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129 results

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Page 1
Does the "Entourage Effect" in Cannabinoids Exist? A Narrative Scoping Review.
Simei JLQ, Souza JDR, Lisboa JR, Campos AC, Guimarães FS, Zuardi A, Crippa JAS. Simei JLQ, et al. Cannabis Cannabinoid Res. 2024 Oct;9(5):1202-1216. doi: 10.1089/can.2023.0052. Epub 2023 Aug 3. Cannabis Cannabinoid Res. 2024. PMID: 37535820
Background: The concept of an "entourage" effect in the cannabis and cannabinoids' field was first introduced in the late 1990s, during a period when most research on medical cannabinoids focused on the effects of isolated cannabinoids, s …
Background: The concept of an "entourage" effect in the cannabis and cannabinoids' field was first introduced in the la …
The "Entourage Effect": Terpenes Coupled with Cannabinoids for the Treatment of Mood Disorders and Anxiety Disorders.
Ferber SG, Namdar D, Hen-Shoval D, Eger G, Koltai H, Shoval G, Shbiro L, Weller A. Ferber SG, et al. Curr Neuropharmacol. 2020;18(2):87-96. doi: 10.2174/1570159X17666190903103923. Curr Neuropharmacol. 2020. PMID: 31481004 Free PMC article. Review.
However, 'cannabis' is not a single compound product but is known for its complicated molecular profile, producing a plethora of phytocannabinoids alongside a vast array of terpenes. Thus, the "entourage effect" is the suggested positive contribution derived from th …
However, 'cannabis' is not a single compound product but is known for its complicated molecular profile, producing a plethora of phytocannab …
The Cannabis Terpenes.
Sommano SR, Chittasupho C, Ruksiriwanich W, Jantrawut P. Sommano SR, et al. Molecules. 2020 Dec 8;25(24):5792. doi: 10.3390/molecules25245792. Molecules. 2020. PMID: 33302574 Free PMC article. Review.
Terpenes are the primary constituents of essential oils and are responsible for the aroma characteristics of cannabis. Together with the cannabinoids, terpenes illustrate synergic and/or entourage effect and their interactions have only been speculated in for …
Terpenes are the primary constituents of essential oils and are responsible for the aroma characteristics of cannabis. Together with the …
The Entourage Effect in Cannabis Medicinal Products: A Comprehensive Review.
André R, Gomes AP, Pereira-Leite C, Marques-da-Costa A, Monteiro Rodrigues L, Sassano M, Rijo P, Costa MDC. André R, et al. Pharmaceuticals (Basel). 2024 Nov 17;17(11):1543. doi: 10.3390/ph17111543. Pharmaceuticals (Basel). 2024. PMID: 39598452 Free PMC article. Review.
This study explores the complementary or synergistic effects of medicinal cannabis constituents, particularly terpenes, concerning their therapeutic potential, known as the entourage effect. ...Further clinical trials are needed to confirm any terpenes "en …
This study explores the complementary or synergistic effects of medicinal cannabis constituents, particularly terpenes, concerning th …
Cannabinoid treatment for autism: a proof-of-concept randomized trial.
Aran A, Harel M, Cassuto H, Polyansky L, Schnapp A, Wattad N, Shmueli D, Golan D, Castellanos FX. Aran A, et al. Mol Autism. 2021 Feb 3;12(1):6. doi: 10.1186/s13229-021-00420-2. Mol Autism. 2021. PMID: 33536055 Free PMC article. Clinical Trial.
Participants (N = 150) received either placebo or cannabinoids for 12-weeks (testing efficacy) followed by a 4-week washout and predetermined cross-over for another 12 weeks to further assess tolerability. ...Evidence for efficacy of these interventions are mixed and insuf …
Participants (N = 150) received either placebo or cannabinoids for 12-weeks (testing efficacy) followed by a 4-week washout and prede …
Decoding the Postulated Entourage Effect of Medicinal Cannabis: What It Is and What It Isn't.
Christensen C, Rose M, Cornett C, Allesø M. Christensen C, et al. Biomedicines. 2023 Aug 21;11(8):2323. doi: 10.3390/biomedicines11082323. Biomedicines. 2023. PMID: 37626819 Free PMC article. Review.
The 'entourage effect' term was originally coined in a pre-clinical study observing endogenous bio-inactive metabolites potentiating the activity of a bioactive endocannabinoid. ...Advocates suggest that the 'entourage effect' is the reason many patien …
The 'entourage effect' term was originally coined in a pre-clinical study observing endogenous bio-inactive metabolites potent …
Entourage Effect and Analytical Chemistry: Chromatography as a Tool in the Analysis of the Secondary Metabolism of Cannabis sativa L.
Silva Sofrás FM, Desimone MF. Silva Sofrás FM, et al. Curr Pharm Des. 2023;29(6):394-406. doi: 10.2174/1381612829666221103093542. Curr Pharm Des. 2023. PMID: 36330630 Review.
Indeed, the superiority of the last one is provoked by the synergy between various different compounds. This improved medicinal effect is called the entourage effect. Chromatography has become the method of choice for the determination of cannabinoids, …
Indeed, the superiority of the last one is provoked by the synergy between various different compounds. This improved medicinal effect …
Endocannabinoids.
Mechoulam R, Fride E, Di Marzo V. Mechoulam R, et al. Eur J Pharmacol. 1998 Oct 16;359(1):1-18. doi: 10.1016/s0014-2999(98)00649-9. Eur J Pharmacol. 1998. PMID: 9831287 Review.
Selected biochemical and pharmacological topics in this field are discussed, the main ones being levels of endocannabinoids in unstimulated tissue and cells, biosynthesis, release and inactivation of endocannabinoids, the effects of 'entourage' compounds on the acti …
Selected biochemical and pharmacological topics in this field are discussed, the main ones being levels of endocannabinoids in unstimulated …
Entourage effects of nonpsychotropic cannabinoids on visceral sensitivity in experimental colitis.
Svendsen K, Bradaia A, Gandini MA, Defaye M, Matisz C, Abdullah NS, Gruber A, Zamponi GW, Sharkey KA, Altier C. Svendsen K, et al. J Pharmacol Exp Ther. 2025 Mar;392(3):103389. doi: 10.1016/j.jpet.2025.103389. Epub 2025 Jan 17. J Pharmacol Exp Ther. 2025. PMID: 39921943
Abdominal pain is the most disabling symptom of inflammatory bowel diseases, but current treatments are limited, leading patients to seek alternatives such as cannabis. Cannabis contains over 100 cannabinoids which, unlike tetrahydrocannabinol, are biologically active comp …
Abdominal pain is the most disabling symptom of inflammatory bowel diseases, but current treatments are limited, leading patients to seek al …
Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects.
Russo EB. Russo EB. Br J Pharmacol. 2011 Aug;163(7):1344-64. doi: 10.1111/j.1476-5381.2011.01238.x. Br J Pharmacol. 2011. PMID: 21749363 Free PMC article. Review.
Terpenoids are quite potent, and affect animal and even human behaviour when inhaled from ambient air at serum levels in the single digits ng.mL(-1) . They display unique therapeutic effects that may contribute meaningfully to the entourage effects of cannabi …
Terpenoids are quite potent, and affect animal and even human behaviour when inhaled from ambient air at serum levels in the single digits n …
129 results