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1953 1
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1962 3
1963 2
1964 2
1965 1
1967 1
1970 2
1971 4
1972 6
1973 3
1974 10
1975 17
1976 28
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1978 30
1979 34
1980 61
1981 82
1982 72
1983 130
1984 117
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1992 168
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1994 229
1995 200
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1997 240
1998 250
1999 240
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2001 269
2002 284
2003 278
2004 273
2005 317
2006 313
2007 361
2008 405
2009 374
2010 406
2011 483
2012 500
2013 522
2014 541
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13,421 results

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Page 1
Cytoplasmic DIS3 is an exosome-independent endoribonuclease with catalytic activity toward circular RNAs.
Latini C, Eichlinger J, Fuchs AL, Zhai SN, Ho-Xuan H, Lehmann G, Glažar P, Rajewsky N, Bruckmann A, Yang L, Sprangers R, Meister G. Latini C, et al. Cell Rep. 2025 Jun 24;44(6):115769. doi: 10.1016/j.celrep.2025.115769. Epub 2025 May 28. Cell Rep. 2025. PMID: 40440169 Free article.
The ribonuclease DIS3 interacts through its PIN domain with the nuclear exosome and degrades linear RNA substrates using its exoribonuclease domain. However, the PIN domain is also an active endoribonuclease, but cellular substrates are largely unknown. Here, we use …
The ribonuclease DIS3 interacts through its PIN domain with the nuclear exosome and degrades linear RNA substrates using its exoribonuclease …
Toxins of Prokaryotic Toxin-Antitoxin Systems with Sequence-Specific Endoribonuclease Activity.
Masuda H, Inouye M. Masuda H, et al. Toxins (Basel). 2017 Apr 14;9(4):140. doi: 10.3390/toxins9040140. Toxins (Basel). 2017. PMID: 28420090 Free PMC article. Review.
Protein translation is the most common target of toxin-antitoxin system (TA) toxins. Sequence-specific endoribonucleases digest RNA in a sequence-specific manner, thereby blocking translation. While past studies mainly focused on the digestion of mRNA, recent analysis reve …
Protein translation is the most common target of toxin-antitoxin system (TA) toxins. Sequence-specific endoribonucleases digest RNA i …
Endoplasmic Reticulum Stress and Unfolded Protein Response in Neurodegenerative Diseases.
Ghemrawi R, Khair M. Ghemrawi R, et al. Int J Mol Sci. 2020 Aug 25;21(17):6127. doi: 10.3390/ijms21176127. Int J Mol Sci. 2020. PMID: 32854418 Free PMC article. Review.
The accumulation of unfolded proteins leads to an ER stress, followed by an adaptive response via the activation of the unfolded protein response (UPR), PKR-like ER kinase (PERK), inositol-requiring transmembrane kinase/endoribonuclease 1alpha (IRE1alpha) and act …
The accumulation of unfolded proteins leads to an ER stress, followed by an adaptive response via the activation of the unfolded prot …
Metal ions govern coronavirus endoribonuclease activity.
Wang X, Li J, Liu Z, Wang L, Zhu B. Wang X, et al. Nucleic Acids Res. 2026 Jan 14;54(2):gkaf1508. doi: 10.1093/nar/gkaf1508. Nucleic Acids Res. 2026. PMID: 41533565 Free PMC article.
Active-site mutation H249A weakens the effects of Co2+, Ni2+, and Zn2+ on SARS-CoV-2 nsp15. Furthermore, the Co2+- or Ni2+-dependent activation of nsp15 is inhibited upon Zn2+ addition, suggesting competitive regulation. Overall, our work identifies the activator …
Active-site mutation H249A weakens the effects of Co2+, Ni2+, and Zn2+ on SARS-CoV-2 nsp15. Furthermore, the Co2+- or Ni2+-dependent …
Phosphorylation-mediated conformational change regulates human SLFN11.
Kugler M, Metzner FJ, Witte G, Hopfner KP, Lammens K. Kugler M, et al. Nat Commun. 2024 Dec 3;15(1):10500. doi: 10.1038/s41467-024-54833-7. Nat Commun. 2024. PMID: 39627193 Free PMC article.
Furthermore, SLFN11 acts as a pattern recognition receptor for single-stranded DNA (ssDNA) and functions as an antiviral restriction factor, targeting translation in a codon-usage-dependent manner through its endoribonuclease activity. However, the regulation of the …
Furthermore, SLFN11 acts as a pattern recognition receptor for single-stranded DNA (ssDNA) and functions as an antiviral restriction factor, …
Targeting IRE1 endoribonuclease activity alleviates cardiovascular lesions in a murine model of Kawasaki disease vasculitis.
