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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2000 5
2001 11
2002 20
2003 13
2004 9
2005 4
2006 8
2007 10
2008 9
2009 2
2010 2
2011 7
2012 4
2013 5
2014 4
2015 2
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125 results

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Page 1
Epitalon protects against post-ovulatory aging-related damage of mouse oocytes in vitro.
Yue X, Liu SL, Guo JN, Meng TG, Zhang XR, Li HX, Song CY, Wang ZB, Schatten H, Sun QY, Guo XP. Yue X, et al. Aging (Albany NY). 2022 Apr 12;14(7):3191-3202. doi: 10.18632/aging.204007. Epub 2022 Apr 12. Aging (Albany NY). 2022. PMID: 35413689 Free PMC article.
It is a potent antioxidant, comparable to melatonin, that may confer longevity benefits. The current study aims to test the protective effects of Epitalon on the quality of post-ovulatory aging oocytes. Epitalon at 0.1mM was added to the culture medium, and the qual …
It is a potent antioxidant, comparable to melatonin, that may confer longevity benefits. The current study aims to test the protective effec …
Epitalon and colon carcinogenesis in rats: proliferative activity and apoptosis in colon tumors and mucosa.
Kossoy G, Zandbank J, Tendler E, Anisimov V, Khavinson V, Popovich I, Zabezhinski M, Zusman I, Ben-Hur H. Kossoy G, et al. Int J Mol Med. 2003 Oct;12(4):473-7. Int J Mol Med. 2003. PMID: 12964022
Rats in group 3 were treated with Epitalon after termination of the carcinogen injections. Rats in group 4 were treated with Epitalon only during the period of DMH exposure (for the first 5 weeks of the experiment). ...Mitotic activity of tumor cells was significant …
Rats in group 3 were treated with Epitalon after termination of the carcinogen injections. Rats in group 4 were treated with Epita
Epitalon influences pineal secretion in stress-exposed rats in the daytime.
Sibarov DA, Kovalenko RI, Malinin VV, Khavinson VKh. Sibarov DA, et al. Neuro Endocrinol Lett. 2002 Oct-Dec;23(5-6):452-4. Neuro Endocrinol Lett. 2002. PMID: 12500171
The dilation of capillaries and pericapillary space induced by an osmotic stress was partially reduced by the intranasal infusions of Epitalon. CONCLUSIONS: Tetrapeptide Epitalon is synthesised on the basis of the amino acid composition of pineal peptide extract Epi …
The dilation of capillaries and pericapillary space induced by an osmotic stress was partially reduced by the intranasal infusions of Epi
Peptides and Ageing.
Khavinson VKh. Khavinson VKh. Neuro Endocrinol Lett. 2002;23 Suppl 3:11-144. Neuro Endocrinol Lett. 2002. PMID: 12374906 Review.
Epitalon reproduces the effects of Epithalamin including those related to its geroprotector activity. In particular, Epitalon increases the lifespan of mice and fruit flies and restores the circadian rhythms of melatonin and cortisol production in old rhesus monkeys
Epitalon reproduces the effects of Epithalamin including those related to its geroprotector activity. In particular, Epitalon
AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism.
Khavinson V, Diomede F, Mironova E, Linkova N, Trofimova S, Trubiani O, Caputi S, Sinjari B. Khavinson V, et al. Molecules. 2020 Jan 30;25(3):609. doi: 10.3390/molecules25030609. Molecules. 2020. PMID: 32019204 Free PMC article.
It was shown that AEDG peptide (Ala-Glu-Asp-Gly, Epitalon) regulates the function of the pineal gland, the retina, and the brain. ...
It was shown that AEDG peptide (Ala-Glu-Asp-Gly, Epitalon) regulates the function of the pineal gland, the retina, and the brain. ...
Effect of epitalon on the lifespan increase in Drosophila melanogaster.
