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Year Number of Results
1945 1
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1947 3
1948 1
1950 1
1951 2
1952 3
1953 9
1954 8
1955 4
1956 8
1957 2
1958 6
1960 6
1961 18
1962 23
1963 13
1964 26
1965 21
1966 19
1967 18
1968 22
1969 28
1970 31
1971 37
1972 61
1973 59
1974 122
1975 387
1976 475
1977 635
1978 724
1979 968
1980 1144
1981 1353
1982 1698
1983 2125
1984 2494
1985 2550
1986 2643
1987 2982
1988 3531
1989 4281
1990 4616
1991 4863
1992 4440
1993 3473
1994 3266
1995 3303
1996 3091
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1998 2946
1999 3218
2000 3932
2001 4476
2002 4433
2003 4877
2004 5141
2005 4915
2006 4087
2007 3950
2008 3875
2009 3346
2010 3520
2011 4253
2012 4321
2013 3786
2014 3630
2015 3589
2016 3502
2017 3347
2018 3309
2019 3455
2020 3403
2021 3333
2022 2985
2023 2679
2024 3088
2025 3263
2026 1263

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155,572 results

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Page 1
Control of Viral Latency by Episome Maintenance Proteins.
De Leo A, Calderon A, Lieberman PM. De Leo A, et al. Trends Microbiol. 2020 Feb;28(2):150-162. doi: 10.1016/j.tim.2019.09.002. Epub 2019 Oct 14. Trends Microbiol. 2020. PMID: 31624007 Free PMC article. Review.
Episome maintenance requires epigenetic programming to ensure the proper control of viral gene expression, DNA replication, and genome copy number. For these viruses, episome maintenance requires a dedicated virus-encoded episome maintenance protein (EMP), na …
Episome maintenance requires epigenetic programming to ensure the proper control of viral gene expression, DNA replication, and genom …
Episome-Based Gene Expression Modulation Platform in the Model Diatom Phaeodactylum tricornutum.
Kassaw TK, Paton AJ, Peers G. Kassaw TK, et al. ACS Synth Biol. 2022 Jan 21;11(1):191-204. doi: 10.1021/acssynbio.1c00367. Epub 2022 Jan 11. ACS Synth Biol. 2022. PMID: 35015507
We developed a highly efficient, tunable, and reversible episome-based transcriptional control system in the model diatom alga, Phaeodactylum tricornutum. ...Addition of either chemical to transgenic strains activates transcription with a dynamic range of up to 180-fold a …
We developed a highly efficient, tunable, and reversible episome-based transcriptional control system in the model diatom alga, Phaeo …
Pore-C sequencing identifies episome-driven chromosome conformation perturbations differentiating pneumococcal epigenetic variants.
Lim TY, Horsfield ST, Troman CM, Bentley SD, Kwun MJ, Croucher NJ. Lim TY, et al. PLoS Pathog. 2025 Aug 14;21(8):e1013392. doi: 10.1371/journal.ppat.1013392. eCollection 2025 Aug. PLoS Pathog. 2025. PMID: 40811750 Free PMC article.
This was driven by copy number variation, resulting from variable excision and replication of the episomal PRCIs. However, the methods were discordant in their identification of the variant in which the PRCI was more actively replicating in both pairs. ...Therefore pneumoc …
This was driven by copy number variation, resulting from variable excision and replication of the episomal PRCIs. However, the method …
Human induced pluripotent stem cells free of vector and transgene sequences.
Yu J, Hu K, Smuga-Otto K, Tian S, Stewart R, Slukvin II, Thomson JA. Yu J, et al. Science. 2009 May 8;324(5928):797-801. doi: 10.1126/science.1172482. Epub 2009 Mar 26. Science. 2009. PMID: 19325077 Free PMC article.
We describe the derivation of human iPS cells with the use of nonintegrating episomal vectors. After removal of the episome, iPS cells completely free of vector and transgene sequences are derived that are similar to human embryonic stem (ES) cells in proliferative …
We describe the derivation of human iPS cells with the use of nonintegrating episomal vectors. After removal of the episome, i …
KSHV episome tethering sites on host chromosomes and regulation of latency-lytic switch by CHD4.
Kumar A, Lyu Y, Yanagihashi Y, Chantarasrivong C, Majerciak V, Salemi M, Wang KH, Inagaki T, Chuang F, Davis RR, Tepper CG, Nakano K, Izumiya C, Shimoda M, Nakajima KI, Merleev A, Zheng ZM, Campbell M, Izumiya Y. Kumar A, et al. Cell Rep. 2022 May 10;39(6):110788. doi: 10.1016/j.celrep.2022.110788. Cell Rep. 2022. PMID: 35545047 Free PMC article.
