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Page 1
The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions.
Rahmioglu N, Mortlock S, Ghiasi M, Møller PL, Stefansdottir L, Galarneau G, Turman C, Danning R, Law MH, Sapkota Y, Christofidou P, Skarp S, Giri A, Banasik K, Krassowski M, Lepamets M, Marciniak B, Nõukas M, Perro D, Sliz E, Sobalska-Kwapis M, Thorleifsson G, Topbas-Selcuki NF, Vitonis A, Westergaard D, Arnadottir R, Burgdorf KS, Campbell A, Cheuk CSK, Clementi C, Cook J, De Vivo I, DiVasta A, Dorien O, Donoghue JF, Edwards T, Fontanillas P, Fung JN, Geirsson RT, Girling JE, Harkki P, Harris HR, Healey M, Heikinheimo O, Holdsworth-Carson S, Hostettler IC, Houlden H, Houshdaran S, Irwin JC, Jarvelin MR, Kamatani Y, Kennedy SH, Kepka E, Kettunen J, Kubo M, Kulig B, Kurra V, Laivuori H, Laufer MR, Lindgren CM, MacGregor S, Mangino M, Martin NG, Matalliotaki C, Matalliotakis M, Murray AD, Ndungu A, Nezhat C, Olsen CM, Opoku-Anane J, Padmanabhan S, Paranjpe M, Peters M, Polak G, Porteous DJ, Rabban J, Rexrode KM, Romanowicz H, Saare M, Saavalainen L, Schork AJ, Sen S, Shafrir AL, Siewierska-Górska A, Słomka M, Smith BH, Smolarz B, Szaflik T, Szyłło K, Takahashi A, Terry KL, Tomassetti C, Treloar SA, Vanhie A, Vincent K, Vo KC, Werring DJ, Zeggini E, Zervou MI; DBDS Genomic Consortium;… See abstract for full author list ➔ Rahmioglu N, et al. Nat Genet. 2023 Mar;55(3):423-436. doi: 10.1038/s41588-023-01323-z. Epub 2023 Mar 13. Nat Genet. 2023. PMID: 36914876 Free PMC article.
We observed significant genetic correlations between endometriosis and 11 pain conditions, including migraine, back and multisite chronic pain (MCP), as well as inflammatory conditions, including asthma and osteoarthritis. Multitrait genetic analyses identified subs …
We observed significant genetic correlations between endometriosis and 11 pain conditions, including migraine, back and multis …
Shared Molecular Genetic Mechanisms Underlie Endometriosis and Migraine Comorbidity.
Adewuyi EO, Sapkota Y, International Endogene Consortium Iec, andMe Research Team, International Headache Genetics Consortium Ihgc, Auta A, Yoshihara K, Nyegaard M, Griffiths LR, Montgomery GW, Chasman DI, Nyholt DR. Adewuyi EO, et al. Genes (Basel). 2020 Feb 29;11(3):268. doi: 10.3390/genes11030268. Genes (Basel). 2020. PMID: 32121467 Free PMC article.
Observational epidemiological studies indicate that endometriosis and migraine co-occur within individuals more than expected by chance. However, the aetiology and biological mechanisms underlying their comorbidity remain unknown. ...Our findings further conf …
Observational epidemiological studies indicate that endometriosis and migraine co-occur within individuals more than expected …
Nociceptor-to-macrophage communication through CGRP/RAMP1 signaling drives endometriosis-associated pain and lesion growth in mice.
Fattori V, Zaninelli TH, Rasquel-Oliveira FS, Heintz OK, Jain A, Sun L, Seshan ML, Peterse D, Lindholm AE, Anchan RM, Verri WA Jr, Rogers MS. Fattori V, et al. Sci Transl Med. 2024 Nov 6;16(772):eadk8230. doi: 10.1126/scitranslmed.adk8230. Epub 2024 Nov 6. Sci Transl Med. 2024. PMID: 39504351
Nociceptors release neuropeptides, such as calcitonin gene-related peptide (CGRP), which are known to shape immunity through neuroimmune communication. Given the comorbidity between endometriosis and migraine and the integral role of immune cells and inflamma …
Nociceptors release neuropeptides, such as calcitonin gene-related peptide (CGRP), which are known to shape immunity through neuroimmune com …
Prolactin and pain of endometriosis.
Lee GJ, Porreca F, Navratilova E. Lee GJ, et al. Pharmacol Ther. 2023 Jul;247:108435. doi: 10.1016/j.pharmthera.2023.108435. Epub 2023 May 9. Pharmacol Ther. 2023. PMID: 37169264 Free PMC article.
The results of this search strongly indicate that serum prolactin levels are increased in patients with endometriosis and support the possibility that high levels of prolactin may promote pelvic pain in these patients and increase vulnerability to other comorbid pai …
The results of this search strongly indicate that serum prolactin levels are increased in patients with endometriosis and support the …
Understanding the impact of endometriosis on women's life: an integrative review of systematic reviews.
