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Enzogenol for cognitive functioning in traumatic brain injury: a pilot placebo-controlled RCT.
Theadom A, Mahon S, Barker-Collo S, McPherson K, Rush E, Vandal AC, Feigin VL. Theadom A, et al. Eur J Neurol. 2013 Aug;20(8):1135-44. doi: 10.1111/ene.12099. Epub 2013 Feb 5. Eur J Neurol. 2013. PMID: 23384428 Clinical Trial.
RESULTS: Enzogenol was found to be safe and well tolerated. Trend and breakpoint analyses showed a significant reduction in cognitive failures after 6 weeks [mean CFQ score, 95% CI, Enzogenol versus placebo -6.9 (-10.8 to -4.1)]. ...CONCLUSIONS: Enzogenol sup …
RESULTS: Enzogenol was found to be safe and well tolerated. Trend and breakpoint analyses showed a significant reduction in cognitive …
Pine bark extract enzogenol attenuated tumor necrosis factor-alpha-induced endothelial cell adhesion and monocyte transmigration.
Kim DS, Kim MS, Kang SW, Sung HY, Kang YH. Kim DS, et al. J Agric Food Chem. 2010 Jun 9;58(11):7088-95. doi: 10.1021/jf1005287. J Agric Food Chem. 2010. PMID: 20465310
Nontoxic enzogenol at 5-25 microg/mL attenuated the expression of all adhesion molecules in a dose-dependent fashion. Consistently, enzogenol suppressed the enhanced THP-1 cell adhesion onto TNF-alpha-activated HUVEC through diminishing integrin beta2 induction. ... …
Nontoxic enzogenol at 5-25 microg/mL attenuated the expression of all adhesion molecules in a dose-dependent fashion. Consistently, …
Enzogenol improves diabetes-related metabolic change in C57BL/KsJ-db/db mice, a model of type 2 diabetes mellitus.
Bang CY, Choung SY. Bang CY, et al. J Pharm Pharmacol. 2014 Jun;66(6):875-85. doi: 10.1111/jphp.12211. Epub 2014 Feb 24. J Pharm Pharmacol. 2014. PMID: 24611864
In this study, we investigated the antidiabetic effects of enzogenol, proanthocyanidins-rich bioflavonoid extract derived from the pine bark of New Zealand Pinus radiata trees, using C57BL/KsJ-db/db mice. METHODS: After 1-week acclimation period, the db/db mice were divide …
In this study, we investigated the antidiabetic effects of enzogenol, proanthocyanidins-rich bioflavonoid extract derived from the pi …
Pharmacologic Neuroprotection for Functional Outcomes After Traumatic Brain Injury: A Systematic Review of the Clinical Literature.
Gruenbaum SE, Zlotnik A, Gruenbaum BF, Hersey D, Bilotta F. Gruenbaum SE, et al. CNS Drugs. 2016 Sep;30(9):791-806. doi: 10.1007/s40263-016-0355-2. CNS Drugs. 2016. PMID: 27339615 Free PMC article. Review.
Eight of these therapies demonstrated possible neuroprotective properties and improved functional outcomes, of which five were investigated with randomized clinical trials: statins, N-acetyl cysteine (NAC), Enzogenol, Cerebrolysin, and nitric oxide synthase inhibitor (VAS2 …
Eight of these therapies demonstrated possible neuroprotective properties and improved functional outcomes, of which five were investigated …
Comparative effects of enzogenol and vitamin C supplementation versus vitamin C alone on endothelial function and biochemical markers of oxidative stress and inflammation in chronic smokers.
Young JM, Shand BI, McGregor PM, Scott RS, Frampton CM. Young JM, et al. Free Radic Res. 2006 Jan;40(1):85-94. doi: 10.1080/10715760500329788. Free Radic Res. 2006. PMID: 16298763 Clinical Trial.
Enzogenol and vitamin C resulted in a significant reduction in fibrinogen levels in heavy smokers compared with vitamin C alone (p < 0.009). ...However, Enzogenol did demonstrate additional favourable effects on protein oxidative damage and fibrinogen levels....