KSHV episomes localize with CHD4 and ADNP proteins, components of the cellular ChAHP complex. ...Viral lncRNA binding competes with CHD4 DNA binding, and KSHV reactivation sequesters CHD4 from the KSHV genome, which is also accompanied by detachment of KSHV episomes …
KSHV episomes localize with CHD4 and ADNP proteins, components of the cellular ChAHP complex. ...Viral lncRNA binding competes with C …
Episome partitioning and symmetric cell divisions: Quantifying the role of random events in the persistence of HPV infections.
Beneteau T, Selinger C, Sofonea MT, Alizon S. Beneteau T, et al. PLoS Comput Biol. 2021 Sep 7;17(9):e1009352. doi: 10.1371/journal.pcbi.1009352. eCollection 2021 Sep. PLoS Comput Biol. 2021. PMID: 34491986 Free PMC article.
We show that the random partitioning of virus episomes upon stem cell division and the occurrence of symmetric divisions dramatically affect viral persistence. ...
We show that the random partitioning of virus episomes upon stem cell division and the occurrence of symmetric divisions dramatically …
Genetic elements promote retention of extrachromosomal DNA in cancer cells.
Sankar V, Hung KL, Gnanasekar A, Wong IT, Shi Q, Kraft K, Jones MG, He BJ, Yan X, Belk JA, Liu KJ, Agarwal S, Wang SK, Henssen AG, Mischel PS, Chang HY. Sankar V, et al. Nature. 2026 Jan;649(8095):152-160. doi: 10.1038/s41586-025-09764-8. Epub 2025 Nov 19. Nature. 2026. PMID: 41261124 Free PMC article.
Here we identify a family of human genomic elements, termed retention elements, that tether episomes to mitotic chromosomes to increase ecDNA transmission to daughter cells. Using Retain-seq, a genome-scale assay that we developed, we reveal thousands of human retention el …
Here we identify a family of human genomic elements, termed retention elements, that tether episomes to mitotic chromosomes to increa …
Kaposi's Sarcoma-Associated Herpesvirus LANA-Adjacent Regions with Distinct Functions in Episome Segregation or Maintenance.
Juillard F, De León Vázquez E, Tan M, Li S, Kaye KM. Juillard F, et al. J Virol. 2019 Mar 5;93(6):e02158-18. doi: 10.1128/JVI.02158-18. Print 2019 Mar 15. J Virol. 2019. PMID: 30626680 Free PMC article.
Although amino- and carboxy-terminal LANA are essential for episome persistence, they are not sufficient, since deletion of all internal LANA sequence renders LANA highly deficient for episome maintenance. ...Therefore, this work identifies adjacent LANA regions wit …
Although amino- and carboxy-terminal LANA are essential for episome persistence, they are not sufficient, since deletion of all inter …
Epstein-Barr Virus Episome Physically Interacts with Active Regions of the Host Genome in Lymphoblastoid Cells.
Wang L, Laing J, Yan B, Zhou H, Ke L, Wang C, Narita Y, Zhang Z, Olson MR, Afzali B, Zhao B, Kazemian M. Wang L, et al. J Virol. 2020 Nov 23;94(24):e01390-20. doi: 10.1128/JVI.01390-20. Print 2020 Nov 23. J Virol. 2020. PMID: 32999023 Free PMC article.
The Epstein-Barr virus (EBV) episome is known to interact with the three-dimensional structure of the human genome in infected cells. ...EBV genomes are maintained by EBNA1, which tethers EBV episomes to the host chromosomes during mitosis. However, little is known …
The Epstein-Barr virus (EBV) episome is known to interact with the three-dimensional structure of the human genome in infected cells. …
Multiple pathways for Epstein-Barr virus episome loss from nasopharyngeal carcinoma.
Dittmer DP, Hilscher CJ, Gulley ML, Yang EV, Chen M, Glaser R. Dittmer DP, et al. Int J Cancer. 2008 Nov 1;123(9):2105-12. doi: 10.1002/ijc.23685. Int J Cancer. 2008. PMID: 18688856 Free PMC article.
Epstein-Barr virus (EBV) is the prototypical example for episomal persistence of genetic information. Yet, little is known about how this viral episome is lost. ...Using whole-genome profiling, we found evidence for 2 different pathways of episome loss: (i) r …
Epstein-Barr virus (EBV) is the prototypical example for episomal persistence of genetic information. Yet, little is known about how …
155,572 results
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