and T regulatory cells play a crucial role in endometriosis. ...Cytokines from …
Genetic predisposition and cytokine gene polymorphisms have been documented. Macrophages, dendritic cells, mast cells, …
Estrogen mediates inflammatory role of mast cells in endometriosis pathophysiology.
McCallion A, Nasirzadeh Y, Lingegowda H, Miller JE, Khalaj K, Ahn S, Monsanto SP, Bidarimath M, Sisnett DJ, Craig AW, Young SL, Lessey BA, Koti M, Tayade C. McCallion A, et al. Front Immunol. 2022 Aug 9;13:961599. doi: 10.3389/fimmu.2022.961599. eCollection 2022. Front Immunol. 2022. PMID: 36016927 Free PMC article.
To further understand the impact of estrogen on mast cells in endometriosis, we induced endometriosis in C57BL/6 mice. Mature mast cells were significantly higher in peritoneal fluid of estrogen-treated mice compared to untreated mice wit …
To further understand the impact of estrogen on mast cells in endometriosis, we induced endometriosis in C57BL/6 …
GPR30-mediated non-classic estrogen pathway in mast cells participates in endometriosis pain via the production of FGF2.
Xu X, Wang J, Guo X, Chen Y, Ding S, Zou G, Zhu L, Li T, Zhang X. Xu X, et al. Front Immunol. 2023 Feb 8;14:1106771. doi: 10.3389/fimmu.2023.1106771. eCollection 2023. Front Immunol. 2023. PMID: 36845134 Free PMC article.
Pain is one of the main clinical symptoms of endometriosis, but its underlying mechanism is still not clear. Recent studies have shown that the secretory mediators of mast cells activated by estrogen are involved in the pathogenesis of endometriosis-re …
Pain is one of the main clinical symptoms of endometriosis, but its underlying mechanism is still not clear. Recent studies have show …
The role of fibrosis in endometriosis: a systematic review.
Vissers G, Giacomozzi M, Verdurmen W, Peek R, Nap A. Vissers G, et al. Hum Reprod Update. 2024 Dec 1;30(6):706-750. doi: 10.1093/humupd/dmae023. Hum Reprod Update. 2024. PMID: 39067455 Free PMC article.
The observational studies showed details about the histologic appearance of fibrosis in endometriosis and the co-occurrence of nerves and immune cells in lesions. The in vitro studies identified several pro-fibrotic pathways in relation to endometriosis. The …
The observational studies showed details about the histologic appearance of fibrosis in endometriosis and the co-occurrence of nerves …
MRGPRX2 Mediates Mast Cell-Induced Endometriosis Pain Through the Sensitization of Sensory Neurons via Histamine/HRH1/TRPV1 Signaling Pathway.
Mao X, Wang J, Ding S, Guo X, Xu X, Xu P, Zhang X. Mao X, et al. FASEB J. 2025 Jul 15;39(13):e70778. doi: 10.1096/fj.202501493R. FASEB J. 2025. PMID: 40600649 Free PMC article.
The studies on how mast cells mediate endometriosis pain are still limited. Mas-related G protein-coupled receptor member X2 (MRGPRX2), a receptor expressed on mast cells, participates in pain, inflammation, and itch. However, it is still unclea …
The studies on how mast cells mediate endometriosis pain are still limited. Mas-related G protein-coupled receptor memb …
The endometrial immune environment of women with endometriosis.
Vallvé-Juanico J, Houshdaran S, Giudice LC. Vallvé-Juanico J, et al. Hum Reprod Update. 2019 Sep 11;25(5):564-591. doi: 10.1093/humupd/dmz018. Hum Reprod Update. 2019. PMID: 31424502 Free PMC article. Review.
OBJECTIVE AND RATIONALE: The objective herein was to determine reproducible and consistent findings regarding specific immune cell populations and their abundance, steroid hormone responsiveness, functionality, activation states, and markers, locally and systemically in women wit …
OBJECTIVE AND RATIONALE: The objective herein was to determine reproducible and consistent findings regarding specific immune cell populatio …
92 results