Enzogenol and vitamin C resulted in a significant reduction in fibrinogen levels in heavy smokers compared with vitamin C alone (p &l
Antioxidant and pro-apoptotic effects of marine-derived, multi-mineral aquamin supplemented with a pine bark extract, Enzogenol, and a green tea extract, Sunphenon.
O'Callaghan YC, Drummond E, O'Gorman DM, O'Brien NM. O'Callaghan YC, et al. J Med Food. 2013 Oct;16(10):920-6. doi: 10.1089/jmf.2012.0258. Epub 2013 Sep 28. J Med Food. 2013. PMID: 24074358
In the present study, Aquamin was supplemented with 8% Enzogenol, a pine bark extract with a high phenolic content, and 2% Sunphenon, a green tea extract that also has a high phenolic content to produce a mixed product (A:E:S). ...The biological effects of Aquamin were enh …
In the present study, Aquamin was supplemented with 8% Enzogenol, a pine bark extract with a high phenolic content, and 2% Sunphenon, …
Systematic Review of Traumatic Brain Injury and the Impact of Antioxidant Therapy on Clinical Outcomes.
Shen Q, Hiebert JB, Hartwell J, Thimmesch AR, Pierce JD. Shen Q, et al. Worldviews Evid Based Nurs. 2016 Oct;13(5):380-389. doi: 10.1111/wvn.12167. Epub 2016 May 31. Worldviews Evid Based Nurs. 2016. PMID: 27243770 Review.
FINDINGS: Critical evaluation of the six studies that met inclusion criteria suggests that antioxidant therapies such as amino acids, vitamins C and E, progesterone, N-acetylcysteine, and enzogenol may be safe and effective adjunctive therapies in adult patients with TBI. …
FINDINGS: Critical evaluation of the six studies that met inclusion criteria suggests that antioxidant therapies such as amino acids, vitami …
Pilot study on the clinical effects of dietary supplementation with Enzogenol, a flavonoid extract of pine bark and vitamin C.
Shand B, Strey C, Scott R, Morrison Z, Gieseg S. Shand B, et al. Phytother Res. 2003 May;17(5):490-4. doi: 10.1002/ptr.1181. Phytother Res. 2003. PMID: 12748985 Clinical Trial.
We carried out a 12-week pilot study on the effects of dietary supplementation with an extract of bioflavonoids prepared from the bark of Pinus radiata trees [Enzogenol] containing added vitamin C. ...The findings of this pilot study indicate that dietary supplementation w …
We carried out a 12-week pilot study on the effects of dietary supplementation with an extract of bioflavonoids prepared from the bark of Pi …
Improved cognitive performance after dietary supplementation with a Pinus radiata bark extract formulation.
Pipingas A, Silberstein RB, Vitetta L, Rooy CV, Harris EV, Young JM, Frampton CM, Sali A, Nastasi J. Pipingas A, et al. Phytother Res. 2008 Sep;22(9):1168-74. doi: 10.1002/ptr.2388. Phytother Res. 2008. PMID: 18683195 Clinical Trial.
The speed of response for the spatial working memory and immediate recognition tasks improved after supplementation with Enzogenol plus vitamin C, whereas vitamin C alone showed no improvements. A trend in a reduction of systolic blood pressure was observed with Enzogen
The speed of response for the spatial working memory and immediate recognition tasks improved after supplementation with Enzogenol pl …
Utilization of flavonoid compounds from bark and wood: a review.
Yazaki Y. Yazaki Y. Nat Prod Commun. 2015 Mar;10(3):513-20. Nat Prod Commun. 2015. PMID: 25924541 Review.
The background and the development of Pycnogenol and the basic difference in the preparation processes between Pycnogenol and Enzogenol are described. On the basis of the discovery that the SOSA value for wattle tannin is approximately 10 times that of extracts from pine b …
The background and the development of Pycnogenol and the basic difference in the preparation processes between Pycnogenol and Enzogenol
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