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2000 6
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2002 19
2003 14
2004 11
2005 4
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2007 10
2008 8
2009 2
2010 1
2011 7
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2013 5
2014 3
2015 2
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Epithalon decelerates aging and suppresses development of breast adenocarcinomas in transgenic her-2/neu mice.
Anisimov VN, Khavinson VKh, Alimova IN, Semchenko AV, Yashin AI. Anisimov VN, et al. Bull Exp Biol Med. 2002 Aug;134(2):187-90. doi: 10.1023/a:1021104819170. Bull Exp Biol Med. 2002. PMID: 12459848
Epithalon prolonged the average and maximum lifetimes of mice by 13.5 (p<0.05) and 13.9%, respectively. ...Epithalon prolonged the lifetime of mice with breast tumors by 1.4 times (p<0.05). ...
Epithalon prolonged the average and maximum lifetimes of mice by 13.5 (p<0.05) and 13.9%, respectively. ...Epithalon prolon
Epithalon inhibits tumor growth and expression of HER-2/neu oncogene in breast tumors in transgenic mice characterized by accelerated aging.
Anisimov VN, Khavinsov VKh, Alimova IN, Provintsiali M, Manchini R, Francheski K. Anisimov VN, et al. Bull Exp Biol Med. 2002 Feb;133(2):167-70. doi: 10.1023/a:1015555023692. Bull Exp Biol Med. 2002. PMID: 12428286
Epithalon markedly inhibited neoplasm development: the maximum size of breast adenocarcinomas was 33% lower than in the control (p < 0.05). The intensity of HER-2/neu mRNA expression in breast tumors of Epithalon-treated mice was 3.7 times lower than in control a
Epithalon markedly inhibited neoplasm development: the maximum size of breast adenocarcinomas was 33% lower than in the control (p &l
Studies of the effects of Vilon and Epithalon on gene expression in mouse heart using DNA-microarray technology.
Anisimov SV, Bokheler KR, Khavinson VKh, Anisimov VN. Anisimov SV, et al. Bull Exp Biol Med. 2002 Mar;133(3):293-9. doi: 10.1023/a:1015859322630. Bull Exp Biol Med. 2002. PMID: 12360356
Vilon changed expression of 36 clones, while Epithalon modulated expression of 98 clones. Combined treatment with Vilon and Epithalon changed expression of 144 clones. ...Our results demonstrate the specific effects of Epithalon and Vilon on gene expression.. …
Vilon changed expression of 36 clones, while Epithalon modulated expression of 98 clones. Combined treatment with Vilon and Epitha
Effect of epithalon on age-specific changes in the retina in rats with hereditary pigmentary dystrophy.
Khavinson VKh, Razumovskii MI, Trofimova SV, Grigor'yan RA, Chaban TV, Oleinik TL, Razumovskaya AM. Khavinson VKh, et al. Bull Exp Biol Med. 2002 Jan;133(1):87-9. doi: 10.1023/a:1015125031829. Bull Exp Biol Med. 2002. PMID: 12170316
The effect of peptide bioregulator Epithalon on the course of hereditary pigmentary retinal degeneration was studied in Campbell rats. Administration of epithalon starting from birth protected morphological structure, increased its bioelectrical activity, and improv …
The effect of peptide bioregulator Epithalon on the course of hereditary pigmentary retinal degeneration was studied in Campbell rats …
Regulatory effect of Epithalon on production of melatonin and cortisol in old monkeys.
Goncharova ND, Khavinson BK, Lapin BA. Goncharova ND, et al. Bull Exp Biol Med. 2001 Apr;131(4):394-6. doi: 10.1023/a:1017928925177. Bull Exp Biol Med. 2001. PMID: 11550036
The effect of Epithalon on melatonin and cortisol secretion in female rhesus monkeys of various ages was evaluated by enzyme immunoassay. Epithalon stimulated evening melatonin production and normalized circadian rhythms of cortisol production in old monkeys....
