Lysosomal proteomics reveals mechanisms of neuronal APOE4-associated lysosomal dysfunction.
Krogsaeter EK, McKetney J, Valiente-Banuet L, Marquez A, Willis A, Cakir Z, Stevenson E, Jang GM, Rao A, Li E, Zhou A, Attili A, Chang TS, Kampmann M, Huang Y, Krogan NJ, Swaney DL.
Krogsaeter EK, et al.
Autophagy. 2025 Dec;21(12):3240-3265. doi: 10.1080/15548627.2025.2576613. Epub 2025 Nov 7.
Autophagy. 2025.
PMID: 41103078
Free PMC article.
Taken together, this work thereby reveals that APOE4 causes widespread lysosomal defects through remodeling the lysosomal proteome, with the lysosomal TMED5 accumulation and LGALS3BP depletion manifesting as lysosomal alkalinization in APOE4 neurons.Abbreviation: Abeta-beta-amylo …
Taken together, this work thereby reveals that APOE4 causes widespread lysosomal defects through remodeling the lysosomal proteome, with the …