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AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism.
Khavinson V, Diomede F, Mironova E, Linkova N, Trofimova S, Trubiani O, Caputi S, Sinjari B. Khavinson V, et al. Molecules. 2020 Jan 30;25(3):609. doi: 10.3390/molecules25030609. Molecules. 2020. PMID: 32019204 Free PMC article.
It was shown that AEDG peptide (Ala-Glu-Asp-Gly, Epitalon) regulates the function of the pineal gland, the retina, and the brain. ...
It was shown that AEDG peptide (Ala-Glu-Asp-Gly, Epitalon) regulates the function of the pineal gland, the retina, and the brain. ...
Epitalon and colon carcinogenesis in rats: proliferative activity and apoptosis in colon tumors and mucosa.
Kossoy G, Zandbank J, Tendler E, Anisimov V, Khavinson V, Popovich I, Zabezhinski M, Zusman I, Ben-Hur H. Kossoy G, et al. Int J Mol Med. 2003 Oct;12(4):473-7. Int J Mol Med. 2003. PMID: 12964022
Rats in group 3 were treated with Epitalon after termination of the carcinogen injections. Rats in group 4 were treated with Epitalon only during the period of DMH exposure (for the first 5 weeks of the experiment). ...Mitotic activity of tumor cells was significant …
Rats in group 3 were treated with Epitalon after termination of the carcinogen injections. Rats in group 4 were treated with Epita
Effects of intranasal administration of epitalon on neuron activity in the rat neocortex.
Sibarov DA, Vol'nova AB, Frolov DS, Nozdrachev AD. Sibarov DA, et al. Neurosci Behav Physiol. 2007 Nov;37(9):889-93. doi: 10.1007/s11055-007-0095-3. Neurosci Behav Physiol. 2007. PMID: 17955380
This report discusses the properties of the synthetic tetrapeptide epitalon (Ala-Glu-Asp-Gly), synthesized on the basis of an epiphyseal peptide extract. Intranasal administration of epitalon was selected as a noninvasive means of applying the agent to the CNS by by …
This report discusses the properties of the synthetic tetrapeptide epitalon (Ala-Glu-Asp-Gly), synthesized on the basis of an epiphys …
Inhibitory effect of the peptide epitalon on the development of spontaneous mammary tumors in HER-2/neu transgenic mice.
Anisimov VN, Khavinson VK, Provinciali M, Alimova IN, Baturin DA, Popovich IG, Zabezhinski MA, Imyanitov EN, Mancini R, Franceschi C. Anisimov VN, et al. Int J Cancer. 2002 Sep 1;101(1):7-10. doi: 10.1002/ijc.10570. Int J Cancer. 2002. PMID: 12209581 Free article.
Epitalon treatment reduced the cumulative number and the maximum size of tumors (p < 0.05). ...A 3.7-fold reduction in the expression of HER-2/neu mRNA was found in mammary tumors from HER-2/neu transgenic mice treated with Epitalon compared to control animals. T
Epitalon treatment reduced the cumulative number and the maximum size of tumors (p < 0.05). ...A 3.7-fold reduction in the express
Effect of the synthetic pineal peptide epitalon on spontaneous carcinogenesis in female C3H/He mice.
Kossoy G, Anisimov VN, Ben-Hur H, Kossoy N, Zusman I. Kossoy G, et al. In Vivo. 2006 Mar-Apr;20(2):253-7. In Vivo. 2006. PMID: 16634527 Free article.
One-year-old female C3H/He mice were kept for 6.5 months under standard conditions. Epitalon was injected at a dose of 0.1 microg, 5 times a week. Long-term exposure to Epitalon in small doses did not show any toxic effect. ...These data highlight the antimetastatic …
One-year-old female C3H/He mice were kept for 6.5 months under standard conditions. Epitalon was injected at a dose of 0.1 microg, 5 …
Inhibitory effect of peptide Epitalon on colon carcinogenesis induced by 1,2-dimethylhydrazine in rats.
Anisimov VN, Khavinson VKh, Popovich IG, Zabezhinski MA. Anisimov VN, et al. Cancer Lett. 2002 Sep 8;183(1):1-8. doi: 10.1016/s0304-3835(02)00090-3. Cancer Lett. 2002. PMID: 12049808
The effect of synthetic pineal peptide Epitalon (Ala-Glu-Asp-Gly) on colon carcinogenesis was firstly studied in rats. ...A trend to decrease the number of tumors in the rectum in rats from groups 2, 3 and 4, treated with Epitalon was found. Epitalon inhibite …
The effect of synthetic pineal peptide Epitalon (Ala-Glu-Asp-Gly) on colon carcinogenesis was firstly studied in rats. ...A trend to …
Effect of epitalon on the lifespan increase in Drosophila melanogaster.
Khavinson VK, Izmaylov DM, Obukhova LK, Malinin VV. Khavinson VK, et al. Mech Ageing Dev. 2000 Dec 1;120(1-3):141-9. doi: 10.1016/s0047-6374(00)00217-7. Mech Ageing Dev. 2000. PMID: 11087911
The geroprotector activity of epitalon, a synthetic tetrapeptide Ala-Glu-Asp-Gly, was studied on the Drosophila melanogaster wild strain Canton-S. ...The possible mechanisms of the antioxidant and regulatory effects of epitalon are discussed....
The geroprotector activity of epitalon, a synthetic tetrapeptide Ala-Glu-Asp-Gly, was studied on the Drosophila melanogaster wild str …
Pineal-regulating tetrapeptide epitalon improves eye retina condition in retinitis pigmentosa.
Khavinson V, Razumovsky M, Trofimova S, Grigorian R, Razumovskaya A. Khavinson V, et al. Neuro Endocrinol Lett. 2002 Aug;23(4):365-8. Neuro Endocrinol Lett. 2002. PMID: 12195242 Clinical Trial.
We have studied the effect of tetrapeptide Epitalon (Ala-Glu-Asp-Gly) on the course of congenital pigmented degeneration of the retina. ...Epitalon therapy in patients with degenerative retinal lesions results in a positive clinical effect in 90% of the cases. ...
We have studied the effect of tetrapeptide Epitalon (Ala-Glu-Asp-Gly) on the course of congenital pigmented degeneration of the retin …
Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice.
Anisimov VN, Khavinson VKh, Popovich IG, Zabezhinski MA, Alimova IN, Rosenfeld SV, Zavarzina NY, Semenchenko AV, Yashin AI. Anisimov VN, et al. Biogerontology. 2003;4(4):193-202. doi: 10.1023/a:1025114230714. Biogerontology. 2003. PMID: 14501183
The results of this study show that treatment with Epitalon did not influence food consumption, body weight or mean life span of mice. ...The data obtained suggest a geroprotector activity of Epitalon and the safety of its long-term administration in mice....
The results of this study show that treatment with Epitalon did not influence food consumption, body weight or mean life span of mice …
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