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Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties.
Araj SK, Brzezik J, Mądra-Gackowska K, Szeleszczuk Ł. Araj SK, et al. Int J Mol Sci. 2025 Mar 17;26(6):2691. doi: 10.3390/ijms26062691. Int J Mol Sci. 2025. PMID: 40141333 Free PMC article. Review.
Although it has been demonstrated that Epitalon exerts, among other effects, a direct influence on melatonin synthesis, alters the mRNA levels of interleukin-2, modulates the mitogenic activity of murine thymocytes, and enhances the activity of various enzymes, including A …
Although it has been demonstrated that Epitalon exerts, among other effects, a direct influence on melatonin synthesis, alters the mR …
Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity.
Al-Dulaimi S, Thomas R, Matta S, Roberts T. Al-Dulaimi S, et al. Biogerontology. 2025 Sep 4;26(5):178. doi: 10.1007/s10522-025-10315-x. Biogerontology. 2025. PMID: 40908429 Free PMC article.
Epitalon, a naturally occurring tetrapeptide, is known for its anti-aging effects on mammalian cells. ...Only a minor increase in ALT activity was observed in Normal cells, thereby showing that it was specific to cancer cells. Our data suggests that epitalon can ext …
Epitalon, a naturally occurring tetrapeptide, is known for its anti-aging effects on mammalian cells. ...Only a minor increase in ALT …
Epitalon-activated telomerase enhance bovine oocyte maturation rate and post-thawed embryo development.
Ullah S, Haider Z, Perera CD, Lee SH, Idrees M, Park S, Kong IK. Ullah S, et al. Life Sci. 2025 Feb 1;362:123381. doi: 10.1016/j.lfs.2025.123381. Epub 2025 Jan 7. Life Sci. 2025. PMID: 39788414

Furthermore, telomerase activity was significantly compromised in post-thawed embryos, and Epitalon treatment significantly improved blastocyst hatching rate and implantation potential (p < 0.05). ...Our results suggest that telomerase activation via Ep

…
Furthermore, telomerase activity was significantly compromised in post-thawed embryos, and Epitalon treatment significantly im …
Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells.
Khavinson VKh, Bondarev IE, Butyugov AA. Khavinson VKh, et al. Bull Exp Biol Med. 2003 Jun;135(6):590-2. doi: 10.1023/a:1025493705728. Bull Exp Biol Med. 2003. PMID: 12937682
Addition of Epithalon peptide in telomerase-negative human fetal fibroblast culture induced expression of the catalytical subunit, enzymatic activity of telomerase, and telomere elongation, which can be due to reactivation of telomerase gene in somatic cells …
Addition of Epithalon peptide in telomerase-negative human fetal fibroblast culture induced expression of the catalytical subunit, en …
Effect of regulatory peptides on gene transcription.
Khavinson VKh, Shataeva LK, Chernova AA. Khavinson VKh, et al. Bull Exp Biol Med. 2003 Sep;136(3):288-90. doi: 10.1023/b:bebm.0000008986.02891.de. Bull Exp Biol Med. 2003. PMID: 14666197
Sequences of nucleotide pairs that can serve as binding sites for tetrapeptide Epithalon were identified in the promoter regions of retinal genes F379, telomerase, and RNA polymerase II....
Sequences of nucleotide pairs that can serve as binding sites for tetrapeptide Epithalon were identified in the promoter regions of retinal …
Peptide promotes overcoming of the division limit in human somatic cell.
Khavinson VKh, Bondarev IE, Butyugov AA, Smirnova TD. Khavinson VKh, et al. Bull Exp Biol Med. 2004 May;137(5):503-6. doi: 10.1023/b:bebm.0000038164.49947.8c. Bull Exp Biol Med. 2004. PMID: 15455129
We previously showed that treatment of normal human diploid cells with Epithalon (Ala-Glu-Asp-Gly) induced expression of telomerase catalytic subunit, its enzymatic activity, and elongation of telomeres. Here we studied the effect of this peptide on proliferative potential …
We previously showed that treatment of normal human diploid cells with Epithalon (Ala-Glu-Asp-Gly) induced expression of telomerase c …
DNA double-helix binds regulatory peptides similarly to transcription factors.
Khavinson V, Shataeva L, Chernova A. Khavinson V, et al. Neuro Endocrinol Lett. 2005 Jun;26(3):237-41. Neuro Endocrinol Lett. 2005. PMID: 15990728
We have used complementary binding model to find a possible base pair sequence ATTTTC for specific binding of synthetic tetrapeptide epitalon. This base pair block and its reverse complement were found repeatedly in the promoter region of telomerase. ...
We have used complementary binding model to find a possible base pair sequence ATTTTC for specific binding of synthetic tetrapeptide epit …