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405 results

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Page 1
An antibiotic preorganized for ribosomal binding overcomes antimicrobial resistance.
Wu KJY, Tresco BIC, Ramkissoon A, Aleksandrova EV, Syroegin EA, See DNY, Liow P, Dittemore GA, Yu M, Testolin G, Mitcheltree MJ, Liu RY, Svetlov MS, Polikanov YS, Myers AG. Wu KJY, et al. Science. 2024 Feb 16;383(6684):721-726. doi: 10.1126/science.adk8013. Epub 2024 Feb 15. Science. 2024. PMID: 38359125 Free PMC article.
We report the design conception, chemical synthesis, and microbiological evaluation of the bridged macrobicyclic antibiotic cresomycin (CRM), which overcomes evolutionarily diverse forms of antimicrobial resistance that render modern antibiotics ineffective. ...Last …
We report the design conception, chemical synthesis, and microbiological evaluation of the bridged macrobicyclic antibiotic cresomyci …
Cyclophostin and Cyclipostins analogues counteract macrolide-induced resistance mediated by erm(41) in Mycobacterium abscessus.
Sarrazin M, Poncin I, Fourquet P, Audebert S, Camoin L, Denis Y, Santucci P, Spilling CD, Kremer L, Le Moigne V, Herrmann JL, Cavalier JF, Canaan S. Sarrazin M, et al. J Biomed Sci. 2024 Dec 3;31(1):103. doi: 10.1186/s12929-024-01091-w. J Biomed Sci. 2024. PMID: 39623375 Free PMC article.
However, prolonged exposure to these macrolides can induce of Erm(41)-mediated resistance, limiting their spectrum of activity and leading to therapeutic failure. Therefore, inhibiting Erm(41) could thwart this resistance mechanism to maintain macrolid …
However, prolonged exposure to these macrolides can induce of Erm(41)-mediated resistance, limiting their spectrum of activity …
Emergence of Inducible Macrolide Resistance in Mycobacterium chelonae Due to Broad-Host-Range Plasmid and Chromosomal Variants of the Novel 23S rRNA Methylase Gene, erm(55).
Brown-Elliott BA, Wallace RJ Jr, Wengenack NL, Workman SD, Cameron ADS, Bush G, Hughes MD, Melton S, Gonzalez-Ramirez B, Rodriguez E, Somayaji K, Klapperich C, Viers M, Bolaji AJ, Rempel E, Alexander DC. Brown-Elliott BA, et al. J Clin Microbiol. 2023 Jul 20;61(7):e0042823. doi: 10.1128/jcm.00428-23. Epub 2023 Jun 22. J Clin Microbiol. 2023. PMID: 37347171 Free PMC article.
Among rapidly growing mycobacteria (RGM), inducible macrolide resistance is associated with four chromosomal 23S rRNA methylase (erm) genes. Beginning in 2018, we detected high-level inducible clarithromycin resistance (MICs of 16mug/mL) in clinical is …
Among rapidly growing mycobacteria (RGM), inducible macrolide resistance is associated with four chromosomal 23S rRNA methylase …
Analysis of virulence factors and antibiotic resistance genes in group B streptococcus from clinical samples.
Mudzana R, Mavenyengwa RT, Gudza-Mugabe M. Mudzana R, et al. BMC Infect Dis. 2021 Jan 28;21(1):125. doi: 10.1186/s12879-021-05820-6. BMC Infect Dis. 2021. PMID: 33509097 Free PMC article.
This study was carried out to identify antibiotic resistance and virulence genes associated with GBS isolated from pregnant women. ...Antibiotic resistance genes among the resistant and intermediate-resistant isolates showed high frequencies for tetM 9 …
This study was carried out to identify antibiotic resistance and virulence genes associated with GBS isolated from pregnant wo …
Erm(X)-mediated resistance to macrolides, lincosamides and streptogramins in Actinobaculum schaalii.
Hays C, Lienhard R, Auzou M, Barraud O, Guérin F, Ploy MC, Cattoir V. Hays C, et al. J Antimicrob Chemother. 2014 Aug;69(8):2056-60. doi: 10.1093/jac/dku099. Epub 2014 Apr 7. J Antimicrob Chemother. 2014. PMID: 24710027
MICs of erythromycin, spiramycin, lincomycin, clindamycin and quinupristin/dalfopristin were determined by the agar dilution method. Resistance genes erm(A), erm(B), erm(C), erm(F), erm(G), erm(X), msr(A) and mef(A) were screened b …
MICs of erythromycin, spiramycin, lincomycin, clindamycin and quinupristin/dalfopristin were determined by the agar dilution method. Resi …
Macrolide resistance due to erm(55).