Marek-Iannucci S, Yildirim AD, Hamid SM, Ozdemir AB, Gomez AC, Kocatürk B, Porritt RA, Fishbein MC, Iwawaki T, Noval Rivas M, Erbay E, Arditi M. Marek-Iannucci S, et al. JCI Insight. 2022 Mar 22;7(6):e157203. doi: 10.1172/jci.insight.157203. JCI Insight. 2022. PMID: 35167493 Free PMC article.
Alleviating ER stress genetically, by conditional deletion of inositol-requiring enzyme 1 (IRE1) in myeloid cells, or pharmacologically, by inhibition of IRE1 endoribonuclease (RNase) activity, led to significant reduction of LCWE-induced cardiovascular lesion forma …
Alleviating ER stress genetically, by conditional deletion of inositol-requiring enzyme 1 (IRE1) in myeloid cells, or pharmacologically, by …
CryoEM structure of the SLFN14 endoribonuclease reveals insight into RNA binding and cleavage.
Van Riper J, Martinez-Claros AO, Wang L, Schneiderman HE, Maheshwari S, Pillon MC. Van Riper J, et al. Nat Commun. 2025 Jul 1;16(1):5848. doi: 10.1038/s41467-025-61091-8. Nat Commun. 2025. PMID: 40592880 Free PMC article.
SLFN14 nuclease activity is linked to antiviral defense and platelet function. Despite its prominent role in gene regulation, the molecular signals regulating SLFN14 substrate recognition and catalytic activation remain unclear. SLFN14 dysregulation is linked to hum …
SLFN14 nuclease activity is linked to antiviral defense and platelet function. Despite its prominent role in gene regulation, the mol …
[Mutational and Kinetic Analysis of APE1 Endoribonuclease Activity].
Kuznetsova AA, Gavrilova AA, Novopashina DS, Fedorova OS, Kuznetsov NA. Kuznetsova AA, et al. Mol Biol (Mosk). 2021 Mar-Apr;55(2):243-257. doi: 10.31857/S0026898421020099. Mol Biol (Mosk). 2021. PMID: 33871438 Free article. Russian.
It was shown that mutation of Asn212, Asp210, and Tyr171 residues leads to the decrease of AP-endonuclease activity while endoribonuclease activity is retained. Also, T268D and M270A APE1 mutants lose specificity to pyrimidine-purine sequences. R177F and R181 …
It was shown that mutation of Asn212, Asp210, and Tyr171 residues leads to the decrease of AP-endonuclease activity while endoribo …
Coronavirus Endoribonuclease Activity in Porcine Epidemic Diarrhea Virus Suppresses Type I and Type III Interferon Responses.
Deng X, van Geelen A, Buckley AC, O'Brien A, Pillatzki A, Lager KM, Faaberg KS, Baker SC. Deng X, et al. J Virol. 2019 Apr 3;93(8):e02000-18. doi: 10.1128/JVI.02000-18. Print 2019 Apr 15. J Virol. 2019. PMID: 30728254 Free PMC article.
How PEDV suppresses the innate immune response was unknown. We found that mutating a viral endoribonuclease, EndoU, results in a virus that activates both the type I interferon response and the type III interferon response in macrophages and epithelial cells. This …
How PEDV suppresses the innate immune response was unknown. We found that mutating a viral endoribonuclease, EndoU, results in a viru …
AUF1 Recognizes 8-Oxo-Guanosine Embedded in DNA and Stimulates APE1 Endoribonuclease Activity.
Malfatti MC, Codrich M, Dalla E, D'Ambrosio C, Storici F, Scaloni A, Tell G. Malfatti MC, et al. Antioxid Redox Signal. 2023 Sep;39(7-9):411-431. doi: 10.1089/ars.2022.0105. Epub 2023 Apr 11. Antioxid Redox Signal. 2023. PMID: 36855946 Free PMC article.
Although human apurinic-apyrimidinic endodeoxyribonuclease 1 (APE1), a key enzyme of the base-excision repair pathway, repairs rAP sites and canonical deoxyribose monophosphate abasic sites with similar efficiency, its incision-repairing activity on 8-oxo-guanosine is very …
Although human apurinic-apyrimidinic endodeoxyribonuclease 1 (APE1), a key enzyme of the base-excision repair pathway, repairs rAP sites and …
13,421 results
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