Khavinson VK, Izmaylov DM, Obukhova LK, Malinin VV. Khavinson VK, et al. Mech Ageing Dev. 2000 Dec 1;120(1-3):141-9. doi: 10.1016/s0047-6374(00)00217-7. Mech Ageing Dev. 2000. PMID: 11087911
The geroprotector activity of epitalon, a synthetic tetrapeptide Ala-Glu-Asp-Gly, was studied on the Drosophila melanogaster wild strain Canton-S. ...The possible mechanisms of the antioxidant and regulatory effects of epitalon are discussed....
The geroprotector activity of epitalon, a synthetic tetrapeptide Ala-Glu-Asp-Gly, was studied on the Drosophila melanogaster wild str …
Inhibitory effect of peptide Epitalon on colon carcinogenesis induced by 1,2-dimethylhydrazine in rats.
Anisimov VN, Khavinson VKh, Popovich IG, Zabezhinski MA. Anisimov VN, et al. Cancer Lett. 2002 Sep 8;183(1):1-8. doi: 10.1016/s0304-3835(02)00090-3. Cancer Lett. 2002. PMID: 12049808
The effect of synthetic pineal peptide Epitalon (Ala-Glu-Asp-Gly) on colon carcinogenesis was firstly studied in rats. ...A trend to decrease the number of tumors in the rectum in rats from groups 2, 3 and 4, treated with Epitalon was found. Epitalon inhibite …
The effect of synthetic pineal peptide Epitalon (Ala-Glu-Asp-Gly) on colon carcinogenesis was firstly studied in rats. ...A trend to …
Effect of the synthetic pineal peptide epitalon on spontaneous carcinogenesis in female C3H/He mice.
Kossoy G, Anisimov VN, Ben-Hur H, Kossoy N, Zusman I. Kossoy G, et al. In Vivo. 2006 Mar-Apr;20(2):253-7. In Vivo. 2006. PMID: 16634527 Free article.
One-year-old female C3H/He mice were kept for 6.5 months under standard conditions. Epitalon was injected at a dose of 0.1 microg, 5 times a week. Long-term exposure to Epitalon in small doses did not show any toxic effect. ...These data highlight the antimetastatic …
One-year-old female C3H/He mice were kept for 6.5 months under standard conditions. Epitalon was injected at a dose of 0.1 microg, 5 …
Effects of intranasal administration of epitalon on neuron activity in the rat neocortex.
Sibarov DA, Vol'nova AB, Frolov DS, Nozdrachev AD. Sibarov DA, et al. Neurosci Behav Physiol. 2007 Nov;37(9):889-93. doi: 10.1007/s11055-007-0095-3. Neurosci Behav Physiol. 2007. PMID: 17955380
This report discusses the properties of the synthetic tetrapeptide epitalon (Ala-Glu-Asp-Gly), synthesized on the basis of an epiphyseal peptide extract. Intranasal administration of epitalon was selected as a noninvasive means of applying the agent to the CNS by by …
This report discusses the properties of the synthetic tetrapeptide epitalon (Ala-Glu-Asp-Gly), synthesized on the basis of an epiphys …
Pineal-regulating tetrapeptide epitalon improves eye retina condition in retinitis pigmentosa.
Khavinson V, Razumovsky M, Trofimova S, Grigorian R, Razumovskaya A. Khavinson V, et al. Neuro Endocrinol Lett. 2002 Aug;23(4):365-8. Neuro Endocrinol Lett. 2002. PMID: 12195242 Clinical Trial.
We have studied the effect of tetrapeptide Epitalon (Ala-Glu-Asp-Gly) on the course of congenital pigmented degeneration of the retina. ...Epitalon therapy in patients with degenerative retinal lesions results in a positive clinical effect in 90% of the cases. ...
We have studied the effect of tetrapeptide Epitalon (Ala-Glu-Asp-Gly) on the course of congenital pigmented degeneration of the retin …
125 results