Alexander DC, Farquhar T, Adams JME, Suchan DM, Workman SD, Wallace RJ Jr, Brown-Elliott BA, El-Halfawy OM, Cameron ADS. Alexander DC, et al. Microbiol Spectr. 2025 Mar 4;13(3):e0239724. doi: 10.1128/spectrum.02397-24. Epub 2025 Jan 16. Microbiol Spectr. 2025. PMID: 39817789 Free PMC article.
The plasmid-borne erm(55)(P), the transposon-associated erm(55)(T), and the chromosomal encoded erm(55)(C) exhibit 82% amino acid sequence identity. ...We previously identified three variants of a newly predicted macrolide resistance gene, erm(5 …
The plasmid-borne erm(55)(P), the transposon-associated erm(55)(T), and the chromosomal encoded erm(55)(C) exhibit 82% …
Identification of allosteric hotspots regulating the ribosomal RNA binding by antibiotic resistance-conferring Erm methyltransferases.
Bhujbalrao R, Gavvala K, Singh RK, Singh J, Boudier C, Chakrabarti S, Patwari GN, Mély Y, Anand R. Bhujbalrao R, et al. J Biol Chem. 2022 Aug;298(8):102208. doi: 10.1016/j.jbc.2022.102208. Epub 2022 Jun 27. J Biol Chem. 2022. PMID: 35772496 Free PMC article.
Antibiotic resistance via epigenetic methylation of ribosomal RNA is one of the most prevalent strategies adopted by multidrug resistant pathogens. The erythromycin-resistance methyltransferase (Erm) methylates rRNA at the conserved A2058 position and …
Antibiotic resistance via epigenetic methylation of ribosomal RNA is one of the most prevalent strategies adopted by multidrug …
Erm(41)-dependent inducible resistance to azithromycin and clarithromycin in clinical isolates of Mycobacterium abscessus.
Maurer FP, Castelberg C, Quiblier C, Böttger EC, Somoskövi A. Maurer FP, et al. J Antimicrob Chemother. 2014 Jun;69(6):1559-63. doi: 10.1093/jac/dku007. Epub 2014 Feb 4. J Antimicrob Chemother. 2014. PMID: 24500188 Free article.
OBJECTIVES: The ribosomal methylase Erm(41) confers inducible resistance to macrolides in Mycobacterium abscessus. The aim of this work was to systematically study and compare drug susceptibility to clarithromycin and azithromycin in M. abscessus and M …
OBJECTIVES: The ribosomal methylase Erm(41) confers inducible resistance to macrolides in Mycobacterium abscessus. The …
Reduction of erythromycin resistance gene erm(F) and class 1 integron-integrase genes in wastewater by Bardenpho treatment.
Schmitz BW, Innes GK, Xue J, Gerba CP, Pepper IL, Sherchan S. Schmitz BW, et al. Water Environ Res. 2020 Jul;92(7):1042-1050. doi: 10.1002/wer.1299. Epub 2020 Feb 17. Water Environ Res. 2020. PMID: 31989707
This study investigated the removal of the erythromycin ribosome methylase class F (erm(F)) and class 1 integron-integrase (intI1) genes at each stage from two water resource recovery facilities in southern Arizona. ...Results from this study support intI1 as one su …
This study investigated the removal of the erythromycin ribosome methylase class F (erm(F)) and class 1 integron-integrase (in …
Mobile lincosamide resistance genes in staphylococci.
Feßler AT, Wang Y, Wu C, Schwarz S. Feßler AT, et al. Plasmid. 2018 Sep;99:22-31. doi: 10.1016/j.plasmid.2018.06.002. Epub 2018 Jun 19. Plasmid. 2018. PMID: 29932965 Review.
Lincosamide resistance in staphylococci is based on the expression of a number of genes which specify three major resistance mechanisms: (i) enzymatic inactivation by lincosamide nucleotidyltransferases, (ii) ribosome protection by ABC-F proteins, and (iii) methylat …
Lincosamide resistance in staphylococci is based on the expression of a number of genes which specify three major resistance m …
405 results