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Page 1
Implication of type 4 NADPH oxidase (NOX4) in tauopathy.
Luengo E, Trigo-Alonso P, Fernández-Mendívil C, Nuñez Á, Campo MD, Porrero C, García-Magro N, Negredo P, Senar S, Sánchez-Ramos C, Bernal JA, Rábano A, Hoozemans J, Casas AI, Schmidt HHHW, López MG. Luengo E, et al. Among authors: lopez mg. Redox Biol. 2022 Feb;49:102210. doi: 10.1016/j.redox.2021.102210. Epub 2021 Dec 10. Redox Biol. 2022. PMID: 34922273 Free PMC article.
Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice.
Caballero B, Bourdenx M, Luengo E, Diaz A, Sohn PD, Chen X, Wang C, Juste YR, Wegmann S, Patel B, Young ZT, Kuo SY, Rodriguez-Navarro JA, Shao H, Lopez MG, Karch CM, Goate AM, Gestwicki JE, Hyman BT, Gan L, Cuervo AM. Caballero B, et al. Among authors: lopez mg, luengo e. Nat Commun. 2021 Apr 14;12(1):2238. doi: 10.1038/s41467-021-22501-9. Nat Commun. 2021. PMID: 33854069 Free PMC article.
ITH14001, a CGP37157-Nimodipine Hybrid Designed to Regulate Calcium Homeostasis and Oxidative Stress, Exerts Neuroprotection in Cerebral Ischemia.
Buendia I, Tenti G, Michalska P, Méndez-López I, Luengo E, Satriani M, Padín-Nogueira F, López MG, Ramos MT, García AG, Menéndez JC, León R. Buendia I, et al. Among authors: lopez mg, luengo e. ACS Chem Neurosci. 2017 Jan 18;8(1):67-81. doi: 10.1021/acschemneuro.6b00181. Epub 2016 Nov 22. ACS Chem Neurosci. 2017. PMID: 27731633
Pharmacological doses of melatonin impede cognitive decline in tau-related Alzheimer models, once tauopathy is initiated, by restoring the autophagic flux.
Luengo E, Buendia I, Fernández-Mendívil C, Trigo-Alonso P, Negredo P, Michalska P, Hernández-García B, Sánchez-Ramos C, Bernal JA, Ikezu T, León R, López MG. Luengo E, et al. Among authors: lopez mg. J Pineal Res. 2019 Aug;67(1):e12578. doi: 10.1111/jpi.12578. Epub 2019 Apr 29. J Pineal Res. 2019. PMID: 30943316
Addition to "ITH14001, a CGP37157-Nimodipine Hybrid Designed to Regulate Calcium Homeostasis and Oxidative Stress, Exerts Neuroprotection in Cerebral Ischemia".
Buendia I, Tenti G, Michalska P, Méndez-López I, Luengo E, Satriani M, Padín-Nogueira F, López MG, Ramos MT, García AG, Menéndez JC, León R. Buendia I, et al. Among authors: lopez mg, luengo e. ACS Chem Neurosci. 2017 Jan 18;8(1):210. doi: 10.1021/acschemneuro.6b00364. Epub 2016 Nov 23. ACS Chem Neurosci. 2017. PMID: 28095680 No abstract available.