Maulenkul T, Kuandyk A, Makhadiyeva D, Dautova A, Terzic M, Oshibayeva A, Moldaliyev I, Ayazbekov A, Maimakov T, Saruarov Y, Foster F, Sarria-Santamera A. Maulenkul T, et al. BMC Womens Health. 2024 Sep 19;24(1):524. doi: 10.1186/s12905-024-03369-5. BMC Womens Health. 2024. PMID: 39300399 Free PMC article.
Participants/population were women with endometriosis, and the outcomes included were all reported outcomes evaluating the impact of endometriosis on women's QoL (PROSPERO 2021 CRD42021289347). RESULTS: 15 systematic reviews were identified. 8 included meta-analysis …
Participants/population were women with endometriosis, and the outcomes included were all reported outcomes evaluating the impact of …
Inflammatory Cytokine Signatures Are Associated With Disease Burden and Comorbidity of Episodic Migraine and Endometriosis.
Albanese M, Ceci V, Carrera G, Selntigia A, Exacoustos C, Tiberi M, Saracini S, Matteocci A, Mercuri NB, Chiurchiù V. Albanese M, et al. Neurol Neuroimmunol Neuroinflamm. 2025 Nov;12(6):e200490. doi: 10.1212/NXI.0000000000200490. Epub 2025 Oct 3. Neurol Neuroimmunol Neuroinflamm. 2025. PMID: 41043084 Free PMC article.
RESULTS: Women with episodic migraine had elevated levels of IL-1beta, IL-6, and TNF-alpha compared with healthy controls, with even higher levels in those with both migraine and endometriosis, indicating a synergistic effect on systemic inflammation. IL-1bet …
RESULTS: Women with episodic migraine had elevated levels of IL-1beta, IL-6, and TNF-alpha compared with healthy controls, with even …
The association between endometriosis and migraine: a systematic review and meta-analysis of observational studies.
Colombo GE, Makieva S, Somigliana E, Schoretsanitis G, Leeners B, Polli C, Salmeri N, Kalaitzopoulos DR, Vigano' P. Colombo GE, et al. J Headache Pain. 2025 Apr 17;26(1):82. doi: 10.1186/s10194-025-02020-4. J Headache Pain. 2025. PMID: 40247158 Free PMC article.
BACKGROUND: Endometriosis affects women of reproductive age. Increasing attention is being given to the characterization of comorbidities in endometriosis to enhance clinical phenotyping. Among these comorbidities, migraine has been reported to …
BACKGROUND: Endometriosis affects women of reproductive age. Increasing attention is being given to the characterization of comorb …
Endometriosis in the era of precision medicine and impact on sexual and reproductive health across the lifespan and in diverse populations.
Giudice LC, Oskotsky TT, Falako S, Opoku-Anane J, Sirota M. Giudice LC, et al. FASEB J. 2023 Sep;37(9):e23130. doi: 10.1096/fj.202300907. FASEB J. 2023. PMID: 37641572 Free PMC article. Review.
Endometriosis is a common estrogen-dependent disorder wherein uterine lining tissue (endometrium) is found mainly in the pelvis where it causes inflammation, chronic pelvic pain, pain with intercourse and menses, and infertility. ...This review summarizes endometriosis …
Endometriosis is a common estrogen-dependent disorder wherein uterine lining tissue (endometrium) is found mainly in the pelvis where …
Prolactin-induced sensitization of trigeminal nociceptors promotes migraine co-morbidity in endometriosis.
Lee GJ, Hode V, Georgieva T, Rau J, Dodick DW, Schwedt TJ, Neugebauer V, Porreca F, Navratilova E. Lee GJ, et al. Cephalalgia. 2025 Jan;45(1):3331024241313378. doi: 10.1177/03331024241313378. Cephalalgia. 2025. PMID: 39814523 Free PMC article.
BACKGROUND: Women with endometriosis are more likely to have migraine. The mechanisms underlying this co-morbidity are unknown. ...CONCLUSIONS: These data demonstrate that circulating prolactin in endometriosis promotes vulnerability to migraine throug …
BACKGROUND: Women with endometriosis are more likely to have migraine. The mechanisms underlying this co-morbidity are unknown …
Chronic Pelvic Pain.
Dydyk AM, Singh C, Gupta N. Dydyk AM, et al. 2025 May 2. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2026 Jan–. 2025 May 2. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2026 Jan–. PMID: 32119472 Free Books & Documents.
Although imaging and laboratory tests are often inconclusive, they can help identify comorbid conditions that contribute to chronic pelvic pain. Despite evaluation, an estimated 50% of cases remain undiagnosed. ...Management typically targets the underlying or suspected et …
Although imaging and laboratory tests are often inconclusive, they can help identify comorbid conditions that contribute to chronic p …
68 results