The effect of Epithalon on melatonin and cortisol secretion in female rhesus monkeys of various ages was evaluated by enzyme immunoas …
Effect of epithalon on the incidence of chromosome aberrations in senescence-accelerated mice.
Rosenfeld SV, Togo EF, Mikheev VS, Popovich IG, Khavinson VKh, Anisimov VN. Rosenfeld SV, et al. Bull Exp Biol Med. 2002 Mar;133(3):274-6. doi: 10.1023/a:1015899003974. Bull Exp Biol Med. 2002. PMID: 12360351
The incidence of chromosome aberrations in bone marrow cells of 12-month-old SAMP-1 female mice characterized by accelerated aging was 1.8 times higher than in wild-type SAMR-1 females and 2.2 times higher than in SHR females of the same age. Treatment with Epithalon (Ala- …
The incidence of chromosome aberrations in bone marrow cells of 12-month-old SAMP-1 female mice characterized by accelerated aging was 1.8 t …
Immunohistochemical and morphometric analysis of effects of vilon and epithalon on functional morphology of radiosensitive organs.
Khavinson VK, Yuzhakov VV, Kvetnoi IM, Malinin VV, Popuchiev VV, Fomina NK. Khavinson VK, et al. Bull Exp Biol Med. 2001 Mar;131(3):285-92. doi: 10.1023/a:1017676104877. Bull Exp Biol Med. 2001. PMID: 11427924
Studies of the effects of vilon and epithalon on functional morphology of the thymus, spleen, and duodenum in intact rats and rats exposed to single whole-body gamma-irradiation in a dose of 6 Gy showed that vilon stimulated proliferative activity of thymocytes and enhance …
Studies of the effects of vilon and epithalon on functional morphology of the thymus, spleen, and duodenum in intact rats and rats ex …
Effects of epithalon on activities gastrointestinal enzymes in young and old rats.
Khavinson VKh, Malinin VV, Timofeeva NM, Egorova VV, Nikitina AA. Khavinson VKh, et al. Bull Exp Biol Med. 2002 Mar;133(3):290-2. doi: 10.1023/a:1015807305791. Bull Exp Biol Med. 2002. PMID: 12360355
Peroral administration of Epithalon (Ala-Glu-Asp-Gly) to male and female Wistar rats aging 3 and 11 months changed activity of enzymes hydrolyzing carbohydrates, proteins, and phosphoric acid esters in various portions of the gastrointestinal tract. ...This effect diminish …
Peroral administration of Epithalon (Ala-Glu-Asp-Gly) to male and female Wistar rats aging 3 and 11 months changed activity of enzyme …
Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells.
Khavinson VKh, Bondarev IE, Butyugov AA. Khavinson VKh, et al. Bull Exp Biol Med. 2003 Jun;135(6):590-2. doi: 10.1023/a:1025493705728. Bull Exp Biol Med. 2003. PMID: 12937682
Addition of Epithalon peptide in telomerase-negative human fetal fibroblast culture induced expression of the catalytical subunit, enzymatic activity of telomerase, and telomere elongation, which can be due to reactivation of telomerase gene in somatic cells and indicates …
Addition of Epithalon peptide in telomerase-negative human fetal fibroblast culture induced expression of the catalytical subunit, en …
Modulating effects of epithalamin and epithalon on the functional morphology of the spleen in old pinealectomized rats.
Khavinson VK, Konovalov SS, Yuzhakov VV, Popuchiev VV, Kvetnoi IM. Khavinson VK, et al. Bull Exp Biol Med. 2001 Nov;132(5):1116-20. doi: 10.1023/a:1017989113287. Bull Exp Biol Med. 2001. PMID: 11865335
Immunohistochemical and morphometric analysis showed that epithalamin and epithalon produced similar effects on the functional morphology of the spleen in pinealectomized rats. ...These findings confirm the data on functional relationships between the pineal gland and immu …
Immunohistochemical and morphometric analysis showed that epithalamin and epithalon produced similar effects on the functional morpho …
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